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Items: 17

1.

VHL Synthetic Lethality Signatures Uncovered by Genotype-Specific CRISPR-Cas9 Screens.

Sun N, Petiwala S, Lu C, Hutti JE, Hu M, Hu M, Domanus MH, Mitra D, Addo SN, Miller CP, Chung N.

CRISPR J. 2019 Aug;2:230-245. doi: 10.1089/crispr.2019.0018.

PMID:
31436504
2.

First-in-Human Study of Mivebresib (ABBV-075), an Oral Pan-Inhibitor of Bromodomain and Extra Terminal Proteins, in Patients with Relapsed/Refractory Solid Tumors.

Piha-Paul SA, Sachdev JC, Barve M, LoRusso P, Szmulewitz R, Patel SP, Lara PN Jr, Chen X, Hu B, Freise KJ, Modi D, Sood A, Hutti JE, Wolff J, O'Neil BH.

Clin Cancer Res. 2019 Nov 1;25(21):6309-6319. doi: 10.1158/1078-0432.CCR-19-0578. Epub 2019 Aug 16.

PMID:
31420359
3.

Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.

Jakob CG, Upadhyay AK, Donner PL, Nicholl E, Addo SN, Qiu W, Ling C, Gopalakrishnan SM, Torrent M, Cepa SP, Shanley J, Shoemaker AR, Sun CC, Vasudevan A, Woller KR, Shotwell JB, Shaw B, Bian Z, Hutti JE.

J Med Chem. 2018 Aug 9;61(15):6647-6657. doi: 10.1021/acs.jmedchem.8b00305. Epub 2018 Jul 30.

PMID:
30004704
4.

Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity.

Hsia HC, Hutti JE, Baldwin AS.

J Biol Chem. 2017 Mar 31;292(13):5405-5417. doi: 10.1074/jbc.M116.771964. Epub 2017 Feb 10.

5.

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.

Hutti JE, Porter MA, Cheely AW, Cantley LC, Wang X, Kireev D, Baldwin AS, Janzen WP.

PLoS One. 2012;7(7):e41494. doi: 10.1371/journal.pone.0041494. Epub 2012 Jul 30.

6.

Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation.

Hutti JE, Pfefferle AD, Russell SC, Sircar M, Perou CM, Baldwin AS.

Cancer Res. 2012 Jul 1;72(13):3260-9. doi: 10.1158/0008-5472.CAN-11-4141. Epub 2012 May 2.

7.

IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.

Marinis JM, Hutti JE, Homer CR, Cobb BA, Cantley LC, McDonald C, Abbott DW.

Mol Cell Biol. 2012 Jul;32(13):2479-89. doi: 10.1128/MCB.00106-12. Epub 2012 Apr 30.

8.

p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.

Comb WC, Hutti JE, Cogswell P, Cantley LC, Baldwin AS.

Mol Cell. 2012 Mar 30;45(6):719-30. doi: 10.1016/j.molcel.2012.01.010. Epub 2012 Feb 16.

9.

Development of an intracellularly acting inhibitory peptide selective for PKN.

Shiga K, Takayama K, Futaki S, Hutti JE, Cantley LC, Ueki K, Ono Y, Mukai H.

Biochem J. 2009 Dec 23;425(2):445-53. doi: 10.1042/BJ20090380.

10.

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR.

Biochem J. 2009 Oct 23;424(1):47-60. doi: 10.1042/BJ20091035.

11.

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC.

Mol Cell. 2009 May 14;34(4):461-72. doi: 10.1016/j.molcel.2009.04.031.

12.

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.

Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW.

Mol Cell Biol. 2007 Nov;27(21):7451-61. Epub 2007 Aug 20.

13.

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC.

Mol Cell Biol. 2007 Sep;27(17):6012-25. Epub 2007 Jun 11.

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Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.

Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8114-9. Epub 2005 May 31.

17.

A rapid method for determining protein kinase phosphorylation specificity.

Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE.

Nat Methods. 2004 Oct;1(1):27-9.

PMID:
15782149

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