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Differential DNA methylation in newborns with maternal exposure to heavy metals from an e-waste recycling area.

Zeng Z, Huo X, Zhang Y, Hylkema MN, Wu Y, Xu X.

Environ Res. 2019 Apr;171:536-545. doi: 10.1016/j.envres.2019.01.007. Epub 2019 Jan 6.


In utero exposure to cigarette smoke and effects across generations: A conference of animals on asthma.

Hammer B, Wagner C, Divac Rankov A, Reuter S, Bartel S, Hylkema MN, Krüger A, Svanes C, Krauss-Etschmann S.

Clin Exp Allergy. 2018 Nov;48(11):1378-1390. doi: 10.1111/cea.13283. Review.


microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA.

Eur Respir J. 2018 Sep 6;52(3). pii: 1701556. doi: 10.1183/13993003.01556-2017. Print 2018 Sep.


Stability of individual LPS-induced ex vivo cytokine release in a whole blood assay over a five-year interval.

Spierenburg EAJ, Portengen L, Smit LAM, Krop EJM, Hylkema MN, Rijkers GT, Heederik D, Wouters IM.

J Immunol Methods. 2018 Sep;460:119-124. doi: 10.1016/j.jim.2018.06.018. Epub 2018 Jul 6.


Dual role of YM1+ M2 macrophages in allergic lung inflammation.

Draijer C, Robbe P, Boorsma CE, Hylkema MN, Melgert BN.

Sci Rep. 2018 Mar 23;8(1):5105. doi: 10.1038/s41598-018-23269-7.


Epiproteome profiling of cadmium-transformed human bronchial epithelial cells by quantitative histone post-translational modification-enzyme-linked immunosorbent assay.

Liang ZL, Wu DD, Yao Y, Yu FY, Yang L, Tan HW, Hylkema MN, Rots MG, Xu YM, Lau ATY.

J Appl Toxicol. 2018 Jun;38(6):888-895. doi: 10.1002/jat.3597. Epub 2018 Feb 9.


Occupational endotoxin exposure in association with atopic sensitization and respiratory health in adults: Results of a 5-year follow-up.

Spierenburg EAJ, Smit LAM, Krop EJM, Heederik D, Hylkema MN, Wouters IM.

PLoS One. 2017 Dec 6;12(12):e0189097. doi: 10.1371/journal.pone.0189097. eCollection 2017.


The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific.

Meyer KF, Verkaik-Schakel RN, Timens W, Kobzik L, Plösch T, Hylkema MN.

Epigenetics. 2017;12(12):1076-1091. doi: 10.1080/15592294.2017.1403691.


Increased memory T cell populations in Pb-exposed children from an e-waste-recycling area.

Cao J, Xu X, Zhang Y, Zeng Z, Hylkema MN, Huo X.

Sci Total Environ. 2018 Mar;616-617:988-995. doi: 10.1016/j.scitotenv.2017.10.220. Epub 2017 Oct 31.


The potential for targeted rewriting of epigenetic marks in COPD as a new therapeutic approach.

Wu DD, Song J, Bartel S, Krauss-Etschmann S, Rots MG, Hylkema MN.

Pharmacol Ther. 2018 Feb;182:1-14. doi: 10.1016/j.pharmthera.2017.08.007. Epub 2017 Aug 19. Review.


Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.

Song J, Heijink IH, Kistemaker LEM, Reinders-Luinge M, Kooistra W, Noordhoek JA, Gosens R, Brandsma CA, Timens W, Hiemstra PS, Rots MG, Hylkema MN.

Clin Epigenetics. 2017 Apr 24;9:42. doi: 10.1186/s13148-017-0341-7. eCollection 2017.


Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring.

Meyer KF, Krauss-Etschmann S, Kooistra W, Reinders-Luinge M, Timens W, Kobzik L, Plösch T, Hylkema MN.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L542-L555. doi: 10.1152/ajplung.00271.2016. Epub 2017 Jan 27.


Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells.

Song J, Cano-Rodriquez D, Winkle M, Gjaltema RA, Goubert D, Jurkowski TP, Heijink IH, Rots MG, Hylkema MN.

Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L334-L347. doi: 10.1152/ajplung.00059.2016. Epub 2016 Dec 23.


Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways.

Draijer C, Boorsma CE, Robbe P, Timens W, Hylkema MN, Ten Hacken NH, van den Berge M, Postma DS, Melgert BN.

J Allergy Clin Immunol. 2017 Jul;140(1):280-283.e3. doi: 10.1016/j.jaci.2016.11.020. Epub 2016 Dec 19. No abstract available.


Atopy and Inhaled Corticosteroid Use Associate with Fewer IL-17+ Cells in Asthmatic Airways.

Fattahi F, Brandsma CA, Lodewijk M, Reinders-Luinge M, Postma DS, Timens W, Hylkema MN, Ten Hacken NH.

PLoS One. 2016 Aug 23;11(8):e0161433. doi: 10.1371/journal.pone.0161433. eCollection 2016.


Early-life Exposure to Widespread Environmental Toxicants and Health Risk: A Focus on the Immune and Respiratory Systems.

Cao J, Xu X, Hylkema MN, Zeng EY, Sly PD, Suk WA, Bergman Å, Huo X.

Ann Glob Health. 2016 Jan-Feb;82(1):119-31. doi: 10.1016/j.aogh.2016.01.023. Review.


The Dutch National Program for Respiratory Research.

Postma DS, Wijkstra PJ, Hiemstra PS, Melgert BN, Braunstahl GJ, Hylkema MN, Sterk PJ.

Lancet Respir Med. 2016 May;4(5):356-7. doi: 10.1016/S2213-2600(16)30035-2. Review. No abstract available.


Sexual maturation protects against development of lung inflammation through estrogen.

Draijer C, Hylkema MN, Boorsma CE, Klok PA, Robbe P, Timens W, Postma DS, Greene CM, Melgert BN.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15;310(2):L166-74. doi: 10.1152/ajplung.00119.2015. Epub 2015 Nov 25.


Old dilemma: asthma with irreversible airway obstruction or COPD.

Fattahi F, Vonk JM, Bulkmans N, Fleischeuer R, Gouw A, Grünberg K, Mauad T, Popper H, Felipe-Silva A, Vrugt B, Wright JL, Yang HM, Kocks JW, Hylkema MN, Postma DS, Timens W, Ten Hacken NH.

Virchows Arch. 2015 Nov;467(5):583-93. doi: 10.1007/s00428-015-1824-6. Epub 2015 Sep 14.


Inter- and transgenerational epigenetic inheritance: evidence in asthma and COPD?

Krauss-Etschmann S, Meyer KF, Dehmel S, Hylkema MN.

Clin Epigenetics. 2015 May 1;7:53. doi: 10.1186/s13148-015-0085-1. eCollection 2015.


Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.

Kistemaker LE, Hiemstra PS, Bos IS, Bouwman S, van den Berge M, Hylkema MN, Meurs H, Kerstjens HA, Gosens R.

Thorax. 2015 Jul;70(7):668-76. doi: 10.1136/thoraxjnl-2014-205731. Epub 2015 May 20.


Healthy worker survivor analysis in an occupational cohort study of Dutch agricultural workers.

Spierenburg EA, Smit LA, Heederik D, Robbe P, Hylkema MN, Wouters IM.

Int Arch Occup Environ Health. 2015 Nov;88(8):1165-73. doi: 10.1007/s00420-015-1047-9. Epub 2015 Mar 21.


Distinct macrophage phenotypes in allergic and nonallergic lung inflammation.

Robbe P, Draijer C, Borg TR, Luinge M, Timens W, Wouters IM, Melgert BN, Hylkema MN.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L358-67. doi: 10.1152/ajplung.00341.2014. Epub 2014 Dec 12.


Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice.

Kistemaker LE, van Os RP, Dethmers-Ausema A, Bos IS, Hylkema MN, van den Berge M, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L96-103. doi: 10.1152/ajplung.00259.2014. Epub 2014 Nov 7.


Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.

Koning H, van Oosterhout AJ, Brouwer U, den Boef LE, Gras R, Reinders-Luinge M, Brandsma CA, van der Toorn M, Hylkema MN, Willemse BW, Sayers I, Koppelman GH, Nawijn MC.

