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Items: 27


The courage to leave.

Huthoff H.

Science. 2019 Feb 22;363(6429):898. doi: 10.1126/science.363.6429.898. No abstract available.


Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1.

Kavanagh Williamson M, Coombes N, Juszczak F, Athanasopoulos M, Khan MB, Eykyn TR, Srenathan U, Taams LS, Dias Zeidler J, Da Poian AT, Huthoff H.

Viruses. 2018 Mar 7;10(3). pii: E114. doi: 10.3390/v10030114.


Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells.

Hegedus A, Kavanagh Williamson M, Khan MB, Dias Zeidler J, Da Poian AT, El-Bacha T, Struys EA, Huthoff H.

AIDS Res Hum Retroviruses. 2017 Dec;33(12):1236-1247. doi: 10.1089/AID.2017.0165. Epub 2017 Oct 4.


HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells.

Hegedus A, Kavanagh Williamson M, Huthoff H.

Retrovirology. 2014 Nov 25;11:98. doi: 10.1186/s12977-014-0098-4.


Rationalisation of the differences between APOBEC3G structures from crystallography and NMR studies by molecular dynamics simulations.

Autore F, Bergeron JR, Malim MH, Fraternali F, Huthoff H.

PLoS One. 2010 Jul 12;5(7):e11515. doi: 10.1371/journal.pone.0011515.


The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.

Bergeron JR, Huthoff H, Veselkov DA, Beavil RL, Simpson PJ, Matthews SJ, Malim MH, Sanderson MR.

PLoS Pathog. 2010 Jun 3;6(6):e1000925. doi: 10.1371/journal.ppat.1000925.


RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1.

Huthoff H, Autore F, Gallois-Montbrun S, Fraternali F, Malim MH.

PLoS Pathog. 2009 Mar;5(3):e1000330. doi: 10.1371/journal.ppat.1000330. Epub 2009 Mar 6.


Restriction of retroviral replication by APOBEC3G/F and TRIM5alpha.

Huthoff H, Towers GJ.

Trends Microbiol. 2008 Dec;16(12):612-9. doi: 10.1016/j.tim.2008.08.013. Epub 2008 Oct 29. Review.


The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation.

Ooms M, Cupac D, Abbink TE, Huthoff H, Berkhout B.

Nucleic Acids Res. 2007;35(5):1649-59. Epub 2007 Feb 18.


A riboswitch regulates RNA dimerization and packaging in human immunodeficiency virus type 1 virions.

Ooms M, Huthoff H, Russell R, Liang C, Berkhout B.

J Virol. 2004 Oct;78(19):10814-9.


A human immunodeficiency virus type 1-infected individual with low viral load harbors a virus variant that exhibits an in vitro RNA dimerization defect.

Huthoff H, Das AT, Vink M, Klaver B, Zorgdrager F, Cornelissen M, Berkhout B.

J Virol. 2004 May;78(9):4907-13.


Evidence for a base triple in the free HIV-1 TAR RNA.

Huthoff H, Girard F, Wijmenga SS, Berkhout B.

RNA. 2004 Mar;10(3):412-23.


Probing alternative foldings of the HIV-1 leader RNA by antisense oligonucleotide scanning arrays.

Ooms M, Verhoef K, Southern E, Huthoff H, Berkhout B.

Nucleic Acids Res. 2004 Feb 3;32(2):819-27. Print 2004.


The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair.

Kulinski T, Olejniczak M, Huthoff H, Bielecki L, Pachulska-Wieczorek K, Das AT, Berkhout B, Adamiak RW.

J Biol Chem. 2003 Oct 3;278(40):38892-901. Epub 2003 Jul 25.


Requirements for RNA heterodimerization of the human immunodeficiency virus type 1 (HIV-1) and HIV-2 genomes.

Dirac AM, Huthoff H, Kjems J, Berkhout B.

J Gen Virol. 2002 Oct;83(Pt 10):2533-42.


Multiple secondary structure rearrangements during HIV-1 RNA dimerization.

Huthoff H, Berkhout B.

Biochemistry. 2002 Aug 20;41(33):10439-45.


Regulated HIV-2 RNA dimerization by means of alternative RNA conformations.

Dirac AM, Huthoff H, Kjems J, Berkhout B.

Nucleic Acids Res. 2002 Jun 15;30(12):2647-55.


In vitro evidence that the untranslated leader of the HIV-1 genome is an RNA checkpoint that regulates multiple functions through conformational changes.

Berkhout B, Ooms M, Beerens N, Huthoff H, Southern E, Verhoef K.

J Biol Chem. 2002 May 31;277(22):19967-75. Epub 2002 Mar 14.


Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.

Berkhout B, Vastenhouw NL, Klasens BI, Huthoff H.

RNA. 2001 Aug;7(8):1097-114.


The dimer initiation site hairpin mediates dimerization of the human immunodeficiency virus, type 2 RNA genome.

Dirac AM, Huthoff H, Kjems J, Berkhout B.

J Biol Chem. 2001 Aug 24;276(34):32345-52. Epub 2001 Jun 7.


Two alternating structures of the HIV-1 leader RNA.

Huthoff H, Berkhout B.

RNA. 2001 Jan;7(1):143-57.


The effect of template RNA structure on elongation by HIV-1 reverse transcriptase.

Klasens BI, Huthoff HT, Das AT, Jeeninga RE, Berkhout B.

Biochim Biophys Acta. 1999 Mar 19;1444(3):355-70.


The mechanism of actinomycin D-mediated inhibition of HIV-1 reverse transcription.

Jeeninga RE, Huthoff HT, Gultyaev AP, Berkhout B.

Nucleic Acids Res. 1998 Dec 1;26(23):5472-9.

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