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Items: 1 to 50 of 70

1.

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model.

Tague AJ, Putsathit P, Hutton ML, Hammer KA, Wales SM, Knight DR, Riley TV, Lyras D, Keller PA, Pyne SG.

Eur J Med Chem. 2019 May 15;170:203-224. doi: 10.1016/j.ejmech.2019.02.068. Epub 2019 Mar 1.

PMID:
30901686
2.

A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain.

Wehrhahn MC, Keighley C, Kurtovic J, Knight DR, Hong S, Hutton ML, Lyras D, Wang Q, Leong R, Borody T, Edye M, Riley TV.

Anaerobe. 2019 Feb;55:117-123. doi: 10.1016/j.anaerobe.2018.11.009. Epub 2018 Nov 27.

PMID:
30500477
3.

Hyperimmune bovine colostrum reduces gastrointestinal carriage of uropathogenic Escherichia coli.

Larcombe S, Hutton ML, Lyras D.

Hum Vaccin Immunother. 2019;15(2):508-513. doi: 10.1080/21645515.2018.1528836. Epub 2018 Oct 31.

PMID:
30277834
4.

Diverse bacterial species contribute to antibiotic-associated diarrhoea and gastrointestinal damage.

Larcombe S, Hutton ML, Riley TV, Abud HE, Lyras D.

J Infect. 2018 Nov;77(5):417-426. doi: 10.1016/j.jinf.2018.06.006. Epub 2018 Jun 30.

PMID:
29964142
5.

Intestinal Colonization Traits of Pandemic Multidrug-Resistant Escherichia coli ST131.

Sarkar S, Hutton ML, Vagenas D, Ruter R, Schüller S, Lyras D, Schembri MA, Totsika M.

J Infect Dis. 2018 Aug 14;218(6):979-990. doi: 10.1093/infdis/jiy031.

6.

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities.

Corriveau RA, Koroshetz WJ, Gladman JT, Jeon S, Babcock D, Bennett DA, Carmichael ST, Dickinson SL, Dickson DW, Emr M, Fillit H, Greenberg SM, Hutton ML, Knopman DS, Manly JJ, Marder KS, Moy CS, Phelps CH, Scott PA, Seeley WW, Sieber BA, Silverberg NB, Sutherland ML, Taylor A, Torborg CL, Waddy SP, Gubitz AK, Holtzman DM.

Neurology. 2017 Dec 5;89(23):2381-2391. doi: 10.1212/WNL.0000000000004717. Epub 2017 Nov 8. Review.

7.

Breadth of Genetic Testing Selected by Patients at Risk of Hereditary Breast and Ovarian Cancer.

Szender JB, Kaur J, Clayback K, Hutton ML, Mikkelson J, Odunsi K, Dresbold C.

Int J Gynecol Cancer. 2018 Jan;28(1):26-33. doi: 10.1097/IGC.0000000000001122.

8.

A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization.

Hutton ML, D'Costa K, Rossiter AE, Wang L, Turner L, Steer DL, Masters SL, Croker BA, Kaparakis-Liaskos M, Ferrero RL.

Front Cell Infect Microbiol. 2017 Jun 6;7:219. doi: 10.3389/fcimb.2017.00219. eCollection 2017.

9.

Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative.

Hutton ML, Cunningham BA, Mackin KE, Lyon SA, James ML, Rood JI, Lyras D.

Sci Rep. 2017 Jun 16;7(1):3665. doi: 10.1038/s41598-017-03982-5.

10.

Altered Synapse Stability in the Early Stages of Tauopathy.

Jackson JS, Witton J, Johnson JD, Ahmed Z, Ward M, Randall AD, Hutton ML, Isaac JT, O'Neill MJ, Ashby MC.

Cell Rep. 2017 Mar 28;18(13):3063-3068. doi: 10.1016/j.celrep.2017.03.013.

11.

Options for improving effectiveness of rotavirus vaccines in developing countries.

Tissera MS, Cowley D, Bogdanovic-Sakran N, Hutton ML, Lyras D, Kirkwood CD, Buttery JP.

Hum Vaccin Immunother. 2017 Apr 3;13(4):921-927. doi: 10.1080/21645515.2016.1252493. Epub 2016 Nov 11. Review.