PLoS One. 2014 Jul 3;9(7):e98197. doi: 10.1371/journal.pone.0098197. eCollection 2014.


Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation.

de Vries M, Heijink IH, Gras R, den Boef LE, Reinders-Luinge M, Pouwels SD, Hylkema MN, van der Toorn M, Brouwer U, van Oosterhout AJ, Nawijn MC.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L240-51. doi: 10.1152/ajplung.00156.2013. Epub 2014 May 9.


Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium.

Zijlstra GJ, Fattahi F, Rozeveld D, Jonker MR, Kliphuis NM, van den Berge M, Hylkema MN, ten Hacken NH, van Oosterhout AJ, Heijink IH.

Eur Respir J. 2014 Aug;44(2):361-70. doi: 10.1183/09031936.00209513. Epub 2014 Mar 13.


Shifted T-cell polarisation after agricultural dust exposure in mice and men.

Robbe P, Spierenburg EA, Draijer C, Brandsma CA, Telenga E, van Oosterhout AJ, van den Berge M, Luinge M, Melgert BN, Heederik D, Timens W, Wouters IM, Hylkema MN.

Thorax. 2014 Jul;69(7):630-7. doi: 10.1136/thoraxjnl-2013-204295. Epub 2014 Feb 17.


Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction.

van de Garde MD, Martinez FO, Melgert BN, Hylkema MN, Jonkers RE, Hamann J.

J Immunol. 2014 Feb 1;192(3):1196-208. doi: 10.4049/jimmunol.1302138. Epub 2014 Jan 6.


Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.

Kistemaker LE, Bos ST, Mudde WM, Hylkema MN, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):690-8. doi: 10.1165/rcmb.2013-0220OC.


Characterization of macrophage phenotypes in three murine models of house-dust-mite-induced asthma.

Draijer C, Robbe P, Boorsma CE, Hylkema MN, Melgert BN.

Mediators Inflamm. 2013;2013:632049. doi: 10.1155/2013/632049. Epub 2013 Feb 27.


Authors’ response to Persson C: primary lysis/necrosis of eosinophils and clinical control of asthma.

Fattahi F, Volbeda F, Broekema M, Lodewijk ME, Hylkema MN, Reddel HK, Timens W, Postma DS, ten Hacken NH.

Thorax. 2013 Mar;68(3):295-6. No abstract available.


Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.

Kistemaker LE, Bos IS, Hylkema MN, Nawijn MC, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R.

Eur Respir J. 2013 Dec;42(6):1677-88. doi: 10.1183/09031936.00112412. Epub 2013 Feb 8.


Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study.

Fattahi F, ten Hacken NH, Löfdahl CG, Hylkema MN, Timens W, Postma DS, Vonk JM.

Respir Res. 2013 Jan 28;14:10. doi: 10.1186/1465-9921-14-10.


Clinical control of asthma associates with measures of airway inflammation.

Volbeda F, Broekema M, Lodewijk ME, Hylkema MN, Reddel HK, Timens W, Postma DS, ten Hacken NH.

Thorax. 2013 Jan;68(1):19-24. doi: 10.1136/thoraxjnl-2012-201861. Epub 2012 Oct 6.


The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster.

Talaei F, Bouma HR, Hylkema MN, Strijkstra AM, Boerema AS, Schmidt M, Henning RH.

J Exp Biol. 2012 Aug 15;215(Pt 16):2912-9. doi: 10.1242/jeb.067363.


Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease.

Krauss-Etschmann S, Bush A, Bellusci S, Brusselle GG, Dahlén SE, Dehmel S, Eickelberg O, Gibson G, Hylkema MN, Knaus P, Königshoff M, Lloyd CM, Macciarini P, Mailleux A, Marsland BJ, Postma DS, Roberts G, Samakovlis C, Stocks J, Vandesompele J, Wjst M, Holloway J.

Thorax. 2013 Apr;68(4):380-4. doi: 10.1136/thoraxjnl-2012-201902. Epub 2012 Jul 10. Review.


Smoking during pregnancy influences the maternal immune response in mice and humans.

