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Items: 23


SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment.

Moncayo G, Grzmil M, Smirnova T, Zmarz P, Huber RM, Hynx D, Kohler H, Wang Y, Hotz HR, Hynes NE, Keller G, Frank S, Merlo A, Hemmings BA.

Neuro Oncol. 2018 Apr 9;20(5):621-631. doi: 10.1093/neuonc/noy008.


mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition.

Xue G, Kohler R, Tang F, Hynx D, Wang Y, Orso F, Prêtre V, Ritschard R, Hirschmann P, Cron P, Roloff T, Dummer R, Mandalà M, Bichet S, Genoud C, Meyer AG, Muraro MG, Spagnoli GC, Taverna D, Rüegg C, Merghoub T, Massi D, Tang H, Levesque MP, Dirnhofer S, Zippelius A, Hemmings BA, Wicki A.

Oncotarget. 2017 May 25;8(41):69204-69218. doi: 10.18632/oncotarget.18213. eCollection 2017 Sep 19.


The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.

Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz-Rohmer D, Hynx D, Zhou D, Zhang L, Xue G, Grzmil M, Yang Z, Hergovich A, Hollaender GA, Stein JV, Hemmings BA, Matthias P.

Sci Signal. 2015 Oct 6;8(397):ra100. doi: 10.1126/scisignal.aab2425.


NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development.

Schmitz-Rohmer D, Probst S, Yang ZZ, Laurent F, Stadler MB, Zuniga A, Zeller R, Hynx D, Hemmings BA, Hergovich A.

PLoS One. 2015 Aug 25;10(8):e0136566. doi: 10.1371/journal.pone.0136566. eCollection 2015.


NDR functions as a physiological YAP1 kinase in the intestinal epithelium.

Zhang L, Tang F, Terracciano L, Hynx D, Kohler R, Bichet S, Hess D, Cron P, Hemmings BA, Hergovich A, Schmitz-Rohmer D.

Curr Biol. 2015 Feb 2;25(3):296-305. doi: 10.1016/j.cub.2014.11.054. Epub 2015 Jan 15.


PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis.

Kim DK, Kim YH, Hynx D, Wang Y, Yang KJ, Ryu D, Kim KS, Yoo EK, Kim JS, Koo SH, Lee IK, Chae HZ, Park J, Lee CH, Biddinger SB, Hemmings BA, Choi HS.

Diabetologia. 2014 Dec;57(12):2576-85. doi: 10.1007/s00125-014-3366-x. Epub 2014 Sep 10.


hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.

Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron PD, Hundsrucker C, Hergovich A, Frank S, Hemmings BA, Schmitz-Rohmer D.

Cancer Res. 2014 Jul 15;74(14):3779-89. doi: 10.1158/0008-5472.CAN-13-3430. Epub 2014 May 28.


Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.

Schultze SM, Dietrich M, Hynx D, Geier A, Niessen M, Spinas GA, Hemmings BA, Tschopp O.

Liver Int. 2015 Apr;35(4):1354-66. doi: 10.1111/liv.12600. Epub 2014 Jun 24.


MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.

Grzmil M, Huber RM, Hess D, Frank S, Hynx D, Moncayo G, Klein D, Merlo A, Hemmings BA.

J Clin Invest. 2014 Feb;124(2):742-54. doi: 10.1172/JCI70198. Epub 2014 Jan 9.


Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.

Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck CK, Genoud C, Cron P, Keusch JJ, Dummler B, Esposti MD, Hemmings BA.

Mol Cell Biol. 2012 Jul;32(14):2685-97. doi: 10.1128/MCB.00312-12. Epub 2012 May 14.


Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

Xue G, Restuccia DF, Lan Q, Hynx D, Dirnhofer S, Hess D, Rüegg C, Hemmings BA.

Cancer Discov. 2012 Mar;2(3):248-59. doi: 10.1158/2159-8290.CD-11-0270. Epub 2012 Jan 25.


Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.

Restuccia DF, Hynx D, Hemmings BA.

Dis Model Mech. 2012 May;5(3):403-11. doi: 10.1242/dmm.008136. Epub 2012 Jan 24.


Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

Cornils H, Stegert MR, Hergovich A, Hynx D, Schmitz D, Dirnhofer S, Hemmings BA.

Sci Signal. 2010 Jun 15;3(126):ra47. doi: 10.1126/scisignal.2000681.


Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.

Buzzi F, Xu L, Zuellig RA, Boller SB, Spinas GA, Hynx D, Chang Z, Yang Z, Hemmings BA, Tschopp O, Niessen M.

Mol Cell Biol. 2010 Feb;30(3):601-12. doi: 10.1128/MCB.00719-09. Epub 2009 Nov 23.


The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics.

Parcellier A, Tintignac LA, Zhuravleva E, Dummler B, Brazil DP, Hynx D, Cron P, Schenk S, Olivieri V, Hemmings BA.

PLoS One. 2009;4(5):e5471. doi: 10.1371/journal.pone.0005471. Epub 2009 May 7.


In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.

Surucu B, Bozulic L, Hynx D, Parcellier A, Hemmings BA.

J Biol Chem. 2008 Oct 31;283(44):30025-33. doi: 10.1074/jbc.M803053200. Epub 2008 Aug 29.


Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.

Yung HW, Calabrese S, Hynx D, Hemmings BA, Cetin I, Charnock-Jones DS, Burton GJ.

Am J Pathol. 2008 Aug;173(2):451-62. doi: 10.2353/ajpath.2008.071193. Epub 2008 Jun 26.


PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival.

Bozulic L, Surucu B, Hynx D, Hemmings BA.

Mol Cell. 2008 Apr 25;30(2):203-13. doi: 10.1016/j.molcel.2008.02.024.


Deletion of PKBalpha/Akt1 affects thymic development.

Fayard E, Gill J, Paolino M, Hynx D, Holländer GA, Hemmings BA.

PLoS One. 2007 Oct 3;2(10):e992.


Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.

Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Butler K.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1183-93. Epub 2007 Aug 24.


Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.

Dummler B, Tschopp O, Hynx D, Yang ZZ, Dirnhofer S, Hemmings BA.

Mol Cell Biol. 2006 Nov;26(21):8042-51. Epub 2006 Aug 21.


Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.

Sandham DA, Barker L, Beattie D, Beer D, Bidlake L, Bentley D, Butler KD, Craig S, Farr D, Ffoulkes-Jones C, Fozard JR, Haberthuer S, Howes C, Hynx D, Jeffers S, Keller TH, Kirkham PA, Maas JC, Mazzoni L, Nicholls A, Pilgrim GE, Schaebulin E, Spooner GM, Stringer R, Tranter P, Turner KL, Tweed MF, Walker C, Watson SJ, Cuenoud BM.

Bioorg Med Chem. 2004 Oct 1;12(19):5213-24.


Physiological functions of protein kinase B/Akt.

Yang ZZ, Tschopp O, Baudry A, Dümmler B, Hynx D, Hemmings BA.

Biochem Soc Trans. 2004 Apr;32(Pt 2):350-4. Review.


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