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A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract.

Pattacini L, Woodward Davis A, Czartoski J, Mair F, Presnell S, Hughes SM, Hyrien O, Lentz GM, Kirby AC, Fialkow MF, Hladik F, Prlic M, Lund JM.

Mucosal Immunol. 2019 Sep;12(5):1118-1129. doi: 10.1038/s41385-019-0186-9. Epub 2019 Jul 16.


Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions.

Wu X, Kabalane H, Kahli M, Petryk N, Laperrousaz B, Jaszczyszyn Y, Drillon G, Nicolini FE, Perot G, Robert A, Fund C, Chibon F, Xia R, Wiels J, Argoul F, Maguer-Satta V, Arneodo A, Audit B, Hyrien O.

Nucleic Acids Res. 2018 Nov 2;46(19):10532. doi: 10.1093/nar/gky849. No abstract available.


Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions.

Wu X, Kabalane H, Kahli M, Petryk N, Laperrousaz B, Jaszczyszyn Y, Drillon G, Nicolini FE, Perot G, Robert A, Fund C, Chibon F, Xia R, Wiels J, Argoul F, Maguer-Satta V, Arneodo A, Audit B, Hyrien O.

Nucleic Acids Res. 2018 Nov 2;46(19):10157-10172. doi: 10.1093/nar/gky797. Erratum in: Nucleic Acids Res. 2018 Nov 2;46(19):10532.


Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, Wu W, Wu X, Day A, Wong N, Yin M, Canela A, Fu H, Redon C, Pruitt SC, Jaszczyszyn Y, Aladjem MI, Aplan PD, Hyrien O, Nussenzweig A.

Cell. 2018 Aug 23;174(5):1127-1142.e19. doi: 10.1016/j.cell.2018.07.011. Epub 2018 Aug 2.


The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation.

Arbona JM, Goldar A, Hyrien O, Arneodo A, Audit B.

Elife. 2018 Jun 1;7. pii: e35192. doi: 10.7554/eLife.35192.


Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.

Wang J, Hilchey SP, DeDiego M, Perry S, Hyrien O, Nogales A, Garigen J, Amanat F, Huertas N, Krammer F, Martinez-Sobrido L, Topham DJ, Treanor JJ, Sangster MY, Zand MS.

PLoS One. 2018 Apr 11;13(4):e0193680. doi: 10.1371/journal.pone.0193680. eCollection 2018.


Effectiveness of Corticosteroid Injections for Treatment of de Quervain's Tenosynovitis.

Oh JK, Messing S, Hyrien O, Hammert WC.

Hand (N Y). 2017 Jul;12(4):357-361. doi: 10.1177/1558944716681976. Epub 2016 Dec 5.


Subcritical Sevastyanov branching processes with nonhomogeneous Poisson immigration.

Hyrien O, Mitov KV, Yanev NM.

J Appl Probab. 2017 Jun;54(2):569-587. doi: 10.1017/jpr.2017.18. Epub 2017 Jun 22.


Single-molecule, antibody-free fluorescent visualisation of replication tracts along barcoded DNA molecules.

De Carli F, Gaggioli V, Millot GA, Hyrien O.

Int J Dev Biol. 2016;60(7-8-9):297-304.


How MCM loading and spreading specify eukaryotic DNA replication initiation sites.

Hyrien O.

F1000Res. 2016 Aug 24;5. pii: F1000 Faculty Rev-2063. doi: 10.12688/f1000research.9008.1. eCollection 2016. Review.


Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.

Nedelkovska H, Rosenberg AF, Hilchey SP, Hyrien O, Burack WR, Quataert SA, Baker CM, Azadniv M, Welle SL, Ansell SM, Kim M, Bernstein SH.

PLoS One. 2016 May 26;11(5):e0155347. doi: 10.1371/journal.pone.0155347. eCollection 2016.


Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations.

Goldar A, Arneodo A, Audit B, Argoul F, Rappailles A, Guilbaud G, Petryk N, Kahli M, Hyrien O.

Sci Rep. 2016 Mar 3;6:22469. doi: 10.1038/srep22469.


Replication landscape of the human genome.

Petryk N, Kahli M, d'Aubenton-Carafa Y, Jaszczyszyn Y, Shen Y, Silvain M, Thermes C, Chen CL, Hyrien O.

Nat Commun. 2016 Jan 11;7:10208. doi: 10.1038/ncomms10208.


Fast Nonparametric Density-Based Clustering of Large Data Sets Using a Stochastic Approximation Mean-Shift Algorithm.

Hyrien O, Baran A.

J Comput Graph Stat. 2016;25(3):899-916. doi: 10.1080/10618600.2015.1051625. Epub 2016 Aug 5.


Down-regulation of cytoplasmic PLZF correlates with high tumor grade and tumor aggression in non-small cell lung carcinoma.

