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Items: 1 to 50 of 420

1.

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells.

Tian C, Clauser KR, Öhlund D, Rickelt S, Huang Y, Gupta M, Mani DR, Carr SA, Tuveson DA, Hynes RO.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19609-19618. doi: 10.1073/pnas.1908626116. Epub 2019 Sep 4.

PMID:
31484774
2.

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet.

Cheng CW, Biton M, Haber AL, Gunduz N, Eng G, Gaynor LT, Tripathi S, Calibasi-Kocal G, Rickelt S, Butty VL, Moreno-Serrano M, Iqbal AM, Bauer-Rowe KE, Imada S, Ulutas MS, Mylonas C, Whary MT, Levine SS, Basbinar Y, Hynes RO, Mino-Kenudson M, Deshpande V, Boyer LA, Fox JG, Terranova C, Rai K, Piwnica-Worms H, Mihaylova MM, Regev A, Yilmaz ÖH.

Cell. 2019 Aug 22;178(5):1115-1131.e15. doi: 10.1016/j.cell.2019.07.048.

PMID:
31442404
3.

Impacts of acidification on brown trout Salmo trutta populations and the contribution of stocking to population recovery and genetic diversity.

Prodöhl PA, Ferguson A, Bradley CR, Ade R, Roberts C, Keay EJ, Costa AR, Hynes R.

J Fish Biol. 2019 Sep;95(3):719-742. doi: 10.1111/jfb.14054. Epub 2019 Jun 24.

4.

Iliolumbar Vein: Anatomy and Surgical Importance During Lateral Transpsoas and Oblique Approaches to Lumbar Spine.

Davis M, Jenkins S, Bordes S, Iwanaga J, Loukas M, Uribe J, Hynes RA, Tubbs RS.

World Neurosurg. 2019 Aug;128:e768-e772. doi: 10.1016/j.wneu.2019.04.252. Epub 2019 May 9.

PMID:
31077904
5.

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.

Jailkhani N, Ingram JR, Rashidian M, Rickelt S, Tian C, Mak H, Jiang Z, Ploegh HL, Hynes RO.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14181-14190. doi: 10.1073/pnas.1817442116. Epub 2019 May 8. Erratum in: Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18745.

6.

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice.

Xie YJ, Dougan M, Jailkhani N, Ingram J, Fang T, Kummer L, Momin N, Pishesha N, Rickelt S, Hynes RO, Ploegh H.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7624-7631. doi: 10.1073/pnas.1817147116. Epub 2019 Apr 1. Erratum in: Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16656.

7.

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis.

Lamar JM, Xiao Y, Norton E, Jiang ZG, Gerhard GM, Kooner S, Warren JSA, Hynes RO.

J Biol Chem. 2019 Feb 15;294(7):2302-2317. doi: 10.1074/jbc.RA118.004364. Epub 2018 Dec 17.

8.

Genome Sequence of a Plant Growth-Promoting Rhizobacterium, Pseudomonas sp. Strain 31-12.

Hynes RK, Dumonceaux TJ, Kangsopa J, Town JR.

Microbiol Resour Announc. 2018 Aug 16;7(6). pii: e00947-18. doi: 10.1128/MRA.00947-18. eCollection 2018 Aug.

9.

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.

Chen MB, Hajal C, Benjamin DC, Yu C, Azizgolshani H, Hynes RO, Kamm RD.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7022-7027. doi: 10.1073/pnas.1715932115. Epub 2018 Jun 18.

10.

Antibodies and methods for immunohistochemistry of extracellular matrix proteins.

Rickelt S, Hynes RO.

Matrix Biol. 2018 Oct;71-72:10-27. doi: 10.1016/j.matbio.2018.04.011. Epub 2018 May 3. Review.

PMID:
29730502
11.

Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.

Steigedal TS, Toraskar J, Redvers RP, Valla M, Magnussen SN, Bofin AM, Opdahl S, Lundgren S, Eckhardt BL, Lamar JM, Doherty J, Hynes RO, Anderson RL, Svineng G.

Neoplasia. 2018 Apr;20(4):387-400. doi: 10.1016/j.neo.2018.02.008. Epub 2018 Mar 11.

12.

