Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 142

1.

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators.

Keinänen TA, Grigorenko N, Khomutov AR, Huang Q, Uimari A, Alhonen L, Hyvönen MT, Vepsäläinen J.

Biosci Rep. 2018 Jul 13. pii: BSR20180527. doi: 10.1042/BSR20180527. [Epub ahead of print]

PMID:
30006473
2.

Novel non-ATP competitive small molecules targeting the CK2 α/β interface.

Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR.

Bioorg Med Chem. 2018 Jul 15;26(11):3016-3020. doi: 10.1016/j.bmc.2018.05.011. Epub 2018 May 9.

3.

Second-generation CK2α inhibitors targeting the αD pocket.

Iegre J, Brear P, De Fusco C, Yoshida M, Mitchell SL, Rossmann M, Carro L, Sore HF, Hyvönen M, Spring DR.

Chem Sci. 2018 Feb 20;9(11):3041-3049. doi: 10.1039/c7sc05122k. eCollection 2018 Mar 21.

4.

Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.

van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, Hyvönen M, Hollfelder F.

J Mol Biol. 2018 Mar 30;430(7):1004-1023. doi: 10.1016/j.jmb.2018.02.010. Epub 2018 Feb 17.

5.

Molecular characterization of latent GDF8 reveals mechanisms of activation.

Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E866-E875. doi: 10.1073/pnas.1714622115. Epub 2018 Jan 18.

PMID:
29348202
6.

Structure of the human myostatin precursor and determinants of growth factor latency.

Cotton TR, Fischer G, Wang X, McCoy JC, Czepnik M, Thompson TB, Hyvönen M.

EMBO J. 2018 Feb 1;37(3):367-383. doi: 10.15252/embj.201797883. Epub 2018 Jan 12.

PMID:
29330193
7.

Controlling of N-alkylpolyamine analogue metabolism by selective deuteration.

Ucal S, Häkkinen MR, Alanne AL, Alhonen L, Vepsäläinen J, Keinänen TA, Hyvönen MT.

Biochem J. 2018 Feb 14;475(3):663-676. doi: 10.1042/BCJ20170887.

PMID:
29301981
8.

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.

Cole DJ, Janecek M, Stokes JE, Rossmann M, Faver JC, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR, Huggins DJ, Jorgensen WL.

Chem Commun (Camb). 2017 Aug 17;53(67):9372-9375. doi: 10.1039/c7cc05379g.

9.

Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.

Xu ER, Blythe EE, Fischer G, Hyvönen M.

J Biol Chem. 2017 Jul 28;292(30):12516-12527. doi: 10.1074/jbc.M117.788992. Epub 2017 Jun 5.

PMID:
28584056
10.

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR.

Bioorg Med Chem. 2017 Jul 1;25(13):3471-3482. doi: 10.1016/j.bmc.2017.04.037. Epub 2017 Apr 30.

11.

Specific inhibition of CK2α from an anchor outside the active site.

Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M.

Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12.

12.

Development of a multipurpose scaffold for the display of peptide loops.

Rossmann M, J Greive S, Moschetti T, Dinan M, Hyvönen M.

Protein Eng Des Sel. 2017 Jun 1;30(6):419-430. doi: 10.1093/protein/gzx017.

13.

From a metagenomic source to a high-resolution structure of a novel alkaline esterase.

Pereira MR, Maester TC, Mercaldi GF, de Macedo Lemos EG, Hyvönen M, Balan A.

Appl Microbiol Biotechnol. 2017 Jun;101(12):4935-4949. doi: 10.1007/s00253-017-8226-4. Epub 2017 Mar 22.

PMID:
28331945
14.

Quantitative Affinity Determination by Fluorescence Anisotropy Measurements of Individual Nanoliter Droplets.

Gielen F, Butz M, Rees EJ, Erdelyi M, Moschetti T, Hyvönen M, Edel JB, Kaminski CF, Hollfelder F.

Anal Chem. 2017 Jan 17;89(2):1092-1101. doi: 10.1021/acs.analchem.6b02528. Epub 2017 Jan 3.

15.

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS.

J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7.

16.

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism.

Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV.

Biochem Biophys Res Commun. 2017 Feb 5;483(2):904-909. doi: 10.1016/j.bbrc.2017.01.032. Epub 2017 Jan 9.

PMID:
28082202
17.

Tailored Dual PEGylation of Inorganic Porous Nanocarriers for Extremely Long Blood Circulation in Vivo.

Nissinen T, Näkki S, Laakso H, Kučiauskas D, Kaupinis A, Kettunen MI, Liimatainen T, Hyvönen M, Valius M, Gröhn O, Lehto VP.

ACS Appl Mater Interfaces. 2016 Dec 7;8(48):32723-32731. Epub 2016 Nov 23.

PMID:
27934159
18.

Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.

