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Items: 23


SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers.

Jones GG, Del Río IB, Sari S, Sekerim A, Young LC, Hartig N, Areso Zubiaur I, El-Bahrawy MA, Hynds RE, Lei W, Molina-Arcas M, Downward J, Rodriguez-Viciana P.

Nat Commun. 2019 Jun 10;10(1):2532. doi: 10.1038/s41467-019-10367-x.


Monitoring neovascularization and integration of decellularized human scaffolds using photoacoustic imaging.

Ogunlade O, Ho JOY, Kalber TL, Hynds RE, Zhang E, Janes SM, Birchall MA, Butler CR, Beard P.

Photoacoustics. 2019 Jan 8;13:76-84. doi: 10.1016/j.pacs.2019.01.001. eCollection 2019 Mar.


Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, Durrenberger PF, Hardavella G, Brown JM, Lynch AG, Farmery H, Paul DS, Chambers RC, McGranahan N, Navani N, Thakrar RM, Swanton C, Beck S, George PJ, Spira A, Campbell PJ, Thirlwell C, Janes SM.

Nat Med. 2019 Mar;25(3):517-525. doi: 10.1038/s41591-018-0323-0. Epub 2019 Jan 21.


Non-Invasive Longitudinal Bioluminescence Imaging of Human Mesoangioblasts in Bioengineered Esophagi.

Crowley C, Butler CR, Camilli C, Hynds RE, Kolluri KK, Janes SM, De Coppi P, Urbani L.

Tissue Eng Part C Methods. 2019 Feb;25(2):103-113. doi: 10.1089/ten.TEC.2018.0351.


Using a Three-Dimensional Collagen Matrix to Deliver Respiratory Progenitor Cells to Decellularized Trachea In Vivo.

Hamilton NJI, Hynds RE, Gowers KHC, Tait A, Butler CR, Hopper C, Burns AJ, Birchall MA, Lowdell M, Janes SM.

Tissue Eng Part C Methods. 2019 Feb;25(2):93-102. doi: 10.1089/ten.TEC.2018.0241.


The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.

Woodcock HV, Eley JD, Guillotin D, Platé M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC.

Nat Commun. 2019 Jan 2;10(1):6. doi: 10.1038/s41467-018-07858-8.


The secret lives of cancer cell lines.

Hynds RE, Vladimirou E, Janes SM.

Dis Model Mech. 2018 Nov 16;11(11). pii: dmm037366. doi: 10.1242/dmm.037366.


Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF.

Hynds RE, Gowers KHC, Nigro E, Butler CR, Bonfanti P, Giangreco A, Prêle CM, Janes SM.

PLoS One. 2018 May 17;13(5):e0197129. doi: 10.1371/journal.pone.0197129. eCollection 2018.


Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors.

Hynds RE, Ben Aissa A, Gowers KHC, Watkins TBK, Bosshard-Carter L, Rowan AJ, Veeriah S, Wilson GA, Quezada SA, Swanton C; TRACERx Consortium, Janes SM.

Int J Cancer. 2018 Jul 1;143(1):160-166. doi: 10.1002/ijc.31383. Epub 2018 Apr 6.


Regenerating human epithelia with cultured stem cells: feeder cells, organoids and beyond.

Hynds RE, Bonfanti P, Janes SM.

EMBO Mol Med. 2018 Feb;10(2):139-150. doi: 10.15252/emmm.201708213. Review.


Autologous Cell Seeding in Tracheal Tissue Engineering.

Maughan EF, Hynds RE, Proctor TJ, Janes SM, Elliott M, Birchall MA, Lowdell MW, De Coppi P.

Curr Stem Cell Rep. 2017;3(4):279-289. doi: 10.1007/s40778-017-0108-2. Epub 2017 Oct 26. Review.


Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma.

Hynds RE, Janes SM.

Cancer Prev Res (Phila). 2017 Sep;10(9):491-493. doi: 10.1158/1940-6207.CAPR-17-0202. Epub 2017 Aug 18.