Xiao GQ, Li F, Findeis-Hosey J, Hyrien O, Unger PD, Xiao L, Dunne R, Kim ES, Yang Q, McMahon L, Burstein DE.

Hum Pathol. 2015 Nov;46(11):1607-15. doi: 10.1016/j.humpath.2015.06.021. Epub 2015 Jul 8.


Multi-Dimensional Measurement of Antibody-Mediated Heterosubtypic Immunity to Influenza.

Wang J, Hilchey SP, Hyrien O, Huertas N, Perry S, Ramanunninair M, Bucher D, Zand MS.

PLoS One. 2015 Jun 23;10(6):e0129858. doi: 10.1371/journal.pone.0129858. eCollection 2015.


Peaks cloaked in the mist: the landscape of mammalian replication origins.

Hyrien O.

J Cell Biol. 2015 Jan 19;208(2):147-60. doi: 10.1083/jcb.201407004. Review.


The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Dashnaw ML, Czerniecka K, Walker CT, Chen M, Hyrien O, Iliff JJ, Deane R, Huang JH, Nedergaard M.

Surg Neurol Int. 2014 Dec 23;5:184. doi: 10.4103/2152-7806.147566. eCollection 2014.


A test of homogeneity for age-dependent branching processes with immigration.

Hyrien O, Yanev NM, Jordan CT.

Electron J Stat. 2015;9(1):898-925. Epub 2015 May 22.


Stochastic modeling of stress erythropoiesis using a two-type age-dependent branching process with immigration.

Hyrien O, Peslak SA, Yanev NM, Palis J.

J Math Biol. 2015 Jun;70(7):1485-521. doi: 10.1007/s00285-014-0803-x. Epub 2014 Jul 3.


Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer.

Hezel AF, Noel MS, Allen JN, Abrams TA, Yurgelun M, Faris JE, Goyal L, Clark JW, Blaszkowsky LS, Murphy JE, Zheng H, Khorana AA, Connolly GC, Hyrien O, Baran A, Herr M, Ng K, Sheehan S, Harris DJ, Regan E, Borger DR, Iafrate AJ, Fuchs C, Ryan DP, Zhu AX.

Br J Cancer. 2014 Jul 29;111(3):430-6. doi: 10.1038/bjc.2014.343. Epub 2014 Jun 24.


Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells.

Brady MT, Hilchey SP, Hyrien O, Spence SA, Bernstein SH.

PLoS One. 2014 May 16;9(5):e97597. doi: 10.1371/journal.pone.0097597. eCollection 2014.


The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH.

J Neurotrauma. 2014 Jul 1;31(13):1211-24. doi: 10.1089/neu.2013.3255. Epub 2014 Jun 12.


Age and Racial Differences among PSA-Detected (AJCC Stage T1cN0M0) Prostate Cancer in the U.S.: A Population-Based Study of 70,345 Men.

Zhang H, Messing EM, Travis LB, Hyrien O, Chen R, Milano MT, Chen Y.

Front Oncol. 2013 Dec 23;3:312. doi: 10.3389/fonc.2013.00312. eCollection 2013.


A phase 1 trial of eltrombopag in patients undergoing stem cell transplantation after total body irradiation.

Liesveld JL, Phillips GL 2nd, Becker M, Constine LS, Friedberg J, Andolina JR, Milner LA, DeBolt J, Smudzin T, Hyrien O, Erickson-Miller CL, Johnson BM, Dawson KL, Chen Y.

Biol Blood Marrow Transplant. 2013 Dec;19(12):1745-52. doi: 10.1016/j.bbmt.2013.10.002. Epub 2013 Oct 8.


From simple bacterial and archaeal replicons to replication N/U-domains.

Hyrien O, Rappailles A, Guilbaud G, Baker A, Chen CL, Goldar A, Petryk N, Kahli M, Ma E, d'Aubenton-Carafa Y, Audit B, Thermes C, Arneodo A.

J Mol Biol. 2013 Nov 29;425(23):4673-89. doi: 10.1016/j.jmb.2013.09.021. Epub 2013 Oct 3. Review.


DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts.

Gaggioli V, Le Viet B, Germe T, Hyrien O.

Nucleic Acids Res. 2013 Aug;41(15):7313-31. doi: 10.1093/nar/gkt494. Epub 2013 Jun 11.


Cdc45 is a critical effector of myc-dependent DNA replication stress.

Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J.

Cell Rep. 2013 May 30;3(5):1629-39. doi: 10.1016/j.celrep.2013.04.002. Epub 2013 May 2.


Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm.

Audit B, Baker A, Chen CL, Rappailles A, Guilbaud G, Julienne H, Goldar A, d'Aubenton-Carafa Y, Hyrien O, Thermes C, Arneodo A.

Nat Protoc. 2013 Jan;8(1):98-110. doi: 10.1038/nprot.2012.145. Epub 2012 Dec 13.