Salvage Strategy for Failed Spinal Fusion Surgery Using Lumbar Lateral Interbody Fusion technique: A Technical Note.

Orita S, Nakajima T, Konno K, Inage K, Sainoh T, Fujimoto K, Sato J, Shiga Y, Kanamoto H, Abe K, Inoue M, Kinoshita H, Norimoto M, Umimura T, Aoki Y, Nakamura J, Matsuura Y, Kubota G, Eguchi Y, Hynes RA, Akazawa T, Suzuki M, Takahashi K, Ohtori S.

Spine Surg Relat Res. 2018 Jan 27;2(1):86-92. doi: 10.22603/ssrr.2017-0035. eCollection 2018.

13.

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.

Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO.

Elife. 2018 Jan 2;7. pii: e29494. doi: 10.7554/eLife.29494.

14.

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.

Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH.

Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211a.

PMID:
29220013
15.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ.

Science. 2017 Dec 1;358(6367). pii: eaal5081. doi: 10.1126/science.aal5081.

16.

Evaluation of the location of intervertebral cages during oblique lateral interbody fusion surgery to achieve sagittal correction.

Shiga Y, Orita S, Inage K, Sato J, Fujimoto K, Kanamoto H, Abe K, Kubota G, Yamauchi K, Eguchi Y, Inoue M, Kinoshita H, Aoki Y, Nakamura J, Matsuura Y, Hynes R, Furuya T, Koda M, Takahashi K, Ohtori S.

Spine Surg Relat Res. 2017 Nov 27;1(4):197-202. doi: 10.22603/ssrr.1.2017-0001. eCollection 2017.

17.

Hand Massage for Cancer Patients Undergoing Chemotherapy as Outpatients: A Pilot Study.

Cutshall SM, Mahapatra S, Hynes RS, Van Rooy KM, Looker SA, Ghosh A, Schleck CD, Bauer BA, Wahner-Roedler DL.

Explore (NY). 2017 Nov - Dec;13(6):393-399. doi: 10.1016/j.explore.2017.06.007. Epub 2017 Aug 25.

PMID:
29097109
18.

Intravital imaging of metastasis in adult Zebrafish.

Benjamin DC, Hynes RO.

BMC Cancer. 2017 Sep 25;17(1):660. doi: 10.1186/s12885-017-3647-0.

19.

Comparison of Pedicle Screw Fixation Strength Among Different Transpedicular Trajectories: A Finite Element Study.

Matsukawa K, Yato Y, Hynes RA, Imabayashi H, Hosogane N, Yoshihara Y, Asazuma T, Nemoto K.

Clin Spine Surg. 2017 Aug;30(7):301-307. doi: 10.1097/BSD.0000000000000258.

PMID:
28746125
20.

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO.

J Proteome Res. 2017 Aug 4;16(8):3083-3091. doi: 10.1021/acs.jproteome.7b00191. Epub 2017 Jul 19.

PMID:
28675934
21.

Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion.

Turner CJ, Badu-Nkansah K, Hynes RO.

Angiogenesis. 2017 Nov;20(4):519-531. doi: 10.1007/s10456-017-9563-8. Epub 2017 Jun 30.

22.

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.

Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Rivera FJ, Kim-Kiselak C, Jailkhani N, Winslow MM, Del Rosario A, Hynes RO, Jacks T.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5625-E5634. doi: 10.1073/pnas.1707054114. Epub 2017 Jun 26.

23.

Cortical Bone Trajectory for Thoracic Pedicle Screws: A Technical Note.

Matsukawa K, Yato Y, Hynes RA, Imabayashi H, Hosogane N, Asazuma T, Matsui T, Kobayashi Y, Nemoto K.

Clin Spine Surg. 2017 Jun;30(5):E497-E504. doi: 10.1097/BSD.0000000000000130.

PMID:
28525468
24.

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses.

Kwan BH, Zhu EF, Tzeng A, Sugito HR, Eltahir AA, Ma B, Delaney MK, Murphy PA, Kauke MJ, Angelini A, Momin N, Mehta NK, Maragh AM, Hynes RO, Dranoff G, Cochran JR, Wittrup KD.

J Exp Med. 2017 Jun 5;214(6):1679-1690. doi: 10.1084/jem.20160831. Epub 2017 May 4.

25.

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.

Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera FJ, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH.

