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Items: 1 to 50 of 106


KEYNOTE-585: Phase III study of perioperative chemotherapy with or without pembrolizumab for gastric cancer.

Bang YJ, Van Cutsem E, Fuchs CS, Ohtsu A, Tabernero J, Ilson DH, Hyung WJ, Strong VE, Goetze TO, Yoshikawa T, Tang LH, Hwang PMT, Webb N, Adelberg D, Shitara K.

Future Oncol. 2019 Mar;15(9):943-952. doi: 10.2217/fon-2018-0581. Epub 2019 Feb 19.


Modeling the prevalent germline TP53 R337H mutation in mouse.

Park JH, Wang PY, Hwang PM.

Oncotarget. 2019 Jan 18;10(6):631-632. doi: 10.18632/oncotarget.26603. eCollection 2019 Jan 18. No abstract available.


Structure and proteolytic susceptibility of the inhibitory C-terminal tail of cardiac troponin I.

Mahmud Z, Zahran S, Liu PB, Reiz B, Chan BYH, Roczkowsky A, McCartney CE, Davies PL, Li L, Schulz R, Hwang PM.

Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):661-671. doi: 10.1016/j.bbagen.2019.01.008. Epub 2019 Jan 16.


Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia.

Huang X, Zhuang J, Chung SW, Huang B, Halpert G, Negron K, Sun X, Yang J, Oh Y, Hwang PM, Hanes J, Suk JS.

ACS Nano. 2019 Jan 22;13(1):236-247. doi: 10.1021/acsnano.8b05399. Epub 2018 Dec 26.


3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP.

Tikunova SB, Cuesta A, Price M, Li MX, Belevych N, Biesiadecki BJ, Reiser PJ, Hwang PM, Davis JP.

J Gen Physiol. 2019 Jan 7;151(1):9-17. doi: 10.1085/jgp.201812131. Epub 2018 Nov 15.


The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C.

Li MX, Gelozia S, Danmaliki GI, Wen Y, Liu PB, Lemieux MJ, West FG, Sykes BD, Hwang PM.

Biochem Biophys Rep. 2018 Nov 1;16:145-151. doi: 10.1016/j.bbrep.2018.10.012. eCollection 2018 Dec.


Structural Changes Induced by the Binding of the Calcium Desensitizer W7 to Cardiac Troponin.

Cai F, Hwang PM, Sykes BD.

Biochemistry. 2018 Nov 20;57(46):6461-6469. doi: 10.1021/acs.biochem.8b00882. Epub 2018 Nov 6.


Mouse Homolog of the Human TP53 R337H Mutation Reveals Its Role in Tumorigenesis.

Park JH, Li J, Starost MF, Liu C, Zhuang J, Chen J, Achatz MI, Kang JG, Wang PY, Savage SA, Hwang PM.

Cancer Res. 2018 Sep 15;78(18):5375-5383. doi: 10.1158/0008-5472.CAN-18-0016. Epub 2018 Jul 24.


Stereoselective Deuteration in Aspartate, Asparagine, Lysine, and Methionine Amino Acid Residues Using Fumarate as a Carbon Source for Escherichia coli in D2O.

Danmaliki GI, Liu PB, Hwang PM.

Biochemistry. 2017 Nov 14;56(45):6015-6029. doi: 10.1021/acs.biochem.7b00991. Epub 2017 Nov 3.


Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome.

Wang PY, Li J, Walcott FL, Kang JG, Starost MF, Talagala SL, Zhuang J, Park JH, Huffstutler RD, Bryla CM, Mai PL, Pollak M, Annunziata CM, Savage SA, Fojo AT, Hwang PM.

J Clin Invest. 2017 Jan 3;127(1):132-136. doi: 10.1172/JCI88668. Epub 2016 Nov 21.


Structures reveal details of small molecule binding to cardiac troponin.

Cai F, Li MX, Pineda-Sanabria SE, Gelozia S, Lindert S, West F, Sykes BD, Hwang PM.

J Mol Cell Cardiol. 2016 Dec;101:134-144. doi: 10.1016/j.yjmcc.2016.10.016. Epub 2016 Nov 5. Review.


Forkhead Box O3A (FOXO3) and the Mitochondrial Disulfide Relay Carrier (CHCHD4) Regulate p53 Protein Nuclear Activity in Response to Exercise.

Zhuang J, Kamp WM, Li J, Liu C, Kang JG, Wang PY, Hwang PM.

