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Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects.

Subissi L, Rodeghiero C, Martini H, Litzroth A, Huygen K, Leroux-Roels G, Piérard D, Desombere I.

Clin Microbiol Infect. 2019 Oct 11. pii: S1198-743X(19)30528-2. doi: 10.1016/j.cmi.2019.10.001. [Epub ahead of print]


IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection.

Loglo AD, Frimpong M, Sarpong Duah M, Sarfo F, Sarpong FN, Agbavor B, Boakye-Appiah JK, Abass KM, Dongyele M, Frempong M, Pidot S, Wansbrough-Jones M, Stinear TP, Roupie V, Huygen K, Phillips RO.

PeerJ. 2018 Jul 31;6:e5294. doi: 10.7717/peerj.5294. eCollection 2018.


Relationship between mold exposure, specific IgE sensitization, and clinical asthma: A case-control study.

Vincent M, Corazza F, Chasseur C, Bladt S, Romano M, Huygen K, Denis O, Michel O.

Ann Allergy Asthma Immunol. 2018 Sep;121(3):333-339. doi: 10.1016/j.anai.2018.06.016. Epub 2018 Jun 23.


Evaluation of mycobacteria-specific gamma interferon and antibody responses before and after a single intradermal skin test in cattle naturally exposed to M. avium subsp. paratuberculosis and experimentally infected with M. bovis.

Roupie V, Alonso-Velasco E, Van Der Heyden S, Holbert S, Duytschaever L, Berthon P, Van Dosselaer I, Van Campe W, Mostin L, Biet F, Roels S, Huygen K, Fretin D.

Vet Immunol Immunopathol. 2018 Feb;196:35-47. doi: 10.1016/j.vetimm.2017.12.007. Epub 2017 Dec 12.


Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Ieven M, Coenen S, Loens K, Lammens C, Coenjaerts F, Vanderstraeten A, Henriques-Normark B, Crook D, Huygen K, Butler CC, Verheij TJM, Little P, Zlateva K, van Loon A, Claas ECJ, Goossens H; GRACE consortium.

Clin Microbiol Infect. 2018 Nov;24(11):1158-1163. doi: 10.1016/j.cmi.2018.02.004. Epub 2018 Feb 12.


Survival of Mycobacterium tuberculosis and Mycobacterium bovis BCG in lysosomes in vivo.

Sundaramurthy V, Korf H, Singla A, Scherr N, Nguyen L, Ferrari G, Landmann R, Huygen K, Pieters J.

Microbes Infect. 2017 Nov;19(11):515-526. doi: 10.1016/j.micinf.2017.06.008. Epub 2017 Jul 6.


Field performance of six Mycobacterium avium subsp. paratuberculosis antigens in a 20h interferon gamma release assay in Belgium.

Dernivoix K, Roupie V, Welby S, Roelandt S, Viart S, Letesson JJ, Wattiez R, Huygen K, Govaerts M.

Vet Immunol Immunopathol. 2017 Jul;189:17-27. doi: 10.1016/j.vetimm.2017.05.008. Epub 2017 May 30.


Pertussis diagnosis in Belgium: results of the National Reference Centre for Bordetella anno 2015.

Martini H, Rodeghiero C, VAN DEN Poel C, Vincent M, Pierard D, Huygen K.

Epidemiol Infect. 2017 Aug;145(11):2366-2373. doi: 10.1017/S0950268817001108. Epub 2017 Jun 5.


Investigation of inflammatory and allergic responses to common mold species: Results from in vitro experiments, from a mouse model of asthma, and from a group of asthmatic patients.

Vincent M, Percier P, De Prins S, Huygen K, Potemberg G, Muraille E, Romano M, Michel O, Denis O.

Indoor Air. 2017 Sep;27(5):933-945. doi: 10.1111/ina.12385. Epub 2017 Apr 24.


Trend analysis suggested a change in subspecies among Mycobacterium avium isolated from pigs in Belgium, 1967-2013.

Soetaert K, Vluggen C, Duytschaever L, Denoël J, Roupie V, Smeets F, Bruffaerts N, Huygen K, Fretin D, Diels M, Rigouts L, Saegerman C, Mathys V.

Vet Rec. 2017 May 6;180(18):449. doi: 10.1136/vr.103951. Epub 2017 Mar 10. No abstract available.


Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium.

Caboré RN, Maertens K, Dobly A, Leuridan E, Van Damme P, Huygen K.

Virulence. 2017 Oct 3;8(7):1245-1254. doi: 10.1080/21505594.2017.1296998. Epub 2017 Feb 22.


Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection.

