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Items: 1 to 50 of 352

1.

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.

Chen MB, Hajal C, Benjamin DC, Yu C, Azizgolshani H, Hynes RO, Kamm RD.

Proc Natl Acad Sci U S A. 2018 Jun 18. pii: 201715932. doi: 10.1073/pnas.1715932115. [Epub ahead of print]

PMID:
29915060
2.

Antibodies and methods for immunohistochemistry of extracellular matrix proteins.

Rickelt S, Hynes RO.

Matrix Biol. 2018 May 3. pii: S0945-053X(18)30162-8. doi: 10.1016/j.matbio.2018.04.011. [Epub ahead of print] Review.

PMID:
29730502
3.

Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.

Steigedal TS, Toraskar J, Redvers RP, Valla M, Magnussen SN, Bofin AM, Opdahl S, Lundgren S, Eckhardt BL, Lamar JM, Doherty J, Hynes RO, Anderson RL, Svineng G.

Neoplasia. 2018 Apr;20(4):387-400. doi: 10.1016/j.neo.2018.02.008. Epub 2018 Mar 11.

4.

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.

Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO.

Elife. 2018 Jan 2;7. pii: e29494. doi: 10.7554/eLife.29494.

5.

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.

Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH.

Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211a.

PMID:
29220013
6.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ.

Science. 2017 Dec 1;358(6367). pii: eaal5081. doi: 10.1126/science.aal5081.

PMID:
29191879
7.

Intravital imaging of metastasis in adult Zebrafish.

Benjamin DC, Hynes RO.

BMC Cancer. 2017 Sep 25;17(1):660. doi: 10.1186/s12885-017-3647-0.

8.

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO.

J Proteome Res. 2017 Aug 4;16(8):3083-3091. doi: 10.1021/acs.jproteome.7b00191. Epub 2017 Jul 19.

PMID:
28675934
9.

Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion.

Turner CJ, Badu-Nkansah K, Hynes RO.

Angiogenesis. 2017 Nov;20(4):519-531. doi: 10.1007/s10456-017-9563-8. Epub 2017 Jun 30.

10.

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.

Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Rivera FJ, Kim-Kiselak C, Jailkhani N, Winslow MM, Del Rosario A, Hynes RO, Jacks T.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5625-E5634. doi: 10.1073/pnas.1707054114. Epub 2017 Jun 26.

11.

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses.

Kwan BH, Zhu EF, Tzeng A, Sugito HR, Eltahir AA, Ma B, Delaney MK, Murphy PA, Kauke MJ, Angelini A, Momin N, Mehta NK, Maragh AM, Hynes RO, Dranoff G, Cochran JR, Wittrup KD.

J Exp Med. 2017 Jun 5;214(6):1679-1690. doi: 10.1084/jem.20160831. Epub 2017 May 4.

12.

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.

Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera FJ, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH.

Nat Biotechnol. 2017 Jun;35(6):569-576. doi: 10.1038/nbt.3836. Epub 2017 May 1. Erratum in: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.

13.

Toward Responsible Human Genome Editing.

Hynes RO, Coller BS, Porteus M.

JAMA. 2017 May 9;317(18):1829-1830. doi: 10.1001/jama.2017.4548. No abstract available.

PMID:
28395003
14.

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM.

Leukemia. 2017 Nov;31(11):2426-2434. doi: 10.1038/leu.2017.102. Epub 2017 Mar 27.

PMID:
28344315
15.

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Ragelle H, Naba A, Larson BL, Zhou F, Prijić M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG.

Biomaterials. 2017 Jun;128:147-159. doi: 10.1016/j.biomaterials.2017.03.008. Epub 2017 Mar 7.

PMID:
28327460
16.

Evolving policy with science.

Charo RA, Hynes RO.

Science. 2017 Mar 3;355(6328):889. doi: 10.1126/science.aan0509. No abstract available.

PMID:
28254888
17.

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.

