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Items: 47


MicroRNA (miRNA)-to-miRNA Regulation of Programmed Cell Death 4 (PDCD4).

Ajuyah P, Hill M, Ahadi A, Lu J, Hutvagner G, Tran N.

Mol Cell Biol. 2019 Aug 27;39(18). pii: e00086-19. doi: 10.1128/MCB.00086-19. Print 2019 Sep 15.


A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation.

Hadzhiev Y, Qureshi HK, Wheatley L, Cooper L, Jasiulewicz A, Van Nguyen H, Wragg JW, Poovathumkadavil D, Conic S, Bajan S, Sik A, Hutvàgner G, Tora L, Gambus A, Fossey JS, Müller F.

Nat Commun. 2019 Feb 11;10(1):691. doi: 10.1038/s41467-019-08487-5.


An isomiR expression panel based novel breast cancer classification approach using improved mutual information.

Lan C, Peng H, McGowan EM, Hutvagner G, Li J.

BMC Med Genomics. 2018 Dec 31;11(Suppl 6):118. doi: 10.1186/s12920-018-0434-y.


Cross disease analysis of co-functional microRNA pairs on a reconstructed network of disease-gene-microRNA tripartite.

Peng H, Lan C, Zheng Y, Hutvagner G, Tao D, Li J.

BMC Bioinformatics. 2017 Mar 24;18(1):193. doi: 10.1186/s12859-017-1605-0.


tRNA-Derived RNA Fragments Associate with Human Multisynthetase Complex (MSC) and Modulate Ribosomal Protein Translation.

Keam SP, Sobala A, Ten Have S, Hutvagner G.

J Proteome Res. 2017 Feb 3;16(2):413-420. doi: 10.1021/acs.jproteome.6b00267. Epub 2016 Dec 12.


Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity.

Cropley JE, Eaton SA, Aiken A, Young PE, Giannoulatou E, Ho JWK, Buckland ME, Keam SP, Hutvagner G, Humphreys DT, Langley KG, Henstridge DC, Martin DIK, Febbraio MA, Suter CM.

Mol Metab. 2016 Jun 23;5(8):699-708. doi: 10.1016/j.molmet.2016.06.008. eCollection 2016 Aug.


The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells.

Connerty P, Bajan S, Remenyi J, Fuller-Pace FV, Hutvagner G.

Biochim Biophys Acta. 2016 Oct;1859(10):1299-305. doi: 10.1016/j.bbagrm.2016.07.013. Epub 2016 Jul 28.


Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes.

Ahadi A, Brennan S, Kennedy PJ, Hutvagner G, Tran N.

Sci Rep. 2016 Apr 22;6:24922. doi: 10.1038/srep24922.


The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132.

Remenyi J, Bajan S, Fuller-Pace FV, Arthur JS, Hutvagner G.

Sci Rep. 2016 Mar 7;6:22848. doi: 10.1038/srep22848.


RNA Binding Proteins in the miRNA Pathway.

Connerty P, Ahadi A, Hutvagner G.

Int J Mol Sci. 2015 Dec 26;17(1). pii: E31. doi: 10.3390/ijms17010031. Review.


tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression.

Keam SP, Hutvagner G.

Life (Basel). 2015 Nov 27;5(4):1638-51. doi: 10.3390/life5041638. Review.


Rule discovery and distance separation to detect reliable miRNA biomarkers for the diagnosis of lung squamous cell carcinoma.

Song R, Liu Q, Hutvagner G, Nguyen H, Ramamohanarao K, Wong L, Li J.

BMC Genomics. 2014;15 Suppl 9:S16. doi: 10.1186/1471-2164-15-S9-S16. Epub 2014 Dec 8.


Sphingosine kinase 1 isoform-specific interactions in breast cancer.

Yagoub D, Wilkins MR, Lay AJ, Kaczorowski DC, Hatoum D, Bajan S, Hutvagner G, Lai JH, Wu W, Martiniello-Wilks R, Xia P, McGowan EM.

Mol Endocrinol. 2014 Nov;28(11):1899-915. doi: 10.1210/me.2013-1423. Epub 2014 Sep 12.


The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells.

Keam SP, Young PE, McCorkindale AL, Dang TH, Clancy JL, Humphreys DT, Preiss T, Hutvagner G, Martin DI, Cropley JE, Suter CM.

Nucleic Acids Res. 2014 Aug;42(14):8984-95. doi: 10.1093/nar/gku620. Epub 2014 Jul 18.


Computational analysis, biochemical purification, and detection of tRNA-derived small RNA fragments.

Keam SP, Sobala A, Humphreys DT, Suter CM, Hutvagner G.

Methods Mol Biol. 2014;1173:157-67. doi: 10.1007/978-1-4939-0931-5_14.


Biogenesis and the regulation of the maturation of miRNAs.

Tran N, Hutvagner G.

Essays Biochem. 2013;54:17-28. doi: 10.1042/bse0540017. Review.


miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity.

Remenyi J, van den Bosch MW, Palygin O, Mistry RB, McKenzie C, Macdonald A, Hutvagner G, Arthur JS, Frenguelli BG, Pankratov Y.

PLoS One. 2013 Apr 26;8(4):e62509. doi: 10.1371/journal.pone.0062509. Print 2013.


Small RNAs derived from the 5' end of tRNA can inhibit protein translation in human cells.

Sobala A, Hutvagner G.