J Biol Chem. 2016 Nov 25;291(48):24819-24827. Epub 2016 Sep 29.


Long-term adaptation to hypoxia preserves hematopoietic stem cell function.

Chen J, Kang JG, Keyvanfar K, Young NS, Hwang PM.

Exp Hematol. 2016 Sep;44(9):866-873.e4. doi: 10.1016/j.exphem.2016.04.010. Epub 2016 Apr 23.


TP53 mutation, mitochondria and cancer.

Kamp WM, Wang PY, Hwang PM.

Curr Opin Genet Dev. 2016 Jun;38:16-22. doi: 10.1016/j.gde.2016.02.007. Epub 2016 Mar 19. Review.


Erratum to: Low ambient oxygen prevents atherosclerosis.

Kang JG, Sung HJ, Amar MJ, Pryor M, Remaley AT, Allen MD, Noguchi AC, Springer DA, Kwon J, Chen J, Park JH, Wang PY, Hwang PM.

J Mol Med (Berl). 2016 Mar;94(3):287-9. doi: 10.1007/s00109-016-1399-y. No abstract available.


Low ambient oxygen prevents atherosclerosis.

Kang JG, Sung HJ, Amar MJ, Pryor M, Remaley AT, Allen MD, Noguchi AC, Springer DA, Kwon J, Chen J, Park JH, Wang PY, Hwang PM.

J Mol Med (Berl). 2016 Mar;94(3):277-86. doi: 10.1007/s00109-016-1386-3. Epub 2016 Feb 2. Erratum in: J Mol Med (Berl). 2016 Mar;94(3):287-9.


p53 as guardian of the mitochondrial genome.

Park JH, Zhuang J, Li J, Hwang PM.

FEBS Lett. 2016 Apr;590(7):924-34. doi: 10.1002/1873-3468.12061. Epub 2016 Feb 3. Review.


'(De-)sensitization' vs. 'Uncoupling': what drives cardiomyopathies in the thin filament?

Hwang PM.

Cardiovasc Res. 2016 Jan 1;109(1):185-6. doi: 10.1093/cvr/cvv232. Epub 2015 Oct 12. No abstract available.


Combining a PagP fusion protein system with nickel ion-catalyzed cleavage to produce intrinsically disordered proteins in E. coli.

Zahran S, Pan JS, Liu PB, Hwang PM.

Protein Expr Purif. 2015 Dec;116:133-8. doi: 10.1016/j.pep.2015.08.018. Epub 2015 Aug 19.


Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs.

Li MX, Hwang PM.

Gene. 2015 Oct 25;571(2):153-66. doi: 10.1016/j.gene.2015.07.074. Epub 2015 Jul 29. Review.


Targeting the sarcomere to correct muscle function.

Hwang PM, Sykes BD.

Nat Rev Drug Discov. 2015 May;14(5):313-28. doi: 10.1038/nrd4554. Epub 2015 Apr 17. Review.


Personalized preventive medicine: genetics and the response to regular exercise in preventive interventions.

Bouchard C, Antunes-Correa LM, Ashley EA, Franklin N, Hwang PM, Mattsson CM, Negrao CE, Phillips SA, Sarzynski MA, Wang PY, Wheeler MT.

Prog Cardiovasc Dis. 2015 Jan-Feb;57(4):337-46. doi: 10.1016/j.pcad.2014.08.005. Epub 2014 Aug 13. Review.


Virologic resistance analysis from a phase 2 study of MK-5172 combined with pegylated interferon/ribavirin in treatment-naive patients with hepatitis C virus genotype 1 infection.

Howe AY, Black S, Curry S, Ludmerer SW, Liu R, Barnard RJ, Newhard W, Hwang PM, Nickle D, Gilbert C, Caro L, DiNubile MJ, Mobashery N.

Clin Infect Dis. 2014 Dec 15;59(12):1657-65. doi: 10.1093/cid/ciu696. Epub 2014 Sep 28.


The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C.

Hwang PM, Cai F, Pineda-Sanabria SE, Corson DC, Sykes BD.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14412-7. doi: 10.1073/pnas.1410775111. Epub 2014 Sep 22.


Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction.

Li J, Ma W, Wang PY, Hurley PJ, Bunz F, Hwang PM.

Free Radic Biol Med. 2014 Aug;73:270-7. doi: 10.1016/j.freeradbiomed.2014.05.022. Epub 2014 Jun 2.