Nat Biotechnol. 2017 Jun;35(6):569-576. doi: 10.1038/nbt.3836. Epub 2017 May 1. Erratum in: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.

26.

Toward Responsible Human Genome Editing.

Hynes RO, Coller BS, Porteus M.

JAMA. 2017 May 9;317(18):1829-1830. doi: 10.1001/jama.2017.4548. No abstract available.

PMID:
28395003
27.

Commentary on 'Inhibition by acetylene of ammonia oxidation in Nitrosomonas europaea'.

Hynes RK.

FEMS Microbiol Lett. 2017 May 1;364(10). doi: 10.1093/femsle/fnx068.

PMID:
28379342
28.

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM.

Leukemia. 2017 Nov;31(11):2426-2434. doi: 10.1038/leu.2017.102. Epub 2017 Mar 27.

PMID:
28344315
29.

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Ragelle H, Naba A, Larson BL, Zhou F, Prijić M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG.

Biomaterials. 2017 Jun;128:147-159. doi: 10.1016/j.biomaterials.2017.03.008. Epub 2017 Mar 7.

PMID:
28327460
30.

Evolving policy with science.

Charo RA, Hynes RO.

Science. 2017 Mar 3;355(6328):889. doi: 10.1126/science.aan0509. No abstract available.

PMID:
28254888
31.

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.

Zhu G, Zhang Q, Reddy EC, Carrim N, Chen Y, Xu XR, Xu M, Wang Y, Hou Y, Ma L, Li Y, Rui M, Petruzziello-Pellegrini TN, Lavalle C, Stratton TW, Lei X, Adili R, Chen P, Zhu C, Wilkins JA, Hynes RO, Freedman J, Ni H.

Blood. 2017 Mar 30;129(13):1840-1854. doi: 10.1182/blood-2016-07-729400. Epub 2017 Jan 25.

32.

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO.

Sci Rep. 2017 Jan 10;7:40495. doi: 10.1038/srep40495.

33.

Technical description of oblique lateral interbody fusion at L1-L5 (OLIF25) and at L5-S1 (OLIF51) and evaluation of complication and fusion rates.

Woods KR, Billys JB, Hynes RA.

Spine J. 2017 Apr;17(4):545-553. doi: 10.1016/j.spinee.2016.10.026. Epub 2016 Nov 21.

PMID:
27884744
34.

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways.

Li R, Hebert JD, Lee TA, Xing H, Boussommier-Calleja A, Hynes RO, Lauffenburger DA, Kamm RD.

Cancer Res. 2017 Jan 15;77(2):279-290. doi: 10.1158/0008-5472.CAN-16-0442. Epub 2016 Nov 21.

35.

PF4 Promotes Platelet Production and Lung Cancer Growth.

Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ.

Cell Rep. 2016 Nov 8;17(7):1764-1772. doi: 10.1016/j.celrep.2016.10.031.

36.

Perioperative Complications in 155 Patients Who Underwent Oblique Lateral Interbody Fusion Surgery: Perspectives and Indications From a Retrospective, Multicenter Survey.

Abe K, Orita S, Mannoji C, Motegi H, Aramomi M, Ishikawa T, Kotani T, Akazawa T, Morinaga T, Fujiyoshi T, Hasue F, Yamagata M, Hashimoto M, Yamauchi T, Eguchi Y, Suzuki M, Hanaoka E, Inage K, Sato J, Fujimoto K, Shiga Y, Kanamoto H, Yamauchi K, Nakamura J, Suzuki T, Hynes RA, Aoki Y, Takahashi K, Ohtori S.

Spine (Phila Pa 1976). 2017 Jan 1;42(1):55-62. doi: 10.1097/BRS.0000000000001650.

PMID:
27116114
37.

One-Year Prospective Evaluation of the Technique of Percutaneous Cortical Bone Trajectory Spondylodesis in Comparison with Percutaneous Pedicle Screw Fixation: A Preliminary Report with Technical Note.

Orita S, Inage K, Kubota G, Sainoh T, Sato J, Fujimoto K, Shiga Y, Nakamura J, Matsuura Y, Eguchi Y, Aoki Y, Toyone T, Yamauchi K, Sakuma Y, Oikawa Y, Suzuki T, Takahashi K, Hynes RA, Ohtori S.

