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Items: 1 to 50 of 192

1.

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.

Jensen AR, Adams Y, Hviid L.

Immunol Rev. 2019 Sep 27. doi: 10.1111/imr.12807. [Epub ahead of print] Review.

PMID:
31562653
2.

Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C.

Olsen RW, Ecklu-Mensah G, Bengtsson A, Ofori MF, Kusi KA, Koram KA, Hviid L, Adams Y, Jensen ATR.

Infect Immun. 2019 Sep 19;87(10). pii: e00224-19. doi: 10.1128/IAI.00224-19. Print 2019 Oct.

3.

Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones.

Quintana MDP, Ecklu-Mensah G, Tcherniuk SO, Ditlev SB, Oleinikov AV, Hviid L, Lopez-Perez M.

Sci Rep. 2019 Apr 15;9(1):6050. doi: 10.1038/s41598-019-42585-0.

4.

Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region.

Doritchamou J, Teo A, Morrison R, Arora G, Kwan J, Manzella-Lapeira J, Medina-Maldonado S, Langhorne J, Hviid L, Narum DL, Dicko A, Fried M, Duffy PE.

Infect Immun. 2019 Jun 20;87(7). pii: e00865-18. doi: 10.1128/IAI.00865-18. Print 2019 Jul.

PMID:
30988054
5.

Looking for Needles in the Plasmodial Haystack.

Hviid L.

mSphere. 2019 Mar 27;4(2). pii: e00146-19. doi: 10.1128/mSphere.00146-19.

6.

Human Vδ1+ T Cells in the Immune Response to Plasmodium falciparum Infection.

Hviid L, Smith-Togobo C, Willcox BE.

Front Immunol. 2019 Feb 14;10:259. doi: 10.3389/fimmu.2019.00259. eCollection 2019. Review.

7.

Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG.

Larsen MD, Quintana MDP, Ditlev SB, Bayarri-Olmos R, Ofori MF, Hviid L, Garred P.

Front Immunol. 2019 Jan 7;9:3088. doi: 10.3389/fimmu.2018.03088. eCollection 2018.

8.

Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools.

Castberg FC, Sarbah EW, Koram KA, Opoku N, Ofori MF, Styrishave B, Hviid L, Kurtzhals JAL.

Malar J. 2018 Dec 11;17(1):464. doi: 10.1186/s12936-018-2609-6.

9.

Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes.

Ecklu-Mensah G, Olsen RW, Bengtsson A, Ofori MF, Hviid L, Jensen ATR, Adams Y.

PLoS One. 2018 Oct 9;13(10):e0204177. doi: 10.1371/journal.pone.0204177. eCollection 2018.

10.

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.

Partey FD, Castberg FC, Sarbah EW, Silk SE, Awandare GA, Draper SJ, Opoku N, Kweku M, Ofori MF, Hviid L, Barfod L.

PLoS One. 2018 Sep 17;13(9):e0204452. doi: 10.1371/journal.pone.0204452. eCollection 2018.

11.

A vaccine targeted specifically to prevent cerebral malaria - is there hope?

Hviid L, Lavstsen T, Jensen AT.

Expert Rev Vaccines. 2018 Jul;17(7):565-567. doi: 10.1080/14760584.2018.1488591. Epub 2018 Jun 25. No abstract available.

PMID:
29898617
12.

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.

Partey FD, Castberg FC, Sarbah EW, Silk SE, Awandare GA, Draper SJ, Opoku N, Kweku M, Ofori MF, Hviid L, Barfod L.

PLoS One. 2018 Jun 8;13(6):e0198371. doi: 10.1371/journal.pone.0198371. eCollection 2018. Erratum in: PLoS One. 2018 Sep 17;13(9):e0204452.

13.

IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax.

Lopez-Perez M, Larsen MD, Bayarri-Olmos R, Ampomah P, Stevenson L, Arévalo-Herrera M, Herrera S, Hviid L.

Infect Immun. 2018 Jul 23;86(8). pii: e00136-18. doi: 10.1128/IAI.00136-18. Print 2018 Aug.

14.

Etiology of Placental Plasmodium falciparum Malaria in African Women.

Ofori MF, Lamptey H, Dickson EK, Kyei-Baafour E, Hviid L.

J Infect Dis. 2018 Jun 20;218(2):277-281. doi: 10.1093/infdis/jiy168.

15.

Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria.

Olsen RW, Ecklu-Mensah G, Bengtsson A, Ofori MF, Lusingu JPA, Castberg FC, Hviid L, Adams Y, Jensen ATR.

Infect Immun. 2018 Mar 22;86(4). pii: e00622-17. doi: 10.1128/IAI.00622-17. Print 2018 Apr.

16.

Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation.

Castberg FC, Maretty L, Staalsoe T, Hempel C, Clasen-Linde E, Hviid L, Kurtzhals JAL.

Malar J. 2018 Jan 16;17(1):34. doi: 10.1186/s12936-018-2186-8.

17.

[Danish malaria research from the frail beginning to internationally acknowledged research].

