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Malformations of Human Neocortex in Development - Their Progenitor Cell Basis and Experimental Model Systems.

Pinson A, Namba T, Huttner WB.

Front Cell Neurosci. 2019 Jul 9;13:305. doi: 10.3389/fncel.2019.00305. eCollection 2019. Review.


The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or p300.

Lukaszewicz AI, Nguyen C, Melendez E, Lin DP, Teo JL, Lai KKY, Huttner WB, Shi SH, Kahn M.

Cancers (Basel). 2019 Jul 9;11(7). pii: E962. doi: 10.3390/cancers11070962.


YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex.

Kostic M, Paridaen JTML, Long KR, Kalebic N, Langen B, Grübling N, Wimberger P, Kawasaki H, Namba T, Huttner WB.

Cell Rep. 2019 Apr 23;27(4):1103-1118.e6. doi: 10.1016/j.celrep.2019.03.091.


Transport, Metabolism, and Function of Thyroid Hormones in the Developing Mammalian Brain.

Stepien BK, Huttner WB.

Front Endocrinol (Lausanne). 2019 Apr 3;10:209. doi: 10.3389/fendo.2019.00209. eCollection 2019. Review.


How the extracellular matrix shapes neural development.

Long KR, Huttner WB.

Open Biol. 2019 Jan 31;9(1):180216. doi: 10.1098/rsob.180216.


Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology.

Kalebic N, Gilardi C, Stepien B, Wilsch-Bräuninger M, Long KR, Namba T, Florio M, Langen B, Lombardot B, Shevchenko A, Kilimann MW, Kawasaki H, Wimberger P, Huttner WB.

Cell Stem Cell. 2019 Apr 4;24(4):535-550.e9. doi: 10.1016/j.stem.2019.02.017. Epub 2019 Mar 21.


The centrosome protein AKNA regulates neurogenesis via microtubule organization.

Camargo Ortega G, Falk S, Johansson PA, Peyre E, Broix L, Sahu SK, Hirst W, Schlichthaerle T, De Juan Romero C, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F, Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB, Wilsch-Bräuninger M, Nguyen L, Götz M.

Nature. 2019 Mar;567(7746):113-117. doi: 10.1038/s41586-019-0962-4. Epub 2019 Feb 20.


Primate neocortex development and evolution: Conserved versus evolved folding.

Namba T, Vaid S, Huttner WB.

J Comp Neurol. 2019 Jul 1;527(10):1621-1632. doi: 10.1002/cne.24606. Epub 2018 Dec 29.


Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.

Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B.

EMBO J. 2019 Jan 15;38(2). pii: e99845. doi: 10.15252/embj.201899845. Epub 2018 Dec 6.


Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex.

Kalebic N, Gilardi C, Albert M, Namba T, Long KR, Kostic M, Langen B, Huttner WB.

Elife. 2018 Nov 28;7. pii: e41241. doi: 10.7554/eLife.41241.


Prominin-1 (CD133) modulates the architecture and dynamics of microvilli.

Thamm K, Šimaitė D, Karbanová J, Bermúdez V, Reichert D, Morgenstern A, Bornhäuser M, Huttner WB, Wilsch-Bräuninger M, Corbeil D.

Traffic. 2019 Jan;20(1):39-60. doi: 10.1111/tra.12618. Epub 2018 Nov 14.


A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex.

Vaid S, Camp JG, Hersemann L, Eugster Oegema C, Heninger AK, Winkler S, Brandl H, Sarov M, Treutlein B, Huttner WB, Namba T.

Development. 2018 Oct 18;145(20). pii: dev169276. doi: 10.1242/dev.169276.


Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex.

Long KR, Newland B, Florio M, Kalebic N, Langen B, Kolterer A, Wimberger P, Huttner WB.

Neuron. 2018 Aug 22;99(4):702-719.e6. doi: 10.1016/j.neuron.2018.07.013. Epub 2018 Aug 2.


Brain organoids as models to study human neocortex development and evolution.

Heide M, Huttner WB, Mora-Bermúdez F.

Curr Opin Cell Biol. 2018 Dec;55:8-16. doi: 10.1016/ Epub 2018 Jul 10. Review.


Epigenetic and Transcriptional Pre-patterning-An Emerging Theme in Cortical Neurogenesis.

Albert M, Huttner WB.

Front Neurosci. 2018 May 29;12:359. doi: 10.3389/fnins.2018.00359. eCollection 2018. Review.


Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.

Florio M, Heide M, Pinson A, Brandl H, Albert M, Winkler S, Wimberger P, Huttner WB, Hiller M.

Elife. 2018 Mar 21;7. pii: e32332. doi: 10.7554/eLife.32332.


Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.

Tavano S, Taverna E, Kalebic N, Haffner C, Namba T, Dahl A, Wilsch-Bräuninger M, Paridaen JTML, Huttner WB.

Neuron. 2018 Mar 21;97(6):1299-1314.e8. doi: 10.1016/j.neuron.2018.01.052. Epub 2018 Mar 1.


Novel gene function and regulation in neocortex expansion.

Heide M, Long KR, Huttner WB.

