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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins.

Wang J, Choi JM, Holehouse AS, Lee HO, Zhang X, Jahnel M, Maharana S, Lemaitre R, Pozniakovsky A, Drechsel D, Poser I, Pappu RV, Alberti S, Hyman AA.

Cell. 2018 Jun 26. pii: S0092-8674(18)30731-1. doi: 10.1016/j.cell.2018.06.006. [Epub ahead of print]


A User's Guide for Phase Separation Assays with Purified Proteins.

Alberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA.

J Mol Biol. 2018 Jun 23. pii: S0022-2836(18)30667-3. doi: 10.1016/j.jmb.2018.06.038. [Epub ahead of print]


The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion.

Ivanov MP, Ladurner R, Poser I, Beveridge R, Rampler E, Hudecz O, Novatchkova M, Hériché JK, Wutz G, van der Lelij P, Kreidl E, Hutchins JR, Axelsson-Ekker H, Ellenberg J, Hyman AA, Mechtler K, Peters JM.

EMBO J. 2018 Jun 21. pii: e97150. doi: 10.15252/embj.201797150. [Epub ahead of print]


Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery.

Kroschwald S, Munder MC, Maharana S, Franzmann TM, Richter D, Ruer M, Hyman AA, Alberti S.

Cell Rep. 2018 Jun 12;23(11):3327-3339. doi: 10.1016/j.celrep.2018.05.041.


RNA buffers the phase separation behavior of prion-like RNA binding proteins.

Maharana S, Wang J, Papadopoulos DK, Richter D, Pozniakovsky A, Poser I, Bickle M, Rizk S, Guillén-Boixet J, Franzmann TM, Jahnel M, Marrone L, Chang YT, Sterneckert J, Tomancak P, Hyman AA, Alberti S.

Science. 2018 May 25;360(6391):918-921. doi: 10.1126/science.aar7366. Epub 2018 Apr 12.


Controlling compartmentalization by non-membrane-bound organelles.

Wheeler RJ, Hyman AA.

Philos Trans R Soc Lond B Biol Sci. 2018 May 26;373(1747). pii: 20170193. doi: 10.1098/rstb.2017.0193. Review.


Protein Dynamics in Complex DNA Lesions.

Aleksandrov R, Dotchev A, Poser I, Krastev D, Georgiev G, Panova G, Babukov Y, Danovski G, Dyankova T, Hubatsch L, Ivanova A, Atemin A, Nedelcheva-Veleva MN, Hasse S, Sarov M, Buchholz F, Hyman AA, Grill SW, Stoynov SS.

Mol Cell. 2018 Mar 15;69(6):1046-1061.e5. doi: 10.1016/j.molcel.2018.02.016.


Tau protein liquid-liquid phase separation can initiate tau aggregation.

Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT.

EMBO J. 2018 Apr 3;37(7). pii: e98049. doi: 10.15252/embj.201798049. Epub 2018 Feb 22.


Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.

Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M.

Elife. 2018 Feb 22;7. pii: e32282. doi: 10.7554/eLife.32282.


Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A.

Nat Commun. 2018 Jan 23;9(1):335. doi: 10.1038/s41467-017-02299-1.


Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.

Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey UB, Hyman AA, Sterneckert JL.

Stem Cell Reports. 2018 Feb 13;10(2):375-389. doi: 10.1016/j.stemcr.2017.12.018. Epub 2018 Jan 18.


Phase separation of a yeast prion protein promotes cellular fitness.

Franzmann TM, Jahnel M, Pozniakovsky A, Mahamid J, Holehouse AS, Nüske E, Richter D, Baumeister W, Grill SW, Pappu RV, Hyman AA, Alberti S.

Science. 2018 Jan 5;359(6371). pii: eaao5654. doi: 10.1126/science.aao5654.


Organization and Function of Non-dynamic Biomolecular Condensates.

Woodruff JB, Hyman AA, Boke E.

Trends Biochem Sci. 2018 Feb;43(2):81-94. doi: 10.1016/j.tibs.2017.11.005. Epub 2017 Dec 16. Review.


Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit.

Enos SJ, Dressler M, Gomes BF, Hyman AA, Woodruff JB.

Biol Open. 2018 Jan 12;7(1). pii: bio029777. doi: 10.1242/bio.029777.


Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.

Toyoda Y, Cattin CJ, Stewart MP, Poser I, Theis M, Kurzchalia TV, Buchholz F, Hyman AA, Müller DJ.

Nat Commun. 2017 Nov 2;8(1):1266. doi: 10.1038/s41467-017-01147-6.


Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.

Hernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA.