J Neurol Surg A Cent Eur Neurosurg. 2016 Nov;77(6):531-537. Epub 2016 Mar 29.

PMID:
27023825
38.

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

Carmona G, Perera U, Gillett C, Naba A, Law AL, Sharma VP, Wang J, Wyckoff J, Balsamo M, Mosis F, De Piano M, Monypenny J, Woodman N, McConnell RE, Mouneimne G, Van Hemelrijck M, Cao Y, Condeelis J, Hynes RO, Gertler FB, Krause M.

Oncogene. 2016 Sep 29;35(39):5155-69. doi: 10.1038/onc.2016.47. Epub 2016 Mar 21.

39.

Elucidation of the Roles of Tumor Integrin β1 in the Extravasation Stage of the Metastasis Cascade.

Chen MB, Lamar JM, Li R, Hynes RO, Kamm RD.

Cancer Res. 2016 May 1;76(9):2513-24. doi: 10.1158/0008-5472.CAN-15-1325. Epub 2016 Mar 17.

40.

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.

Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A.

Nat Commun. 2016 Mar 11;7:10917. doi: 10.1038/ncomms10917.

41.

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.

Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ.

Immunity. 2016 Feb 16;44(2):343-54. doi: 10.1016/j.immuni.2015.11.024. Epub 2016 Feb 9.

42.

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB.

Cancer Discov. 2016 May;6(5):516-31. doi: 10.1158/2159-8290.CD-15-1183. Epub 2016 Jan 25.

43.

Integrating Male Reproductive Health Services: One University Clinic's Story.

Koren A, Giannetti M, Hynes R, Favre M.

J Sex Marital Ther. 2017 Jan 2;43(1):15-23. doi: 10.1080/0092623X.2015.1113594. Epub 2015 Dec 18.

PMID:
26683806
44.

Deformability of Tumor Cells versus Blood Cells.

Shaw Bagnall J, Byun S, Begum S, Miyamoto DT, Hecht VC, Maheswaran S, Stott SL, Toner M, Hynes RO, Manalis SR.

Sci Rep. 2015 Dec 18;5:18542. doi: 10.1038/srep18542.

45.

Preceptor doctors' assessment of the clinical skills of chiropractic externs.

Hynes RJ, Callender AK, Hynes RA, Gran DF.

J Chiropr Educ. 2016 Mar;30(1):37-41. doi: 10.7899/JCE-14-19. Epub 2015 Nov 24.

46.

A Quantitative System for Studying Metastasis Using Transparent Zebrafish.

Heilmann S, Ratnakumar K, Langdon E, Kansler E, Kim I, Campbell NR, Perry E, McMahon A, Kaufman C, van Rooijen E, Lee W, Iacobuzio-Donahue C, Hynes R, Zon L, Xavier J, White RM.

Cancer Res. 2015 Oct 15;75(20):4272-4282. doi: 10.1158/0008-5472.CAN-14-3319. Epub 2015 Aug 17.

47.

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis.

Naba A, Clauser KR, Hynes RO.

J Vis Exp. 2015 Jul 23;(101):e53057. doi: 10.3791/53057.

48.

The extracellular matrix: Tools and insights for the "omics" era.

Naba A, Clauser KR, Ding H, Whittaker CA, Carr SA, Hynes RO.

Matrix Biol. 2016 Jan;49:10-24. doi: 10.1016/j.matbio.2015.06.003. Epub 2015 Jul 8. Review.

49.

Quantifying heritable variation in fitness-related traits of wild, farmed and hybrid Atlantic salmon families in a wild river environment.

Reed TE, Prodöhl P, Hynes R, Cross T, Ferguson A, McGinnity P.

Heredity (Edinb). 2015 Aug;115(2):173-84. doi: 10.1038/hdy.2015.29. Epub 2015 Apr 29.

50.

Where the lake meets the sea: strong reproductive isolation is associated with adaptive divergence between lake resident and anadromous three-spined sticklebacks.

Ravinet M, Hynes R, Poole R, Cross TF, McGinnity P, Harrod C, Prodöhl PA.

PLoS One. 2015 Apr 14;10(4):e0122825. doi: 10.1371/journal.pone.0122825. eCollection 2015.

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