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Items: 1 to 50 of 207

1.

ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study.

Wenzlau JM, Fain PR, Gardner TJ, Frisch LM, Annibale B, Hutton JC.

Diabetes Care. 2015 Oct;38 Suppl 2:S29-36. doi: 10.2337/dcs15-2006.

2.

Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop.

Wenzlau JM, Frisch LM, Hutton JC, Fain PR, Davidson HW.

Diabetes Care. 2015 Oct;38 Suppl 2:S14-20. doi: 10.2337/dcs15-2004.

3.

Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants.

Vendrame F, Hopfner YY, Diamantopoulos S, Virdi SK, Allende G, Snowhite IV, Reijonen HK, Chen L, Ruiz P, Ciancio G, Hutton JC, Messinger S, Burke GW 3rd, Pugliese A.

Am J Transplant. 2016 Jan;16(1):235-45. doi: 10.1111/ajt.13426. Epub 2015 Aug 28.

4.

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes.

Brorsson CA, Onengut S, Chen WM, Wenzlau J, Yu L, Baker P, Williams AJ, Bingley PJ, Hutton JC, Eisenbarth GS, Concannon P, Rich SS, Pociot F; Type 1 Diabetes Genetics Consortium.

Diabetes. 2015 Aug;64(8):3017-27. doi: 10.2337/db14-1730. Epub 2015 Mar 31.

5.

Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: relation to autoantibody status and comparison with Belgian patients.

Asanghanwa M, Gorus FK, Weets I, der Auwera BV, Aminkeng F, Mbunwe E, Goubert P, Verhaeghen K, Sobngwi E, Wenzlau JM, Hutton JC, Pipeleers DG, Keymeulen B, Mbanya JC, van Schravendijk C.

Diabetes Res Clin Pract. 2014 Jan;103(1):97-105. doi: 10.1016/j.diabres.2013.11.013. Epub 2013 Nov 20.

6.

Novel diabetes autoantibodies and prediction of type 1 diabetes.

Wenzlau JM, Hutton JC.

Curr Diab Rep. 2013 Oct;13(5):608-15. doi: 10.1007/s11892-013-0405-9. Review.

7.

In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions.

Mbunwe E, Van der Auwera BJ, Weets I, Van Crombrugge P, Crenier L, Coeckelberghs M, Seret N, Decochez K, Vandemeulebroucke E, Gillard P, Keymeulen B, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2013 Sep;56(9):1964-70. doi: 10.1007/s00125-013-2951-8. Epub 2013 May 28.

8.

G6PC2: a negative regulator of basal glucose-stimulated insulin secretion.

Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM.

Diabetes. 2013 May;62(5):1547-56. doi: 10.2337/db12-1067. Epub 2012 Dec 28.

9.

Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients.

Gorus FK, Balti EV, Vermeulen I, Demeester S, Van Dalem A, Costa O, Dorchy H, Tenoutasse S, Mouraux T, De Block C, Gillard P, Decochez K, Wenzlau JM, Hutton JC, Pipeleers DG, Weets I; Belgian Diabetes Registry.

Clin Exp Immunol. 2013 Jan;171(1):82-90. doi: 10.1111/j.1365-2249.2012.04675.x.

10.

HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients.

Mbunwe E, Van der Auwera BJ, Vermeulen I, Demeester S, Van Dalem A, Balti EV, Van Aken S, Derdelinckx L, Dorchy H, De Schepper J, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers D, Weets I, Gorus FK; Belgian Diabetes Registry.

Diabetes. 2013 Apr;62(4):1345-50. doi: 10.2337/db12-0747. Epub 2012 Nov 16.

11.

Mapping I-A(g7) restricted epitopes in murine G6PC2.

Yang T, Hohenstein AC, Lee CE, Hutton JC, Davidson HW.

Immunol Res. 2013 Mar;55(1-3):91-9. doi: 10.1007/s12026-012-8368-5.

12.

The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.

Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM.

PLoS One. 2012;7(7):e40972. doi: 10.1371/journal.pone.0040972. Epub 2012 Jul 19.

13.

Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients.

Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA, Hutton JC, Davidson HW, Mallone R.

Diabetologia. 2012 Jul;55(7):2026-31. doi: 10.1007/s00125-012-2543-z. Epub 2012 Apr 20.

14.

Synergizing genomic analysis with biological knowledge to identify and validate novel genes in pancreatic development.

Sarkar SA, Lee CE, Tipney H, Karimpour-Fard A, Dinella JD, Juhl K, Walters JA, Hutton JC, Hunter LE.

Pancreas. 2012 Aug;41(6):962-9. doi: 10.1097/MPA.0b013e31823d0160.

15.

Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.

Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2012 Jun;35(6):1213-8. doi: 10.2337/dc11-2081. Epub 2012 Mar 23.

16.

Glycotoxin and autoantibodies are additive environmentally determined predictors of type 1 diabetes: a twin and population study.