12.

CdtR Regulates TcdA and TcdB Production in Clostridium difficile.

Lyon SA, Hutton ML, Rood JI, Cheung JK, Lyras D.

PLoS Pathog. 2016 Jul 14;12(7):e1005758. doi: 10.1371/journal.ppat.1005758. eCollection 2016 Jul.

13.

Involvement of Bacteria Other Than Clostridium difficile in Antibiotic-Associated Diarrhoea.

Larcombe S, Hutton ML, Lyras D.

Trends Microbiol. 2016 Jun;24(6):463-476. doi: 10.1016/j.tim.2016.02.001. Epub 2016 Feb 17. Review.

PMID:
26897710
14.

Disruption of the Gut Microbiome: Clostridium difficile Infection and the Threat of Antibiotic Resistance.

Johanesen PA, Mackin KE, Hutton ML, Awad MM, Larcombe S, Amy JM, Lyras D.

Genes (Basel). 2015 Dec 21;6(4):1347-60. doi: 10.3390/genes6041347. Review.

15.

Increased Outer Membrane Vesicle Formation in a Helicobacter pylori tolB Mutant.

Turner L, Praszkier J, Hutton ML, Steer D, Ramm G, Kaparakis-Liaskos M, Ferrero RL.

Helicobacter. 2015 Aug;20(4):269-83. doi: 10.1111/hel.12196. Epub 2015 Feb 9.

PMID:
25669590
16.

Conformation determines the seeding potencies of native and recombinant Tau aggregates.

Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S.

J Biol Chem. 2015 Jan 9;290(2):1049-65. doi: 10.1074/jbc.M114.589309. Epub 2014 Nov 18.

17.

Astrocytes and neuroinflammation in Alzheimer's disease.

Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W.

Biochem Soc Trans. 2014 Oct;42(5):1321-5. doi: 10.1042/BST20140155.

PMID:
25233410
18.

Anti-Aβ antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803-810 (2014).

Siemers E, Dean RA, DeMattos RB, Hutton ML, Blennow K, Shaw LM, Holtzman DM.

Acta Neuropathol. 2014 Oct;128(4):609-10. doi: 10.1007/s00401-014-1332-9. Epub 2014 Aug 14. No abstract available.

PMID:
25120192
19.

Recommendations of the Alzheimer's disease-related dementias conference.

Montine TJ, Koroshetz WJ, Babcock D, Dickson DW, Galpern WR, Glymour MM, Greenberg SM, Hutton ML, Knopman DS, Kuzmichev AN, Manly JJ, Marder KS, Miller BL, Phelps CH, Seeley WW, Sieber BA, Silverberg NB, Sutherland M, Torborg CL, Waddy SP, Zlokovic BV, Corriveau RA; ADRD 2013 Conference Organizing Committee.

Neurology. 2014 Aug 26;83(9):851-60. doi: 10.1212/WNL.0000000000000733. Epub 2014 Jul 30. Review.

20.

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.

Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ.

Acta Neuropathol. 2014 May;127(5):667-83. doi: 10.1007/s00401-014-1254-6. Epub 2014 Feb 16.

21.

Small animal models for the study of Clostridium difficile disease pathogenesis.

Hutton ML, Mackin KE, Chakravorty A, Lyras D.

FEMS Microbiol Lett. 2014 Mar;352(2):140-9. doi: 10.1111/1574-6968.12367. Epub 2014 Jan 7. Review.

22.

SLC20A2 and THAP1 deletion in familial basal ganglia calcification with dystonia.

Baker M, Strongosky AJ, Sanchez-Contreras MY, Yang S, Ferguson W, Calne DB, Calne S, Stoessl AJ, Allanson JE, Broderick DF, Hutton ML, Dickson DW, Ross OA, Wszolek ZK, Rademakers R.

Neurogenetics. 2014 Mar;15(1):23-30. doi: 10.1007/s10048-013-0378-5. Epub 2013 Oct 18.

23.

A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice.

Demattos RB, Lu J, Tang Y, Racke MM, Delong CA, Tzaferis JA, Hole JT, Forster BM, McDonnell PC, Liu F, Kinley RD, Jordan WH, Hutton ML.