Moschetti T, Sharpe T, Fischer G, Marsh ME, Ng HK, Morgan M, Scott DE, Blundell TL, R Venkitaraman A, Skidmore J, Abell C, Hyvönen M.

J Mol Biol. 2016 Nov 20;428(23):4589-4607. doi: 10.1016/j.jmb.2016.10.009. Epub 2016 Oct 8.

19.

Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer.

Thomas TJ, Thomas T, John S, Hsu HC, Yang P, Keinänen TA, Hyvönen MT.

Amino Acids. 2016 Oct;48(10):2293-302. doi: 10.1007/s00726-016-2300-6. Epub 2016 Jul 20.

PMID:
27438264
20.

ATP half-sites in RadA and RAD51 recombinases bind nucleotides.

Marsh ME, Scott DE, Ehebauer MT, Abell C, Blundell TL, Hyvönen M.

FEBS Open Bio. 2016 Apr 6;6(5):372-85. doi: 10.1002/2211-5463.12052. eCollection 2016 May.

21.

Structure and activation of pro-activin A.

Wang X, Fischer G, Hyvönen M.

Nat Commun. 2016 Jul 4;7:12052. doi: 10.1038/ncomms12052.

22.

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR.

Sci Rep. 2016 Jun 24;6:28528. doi: 10.1038/srep28528.

23.

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.

Kasbekar M, Fischer G, Mott BT, Yasgar A, Hyvönen M, Boshoff HI, Abell C, Barry CE 3rd, Thomas CJ.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7503-8. doi: 10.1073/pnas.1600630113. Epub 2016 Jun 20.

24.

Structure of Gremlin-1 and analysis of its interaction with BMP-2.

Kišonaitė M, Wang X, Hyvönen M.

Biochem J. 2016 Jun 1;473(11):1593-604. doi: 10.1042/BCJ20160254. Epub 2016 Apr 1.

25.

Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.

Hyvönen MT, Ucal S, Pasanen M, Peräniemi S, Weisell J, Khomutov M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2016 May 15;473(10):1433-41. doi: 10.1042/BCJ20160134. Epub 2016 Mar 21.

PMID:
27001865
26.

Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction.

Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M.

FEBS Lett. 2016 Apr;590(8):1094-102. doi: 10.1002/1873-3468.12139. Epub 2016 Apr 6.

27.

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR.

Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15410-3. doi: 10.1002/anie.201508416. Epub 2015 Nov 2.

28.

[Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines].

Khomutov MA, Keinanen TA, Hyvonen MT, Weisell J, Vepsalainen J, Alhonen L, Kochetkov SN, Khomutov AR.

Bioorg Khim. 2015 Sep-Oct;41(5):612-8. Russian.

PMID:
26762100
29.

Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.

Colin PY, Kintses B, Gielen F, Miton CM, Fischer G, Mohamed MF, Hyvönen M, Morgavi DP, Janssen DB, Hollfelder F.

Nat Commun. 2015 Dec 7;6:10008. doi: 10.1038/ncomms10008.

30.

Identification and Characterization of Homing Peptides Using In Vivo Peptide Phage Display.

Hyvönen M, Laakkonen P.

Methods Mol Biol. 2015;1324:205-22. doi: 10.1007/978-1-4939-2806-4_14. Review.

PMID:
26202272
31.

Early-onset diabetic E1-DN mice develop albuminuria and glomerular injury typical of diabetic nephropathy.

Hyvönen ME, Dumont V, Tienari J, Lehtonen E, Ustinov J, Havana M, Jalanko H, Otonkoski T, Miettinen PJ, Lehtonen S.

Biomed Res Int. 2015;2015:102969. doi: 10.1155/2015/102969. Epub 2015 Apr 27.

32.

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway.

Saurus P, Kuusela S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, Tienari J, Lassenius MI, Forsblom C, Lehto M, Saleem MA, Groop PH, Holthöfer H, Lehtonen S.

Cell Death Dis. 2015 May 7;6:e1752. doi: 10.1038/cddis.2015.125.

33.

Alternative modulation of protein-protein interactions by small molecules.

Fischer G, Rossmann M, Hyvönen M.

Curr Opin Biotechnol. 2015 Dec;35:78-85. doi: 10.1016/j.copbio.2015.04.006. Epub 2015 May 15. Review.

34.

Multifunctional porous silicon nanoparticles for cancer theranostics.

Wang CF, Sarparanta MP, Mäkilä EM, Hyvönen ML, Laakkonen PM, Salonen JJ, Hirvonen JT, Airaksinen AJ, Santos HA.

Biomaterials. 2015 Apr;48:108-18. doi: 10.1016/j.biomaterials.2015.01.008. Epub 2015 Feb 11.

PMID:
25701036
35.

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Hyvönen MT, Khomutov M, Petit M, Weisell J, Kochetkov SN, Alhonen L, Vepsäläinen J, Khomutov AR, Keinänen TA.