Bruffaerts N, Vluggen C, Roupie V, Duytschaever L, Van den Poel C, Denoël J, Wattiez R, Letesson JJ, Fretin D, Rigouts L, Chapeira O, Mathys V, Saegerman C, Huygen K.

PLoS One. 2017 Feb 9;12(2):e0171895. doi: 10.1371/journal.pone.0171895. eCollection 2017.


Development of a Dot-Blot Assay for the Detection of Mould-Specific IgE in the Belgian Population.

Vincent M, Romano M, Corazza F, Huygen K, Michel O, Denis O.

Mycopathologia. 2017 Apr;182(3-4):319-329. doi: 10.1007/s11046-016-0091-7. Epub 2016 Nov 22.


Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

Tima HG, Al Dulayymi JR, Denis O, Lehebel P, Baols KS, Mohammed MO, L'Homme L, Sahb MM, Potemberg G, Legrand S, Lang R, Beyaert R, Piette J, Baird MS, Huygen K, Romano M.

J Innate Immun. 2017;9(2):162-180. doi: 10.1159/000450955. Epub 2016 Nov 18.


The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam.

Maertens K, Hoang TT, Nguyen TD, Caboré RN, Duong TH, Huygen K, Hens N, Van Damme P, Dang DA, Leuridan E.

Clin Infect Dis. 2016 Dec 1;63(suppl 4):S197-S204.


Correction: Capture-Recapture Estimators in Epidemiology with Applications to Pertussis and Pneumococcal Invasive Disease Surveillance.

Braeye T, Verhaegen J, Mignon A, Flipse W, Pierard D, Huygen K, Schirvel C, Hens N.

PLoS One. 2016 Oct 18;11(10):e0165351. doi: 10.1371/journal.pone.0165351. eCollection 2016.


Capture-Recapture Estimators in Epidemiology with Applications to Pertussis and Pneumococcal Invasive Disease Surveillance.

Braeye T, Verheagen J, Mignon A, Flipse W, Pierard D, Huygen K, Schirvel C, Hens N.

PLoS One. 2016 Aug 16;11(8):e0159832. doi: 10.1371/journal.pone.0159832. eCollection 2016. Erratum in: PLoS One. 2016 Oct 18;11(10 ):e0165351.


Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity.

Smet M, Pollard C, De Beuckelaer A, Van Hoecke L, Vander Beken S, De Koker S, Al Dulayymi JR, Huygen K, Verschoor J, Baird MS, Grooten J.

Eur J Immunol. 2016 Sep;46(9):2149-54. doi: 10.1002/eji.201646357. Epub 2016 Jul 29.


Genome Sequences of Four Strains of Mycobacterium avium subsp. hominissuis, Isolated from Swine and Humans, Differing in Virulence in a Murine Intranasal Infection Model.

Bruffaerts N, Vluggen C, Duytschaever L, Mathys V, Saegerman C, Chapeira O, Huygen K.

Genome Announc. 2016 Jun 16;4(3). pii: e00533-16. doi: 10.1128/genomeA.00533-16.


Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines.

Tima HG, Huygen K, Romano M.

Expert Rev Vaccines. 2016 Nov;15(11):1409-1420. Epub 2016 May 30. Review.


Development of human monoclonal antibodies to diphtheria toxin: A solution for the increasing lack of equine DAT for therapeutic use?

Huygen K.

Virulence. 2016 Aug 17;7(6):613-5. doi: 10.1080/21505594.2016.1190062. Epub 2016 May 19. No abstract available.


A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex.

Caboré RN, Piérard D, Huygen K.

Vaccines (Basel). 2016 May 10;4(2). pii: E16. doi: 10.3390/vaccines4020016.


Pertussis vaccination during pregnancy in Belgium: Follow-up of infants until 1 month after the fourth infant pertussis vaccination at 15 months of age.

Maertens K, Caboré RN, Huygen K, Vermeiren S, Hens N, Van Damme P, Leuridan E.

Vaccine. 2016 Jun 30;34(31):3613-9. doi: 10.1016/j.vaccine.2016.04.066. Epub 2016 Apr 30.


Serodiagnosis of whooping cough in Belgium: results of the National Reference Centre for Bordetella pertussis anno 2013.

Duterme S, Vanhoof R, Vanderpas J, Pierard D, Huygen K.

Acta Clin Belg. 2016 Apr;71(2):86-91. doi: 10.1080/17843286.2015.1105607. Epub 2016 Feb 6.


Genotyping and strain distribution of Mycobacterium avium subspecies hominissuis isolated from humans and pigs in Belgium, 2011-2013.

Vluggen C, Soetaert K, Duytschaever L, Denoël J, Fauville-Dufaux M, Smeets F, Bruffaerts N, Huygen K, Fretin D, Rigouts L, Saegerman C, Mathys V.