Curr Opin Cell Biol. 2017 Dec;49:22-30. doi: 10.1016/ Epub 2017 Dec 8. Review.


ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

Gai M, Bianchi FT, Vagnoni C, Vernì F, Bonaccorsi S, Pasquero S, Berto GE, Sgrò F, Chiotto AA, Annaratone L, Sapino A, Bergo A, Landsberger N, Bond J, Huttner WB, Di Cunto F.

EMBO Rep. 2017 Oct;18(10):1870. doi: 10.15252/embr.201745023. No abstract available.


Epigenome profiling and editing of neocortical progenitor cells during development.

Albert M, Kalebic N, Florio M, Lakshmanaperumal N, Haffner C, Brandl H, Henry I, Huttner WB.

EMBO J. 2017 Sep 1;36(17):2642-2658. doi: 10.15252/embj.201796764. Epub 2017 Aug 1.


A tunable refractive index matching medium for live imaging cells, tissues and model organisms.

Boothe T, Hilbert L, Heide M, Berninger L, Huttner WB, Zaburdaev V, Vastenhouw NL, Myers EW, Drechsel DN, Rink JC.

Elife. 2017 Jul 14;6. pii: e27240. doi: 10.7554/eLife.27240.


Specific membrane dynamics during neural stem cell division.

Ettinger A, Kosodo Y, Huttner WB.

Methods Cell Biol. 2017;137:143-172. doi: 10.1016/bs.mcb.2016.05.007. Epub 2016 Jun 17.


A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.

Florio M, Namba T, Pääbo S, Hiller M, Huttner WB.

Sci Adv. 2016 Dec 7;2(12):e1601941. eCollection 2016 Dec.


Human-specific genomic signatures of neocortical expansion.

Florio M, Borrell V, Huttner WB.

Curr Opin Neurobiol. 2017 Feb;42:33-44. doi: 10.1016/j.conb.2016.11.004. Epub 2016 Nov 29. Review.


Neural progenitor cells and their role in the development and evolutionary expansion of the neocortex.

Namba T, Huttner WB.

Wiley Interdiscip Rev Dev Biol. 2017 Jan;6(1). doi: 10.1002/wdev.256. Epub 2016 Nov 16. Review.


Monoclonal Antibodies 13A4 and AC133 Do Not Recognize the Canine Ortholog of Mouse and Human Stem Cell Antigen Prominin-1 (CD133).

Thamm K, Graupner S, Werner C, Huttner WB, Corbeil D.

PLoS One. 2016 Oct 4;11(10):e0164079. doi: 10.1371/journal.pone.0164079. eCollection 2016.


Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development.

Mora-Bermúdez F, Badsha F, Kanton S, Camp JG, Vernot B, Köhler K, Voigt B, Okita K, Maricic T, He Z, Lachmann R, Pääbo S, Treutlein B, Huttner WB.

Elife. 2016 Sep 26;5. pii: e18683. doi: 10.7554/eLife.18683.


ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

Gai M, Bianchi FT, Vagnoni C, Vernì F, Bonaccorsi S, Pasquero S, Berto GE, Sgrò F, Chiotto AM, Annaratone L, Sapino A, Bergo A, Landsberger N, Bond J, Huttner WB, Di Cunto F.

EMBO Rep. 2016 Oct;17(10):1396-1409. Epub 2016 Aug 25. Erratum in: EMBO Rep. 2017 Oct;18(10 ):1870.


Neocortex expansion in development and evolution - from cell biology to single genes.

Wilsch-Bräuninger M, Florio M, Huttner WB.

Curr Opin Neurobiol. 2016 Aug;39:122-32. doi: 10.1016/j.conb.2016.05.004. Epub 2016 May 31. Review.


GEMC1 is a critical regulator of multiciliated cell differentiation.

Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanović M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V, Stracker TH.

EMBO J. 2016 May 2;35(9):942-60. doi: 10.15252/embj.201592821. Epub 2016 Mar 1.


Comment on "Cortical folding scales universally with surface area and thickness, not number of neurons".

Lewitus E, Kelava I, Kalinka AT, Tomancak P, Huttner WB.

Science. 2016 Feb 19;351(6275):825. doi: 10.1126/science.aad2029.


Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells.

Taverna E, Mora-Bermúdez F, Strzyz PJ, Florio M, Icha J, Haffner C, Norden C, Wilsch-Bräuninger M, Huttner WB.

Sci Rep. 2016 Feb 16;6:21206. doi: 10.1038/srep21206.


Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.

Lange C, Turrero Garcia M, Decimo I, Bifari F, Eelen G, Quaegebeur A, Boon R, Zhao H, Boeckx B, Chang J, Wu C, Le Noble F, Lambrechts D, Dewerchin M, Kuo CJ, Huttner WB, Carmeliet P.

EMBO J. 2016 May 2;35(9):924-41. doi: 10.15252/embj.201592372. Epub 2016 Feb 8.


CRISPR/Cas9-induced disruption of gene expression in mouse embryonic brain and single neural stem cells in vivo.

Kalebic N, Taverna E, Tavano S, Wong FK, Suchold D, Winkler S, Huttner WB, Sarov M.

