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Items: 42


Correction to: HLA-F*01:01 presents peptides with N-terminal flexibility and a preferred length of 16 residues.

Hò GT, Heinen FJ, Huyton T, Blasczyk R, Bade-Döding C.

Immunogenetics. 2019 May;71(5-6):361. doi: 10.1007/s00251-019-01116-x.


HLA-F*01:01 presents peptides with N-terminal flexibility and a preferred length of 16 residues.

Hò GT, Heinen FJ, Huyton T, Blasczyk R, Bade-Döding C.

Immunogenetics. 2019 May;71(5-6):353-360. doi: 10.1007/s00251-019-01112-1. Epub 2019 Apr 2. Erratum in: Immunogenetics. 2019 Apr 24;:.


Releasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity.

Pump WC, Schulz R, Huyton T, Kunze-Schumacher H, Martens J, Hò GT, Blasczyk R, Bade-Doeding C.

HLA. 2019 Jul;94(1):25-38. doi: 10.1111/tan.13537. Epub 2019 Apr 14.


Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8⁺ T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia.

Pump WC, Kraemer T, Huyton T, Hò GT, Blasczyk R, Bade-Doeding C.

Int J Mol Sci. 2019 Mar 22;20(6). pii: E1454. doi: 10.3390/ijms20061454.


Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02.

Simper GS, Hò GT, Celik AA, Huyton T, Kuhn J, Kunze-Schumacher H, Blasczyk R, Bade-Döding C.

J Immunol Res. 2018 Sep 13;2018:5086503. doi: 10.1155/2018/5086503. eCollection 2018.


Surface Properties Determining Passage Rates of Proteins through Nuclear Pores.

Frey S, Rees R, Schünemann J, Ng SC, Fünfgeld K, Huyton T, Görlich D.

Cell. 2018 Jun 28;174(1):202-217.e9. doi: 10.1016/j.cell.2018.05.045.


HLA-G mediated immune regulation is impaired by a single amino acid exchange in the alpha 2 domain.

Celik AA, Simper GS, Huyton T, Blasczyk R, Bade-Döding C.

Hum Immunol. 2018 Jun;79(6):453-462. doi: 10.1016/j.humimm.2018.03.010. Epub 2018 Mar 29.


Understanding the obstacle of incompatibility at residue 156 within HLA-B*35 subtypes.

Manandhar T, Kunze-Schumacher H, Huyton T, Celik AA, Blasczyk R, Bade-Doeding C.

Immunogenetics. 2016 Apr;68(4):247-60. doi: 10.1007/s00251-015-0896-4. Epub 2016 Jan 12.


The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch.

Celik AA, Kraemer T, Huyton T, Blasczyk R, Bade-Döding C.

Immunogenetics. 2016 Jan;68(1):29-41. doi: 10.1007/s00251-015-0880-z. Epub 2015 Nov 9.


HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response-Implications on HSCT Outcome.

Kraemer T, Celik AA, Huyton T, Kunze-Schumacher H, Blasczyk R, Bade-Döding C.

Stem Cells Int. 2015;2015:346714. doi: 10.1155/2015/346714. Epub 2015 Aug 12.


Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90.

Yuzefovych Y, Blasczyk R, Huyton T.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2338-48. doi: 10.1016/j.bbamcr.2015.06.007. Epub 2015 Jun 22.


A Micropolymorphism Altering the Residue Triad 97/114/156 Determines the Relative Levels of Tapasin Independence and Distinct Peptide Profiles for HLA-A(*)24 Allotypes.

Badrinath S, Kunze-Schumacher H, Blasczyk R, Huyton T, Bade-Doeding C.

J Immunol Res. 2014;2014:298145. doi: 10.1155/2014/298145. Epub 2014 Dec 4.


Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod).

Buddaseth S, Göttmann W, Blasczyk R, Huyton T.

Cancer Biol Ther. 2014 Mar 1;15(3):289-96. doi: 10.4161/cbt.27307. Epub 2013 Dec 12.