ACS Chem Biol. 2015 Jun 19;10(6):1417-24. doi: 10.1021/cb500938e. Epub 2015 Feb 27.

PMID:
25689365
36.

Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases.

Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M.

ChemMedChem. 2015 Feb;10(2):296-303. doi: 10.1002/cmdc.201402428. Epub 2014 Dec 2.

37.

Maintenance of white adipose tissue in man.

Hyvönen MT, Spalding KL.

Int J Biochem Cell Biol. 2014 Nov;56:123-32. doi: 10.1016/j.biocel.2014.09.013. Epub 2014 Sep 20. Review.

PMID:
25240584
38.

Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes.

Wasik AA, Koskelainen S, Hyvönen ME, Musante L, Lehtonen E, Koskenniemi K, Tienari J, Vaheri A, Kerjaschki D, Szalay C, Révész C, Varmanen P, Nyman TA, Hamar P, Holthöfer H, Lehtonen S.

Am J Pathol. 2014 Jun;184(6):1727-39. doi: 10.1016/j.ajpath.2014.03.002. Epub 2014 Apr 13.

PMID:
24726496
39.

Novel target for peptide-based imaging and treatment of brain tumors.

Hyvönen M, Enbäck J, Huhtala T, Lammi J, Sihto H, Weisell J, Joensuu H, Rosenthal-Aizman K, El-Andaloussi S, Langel U, Närvänen A, Bergers G, Laakkonen P.

Mol Cancer Ther. 2014 Apr;13(4):996-1007. doi: 10.1158/1535-7163.MCT-13-0684. Epub 2014 Feb 3.

40.

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN.

Biochemistry (Mosc). 2013 Dec;78(13):1431-46. doi: 10.1134/S0006297913130051. Review.

41.

Selective regulation of polyamine metabolism with methylated polyamine analogues.

Keinänen TA, Hyvönen MT, Alhonen L, Vepsäläinen J, Khomutov AR.

Amino Acids. 2014 Mar;46(3):605-20. Epub 2013 Oct 10. Review.

PMID:
24022706
42.

Tumour homing peptide-functionalized porous silicon nanovectors for cancer therapy.

Kinnari PJ, Hyvönen ML, Mäkilä EM, Kaasalainen MH, Rivinoja A, Salonen JJ, Hirvonen JT, Laakkonen PM, Santos HA.

Biomaterials. 2013 Dec;34(36):9134-41. doi: 10.1016/j.biomaterials.2013.08.034. Epub 2013 Sep 3.

PMID:
24008034
43.

Charge deficient analogues of the natural polyamines.

Weisell J, Hyvönen MT, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

Curr Pharm Des. 2014;20(2):262-77. Review.

PMID:
23701551
44.

CD2AP is associated with end-stage renal disease in patients with type 1 diabetes.

Hyvönen ME, Ihalmo P, Sandholm N, Stavarachi M, Forsblom C, McKnight AJ, Lajer M, Maestroni A, Lewis G, Tarnow L, Maestroni S, Zerbini G, Parving HH, Maxwell AP, Groop PH, Lehtonen S.

Acta Diabetol. 2013 Dec;50(6):887-97. doi: 10.1007/s00592-013-0475-9. Epub 2013 May 17.

PMID:
23681557
45.

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A.

Hyvönen MT, Koponen T, Weisell J, Pietilä M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2013 Aug 1;453(3):467-74. doi: 10.1042/BJ20130263.

PMID:
23672317
46.

Osteoinduction by combining bone morphogenetic protein (BMP)-2 with a bioactive novel nanocomposite.

Sharma A, Meyer F, Hyvonen M, Best SM, Cameron RE, Rushton N.

Bone Joint Res. 2012 Jul 1;1(7):145-51. doi: 10.1302/2046-3758.17.2000082. Print 2012 Jul.

47.

Using a fragment-based approach to target protein-protein interactions.

Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M.

Chembiochem. 2013 Feb 11;14(3):332-42. doi: 10.1002/cbic.201200521. Epub 2013 Jan 23.

48.

Metastasis-associated cell surface oncoproteomics.

Karhemo PR, Hyvönen M, Laakkonen P.

Front Pharmacol. 2012 Nov 7;3:192. doi: 10.3389/fphar.2012.00192. eCollection 2012.

49.

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.

Hyvönen MT, Weisell J, Khomutov AR, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2013 Jan;41(1):30-2. doi: 10.1124/dmd.112.047274. Epub 2012 Sep 28.

50.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

Smirnova OA, Isaguliants MG, Hyvonen MT, Keinanen TA, Tunitskaya VL, Vepsalainen J, Alhonen L, Kochetkov SN, Ivanov AV.

Biochimie. 2012 Sep;94(9):1876-83. doi: 10.1016/j.biochi.2012.04.023. Epub 2012 May 8.

PMID:
22579641

Supplemental Content

Loading ...
Support Center