A comparison of tracheal scaffold strategies for pediatric transplantation in a rabbit model.

Maughan EF, Butler CR, Crowley C, Teoh GZ, den Hondt M, Hamilton NJ, Hynds RE, Lange P, Ansari T, Urbani L, Janes SM, de Coppi P, Birchall MA, Elliott MJ.

Laryngoscope. 2017 Dec;127(12):E449-E457. doi: 10.1002/lary.26611. Epub 2017 Aug 4.


Tracheal Replacement Therapy with a Stem Cell-Seeded Graft: Lessons from Compassionate Use Application of a GMP-Compliant Tissue-Engineered Medicine.

Elliott MJ, Butler CR, Varanou-Jenkins A, Partington L, Carvalho C, Samuel E, Crowley C, Lange P, Hamilton NJ, Hynds RE, Ansari T, Sibbons P, Fierens A, McLaren C, Roebuck D, Wallis C, Muthialu N, Hewitt R, Crabbe D, Janes SM, De Coppi P, Lowdell MW, Birchall MA.

Stem Cells Transl Med. 2017 Jun;6(6):1458-1464. doi: 10.1002/sctm.16-0443.


Optimized isolation and expansion of human airway epithelial basal cells from endobronchial biopsy samples.

Gowers KHC, Hynds RE, Thakrar RM, Carroll B, Birchall MA, Janes SM.

J Tissue Eng Regen Med. 2018 Jan;12(1):e313-e317. doi: 10.1002/term.2466. Epub 2017 Aug 22.


Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds.

Butler CR, Hynds RE, Crowley C, Gowers KH, Partington L, Hamilton NJ, Carvalho C, Platé M, Samuel ER, Burns AJ, Urbani L, Birchall MA, Lowdell MW, De Coppi P, Janes SM.

Biomaterials. 2017 Apr;124:95-105. doi: 10.1016/j.biomaterials.2017.02.001. Epub 2017 Feb 5.


Expansion of Human Airway Basal Stem Cells and Their Differentiation as 3D Tracheospheres.

Hynds RE, Butler CR, Janes SM, Giangreco A.

Methods Mol Biol. 2019;1576:43-53. doi: 10.1007/7651_2016_5.


Airway tissue engineering for congenital laryngotracheal disease.

Maughan E, Lesage F, Butler CR, Hynds RE, Hewitt R, Janes SM, Deprest JA, Coppi PD.

Semin Pediatr Surg. 2016 Jun;25(3):186-90. doi: 10.1053/j.sempedsurg.2016.02.012. Epub 2016 Feb 22. Review.


Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering.

Butler CR, Hynds RE, Gowers KH, Lee Ddo H, Brown JM, Crowley C, Teixeira VH, Smith CM, Urbani L, Hamilton NJ, Thakrar RM, Booth HL, Birchall MA, De Coppi P, Giangreco A, O'Callaghan C, Janes SM.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):156-68. doi: 10.1164/rccm.201507-1414OC.


Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.

Crowley C, Klanrit P, Butler CR, Varanou A, Platé M, Hynds RE, Chambers RC, Seifalian AM, Birchall MA, Janes SM.

Biomaterials. 2016 Mar;83:283-93. doi: 10.1016/j.biomaterials.2016.01.005. Epub 2016 Jan 5.


Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities.

Vallath S, Hynds RE, Succony L, Janes SM, Giangreco A.

Eur Respir J. 2014 Aug;44(2):513-22. doi: 10.1183/09031936.00146413. Epub 2014 Jan 16. Review.


Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine.

Hynds RE, Giangreco A.

Stem Cells. 2013 Mar;31(3):417-22. doi: 10.1002/stem.1290. Review.


Divergent cellular pathways of hippocampal memory consolidation and reconsolidation.

Lee JL, Hynds RE.

Hippocampus. 2013 Mar;23(3):233-44. doi: 10.1002/hipo.22083. Epub 2012 Nov 29.

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