Autocrine GM-CSF transcription in the leukemic progenitor cell line KG1a is mediated by the transcription factor ETS1 and is negatively regulated through SECTM1 mediated ligation of CD7.

Bade-Döding C, Göttmann W, Baigger A, Farren M, Lee KP, Blasczyk R, Huyton T.

Biochim Biophys Acta. 2014 Mar;1840(3):1004-13. doi: 10.1016/j.bbagen.2013.10.043. Epub 2013 Nov 6.


Dysregulation of cell cycle control caused by overexpression of the oncogene pp32r1 (ANP32C) and the Tyr>His mutant pp32r1Y140H.

Buddaseth S, Göttmann W, Blasczyk R, Huyton T.

Biochim Biophys Acta. 2013 May;1833(5):1212-21. doi: 10.1016/j.bbamcr.2013.02.001. Epub 2013 Feb 8.


Pocketcheck: updating the HLA class I peptide specificity roadmap.

Huyton T, Ladas N, Schumacher H, Blasczyk R, Bade-Doeding C.

Tissue Antigens. 2012 Sep;80(3):239-48. doi: 10.1111/j.1399-0039.2012.01928.x. Epub 2012 Jul 14.


Residue 81 confers a restricted C-terminal peptide binding motif in HLA-B*44:09.

Huyton T, Schumacher H, Blasczyk R, Bade-Doeding C.

Immunogenetics. 2012 Sep;64(9):663-8. doi: 10.1007/s00251-012-0625-1. Epub 2012 Jun 16.


The new allele HLA-B*35:87 was generated by recombination between HLA-B*35:01 and B*08:01 in intron 2.

Buddaseth S, Müller K, Bade-Doeding C, Blasczyk R, Huyton T.

Tissue Antigens. 2012 Mar;79(3):211-2. doi: 10.1111/j.1399-0039.2011.01817.x. Epub 2011 Dec 16.


Position 45 influences the peptide binding motif of HLA-B*44:08.

Badrinath S, Huyton T, Schumacher H, Blasczyk R, Bade-Doeding C.

Immunogenetics. 2012 Mar;64(3):245-9. doi: 10.1007/s00251-011-0583-z. Epub 2011 Oct 19.


Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes.

Badrinath S, Saunders P, Huyton T, Aufderbeck S, Hiller O, Blasczyk R, Bade-Doeding C.

Haematologica. 2012 Jan;97(1):98-106. doi: 10.3324/haematol.2011.046037. Epub 2011 Oct 11.


Mismatches outside exons 2 and 3 do not alter the peptide motif of the allele group B*44:02P.

Bade-Doeding C, Cano P, Huyton T, Badrinath S, Eiz-Vesper B, Hiller O, Blasczyk R.

Hum Immunol. 2011 Nov;72(11):1039-44. doi: 10.1016/j.humimm.2011.08.004. Epub 2011 Aug 10.


The composition of the F pocket in HLA-A*74 generates C-terminal promiscuity among its bound peptides.

Bade-Doeding C, Huyton T, Eiz-Vesper B, Blasczyk R.

Tissue Antigens. 2011 Nov;78(5):378-81. doi: 10.1111/j.1399-0039.2011.01745.x. Epub 2011 Jul 18.


The T/NK cell co-stimulatory molecule SECTM1 is an IFN "early response gene" that is negatively regulated by LPS in human monocytic cells.

Huyton T, Göttmann W, Bade-Döding C, Paine A, Blasczyk R.

Biochim Biophys Acta. 2011 Dec;1810(12):1294-301. doi: 10.1016/j.bbagen.2011.06.020. Epub 2011 Jul 1.


Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions.

Gorman MA, Uboldi AD, Walsh PJ, Tan KS, Hansen G, Huyton T, Ji H, Curtis J, Kedzierski L, Papenfuss AT, Dogovski C, Perugini MA, Simpson RJ, Handman E, Parker MW.