Neuron. 2012 Dec 6;76(5):908-20. doi: 10.1016/j.neuron.2012.10.029.

24.

A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system.

Gorrell RJ, Guan J, Xin Y, Tafreshi MA, Hutton ML, McGuckin MA, Ferrero RL, Kwok T.

Cell Microbiol. 2013 Apr;15(4):554-70. doi: 10.1111/cmi.12055. Epub 2012 Nov 21.

PMID:
23107019
25.

The use of AlbuMAX II(®) as a blood or serum alternative for the culture of Helicobacter pylori.

Hutton ML, Kaparakis-Liaskos M, Ferrero RL.

Helicobacter. 2012 Feb;17(1):68-76. doi: 10.1111/j.1523-5378.2011.00914.x.

PMID:
22221619
26.

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O'Neill MJ, Hutton ML, Citron M.

J Biol Chem. 2011 Sep 30;286(39):34457-67. doi: 10.1074/jbc.M111.229633. Epub 2011 Aug 12.

27.

Helicobacter pylori exploits cholesterol-rich microdomains for induction of NF-kappaB-dependent responses and peptidoglycan delivery in epithelial cells.

Hutton ML, Kaparakis-Liaskos M, Turner L, Cardona A, Kwok T, Ferrero RL.

Infect Immun. 2010 Nov;78(11):4523-31. doi: 10.1128/IAI.00439-10. Epub 2010 Aug 16.

28.

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.

Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J.

Am J Pathol. 2010 Jul;177(1):311-24. doi: 10.2353/ajpath.2010.090915. Epub 2010 Jun 3. Erratum in: Am J Pathol. 2010 Oct;177(4):2146. Wuertzer, Charles A [added].

29.

Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis.

Webster J, Reiman EM, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Rogers J, Heun R, Jessen F, Kölsch H, Heward CB, Ravid R, Hutton ML, Melquist S, Petersen RC, Caselli RJ, Papassotiropoulos A, Stephan DA, Hardy J, Myers A.

Int J Mol Epidemiol Genet. 2010;1(1):19-30. Epub 2009 Jul 26.

30.

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells.

Kaparakis M, Turnbull L, Carneiro L, Firth S, Coleman HA, Parkington HC, Le Bourhis L, Karrar A, Viala J, Mak J, Hutton ML, Davies JK, Crack PJ, Hertzog PJ, Philpott DJ, Girardin SE, Whitchurch CB, Ferrero RL.

Cell Microbiol. 2010 Mar;12(3):372-85. doi: 10.1111/j.1462-5822.2009.01404.x. Epub 2009 Nov 2.

PMID:
19888989
31.

Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.

Tatom JB, Wang DB, Dayton RD, Skalli O, Hutton ML, Dickson DW, Klein RL.

Mol Ther. 2009 Apr;17(4):607-13. doi: 10.1038/mt.2009.3. Epub 2009 Feb 17.

32.

Evidence for an association between KIBRA and late-onset Alzheimer's disease.

Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ.

Neurobiol Aging. 2010 Jun;31(6):901-9. doi: 10.1016/j.neurobiolaging.2008.07.014. Epub 2008 Sep 13.

33.

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.

Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, Wszolek ZK, Uitti RJ, Feldman H, Hutton ML, Mackenzie IR, Graff-Radford NR, Dickson DW.

Hum Mol Genet. 2008 Dec 1;17(23):3631-42. doi: 10.1093/hmg/ddn257. Epub 2008 Aug 21.

34.

Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1.

Rudzinski LA, Fletcher RM, Dickson DW, Crook R, Hutton ML, Adamson J, Graff-Radford NR.

Alzheimer Dis Assoc Disord. 2008 Jul-Sep;22(3):299-307. doi: 10.1097/WAD.0b013e3181732399.

35.

Progranulin gene mutation with an unusual clinical and neuropathologic presentation.

Wider C, Uitti RJ, Wszolek ZK, Fang JY, Josephs KA, Baker MC, Rademakers R, Hutton ML, Dickson DW.

Mov Disord. 2008 Jun 15;23(8):1168-73. doi: 10.1002/mds.22065.