Beyan H, Riese H, Hawa MI, Beretta G, Davidson HW, Hutton JC, Burger H, Schlosser M, Snieder H, Boehm BO, Leslie RD.

Diabetes. 2012 May;61(5):1192-8. doi: 10.2337/db11-0971. Epub 2012 Mar 6.

17.

An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age.

Vermeulen I, Weets I, Costa O, Asanghanwa M, Verhaeghen K, Decochez K, Ruige J, Casteels K, Wenzlau J, Hutton JC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2012 Feb;55(2):413-20. doi: 10.1007/s00125-011-2376-1. Epub 2011 Nov 18.

18.

Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals.

Wenzlau JM, Gardner TJ, Frisch LM, Davidson HW, Hutton JC.

Diabetes Metab Res Rev. 2011 Nov;27(8):887-90. doi: 10.1002/dmrr.1267.

19.

Mapping of conformational autoantibody epitopes in ZNT8.

Wenzlau JM, Frisch LM, Hutton JC, Davidson HW.

Diabetes Metab Res Rev. 2011 Nov;27(8):883-6. doi: 10.1002/dmrr.1266.

20.

Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8.

Lampasona V, Schlosser M, Mueller PW, Williams AJ, Wenzlau JM, Hutton JC, Achenbach P.

Clin Chem. 2011 Dec;57(12):1693-702. doi: 10.1373/clinchem.2011.170662. Epub 2011 Oct 6.

21.

Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice.

Oeser JK, Parekh VV, Wang Y, Jegadeesh NK, Sarkar SA, Wong R, Lee CE, Pound LD, Hutton JC, Van Kaer L, O'Brien RM.

Diabetes. 2011 Nov;60(11):2922-7. doi: 10.2337/db11-0220. Epub 2011 Sep 6.

22.

Characterization of the human SLC30A8 promoter and intronic enhancer.

Pound LD, Sarkar SA, Cauchi S, Wang Y, Oeser JK, Lee CE, Froguel P, Hutton JC, O'Brien RM.

J Mol Endocrinol. 2011 Sep 30;47(3):251-9. doi: 10.1530/JME-11-0055. Print 2011 Dec.

23.

Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age.

Vermeulen I, Weets I, Asanghanwa M, Ruige J, Van Gaal L, Mathieu C, Keymeulen B, Lampasona V, Wenzlau JM, Hutton JC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2011 Aug;34(8):1760-5. doi: 10.2337/dc10-2268. Epub 2011 Jun 29.

24.

Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young.

Steck AK, Johnson K, Barriga KJ, Miao D, Yu L, Hutton JC, Eisenbarth GS, Rewers MJ.

Diabetes Care. 2011 Jun;34(6):1397-9. doi: 10.2337/dc10-2088. Epub 2011 May 11.

25.

Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.

Dang M, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, Gottlieb PA, Davidson HW.

J Immunol. 2011 May 15;186(10):6056-63. doi: 10.4049/jimmunol.1003815. Epub 2011 Apr 6.

26.

[Value of zinc transporter 8 autoantibody in the diagnostic classification of acute-onset diabetics].

YANG L, LUO SM, HUANG G, PENG J, YAN X, WENZLAU J, DAVIDSON HW, HUTTON JC, ZHOU ZG.

Zhonghua Yi Xue Za Zhi. 2010 Sep 28;90(36):2536-40. Chinese.

PMID:
21092458
27.

The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer.

Pound LD, Hang Y, Sarkar SA, Wang Y, Milam LA, Oeser JK, Printz RL, Lee CE, Stein R, Hutton JC, O'Brien RM.

Biochem J. 2011 Jan 1;433(1):95-105. doi: 10.1042/BJ20101488.

28.

Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY).

Stene LC, Oikarinen S, Hyöty H, Barriga KJ, Norris JM, Klingensmith G, Hutton JC, Erlich HA, Eisenbarth GS, Rewers M.

Diabetes. 2010 Dec;59(12):3174-80. doi: 10.2337/db10-0866. Epub 2010 Sep 21.

29.

The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese.

Yang L, Luo S, Huang G, Peng J, Li X, Yan X, Lin J, Wenzlau JM, Davidson HW, Hutton JC, Zhou Z.

Diabetes Metab Res Rev. 2010 Oct;26(7):579-84. doi: 10.1002/dmrr.1128.

30.

Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.

Wenzlau JM, Walter M, Gardner TJ, Frisch LM, Yu L, Eisenbarth GS, Ziegler AG, Davidson HW, Hutton JC.

J Clin Endocrinol Metab. 2010 Oct;95(10):4712-9. doi: 10.1210/jc.2010-0169. Epub 2010 Jul 7.

31.

Getting beta all the time: discovery of reliable markers of beta cell mass.

Hutton JC, Davidson HW.

Diabetologia. 2010 Jul;53(7):1254-7. doi: 10.1007/s00125-010-1762-4. Epub 2010 Apr 22. No abstract available.