Cell-based measurements of mitochondrial function in human subjects.

Kang JG, Wang PY, Hwang PM.

Methods Enzymol. 2014;542:209-21. doi: 10.1016/B978-0-12-416618-9.00011-X.


Combination of vaniprevir with peginterferon and ribavirin significantly increases the rate of SVR in treatment-experienced patients with chronic HCV genotype 1 infection and cirrhosis.

Rodriguez-Torres M, Stoehr A, Gane EJ, Serfaty L, Lawitz E, Zhou A, Bourque M, Bhanja S, Strizki J, Barnard RJ, Hwang PM, DiNubile MJ, Mobashery N.

Clin Gastroenterol Hepatol. 2014 Jun;12(6):1029-37.e5. doi: 10.1016/j.cgh.2013.09.067. Epub 2013 Oct 10.


Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.

Zhuang J, Wang PY, Huang X, Chen X, Kang JG, Hwang PM.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17356-61. doi: 10.1073/pnas.1310908110. Epub 2013 Oct 7.


Targeted expression, purification, and cleavage of fusion proteins from inclusion bodies in Escherichia coli.

Hwang PM, Pan JS, Sykes BD.

FEBS Lett. 2014 Jan 21;588(2):247-52. doi: 10.1016/j.febslet.2013.09.028. Epub 2013 Sep 27. Review.


Emergence of resistance-associated variants after failed triple therapy with vaniprevir in treatment-experienced non-cirrhotic patients with hepatitis C-genotype 1 infection: a population and clonal analysis.

Barnard RJ, McHale CM, Newhard W, Cheney CA, Graham DJ, Himmelberger AL, Strizki J, Hwang PM, Rivera AA, Reeves JD, Nickle D, Dinubile MJ, Hazuda DJ, Mobashery N.

Virology. 2013 Sep 1;443(2):278-84. doi: 10.1016/j.virol.2013.05.013. Epub 2013 Jun 10.


Characterization of vaniprevir, a hepatitis C virus NS3/4A protease inhibitor, in patients with HCV genotype 1 infection: safety, antiviral activity, resistance, and pharmacokinetics.

Lawitz E, Sulkowski M, Jacobson I, Kraft WK, Maliakkal B, Al-Ibrahim M, Gordon SC, Kwo P, Rockstroh JK, Panorchan P, Miller M, Caro L, Barnard R, Hwang PM, Gress J, Quirk E, Mobashery N.

Antiviral Res. 2013 Sep;99(3):214-20. doi: 10.1016/j.antiviral.2013.05.015. Epub 2013 Jun 7.


Increased oxidative metabolism in the Li-Fraumeni syndrome.

Wang PY, Ma W, Park JY, Celi FS, Arena R, Choi JW, Ali QA, Tripodi DJ, Zhuang J, Lago CU, Strong LC, Talagala SL, Balaban RS, Kang JG, Hwang PM.

N Engl J Med. 2013 Mar 14;368(11):1027-32. doi: 10.1056/NEJMoa1214091.


Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium.

Mai PL, Malkin D, Garber JE, Schiffman JD, Weitzel JN, Strong LC, Wyss O, Locke L, Means V, Achatz MI, Hainaut P, Frebourg T, Evans DG, Bleiker E, Patenaude A, Schneider K, Wilfond B, Peters JA, Hwang PM, Ford J, Tabori U, Ognjanovic S, Dennis PA, Wentzensen IM, Greene MH, Fraumeni JF Jr, Savage SA.

Cancer Genet. 2012 Oct;205(10):479-87. doi: 10.1016/j.cancergen.2012.06.008. Epub 2012 Aug 29.


A PagP fusion protein system for the expression of intrinsically disordered proteins in Escherichia coli.

Hwang PM, Pan JS, Sykes BD.

Protein Expr Purif. 2012 Sep;85(1):148-51. doi: 10.1016/j.pep.2012.07.007. Epub 2012 Jul 25.


Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology?

Zhuang J, Ma W, Lago CU, Hwang PM.

Free Radic Biol Med. 2012 Sep 15;53(6):1279-85. doi: 10.1016/j.freeradbiomed.2012.07.026. Epub 2012 Jul 25. Review.


Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C: a randomized phase II study.

Manns MP, Gane E, Rodriguez-Torres M, Stoehr A, Yeh CT, Marcellin P, Wiedmann RT, Hwang PM, Caro L, Barnard RJ, Lee AW; MK-7009 Protocol 007 Study Group.