Zhu G, Zhang Q, Reddy EC, Carrim N, Chen Y, Xu XR, Xu M, Wang Y, Hou Y, Ma L, Li Y, Rui M, Petruzziello-Pellegrini TN, Lavalle C, Stratton TW, Lei X, Adili R, Chen P, Zhu C, Wilkins JA, Hynes RO, Freedman J, Ni H.

Blood. 2017 Mar 30;129(13):1840-1854. doi: 10.1182/blood-2016-07-729400. Epub 2017 Jan 25.

18.

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO.

Sci Rep. 2017 Jan 10;7:40495. doi: 10.1038/srep40495.

19.

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways.

Li R, Hebert JD, Lee TA, Xing H, Boussommier-Calleja A, Hynes RO, Lauffenburger DA, Kamm RD.

Cancer Res. 2017 Jan 15;77(2):279-290. doi: 10.1158/0008-5472.CAN-16-0442. Epub 2016 Nov 21.

20.

PF4 Promotes Platelet Production and Lung Cancer Growth.

Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ.

Cell Rep. 2016 Nov 8;17(7):1764-1772. doi: 10.1016/j.celrep.2016.10.031.

21.

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

Carmona G, Perera U, Gillett C, Naba A, Law AL, Sharma VP, Wang J, Wyckoff J, Balsamo M, Mosis F, De Piano M, Monypenny J, Woodman N, McConnell RE, Mouneimne G, Van Hemelrijck M, Cao Y, Condeelis J, Hynes RO, Gertler FB, Krause M.

Oncogene. 2016 Sep 29;35(39):5155-69. doi: 10.1038/onc.2016.47. Epub 2016 Mar 21.

22.

Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade.

Chen MB, Lamar JM, Li R, Hynes RO, Kamm RD.

Cancer Res. 2016 May 1;76(9):2513-24. doi: 10.1158/0008-5472.CAN-15-1325. Epub 2016 Mar 17.

23.

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.

Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A.

Nat Commun. 2016 Mar 11;7:10917. doi: 10.1038/ncomms10917.

24.

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.

Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ.

Immunity. 2016 Feb 16;44(2):343-54. doi: 10.1016/j.immuni.2015.11.024. Epub 2016 Feb 9.

25.

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB.

Cancer Discov. 2016 May;6(5):516-31. doi: 10.1158/2159-8290.CD-15-1183. Epub 2016 Jan 25.

26.

Deformability of Tumor Cells versus Blood Cells.

Shaw Bagnall J, Byun S, Begum S, Miyamoto DT, Hecht VC, Maheswaran S, Stott SL, Toner M, Hynes RO, Manalis SR.

Sci Rep. 2015 Dec 18;5:18542. doi: 10.1038/srep18542.

27.

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis.

Naba A, Clauser KR, Hynes RO.

J Vis Exp. 2015 Jul 23;(101):e53057. doi: 10.3791/53057.

28.

The extracellular matrix: Tools and insights for the "omics" era.

Naba A, Clauser KR, Ding H, Whittaker CA, Carr SA, Hynes RO.

Matrix Biol. 2016 Jan;49:10-24. doi: 10.1016/j.matbio.2015.06.003. Epub 2015 Jul 8. Review.

29.

Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors.

Murphy PA, Begum S, Hynes RO.

PLoS One. 2015 Mar 25;10(3):e0120872. doi: 10.1371/journal.pone.0120872. eCollection 2015.

30.

α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo.

Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO.

Development. 2015 Feb 15;142(4):797-808. doi: 10.1242/dev.117572.

31.

Stretching the boundaries of extracellular matrix research.

Hynes RO.

Nat Rev Mol Cell Biol. 2014 Dec;15(12):761-3.

PMID:
25574535
32.

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO.

BMC Cancer. 2014 Jul 18;14:518. doi: 10.1186/1471-2407-14-518.

33.

Platelets guide the formation of early metastatic niches.