PMID:
20411233
32.

Cytokine-induced dicing and splicing in the beta-cell and the immune response in type 1 diabetes.

Hutton JC, Davidson HW.

Diabetes. 2010 Feb;59(2):335-6. doi: 10.2337/db09-1767. No abstract available.

33.

Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials.

De Grijse J, Asanghanwa M, Nouthe B, Albrecher N, Goubert P, Vermeulen I, Van Der Meeren S, Decochez K, Weets I, Keymeulen B, Lampasona V, Wenzlau J, Hutton JC, Pipeleers D, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2010 Mar;53(3):517-24. doi: 10.1007/s00125-009-1618-y. Epub 2009 Nov 29.

PMID:
20091020
34.

Glucose-6-phosphatase catalytic subunit gene family.

Hutton JC, O'Brien RM.

J Biol Chem. 2009 Oct 23;284(43):29241-5. doi: 10.1074/jbc.R109.025544. Epub 2009 Aug 20. Review.

35.

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM.

Biochem J. 2009 Jul 15;421(3):371-6. doi: 10.1042/BJ20090530.

36.

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line.

Sarkar SA, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee CE, Wong R, Valentine A, Davidson HW, Hutton JC, Pugazhenthi S.

Diabetologia. 2009 Jun;52(6):1092-101. doi: 10.1007/s00125-009-1331-x. Epub 2009 Apr 3.

PMID:
19343319
37.

Novel antigens in type 1 diabetes: the importance of ZnT8.

Wenzlau JM, Frisch LM, Gardner TJ, Sarkar S, Hutton JC, Davidson HW.

Curr Diab Rep. 2009 Apr;9(2):105-12. Review.

PMID:
19323954
38.

Isolation of dense core secretory vesicles from pancreatic endocrine cells by differential and density gradient centrifugation.

Hutton JC, Wong R, Davidson HW.

Curr Protoc Cell Biol. 2009 Mar;Chapter 3:Unit 3.32. doi: 10.1002/0471143030.cb0332s42.

PMID:
19283733
39.

SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes.

Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, Eisenbarth GS, Davidson HW, Hutton JC.

Ann N Y Acad Sci. 2008 Dec;1150:256-9. doi: 10.1196/annals.1447.029.

PMID:
19120307
40.

Identification of a major humoral epitope in Slc30A8 (ZnT8).

Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:252-5. doi: 10.1196/annals.1447.028.

PMID:
19120306
41.

Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens.

Liu Y, Wenzlau JM, Yu L, Patel C, Eisenbarth GS, Hutton JC, Davidson HW.

Ann N Y Acad Sci. 2008 Dec;1150:245-7. doi: 10.1196/annals.1447.035.

PMID:
19120304
42.

Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.

Kawasaki E, Uga M, Nakamura K, Kuriya G, Satoh T, Fujishima K, Ozaki M, Abiru N, Yamasaki H, Wenzlau JM, Davidson HW, Hutton JC, Eguchi K.

Diabetologia. 2008 Dec;51(12):2299-302. doi: 10.1007/s00125-008-1165-y. Epub 2008 Oct 11.

PMID:
18850084
43.

GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist.

Quayum N, Kutchma A, Sarkar SA, Juhl K, Gradwohl G, Mellitzer G, Hutton JC, Jensen J.

Exp Diabetes Res. 2008;2008:312060. doi: 10.1155/2008/312060.

44.

Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse.

Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC.

Diabetes. 2008 Oct;57(10):2755-61. doi: 10.2337/db07-1126. Epub 2008 Jul 3.

45.

New antigenic targets in type 1 diabetes.

Wenzlau JM, Hutton JC, Davidson HW.

Curr Opin Endocrinol Diabetes Obes. 2008 Aug;15(4):315-20. doi: 10.1097/MED.0b013e328308192b. Review.

PMID:
18594270
46.

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.

Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S, Walters J, Eisenbarth GS, Davidson HW, Hutton JC.

Diabetes. 2008 Oct;57(10):2693-7. doi: 10.2337/db08-0522. Epub 2008 Jun 30.

47.

Global gene expression profiling and histochemical analysis of the developing human fetal pancreas.

Sarkar SA, Kobberup S, Wong R, Lopez AD, Quayum N, Still T, Kutchma A, Jensen JN, Gianani R, Beattie GM, Jensen J, Hayek A, Hutton JC.

Diabetologia. 2008 Feb;51(2):285-97. Epub 2007 Dec 18.

PMID:
18094957
48.

Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo.

Wang Y, Flemming BP, Martin CC, Allen SR, Walters J, Oeser JK, Hutton JC, O'Brien RM.

Diabetes. 2008 Jan;57(1):133-41. Epub 2007 Oct 17.

49.

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.

Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17040-5. Epub 2007 Oct 17.

50.

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.

Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S.

Diabetologia. 2007 Aug;50(8):1649-59. Epub 2007 Jun 26.

PMID:
17593347

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