Clinical factors affecting engraftment and transfusion needs in SCT: a single-center retrospective analysis.

Liesveld J, Pawlowski J, Chen R, Hyrien O, Debolt J, Becker M, Phillips G 2nd, Chen Y.

Bone Marrow Transplant. 2013 May;48(5):691-7. doi: 10.1038/bmt.2012.194. Epub 2012 Oct 22.


Inhibition of Nogo-66 receptor 1 enhances recovery of cognitive function after traumatic brain injury in mice.

Tong J, Liu W, Wang X, Han X, Hyrien O, Samadani U, Smith DH, Huang JH.

J Neurotrauma. 2013 Feb 15;30(4):247-58. doi: 10.1089/neu.2012.2493. Epub 2013 Feb 4.


Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines.

Baker A, Audit B, Chen CL, Moindrot B, Leleu A, Guilbaud G, Rappailles A, Vaillant C, Goldar A, Mongelard F, d'Aubenton-Carafa Y, Hyrien O, Thermes C, Arneodo A.

PLoS Comput Biol. 2012;8(4):e1002443. doi: 10.1371/journal.pcbi.1002443. Epub 2012 Apr 5.


Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.

Guilbaud G, Rappailles A, Baker A, Chen CL, Arneodo A, Goldar A, d'Aubenton-Carafa Y, Thermes C, Audit B, Hyrien O.

PLoS Comput Biol. 2011 Dec;7(12):e1002322. doi: 10.1371/journal.pcbi.1002322. Epub 2011 Dec 29.


Do replication forks control late origin firing in Saccharomyces cerevisiae?

Ma E, Hyrien O, Goldar A.

Nucleic Acids Res. 2012 Mar;40(5):2010-9. doi: 10.1093/nar/gkr982. Epub 2011 Nov 15.


Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation.

Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH.

Blood. 2011 Sep 29;118(13):3591-602. doi: 10.1182/blood-2011-03-340646. Epub 2011 Aug 5.


Biodosimetry using radiation-induced micronuclei in skin fibroblasts.

Kaspler P, Chen R, Hyrien O, Jelveh S, Bristow RG, Hill RP.

Int J Radiat Biol. 2011 Aug;87(8):824-38. doi: 10.3109/09553002.2011.582927.


Impact of radiotherapy on laryngeal cancer survival: a population-based study of 13,808 US patients.

Zhang H, Travis LB, Chen R, Hyrien O, Milano MT, Newlands SD, Chen Y.

Cancer. 2012 Mar 1;118(5):1276-87. doi: 10.1002/cncr.26357. Epub 2011 Jul 19.


Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts.

Le Breton C, Hennion M, Arimondo PB, Hyrien O.

PLoS One. 2011 Apr 15;6(4):e18554. doi: 10.1371/journal.pone.0018554.


Replication-associated mutational asymmetry in the human genome.

Chen CL, Duquenne L, Audit B, Guilbaud G, Rappailles A, Baker A, Huvet M, d'Aubenton-Carafa Y, Hyrien O, Arneodo A, Thermes C.

Mol Biol Evol. 2011 Aug;28(8):2327-37. doi: 10.1093/molbev/msr056. Epub 2011 Mar 2.


Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors.

Hyrien O, Dietrich J, Noble M.

Cancer Res. 2010 Dec 15;70(24):10051-9. doi: 10.1158/0008-5472.CAN-10-1400. Epub 2010 Nov 5.


A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process.

Chen R, Hyrien O, Noble M, Mayer-Pröschel M.

Biostatistics. 2011 Jan;12(1):173-91. doi: 10.1093/biostatistics/kxq050. Epub 2010 Aug 23.


Preclinical and pilot clinical studies of docetaxel chemoradiation for Stage III non-small-cell lung cancer.

Chen Y, Pandya KJ, Hyrien O, Keng PC, Smudzin T, Anderson J, Qazi R, Smith B, Watson TJ, Feins RH, Johnstone DW.

Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1358-64. doi: 10.1016/j.ijrobp.2010.04.060. Epub 2010 Aug 12.


An age-dependent branching process model for the analysis of CFSE-labeling experiments.

Hyrien O, Chen R, Zand MS.

Biol Direct. 2010 Jun 22;5:41. doi: 10.1186/1745-6150-5-41.


Mathematical modelling of eukaryotic DNA replication.

Hyrien O, Goldar A.

Chromosome Res. 2010 Jan;18(1):147-61. doi: 10.1007/s10577-009-9092-4.


Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.

Dertinger SD, Phonethepswath S, Franklin D, Weller P, Torous DK, Bryce SM, Avlasevich S, Bemis JC, Hyrien O, Palis J, MacGregor JT.

Toxicol Sci. 2010 Jun;115(2):401-11. doi: 10.1093/toxsci/kfq070. Epub 2010 Mar 4.

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