Jepsen MPG, Jepsen S, Kurtzhals J, Hviid L.

Ugeskr Laeger. 2017 May 15;179(20). pii: V10160756. Review. Danish.

PMID:
28504626
18.

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.

Lennartz F, Adams Y, Bengtsson A, Olsen RW, Turner L, Ndam NT, Ecklu-Mensah G, Moussiliou A, Ofori MF, Gamain B, Lusingu JP, Petersen JE, Wang CW, Nunes-Silva S, Jespersen JS, Lau CK, Theander TG, Lavstsen T, Hviid L, Higgins MK, Jensen AT.

Cell Host Microbe. 2017 Mar 8;21(3):403-414. doi: 10.1016/j.chom.2017.02.009.

19.

[A worm in the toilet].

Hviid L, Møller-Bisgaard S, Kurtzhals J.

Ugeskr Laeger. 2016 Feb 15;178(7):V67428. Danish. No abstract available.

PMID:
27063009
20.

Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria.

Pleass RJ, Moore SC, Stevenson L, Hviid L.

Trends Parasitol. 2016 Feb;32(2):108-119. doi: 10.1016/j.pt.2015.09.007. Epub 2015 Nov 18. Review.

PMID:
26597020
21.

Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed.

Subramani R, Quadt K, Jeppesen AE, Hempel C, Petersen JE, Hassenkam T, Hviid L, Barfod L.

MBio. 2015 Oct 6;6(5):e01456-15. doi: 10.1128/mBio.01456-15.

22.

Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ.

Jeppesen A, Ditlev SB, Soroka V, Stevenson L, Turner L, Dzikowski R, Hviid L, Barfod L.

Infect Immun. 2015 Oct;83(10):3972-81. doi: 10.1128/IAI.00337-15. Epub 2015 Jul 27.

23.

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes.

Stevenson L, Laursen E, Cowan GJ, Bandoh B, Barfod L, Cavanagh DR, Andersen GR, Hviid L.

PLoS Pathog. 2015 Jul 2;11(7):e1005022. doi: 10.1371/journal.ppat.1005022. eCollection 2015 Jul.

24.

Rifins, rosetting, and red blood cells.

Wang CW, Hviid L.

Trends Parasitol. 2015 Jul;31(7):285-6. doi: 10.1016/j.pt.2015.04.009. Epub 2015 May 7.

PMID:
25959958
25.

PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis.

Hviid L, Jensen AT.

Adv Parasitol. 2015 Apr;88:51-84. doi: 10.1016/bs.apar.2015.02.004. Epub 2015 Mar 23. Review.

PMID:
25911365
26.

Trying to remember: immunological B cell memory to malaria.

Hviid L, Barfod L, Fowkes FJ.

Trends Parasitol. 2015 Mar;31(3):89-94. doi: 10.1016/j.pt.2014.12.009. Epub 2015 Jan 14. Review.

PMID:
25596801
27.

Investigating the function of Fc-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting.

Stevenson L, Huda P, Jeppesen A, Laursen E, Rowe JA, Craig A, Streicher W, Barfod L, Hviid L.

Cell Microbiol. 2015 Jun;17(6):819-31. doi: 10.1111/cmi.12403. Epub 2015 Jan 28.

28.

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Sleebs BE, Lopaticki S, Marapana DS, O'Neill MT, Rajasekaran P, Gazdik M, Günther S, Whitehead LW, Lowes KN, Barfod L, Hviid L, Shaw PJ, Hodder AN, Smith BJ, Cowman AF, Boddey JA.

PLoS Biol. 2014 Jul 1;12(7):e1001897. doi: 10.1371/journal.pbio.1001897. eCollection 2014 Jul.

29.

Kinetics of B cell responses to Plasmodium falciparum erythrocyte membrane protein 1 in Ghanaian women naturally exposed to malaria parasites.

Ampomah P, Stevenson L, Ofori MF, Barfod L, Hviid L.

J Immunol. 2014 Jun 1;192(11):5236-44. doi: 10.4049/jimmunol.1400325. Epub 2014 Apr 23.

30.

B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites.

Ampomah P, Stevenson L, Ofori MF, Barfod L, Hviid L.

Infect Immun. 2014 May;82(5):1860-71. doi: 10.1128/IAI.01514-13. Epub 2014 Feb 24.

31.

Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.

Bandeiras C, Trovoada MJ, Gonçalves LA, Marinho CR, Turner L, Hviid L, Penha-Gonçalves C, Gomes MG.

PLoS One. 2014 Feb 10;9(2):e88110. doi: 10.1371/journal.pone.0088110. eCollection 2014.

32.
33.

Transfected HEK293 cells expressing functional recombinant intercellular adhesion molecule 1 (ICAM-1)--a receptor associated with severe Plasmodium falciparum malaria.

Bengtsson A, Joergensen L, Barbati ZR, Craig A, Hviid L, Jensen AT.

PLoS One. 2013 Jul 25;8(7):e69999. doi: 10.1371/journal.pone.0069999. Print 2013.

34.

Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.