EMBO Rep. 2016 Mar;17(3):338-48. doi: 10.15252/embr.201541715. Epub 2016 Jan 12.


Abnormal spindle-like microcephaly-associated (ASPM) mutations strongly disrupt neocortical structure but spare the hippocampus and long-term memory.

Passemard S, Verloes A, Billette de Villemeur T, Boespflug-Tanguy O, Hernandez K, Laurent M, Isidor B, Alberti C, Pouvreau N, Drunat S, Gérard B, El Ghouzzi V, Gallego J, Elmaleh-Bergès M, Huttner WB, Eliez S, Gressens P, Schaer M.

Cortex. 2016 Jan;74:158-76. doi: 10.1016/j.cortex.2015.10.010. Epub 2015 Oct 31.


Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.

Camp JG, Badsha F, Florio M, Kanton S, Gerber T, Wilsch-Bräuninger M, Lewitus E, Sykes A, Hevers W, Lancaster M, Knoblich JA, Lachmann R, Pääbo S, Huttner WB, Treutlein B.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15672-7. doi: 10.1073/pnas.1520760112. Epub 2015 Dec 7.


Novel insights into mammalian embryonic neural stem cell division: focus on microtubules.

Mora-Bermúdez F, Huttner WB.

Mol Biol Cell. 2015 Dec 1;26(24):4302-6. doi: 10.1091/mbc.E15-03-0152.


Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation.

Sgrò F, Bianchi FT, Falcone M, Pallavicini G, Gai M, Chiotto AM, Berto GE, Turco E, Chang YJ, Huttner WB, Di Cunto F.

Cell Death Differ. 2016 May;23(5):801-13. doi: 10.1038/cdd.2015.142. Epub 2015 Nov 20.


Lipidome of midbody released from neural stem and progenitor cells during mammalian cortical neurogenesis.

Arai Y, Sampaio JL, Wilsch-Bräuninger M, Ettinger AW, Haffner C, Huttner WB.

Front Cell Neurosci. 2015 Aug 28;9:325. doi: 10.3389/fncel.2015.00325. eCollection 2015.


Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex.

Wong FK, Fei JF, Mora-Bermúdez F, Taverna E, Haffner C, Fu J, Anastassiadis K, Stewart AF, Huttner WB.

PLoS Biol. 2015 Aug 7;13(8):e1002217. doi: 10.1371/journal.pbio.1002217. eCollection 2015 Aug.


Neurodevelopmental LincRNA Microsyteny Conservation and Mammalian Brain Size Evolution.

Lewitus E, Huttner WB.

PLoS One. 2015 Jul 2;10(7):e0131818. doi: 10.1371/journal.pone.0131818. eCollection 2015.


Clever space saving—how the cerebral cortex folds.

Albert M, Huttner WB.

EMBO J. 2015 Jul 14;34(14):1845-7. doi: 10.15252/embj.201591952. Epub 2015 May 28. No abstract available.


S-phase duration is the main target of cell cycle regulation in neural progenitors of developing ferret neocortex.

Turrero García M, Chang Y, Arai Y, Huttner WB.

J Comp Neurol. 2016 Feb 15;524(3):456-70. doi: 10.1002/cne.23801. Epub 2015 Jun 3.


Stem cells: slow and steady wins the race.

Huttner WB.

Nat Neurosci. 2015 May;18(5):613-4. doi: 10.1038/nn.4009. No abstract available.


Analysis of primary cilia in the developing mouse brain.

Paridaen JT, Huttner WB, Wilsch-Bräuninger M.

Methods Cell Biol. 2015;127:93-129. doi: 10.1016/bs.mcb.2014.12.012. Epub 2015 Feb 14.


Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.

Florio M, Albert M, Taverna E, Namba T, Brandl H, Lewitus E, Haffner C, Sykes A, Wong FK, Peters J, Guhr E, Klemroth S, Prüfer K, Kelso J, Naumann R, Nüsslein I, Dahl A, Lachmann R, Pääbo S, Huttner WB.

Science. 2015 Mar 27;347(6229):1465-70. doi: 10.1126/science.aaa1975. Epub 2015 Feb 26.


An adaptive threshold in mammalian neocortical evolution.

Lewitus E, Kelava I, Kalinka AT, Tomancak P, Huttner WB.

PLoS Biol. 2014 Nov 18;12(11):e1002000. doi: 10.1371/journal.pbio.1002000. eCollection 2014 Nov.


The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration.

Schmid MT, Weinandy F, Wilsch-Bräuninger M, Huttner WB, Cappello S, Götz M.

Front Cell Neurosci. 2014 Aug 7;8:215. doi: 10.3389/fncel.2014.00215. eCollection 2014.


The cell biology of neurogenesis: toward an understanding of the development and evolution of the neocortex.

Taverna E, Götz M, Huttner WB.

Annu Rev Cell Dev Biol. 2014;30:465-502. doi: 10.1146/annurev-cellbio-101011-155801. Epub 2014 Jun 27. Review.


Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division.

Mora-Bermúdez F, Matsuzaki F, Huttner WB.

Elife. 2014 Jul 4;3. doi: 10.7554/eLife.02875.

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