Prins JR, Hylkema MN, Erwich JJ, Huitema S, Dekkema GJ, Dijkstra FE, Faas MM, Melgert BN.

Am J Obstet Gynecol. 2012 Jul;207(1):76.e1-14. doi: 10.1016/j.ajog.2012.04.017. Epub 2012 Apr 16.


Altered expression of immune-associated genes in first-trimester human decidua of pregnancies later complicated with hypertension or foetal growth restriction.

Prins JR, Faas MM, Melgert BN, Huitema S, Timmer A, Hylkema MN, Erwich JJ.

Placenta. 2012 May;33(5):453-5. doi: 10.1016/j.placenta.2012.02.010. Epub 2012 Mar 3.


Differential switching to IgG and IgA in active smoking COPD patients and healthy controls.

Brandsma CA, Kerstjens HA, van Geffen WH, Geerlings M, Postma DS, Hylkema MN, Timens W.

Eur Respir J. 2012 Aug;40(2):313-21. doi: 10.1183/09031936.00011211. Epub 2012 Jan 12.


The search for autoantibodies against elastin, collagen and decorin in COPD.

Brandsma CA, Kerstjens HA, Geerlings M, Kerkhof M, Hylkema MN, Postma DS, Timens W.

Eur Respir J. 2011 May;37(5):1289-92. doi: 10.1183/09031936.00116710. No abstract available.


Reversible remodeling of lung tissue during hibernation in the Syrian hamster.

Talaei F, Hylkema MN, Bouma HR, Boerema AS, Strijkstra AM, Henning RH, Schmidt M.

J Exp Biol. 2011 Apr 15;214(Pt 8):1276-82. doi: 10.1242/jeb.052704.


Smoking and nonsmoking asthma: differences in clinical outcome and pathogenesis.

Fattahi F, Hylkema MN, Melgert BN, Timens W, Postma DS, ten Hacken NH.

Expert Rev Respir Med. 2011 Feb;5(1):93-105. doi: 10.1586/ers.10.85. Review.


More alternative activation of macrophages in lungs of asthmatic patients.

Melgert BN, ten Hacken NH, Rutgers B, Timens W, Postma DS, Hylkema MN.

J Allergy Clin Immunol. 2011 Mar;127(3):831-3. doi: 10.1016/j.jaci.2010.10.045. Epub 2010 Dec 17. No abstract available.


Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice.

Brandsma CA, Timens W, Geerlings M, Jekel H, Postma DS, Hylkema MN, Kerstjens HA.

BMC Pulm Med. 2010 Dec 13;10:64. doi: 10.1186/1471-2466-10-64.


Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.

Nawijn MC, Piavaux BJ, Jeurink PV, Gras R, Reinders MA, Stearns T, Foote S, Hylkema MN, Groot PC, Korstanje R, Oosterhout AJ.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):295-303. doi: 10.1165/rcmb.2009-0369OC. Epub 2010 Oct 22.


Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma.

Broekema M, Timens W, Vonk JM, Volbeda F, Lodewijk ME, Hylkema MN, Ten Hacken NH, Postma DS.

Am J Respir Crit Care Med. 2011 Feb 1;183(3):310-6. doi: 10.1164/rccm.201003-0494OC. Epub 2010 Sep 2.


Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?

Volbeda F, ten Hacken NH, Lodewijk ME, Dijkstra A, Hylkema MN, Broekema M, Timens W, Postma DS.

Respir Res. 2010 Aug 2;11:106. doi: 10.1186/1465-9921-11-106.


Maternal smoking during pregnancy decreases Wnt signalling in neonatal mice.

Blacquière MJ, Timens W, van den Berg A, Geerlings M, Postma DS, Hylkema MN.

Thorax. 2010 Jun;65(6):553-4. doi: 10.1136/thx.2009.120154. No abstract available.


Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1).

Broekema M, Volbeda F, Timens W, Dijkstra A, Lee NA, Lee JJ, Lodewijk ME, Postma DS, Hylkema MN, ten Hacken NH.

Respir Med. 2010 Sep;104(9):1254-62. doi: 10.1016/j.rmed.2010.03.030.

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