Euro Surveill. 2016;21(3):30111. doi: 10.2807/1560-7917.ES.2016.21.3.30111.


Synthesis and anti-tubercular activity of N(2)-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides.

Rotthier G, Cappoen D, Nguyen QT, Dang Thi TA, Mathys V, Nguyen VT, Huygen K, Maes L, Cos P, Abbaspour Tehrani K.

Org Biomol Chem. 2016 Feb 14;14(6):2041-51. doi: 10.1039/c5ob02138c.


Pertussis vaccination during pregnancy in Belgium: Results of a prospective controlled cohort study.

Maertens K, Caboré RN, Huygen K, Hens N, Van Damme P, Leuridan E.

Vaccine. 2016 Jan 2;34(1):142-50. doi: 10.1016/j.vaccine.2015.10.100. Epub 2015 Nov 16.


Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy.

Hoang HT, Leuridan E, Maertens K, Nguyen TD, Hens N, Vu NH, Caboré RN, Duong HT, Huygen K, Van Damme P, Dang AD.

Vaccine. 2016 Jan 2;34(1):151-9. doi: 10.1016/j.vaccine.2015.10.098. Epub 2015 Oct 31.


Prevalence, diagnosis, and disease course of pertussis in adults with acute cough: a prospective, observational study in primary care.

Teepe J, Broekhuizen BD, Ieven M, Loens K, Huygen K, Kretzschmar M, de Melker H, Butler CC, Little P, Stuart B, Coenen S, Goossens H, Verheij TJ; GRACE consortium.

Br J Gen Pract. 2015 Oct;65(639):e662-7. doi: 10.3399/bjgp15X686917.


In silico epitope analysis of unique and membrane associated proteins from Mycobacterium avium subsp. paratuberculosis for immunogenicity and vaccine evaluation.

Carlos P, Roupie V, Holbert S, Ascencio F, Huygen K, Gomez-Anduro G, Branger M, Reyes-Becerril M, Angulo C.

J Theor Biol. 2015 Nov 7;384:1-9. doi: 10.1016/j.jtbi.2015.08.003. Epub 2015 Aug 13.


Humoral and cell mediated immune responses to a pertussis containing vaccine in pregnant and nonpregnant women.

Huygen K, Caboré RN, Maertens K, Van Damme P, Leuridan E.

Vaccine. 2015 Aug 7;33(33):4117-23. doi: 10.1016/j.vaccine.2015.06.108. Epub 2015 Jul 14.


Increased B and T Cell Responses in M. bovis Bacille Calmette-Guérin Vaccinated Pigs Co-Immunized with Plasmid DNA Encoding a Prototype Tuberculosis Antigen.

Bruffaerts N, Pedersen LE, Vandermeulen G, Préat V, Stockhofe-Zurwieden N, Huygen K, Romano M.

PLoS One. 2015 Jul 14;10(7):e0132288. doi: 10.1371/journal.pone.0132288. eCollection 2015.


Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial.

Ndiaye BP, Thienemann F, Ota M, Landry BS, Camara M, Dièye S, Dieye TN, Esmail H, Goliath R, Huygen K, January V, Ndiaye I, Oni T, Raine M, Romano M, Satti I, Sutton S, Thiam A, Wilkinson KA, Mboup S, Wilkinson RJ, McShane H; MVA85A 030 trial investigators.

Lancet Respir Med. 2015 Mar;3(3):190-200. doi: 10.1016/S2213-2600(15)00037-5. Epub 2015 Feb 26.


DNA vaccines against tuberculosis.

Bruffaerts N, Huygen K, Romano M.

Expert Opin Biol Ther. 2014 Dec;14(12):1801-13. doi: 10.1517/14712598.2014.951630. Epub 2014 Aug 22. Review.


The Immunodominant T-Cell Epitopes of the Mycolyl-Transferases of the Antigen 85 Complex of M. tuberculosis.

Huygen K.

Front Immunol. 2014 Jul 9;5:321. doi: 10.3389/fimmu.2014.00321. eCollection 2014. Review.


2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.

Claes P, Cappoen D, Uythethofken C, Jacobs J, Mertens B, Mathys V, Verschaeve L, Huygen K, De Kimpe N.

Eur J Med Chem. 2014 Apr 22;77:409-21. doi: 10.1016/j.ejmech.2014.03.024. Epub 2014 Mar 12.


Anti-mycobacterial activity of 1,3-diaryltriazenes.

Cappoen D, Vajs J, Uythethofken C, Virag A, Mathys V, Kočevar M, Verschaeve L, Gazvoda M, Polanc S, Huygen K, Košmrlj J.

Eur J Med Chem. 2014 Apr 22;77:193-203. doi: 10.1016/j.ejmech.2014.02.065. Epub 2014 Mar 1.