Protein Sci. 2011 Jun;20(6):1060-8. doi: 10.1002/pro.631. Epub 2011 Apr 27.


The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.

Bade-Döding C, Theodossis A, Gras S, Kjer-Nielsen L, Eiz-Vesper B, Seltsam A, Huyton T, Rossjohn J, McCluskey J, Blasczyk R.

Haematologica. 2011 Jan;96(1):110-8. doi: 10.3324/haematol.2010.030924. Epub 2010 Oct 7.


The nature of peptides presented by an HLA class I low expression allele.

Hinrichs J, Föll D, Bade-Döding C, Huyton T, Blasczyk R, Eiz-Vesper B.

Haematologica. 2010 Aug;95(8):1373-80. doi: 10.3324/haematol.2009.016089. Epub 2010 Mar 10.


Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor.

Carbone V, Giglio M, Chung R, Huyton T, Adams J, Maccari R, Ottana R, Hara A, El-Kabbani O.

Eur J Med Chem. 2010 Mar;45(3):1140-5. doi: 10.1016/j.ejmech.2009.12.019. Epub 2009 Dec 21.


Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.

Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, Orchard SG, Clayton AH, Nice EC, Rothacker J, Catimel B, Cavenee WK, Old LJ, Stockert E, Ritter G, Adams TE, Hoyne PA, Wittrup D, Chao G, Cochran JR, Luo C, Lou M, Huyton T, Xu Y, Fairlie WD, Yao S, Scott AM, Johns TG.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5082-7. doi: 10.1073/pnas.0811559106. Epub 2009 Mar 16.


CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.

Petrie EJ, Clements CS, Lin J, Sullivan LC, Johnson D, Huyton T, Heroux A, Hoare HL, Beddoe T, Reid HH, Wilce MC, Brooks AG, Rossjohn J.

J Exp Med. 2008 Mar 17;205(3):725-35. doi: 10.1084/jem.20072525. Epub 2008 Mar 10.


The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease.

Henderson KN, Reid HH, Borg NA, Broughton SE, Huyton T, Anderson RP, McCluskey J, Rossjohn J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1021-5. Epub 2007 Nov 21.


The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, Huyton T, Hopkins EJ, Reid HH, Wilce MC, Kabat J, Borrego F, Coligan JE, Rossjohn J, Brooks AG.

Immunity. 2007 Dec;27(6):900-11.


An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.

Huyton T, Zhang JG, Luo CS, Lou MZ, Hilton DJ, Nicola NA, Garrett TP.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12737-42. Epub 2007 Jul 24.


Toll-like receptors: structural pieces of a curve-shaped puzzle.

Huyton T, Rossjohn J, Wilce M.

Immunol Cell Biol. 2007 Aug-Sep;85(6):406-10. Epub 2007 Jul 3. Review.


Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding.

Smith BJ, Huyton T, Joosten RP, McKimm-Breschkin JL, Zhang JG, Luo CS, Lou MZ, Labrou NE, Garrett TP.

Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):947-52. Epub 2006 Aug 19.


Structure-guided design of a novel class of benzyl-sulfonate inhibitors for influenza virus neuraminidase.

Platis D, Smith BJ, Huyton T, Labrou NE.

Biochem J. 2006 Oct 15;399(2):215-23.


Solution structure and interactions of the Escherichia coli cell division activator protein CedA.

Chen HA, Simpson P, Huyton T, Roper D, Matthews S.

Biochemistry. 2005 May 10;44(18):6738-44.


Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysis.

Lloyd AJ, Huyton T, Turkenburg J, Roper DI.

Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):397-400. Epub 2004 Jan 23.


The crystal structure of murine p97/VCP at 3.6A.

Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS.

J Struct Biol. 2003 Dec;144(3):337-48.


The BRCA1 C-terminal domain: structure and function.

Huyton T, Bates PA, Zhang X, Sternberg MJ, Freemont PS.

Mutat Res. 2000 Aug 30;460(3-4):319-32.


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