RNA Biol. 2013 Apr;10(4):553-63. doi: 10.4161/rna.24285. Epub 2013 Apr 1.


Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation.

Engels B, Jannot G, Remenyi J, Simard MJ, Hutvagner G.

PLoS One. 2012;7(3):e33144. doi: 10.1371/journal.pone.0033144. Epub 2012 Mar 9.


Another "loophole" in miRNA processing.

Bajan S, Hutvagner G.

Mol Cell. 2011 Nov 4;44(3):345-7. doi: 10.1016/j.molcel.2011.10.010.


Transfer RNA-derived fragments: origins, processing, and functions.

Sobala A, Hutvagner G.

Wiley Interdiscip Rev RNA. 2011 Nov-Dec;2(6):853-62. doi: 10.1002/wrna.96. Epub 2011 Jun 30. Review.


Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation.

Johnston M, Hutvagner G.

Silence. 2011 Sep 26;2:5. doi: 10.1186/1758-907X-2-5.


The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans.

Jannot G, Bajan S, Giguère NJ, Bouasker S, Banville IH, Piquet S, Hutvagner G, Simard MJ.

EMBO Rep. 2011 Jun;12(6):581-6. doi: 10.1038/embor.2011.66. Epub 2011 Apr 28.


An evolutionarily conserved, alternatively spliced, intron in the p68/DDX5 DEAD-box RNA helicase gene encodes a novel miRNA.

Moore HC, Johnston M, Nicol SM, Bourdon JC, Thompson AM, Hutvagner G, Fuller-Pace FV.

RNA. 2011 Apr;17(4):555-62. doi: 10.1261/rna.2591611. Epub 2011 Feb 23.


Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects.

Hain D, Bettencourt BR, Okamura K, Csorba T, Meyer W, Jin Z, Biggerstaff J, Siomi H, Hutvagner G, Lai EC, Welte M, Müller HA.

PLoS One. 2010 Dec 17;5(12):e15264. doi: 10.1371/journal.pone.0015264.


Regulation of miRNA transcription in macrophages in response to Candida albicans.

Monk CE, Hutvagner G, Arthur JS.

PLoS One. 2010 Oct 27;5(10):e13669. doi: 10.1371/journal.pone.0013669.


Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes.

Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, Roder K, Babraj J, Wahlestedt C, Hutvagner G, Pedersen BK, Timmons JA.

Genome Med. 2010 Feb 1;2(2):9. doi: 10.1186/gm130.


Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins.

Remenyi J, Hunter CJ, Cole C, Ando H, Impey S, Monk CE, Martin KJ, Barton GJ, Hutvagner G, Arthur JS.

Biochem J. 2010 May 13;428(2):281-91. doi: 10.1042/BJ20100024.


HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells.

Johnston M, Geoffroy MC, Sobala A, Hay R, Hutvagner G.

Mol Biol Cell. 2010 May 1;21(9):1462-9. doi: 10.1091/mbc.E09-10-0885. Epub 2010 Mar 17.


Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1.

Csorba T, Lózsa R, Hutvágner G, Burgyán J.

Plant J. 2010 May;62(3):463-72. doi: 10.1111/j.1365-313X.2010.04163.x. Epub 2010 Feb 1.


Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs.

Cole C, Sobala A, Lu C, Thatcher SR, Bowman A, Brown JW, Green PJ, Barton GJ, Hutvagner G.

RNA. 2009 Dec;15(12):2147-60. doi: 10.1261/rna.1738409. Epub 2009 Oct 22.


Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.

Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN.

J Cell Biol. 2008 Jun 30;181(7):1055-63. doi: 10.1083/jcb.200802105.


Argonaute proteins: key players in RNA silencing.

Hutvagner G, Simard MJ.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):22-32. Review.


Principles and effects of microRNA-mediated post-transcriptional gene regulation.

Engels BM, Hutvagner G.

Oncogene. 2006 Oct 9;25(46):6163-9. Review.


Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation.

Hutvagner G.

FEBS Lett. 2005 Oct 31;579(26):5850-7. Epub 2005 Sep 20. Review.


Sequence-specific inhibition of small RNA function.

Hutvágner G, Simard MJ, Mello CC, Zamore PD.

PLoS Biol. 2004 Apr;2(4):E98. Epub 2004 Feb 24.


Asymmetry in the assembly of the RNAi enzyme complex.

Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD.

Cell. 2003 Oct 17;115(2):199-208.


Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

Schwarz DS, Hutvágner G, Haley B, Zamore PD.

Mol Cell. 2002 Sep;10(3):537-48.


A microRNA in a multiple-turnover RNAi enzyme complex.

Hutvágner G, Zamore PD.

Science. 2002 Sep 20;297(5589):2056-60. Epub 2002 Aug 1.


RNAi: nature abhors a double-strand.

Hutvágner G, Zamore PD.

Curr Opin Genet Dev. 2002 Apr;12(2):225-32. Review.


A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.

Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD.

Science. 2001 Aug 3;293(5531):834-8. Epub 2001 Jul 12.


Potato protein kinase StCPK1: a putative evolutionary link between CDPKs and CRKs.

Lakatos L, Hutvágner G, Bánfalvi Z.

Biochim Biophys Acta. 1998 Nov 8;1442(2-3):101-8.


Isolation and characterization of a water-stress-inducible cDNA clone from Solanum chacoense.

Silhavy D, Hutvágner G, Barta E, Bánfalvi Z.

Plant Mol Biol. 1995 Feb;27(3):587-95.


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