Cell Rep. 2017 Sep 5;20(10):2304-2312. doi: 10.1016/j.celrep.2017.08.042.


RNA gets in phase.

Saha S, Hyman AA.

J Cell Biol. 2017 Aug 7;216(8):2235-2237. doi: 10.1083/jcb.201706034. Epub 2017 Jun 30.


Molecular biology: A liquid reservoir for silent chromatin.

Klosin A, Hyman AA.

Nature. 2017 Jul 13;547(7662):168-170. doi: 10.1038/nature23089. Epub 2017 Jun 21. No abstract available.


The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin.

Woodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A, Hyman AA.

Cell. 2017 Jun 1;169(6):1066-1077.e10. doi: 10.1016/j.cell.2017.05.028.


Stem cells: the new "model organism".

Drubin DG, Hyman AA.

Mol Biol Cell. 2017 Jun 1;28(11):1409-1411. doi: 10.1091/mbc.E17-03-0183.


ATP as a biological hydrotrope.

Patel A, Malinovska L, Saha S, Wang J, Alberti S, Krishnan Y, Hyman AA.

Science. 2017 May 19;356(6339):753-756. doi: 10.1126/science.aaf6846.


An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function.

Mateju D, Franzmann TM, Patel A, Kopach A, Boczek EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S.

EMBO J. 2017 Jun 14;36(12):1669-1687. doi: 10.15252/embj.201695957. Epub 2017 Apr 4.


Biomolecular condensates: organizers of cellular biochemistry.

Banani SF, Lee HO, Hyman AA, Rosen MK.

Nat Rev Mol Cell Biol. 2017 May;18(5):285-298. doi: 10.1038/nrm.2017.7. Epub 2017 Feb 22. Review.


In vitro Reconstitution of a Membrane Switch Mechanism for the Polarity Protein LGL.

Visco I, Hoege C, Hyman AA, Schwille P.

J Mol Biol. 2016 Dec 4;428(24 Pt A):4828-4842. doi: 10.1016/j.jmb.2016.10.003. Epub 2016 Oct 6.


The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability.

Pécréaux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J.

Biophys J. 2016 Oct 18;111(8):1773-1784. doi: 10.1016/j.bpj.2016.09.007.


Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.

Saha S, Weber CA, Nousch M, Adame-Arana O, Hoege C, Hein MY, Osborne-Nishimura E, Mahamid J, Jahnel M, Jawerth L, Pozniakovski A, Eckmann CR, Jülicher F, Hyman AA.

Cell. 2016 Sep 8;166(6):1572-1584.e16. doi: 10.1016/j.cell.2016.08.006. Epub 2016 Sep 1.


Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation.

Wueseke O, Zwicker D, Schwager A, Wong YL, Oegema K, Jülicher F, Hyman AA, Woodruff JB.

Biol Open. 2016 Oct 15;5(10):1431-1440. doi: 10.1242/bio.020990.


Are aberrant phase transitions a driver of cellular aging?

Alberti S, Hyman AA.

Bioessays. 2016 Oct;38(10):959-68. doi: 10.1002/bies.201600042. Epub 2016 Aug 24. Review.


Rheology of the Active Cell Cortex in Mitosis.

Fischer-Friedrich E, Toyoda Y, Cattin CJ, Müller DJ, Hyman AA, Jülicher F.

Biophys J. 2016 Aug 9;111(3):589-600. doi: 10.1016/j.bpj.2016.06.008.


Amyloid-like Self-Assembly of a Cellular Compartment.

Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ.

Cell. 2016 Jul 28;166(3):637-650. doi: 10.1016/j.cell.2016.06.051.


A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher temperatures.

Leaver M, Kienle S, Begasse ML, Sommer RJ, Hyman AA.

Biol Open. 2016 Aug 15;5(8):1111-7. doi: 10.1242/bio.018127.


Ki-67 acts as a biological surfactant to disperse mitotic chromosomes.

Cuylen S, Blaukopf C, Politi AZ, Müller-Reichert T, Neumann B, Poser I, Ellenberg J, Hyman AA, Gerlich DW.

Nature. 2016 Jul 14;535(7611):308-12. doi: 10.1038/nature18610. Epub 2016 Jun 29.


Priority of discovery in the life sciences.

Vale RD, Hyman AA.

Elife. 2016 Jun 16;5. pii: e16931. doi: 10.7554/eLife.16931.


Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.

Zheng X, Ramani A, Soni K, Gottardo M, Zheng S, Ming Gooi L, Li W, Feng S, Mariappan A, Wason A, Widlund P, Pozniakovsky A, Poser I, Deng H, Ou G, Riparbelli M, Giuliano C, Hyman AA, Sattler M, Gopalakrishnan J, Li H.