PMID:
18442119
36.

APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway.

Sando SB, Melquist S, Cannon A, Hutton ML, Sletvold O, Saltvedt I, White LR, Lydersen S, Aasly JO.

BMC Neurol. 2008 Apr 16;8:9. doi: 10.1186/1471-2377-8-9.

37.

Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families.

Ertekin-Taner N, Younkin LH, Yager DM, Parfitt F, Baker MC, Asthana S, Hutton ML, Younkin SG, Graff-Radford NR.

Neurology. 2008 Feb 19;70(8):596-606. Epub 2007 Oct 3.

PMID:
17914065
38.

Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.

Caselli RJ, Reiman EM, Locke DE, Hutton ML, Hentz JG, Hoffman-Snyder C, Woodruff BK, Alexander GE, Osborne D.

Arch Neurol. 2007 Sep;64(9):1306-11.

PMID:
17846270
39.

GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA.

Neuron. 2007 Jun 7;54(5):713-20.

40.

Progressive supranuclear palsy: pathology and genetics.

Dickson DW, Rademakers R, Hutton ML.

Brain Pathol. 2007 Jan;17(1):74-82. Review.

PMID:
17493041
41.

TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease.

Amador-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R, Graff-Radford NR, Hutton ML, Dickson DW.

Ann Neurol. 2007 May;61(5):435-45.

42.

Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease.

Roder HM, Hutton ML.

Expert Opin Ther Targets. 2007 Apr;11(4):435-42. Review.

PMID:
17373874
43.

Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations.

Whitwell JL, Jack CR Jr, Baker M, Rademakers R, Adamson J, Boeve BF, Knopman DS, Parisi JF, Petersen RC, Dickson DW, Hutton ML, Josephs KA.

Arch Neurol. 2007 Mar;64(3):371-6.

44.

Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation.

Baba Y, Baker MC, Le Ber I, Brice A, Maeck L, Kohlhase J, Yasuda M, Stoppe G, Bugiani O, Sperfeld AD, Tsuboi Y, Uitti RJ, Farrer MJ, Ghetti B, Hutton ML, Wszolek ZK.

J Neural Transm (Vienna). 2007 Jul;114(7):947-50. Epub 2007 Feb 23.

PMID:
17318302
45.

Progranulin in frontotemporal lobar degeneration and neuroinflammation.

Ahmed Z, Mackenzie IR, Hutton ML, Dickson DW.

J Neuroinflammation. 2007 Feb 11;4:7. Review.

46.

Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.

Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, Dickson DW.

J Neuropathol Exp Neurol. 2007 Feb;66(2):142-51.

PMID:
17278999
47.

Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families.

Mesulam M, Johnson N, Krefft TA, Gass JM, Cannon AD, Adamson JL, Bigio EH, Weintraub S, Dickson DW, Hutton ML, Graff-Radford NR.

Arch Neurol. 2007 Jan;64(1):43-7.

PMID:
17210807
48.

Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation).

Arvanitakis Z, Witte RJ, Dickson DW, Tsuboi Y, Uitti RJ, Slowinski J, Hutton ML, Lin SC, Boeve BF, Cheshire WP, Pooley RA, Liss JM, Caviness JN, Strongosky AJ, Wszolek ZK.

Parkinsonism Relat Disord. 2007 May;13(4):230-9. Epub 2006 Dec 29.

PMID:
17196872
49.

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.

Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chiò A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, Hutton ML, Rogaeva E, St George-Hyslop P, Rothstein JD, Hardiman O, Grafman J, Singleton A, Hardy J, Traynor BJ.

BMC Neurol. 2006 Dec 13;6:44.

50.

Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.

Pearson JV, Huentelman MJ, Halperin RF, Tembe WD, Melquist S, Homer N, Brun M, Szelinger S, Coon KD, Zismann VL, Webster JA, Beach T, Sando SB, Aasly JO, Heun R, Jessen F, Kolsch H, Tsolaki M, Daniilidou M, Reiman EM, Papassotiropoulos A, Hutton ML, Stephan DA, Craig DW.

Am J Hum Genet. 2007 Jan;80(1):126-39. Epub 2006 Dec 6.

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