Labelle M, Begum S, Hynes RO.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3053-61. doi: 10.1073/pnas.1411082111. Epub 2014 Jul 14.

34.

Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall.

Murphy PA, Hynes RO.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2042-50. doi: 10.1161/ATVBAHA.114.303879. Epub 2014 Jun 5.

35.

Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation.

Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO.

Dev Biol. 2014 Aug 15;392(2):381-92. doi: 10.1016/j.ydbio.2014.05.006. Epub 2014 May 21.

36.

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.

Naba A, Clauser KR, Lamar JM, Carr SA, Hynes RO.

Elife. 2014 Mar 11;3:e01308. doi: 10.7554/eLife.01308.

37.

Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells.

Yao X, Labelle M, Lamb CR, Dugan JM, Williamson CA, Spencer DR, Christ KR, Keating RO, Lee WD, Paradis GA, Begum S, Hynes RO, Wittrup KD.

Int J Cancer. 2013 Dec 15;133(12):2925-33. doi: 10.1002/ijc.28312. Epub 2013 Jul 13.

38.

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.

Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL.

Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13.

39.

Towards definition of an ECM parts list: an advance on GO categories.

Naba A, Hoersch S, Hynes RO.

Matrix Biol. 2012 Sep-Oct;31(7-8):371-2. doi: 10.1016/j.matbio.2012.11.008. No abstract available.

40.

The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination.

Labelle M, Hynes RO.

Cancer Discov. 2012 Dec;2(12):1091-9. doi: 10.1158/2159-8290.CD-12-0329. Epub 2012 Nov 19. Review.

41.

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis.

Reticker-Flynn NE, Malta DF, Winslow MM, Lamar JM, Xu MJ, Underhill GH, Hynes RO, Jacks TE, Bhatia SN.

Nat Commun. 2012;3:1122. doi: 10.1038/ncomms2128.

42.

Mena binds α5 integrin directly and modulates α5β1 function.

Gupton SL, Riquelme D, Hughes-Alford SK, Tadros J, Rudina SS, Hynes RO, Lauffenburger D, Gertler FB.

J Cell Biol. 2012 Aug 20;198(4):657-76. doi: 10.1083/jcb.201202079.

43.

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain.

Lamar JM, Stern P, Liu H, Schindler JW, Jiang ZG, Hynes RO.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2441-50. doi: 10.1073/pnas.1212021109. Epub 2012 Aug 13.

44.

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia.

Li L, Welser-Alves J, van der Flier A, Boroujerdi A, Hynes RO, Milner R.

Exp Neurol. 2012 Sep;237(1):46-54. doi: 10.1016/j.expneurol.2012.06.005. Epub 2012 Jun 18.

45.

The evolution of metazoan extracellular matrix.

Hynes RO.

J Cell Biol. 2012 Mar 19;196(6):671-9. doi: 10.1083/jcb.201109041. Review.

46.

Metastatic cells will take any help they can get.

Hynes RO.

Cancer Cell. 2011 Dec 13;20(6):689-90. doi: 10.1016/j.ccr.2011.11.022.

47.

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO.

Mol Cell Proteomics. 2012 Apr;11(4):M111.014647. doi: 10.1074/mcp.M111.014647. Epub 2011 Dec 9.

48.

Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis.

Labelle M, Begum S, Hynes RO.

Cancer Cell. 2011 Nov 15;20(5):576-90. doi: 10.1016/j.ccr.2011.09.009.

49.

Extracellular matrix proteins in hemostasis and thrombosis.

Bergmeier W, Hynes RO.

Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2). pii: a005132. doi: 10.1101/cshperspect.a005132. Review.

50.

Overview of the matrisome--an inventory of extracellular matrix constituents and functions.

Hynes RO, Naba A.

Cold Spring Harb Perspect Biol. 2012 Jan 1;4(1):a004903. doi: 10.1101/cshperspect.a004903. Review.

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