Hepatology. 2012 Sep;56(3):884-93. doi: 10.1002/hep.25743. Epub 2012 Jul 17.


p53: exercise capacity and metabolism.

Wang PY, Zhuang J, Hwang PM.

Curr Opin Oncol. 2012 Jan;24(1):76-82. doi: 10.1097/CCO.0b013e32834de1d8. Review.


Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.

Kang JG, Amar MJ, Remaley AT, Kwon J, Blackshear PJ, Wang PY, Hwang PM.

J Immunol. 2011 Sep 1;187(5):2696-701. doi: 10.4049/jimmunol.1101149. Epub 2011 Jul 22.


Ambient oxygen promotes tumorigenesis.

Sung HJ, Ma W, Starost MF, Lago CU, Lim PK, Sack MN, Kang JG, Wang PY, Hwang PM.

PLoS One. 2011 May 12;6(5):e19785. doi: 10.1371/journal.pone.0019785.


Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension.

Shah S, Hermanowski-Vosatka A, Gibson K, Ruck RA, Jia G, Zhang J, Hwang PM, Ryan NW, Langdon RB, Feig PU.

J Am Soc Hypertens. 2011 May-Jun;5(3):166-76. doi: 10.1016/j.jash.2011.01.009. Epub 2011 Mar 21.


Mitochondrial respiration protects against oxygen-associated DNA damage.

Sung HJ, Ma W, Wang PY, Hynes J, O'Riordan TC, Combs CA, McCoy JP Jr, Bunz F, Kang JG, Hwang PM.

Nat Commun. 2010 Apr 12;1:5. doi: 10.1038/ncomms1003.


p53, aerobic metabolism, and cancer.

Lago CU, Sung HJ, Ma W, Wang PY, Hwang PM.

Antioxid Redox Signal. 2011 Sep 15;15(6):1739-48. doi: 10.1089/ars.2010.3650. Epub 2011 Apr 14. Review.


FOS expression in blood as a LDL-independent marker of statin treatment.

Kang JG, Sung HJ, Jawed SI, Brenneman CL, Rao YN, Sher S, Facio FM, Biesecker LG, Quyyumi AA, Sachdev V, Hwang PM.

Atherosclerosis. 2010 Oct;212(2):567-70. doi: 10.1016/j.atherosclerosis.2010.06.023. Epub 2010 Jun 19.


Polo-like kinases mediate cell survival in mitochondrial dysfunction.

Matsumoto T, Wang PY, Ma W, Sung HJ, Matoba S, Hwang PM.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14542-6. doi: 10.1073/pnas.0904229106. Epub 2009 Aug 11.


p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content.

Park JY, Wang PY, Matsumoto T, Sung HJ, Ma W, Choi JW, Anderson SA, Leary SC, Balaban RS, Kang JG, Hwang PM.

Circ Res. 2009 Sep 25;105(7):705-12, 11 p following 712. doi: 10.1161/CIRCRESAHA.109.205310. Epub 2009 Aug 20.


The Krebs cycle meets the cell cycle: mitochondria and the G1-S transition.

Finkel T, Hwang PM.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11825-6. doi: 10.1073/pnas.0906430106. Epub 2009 Jul 15. No abstract available.


Increased peripheral benzodiazepine receptors in arterial plaque of patients with atherosclerosis: an autoradiographic study with [(3)H]PK 11195.

Fujimura Y, Hwang PM, Trout Iii H, Kozloff L, Imaizumi M, Innis RB, Fujita M.

Atherosclerosis. 2008 Nov;201(1):108-11. doi: 10.1016/j.atherosclerosis.2008.02.032. Epub 2008 Mar 14.


Hepatic effects of lovastatin exposure in patients with liver disease: a retrospective cohort study.

Avins AL, Manos MM, Ackerson L, Zhao W, Murphy R, Levin TR, Watson DJ, Hwang PM, Replogle A, Levine JG.

Drug Saf. 2008;31(4):325-34.


How does p53 regulate mitochondrial respiration?

Fields J, Hanisch JJ, Choi JW, Hwang PM.

IUBMB Life. 2007 Oct;59(10):682-4. Review. No abstract available.


Augmented Wnt signaling in a mammalian model of accelerated aging.

Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T.

Science. 2007 Aug 10;317(5839):803-6.

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