Nat Commun. 2016 Jun 16;7:11874. doi: 10.1038/ncomms11874.


PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.

Guerrera D, Shah J, Vasileva E, Sluysmans S, Méan I, Jond L, Poser I, Mann M, Hyman AA, Citi S.

J Biol Chem. 2016 May 20;291(21):11016-29. doi: 10.1074/jbc.M115.712935. Epub 2016 Apr 4.


CPAP promotes timely cilium disassembly to maintain neural progenitor pool.

Gabriel E, Wason A, Ramani A, Gooi LM, Keller P, Pozniakovsky A, Poser I, Noack F, Telugu NS, Calegari F, Šarić T, Hescheler J, Hyman AA, Gottardo M, Callaini G, Alkuraya FS, Gopalakrishnan J.

EMBO J. 2016 Apr 15;35(8):803-19. doi: 10.15252/embj.201593679. Epub 2016 Feb 29.


Visualizing the molecular sociology at the HeLa cell nuclear periphery.

Mahamid J, Pfeffer S, Schaffer M, Villa E, Danev R, Cuellar LK, Förster F, Hyman AA, Plitzko JM, Baumeister W.

Science. 2016 Feb 26;351(6276):969-72. doi: 10.1126/science.aad8857.


Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy.

Arnold J, Mahamid J, Lucic V, de Marco A, Fernandez JJ, Laugks T, Mayer T, Hyman AA, Baumeister W, Plitzko JM.

Biophys J. 2016 Feb 23;110(4):860-9. doi: 10.1016/j.bpj.2015.10.053. Epub 2016 Jan 5.


Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement.

Sorce B, Escobedo C, Toyoda Y, Stewart MP, Cattin CJ, Newton R, Banerjee I, Stettler A, Roska B, Eaton S, Hyman AA, Hierlemann A, Müller DJ.

Nat Commun. 2015 Nov 25;6:8872. doi: 10.1038/ncomms9872.


A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M.

Cell. 2015 Oct 22;163(3):712-23. doi: 10.1016/j.cell.2015.09.053. Epub 2015 Oct 22.


TransgeneOmics--A transgenic platform for protein localization based function exploration.

Hasse S, Hyman AA, Sarov M.

Methods. 2016 Mar 1;96:69-74. doi: 10.1016/j.ymeth.2015.10.005. Epub 2015 Oct 17. Review.


A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S.

Cell. 2015 Aug 27;162(5):1066-77. doi: 10.1016/j.cell.2015.07.047.


Suppression of Ostwald ripening in active emulsions.

Zwicker D, Hyman AA, Jülicher F.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jul;92(1):012317. Epub 2015 Jul 22.


A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms.

Mahamid J, Schampers R, Persoon H, Hyman AA, Baumeister W, Plitzko JM.

J Struct Biol. 2015 Nov;192(2):262-9. doi: 10.1016/j.jsb.2015.07.012. Epub 2015 Jul 26.


Method: In vitro analysis of pericentriolar material assembly.

Woodruff JB, Hyman AA.

Methods Cell Biol. 2015;129:369-82. doi: 10.1016/bs.mcb.2015.04.006. Epub 2015 Jun 19.


Emergent Properties of the Metaphase Spindle.

Reber S, Hyman AA.

Cold Spring Harb Perspect Biol. 2015 Jul 1;7(7):a015784. doi: 10.1101/cshperspect.a015784. Review.


Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro.

Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA.

Science. 2015 May 15;348(6236):808-12. doi: 10.1126/science.aaa3923.


Temperature Dependence of Cell Division Timing Accounts for a Shift in the Thermal Limits of C. elegans and C. briggsae.

Begasse ML, Leaver M, Vazquez F, Grill SW, Hyman AA.

Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00007-8. doi: 10.1016/j.celrep.2015.01.006. [Epub ahead of print]


Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement.

Ramanathan SP, Helenius J, Stewart MP, Cattin CJ, Hyman AA, Muller DJ.

Nat Cell Biol. 2015 Feb;17(2):148-59. doi: 10.1038/ncb3098. Epub 2015 Jan 26.


Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis.

Özlü N, Qureshi MH, Toyoda Y, Renard BY, Mollaoglu G, Özkan NE, Bulbul S, Poser I, Timm W, Hyman AA, Mitchison TJ, Steen JA.

EMBO J. 2015 Jan 13;34(2):251-65. doi: 10.15252/embj.201385162. Epub 2014 Dec 4.

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