1,2,3,4,8,9,10,11-octahydrobenzo[j]phenanthridine-7,12-diones as new leads against Mycobacterium tuberculosis.

Cappoen D, Claes P, Jacobs J, Anthonissen R, Mathys V, Verschaeve L, Huygen K, De Kimpe N.

J Med Chem. 2014 Apr 10;57(7):2895-907. doi: 10.1021/jm401735w. Epub 2014 Mar 21.


Biological evaluation of diazene derivatives as anti-tubercular compounds.

Cappoen D, Majce V, Uythethofken C, Urankar D, Mathys V, Kočevar M, Verschaeve L, Polanc S, Huygen K, Košmrlj J.

Eur J Med Chem. 2014 Mar 3;74:85-94. doi: 10.1016/j.ejmech.2013.12.057. Epub 2014 Jan 8.


Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.

Roupie V, Pidot SJ, Einarsdottir T, Van Den Poel C, Jurion F, Stinear TP, Huygen K.

PLoS Negl Trop Dis. 2014 Jan 2;8(1):e2604. doi: 10.1371/journal.pntd.0002604. eCollection 2014.


Novel GMO-Based Vaccines against Tuberculosis: State of the Art and Biosafety Considerations.

Leunda A, Baldo A, Goossens M, Huygen K, Herman P, Romano M.

Vaccines (Basel). 2014 Jun 16;2(2):463-99. doi: 10.3390/vaccines2020463. Review.


Increasing the Vaccine Potential of Live M. bovis BCG by Coadministration with Plasmid DNA Encoding a Tuberculosis Prototype Antigen.

Bruffaerts N, Romano M, Denis O, Jurion F, Huygen K.

Vaccines (Basel). 2014 Mar 5;2(1):181-95. doi: 10.3390/vaccines2010181.


M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.

Hedhli D, Denis O, Barkan D, Daffé M, Glickman MS, Huygen K.

PLoS One. 2013 Oct 17;8(10):e76442. doi: 10.1371/journal.pone.0076442. eCollection 2013.


Bordetella pertussis seroprevalence in Belgian adults aged 20-39 years, 2012.

Huygen K, Rodeghiero C, Govaerts D, Leroux-Roels I, Melin P, Reynders M, Van Der Meeren S, Van Den Wijngaert S, Pierard D.

Epidemiol Infect. 2014 Apr;142(4):724-8. doi: 10.1017/S0950268813002458. Epub 2013 Sep 27.


Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine.

Claes P, Cappoen D, Mbala BM, Jacobs J, Mertens B, Mathys V, Verschaeve L, Huygen K, De Kimpe N.

Eur J Med Chem. 2013 Sep;67:98-110. doi: 10.1016/j.ejmech.2013.06.010. Epub 2013 Jun 18.


Use of Strep-tag II for rapid detection and purification of Mycobacterium tuberculosis recombinant antigens secreted by Streptomyces lividans.

Ayala JC, Pimienta E, Rodríguez C, Anné J, Vallín C, Milanés MT, King-Batsios E, Huygen K, Van Mellaert L.

J Microbiol Methods. 2013 Sep;94(3):192-8. doi: 10.1016/j.mimet.2013.06.004. Epub 2013 Jun 17.


[Hooping cough in adults, think about it!].

Toukouki A, Frippiat F, Frusch N, Leonard P, Caprasse P, Meuris C, Rodeghiero C, Vanhoof R, Pierard D, Moutschen M, Huygen K, Giot JB.

Rev Med Liege. 2013 Apr;68(4):177-9. French.


Mice genetically inactivated in interleukin-17A receptor are defective in long-term control of Mycobacterium tuberculosis infection.

Freches D, Korf H, Denis O, Havaux X, Huygen K, Romano M.

Immunology. 2013 Oct;140(2):220-31. doi: 10.1111/imm.12130.


Mucosal and systemic immune responses to Mycobacterium tuberculosis antigen 85A following its co-delivery with CpG, MPLA or LTB to the lungs in mice.

Todoroff J, Lemaire MM, Fillee C, Jurion F, Renauld JC, Huygen K, Vanbever R.

PLoS One. 2013 May 10;8(5):e63344. doi: 10.1371/journal.pone.0063344. Print 2013.


Biological evaluation of bisbenzaldehydes against four Mycobacterium species.

Cappoen D, Forge D, Vercammen F, Mathys V, Kiass M, Roupie V, Anthonissen R, Verschaeve L, Vanden Eynde JJ, Huygen K.

Eur J Med Chem. 2013 May;63:731-8. doi: 10.1016/j.ejmech.2013.03.023. Epub 2013 Mar 18.


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