Berger SS, Turner L, Wang CW, Petersen JE, Kraft M, Lusingu JP, Mmbando B, Marquard AM, Bengtsson DB, Hviid L, Nielsen MA, Theander TG, Lavstsen T.

PLoS One. 2013 Jul 9;8(7):e69117. doi: 10.1371/journal.pone.0069117. Print 2013.

35.

A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies.

Bengtsson A, Joergensen L, Rask TS, Olsen RW, Andersen MA, Turner L, Theander TG, Hviid L, Higgins MK, Craig A, Brown A, Jensen AT.

J Immunol. 2013 Jan 1;190(1):240-9. doi: 10.4049/jimmunol.1202578. Epub 2012 Dec 3.

36.

The density of knobs on Plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates.

Quadt KA, Barfod L, Andersen D, Bruun J, Gyan B, Hassenkam T, Ofori MF, Hviid L.

PLoS One. 2012;7(9):e45658. doi: 10.1371/journal.pone.0045658. Epub 2012 Sep 20.

37.

Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia.

Boeuf PS, Loizon S, Awandare GA, Tetteh JK, Addae MM, Adjei GO, Goka B, Kurtzhals JA, Puijalon O, Hviid L, Akanmori BD, Behr C.

Malar J. 2012 Aug 1;11:253. doi: 10.1186/1475-2875-11-253.

38.

Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction.

Kapishnikov S, Berthing T, Hviid L, Dierolf M, Menzel A, Pfeiffer F, Als-Nielsen J, Leiserowitz L.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11184-7. doi: 10.1073/pnas.1118134109. Epub 2012 Jun 25.

39.

The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria.

Hviid L.

Expert Rev Vaccines. 2011 Oct;10(10):1405-14. doi: 10.1586/erv.11.113.

PMID:
21988306
40.

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1.

Barfod L, Dalgaard MB, Pleman ST, Ofori MF, Pleass RJ, Hviid L.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12485-90. doi: 10.1073/pnas.1103708108. Epub 2011 Jul 11.

41.

Cognitive deterioration in patients with early multiple sclerosis: a 5-year study.

Glanz BI, Healy BC, Hviid LE, Chitnis T, Weiner HL.

J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):38-43. doi: 10.1136/jnnp.2010.237834. Epub 2011 Jul 11.

PMID:
21746743
42.

Patient reported outcomes in benign multiple sclerosis.

Hviid LE, Healy BC, Rintell DJ, Chitnis T, Weiner HL, Glanz BI.

Mult Scler. 2011 Jul;17(7):876-84. doi: 10.1177/1352458511398370. Epub 2011 Mar 3.

PMID:
21372114
43.

Longitudinal MR study of brain structure and hippocampus volume in major depressive disorder.

Ahdidan J, Hviid LB, Chakravarty MM, Ravnkilde B, Rosenberg R, Rodell A, Stødkilde-Jørgensen H, Videbech P.

Acta Psychiatr Scand. 2011 Mar;123(3):211-9. doi: 10.1111/j.1600-0447.2010.01644.x. Epub 2011 Jan 11.

PMID:
21219263
44.

Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.

Barfod L, Dobrilovic T, Magistrado P, Khunrae P, Viwami F, Bruun J, Dahlbäck M, Bernasconi NL, Fried M, John D, Duffy PE, Salanti A, Lanzavecchia A, Lim CT, Ndam NT, Higgins MK, Hviid L.

J Immunol. 2010 Dec 15;185(12):7553-61. doi: 10.4049/jimmunol.1002390. Epub 2010 Nov 15.

45.

Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children.

Cham GK, Turner L, Kurtis JD, Mutabingwa T, Fried M, Jensen AT, Lavstsen T, Hviid L, Duffy PE, Theander TG.

Infect Immun. 2010 Nov;78(11):4653-9. doi: 10.1128/IAI.00593-10. Epub 2010 Sep 7.

46.

Of mice and women: rodent models of placental malaria.

Hviid L, Marinho CR, Staalsoe T, Penha-Gonçalves C.

Trends Parasitol. 2010 Aug;26(8):412-9. doi: 10.1016/j.pt.2010.04.010. Epub 2010 May 31. Review.

PMID:
20605743
47.

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs.

Joergensen LM, Salanti A, Dobrilovic T, Barfod L, Hassenkam T, Theander TG, Hviid L, Arnot DE.

Malar J. 2010 Apr 19;9:100. doi: 10.1186/1475-2875-9-100.

48.

Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum--a mathematical model.

van Noort SP, Nunes MC, Weedall GD, Hviid L, Gomes MG.

PLoS One. 2010 Mar 22;5(3):e9778. doi: 10.1371/journal.pone.0009778.

49.

Hippocampal visuospatial function and volume in remitted depressed patients: an 8-year follow-up study.

Hviid LB, Ravnkilde B, Ahdidan J, Rosenberg R, Stødkilde-Jørgensen H, Videbech P.

J Affect Disord. 2010 Sep;125(1-3):177-83. doi: 10.1016/j.jad.2010.01.002. Epub 2010 Mar 9.

PMID:
20219249
50.

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