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Items: 1 to 50 of 52

1.

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules.

De Nicola GF, Bassi R, Nichols C, Fernandez-Caggiano M, Golforoush PA, Thapa D, Anderson R, Martin ED, Verma S, Kleinjung J, Laing A, Hutchinson JP, Eaton P, Clark J, Marber MS.

JCI Insight. 2018 Aug 23;3(16). pii: 121144. doi: 10.1172/jci.insight.121144. [Epub ahead of print]

2.

Timing of onset of symptoms in people with idiopathic pulmonary fibrosis.

Hewson T, McKeever TM, Gibson JE, Navaratnam V, Hubbard RB, Hutchinson JP.

Thorax. 2017 Oct 11. pii: thoraxjnl-2017-210177. doi: 10.1136/thoraxjnl-2017-210177. [Epub ahead of print]

PMID:
29021387
3.

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.

Hutchinson JP, Rowland P, Taylor MRD, Christodoulou EM, Haslam C, Hobbs CI, Holmes DS, Homes P, Liddle J, Mole DJ, Uings I, Walker AL, Webster SP, Mowat CG, Chung CW.

Nat Commun. 2017 Jun 12;8:15827. doi: 10.1038/ncomms15827.

4.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Walker AL, Ancellin N, Beaufils B, Bergeal M, Binnie M, Bouillot A, Clapham D, Denis A, Haslam CP, Holmes DS, Hutchinson JP, Liddle J, McBride A, Mirguet O, Mowat CG, Rowland P, Tiberghien N, Trottet L, Uings I, Webster SP, Zheng X, Mole DJ.

J Med Chem. 2017 Apr 27;60(8):3383-3404. doi: 10.1021/acs.jmedchem.7b00055. Epub 2017 Apr 11.

PMID:
28398044
5.

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

Liddle J, Beaufils B, Binnie M, Bouillot A, Denis AA, Hann MM, Haslam CP, Holmes DS, Hutchinson JP, Kranz M, McBride A, Mirguet O, Mole DJ, Mowat CG, Pal S, Rowland P, Trottet L, Uings IJ, Walker AL, Webster SP.

Bioorg Med Chem Lett. 2017 May 1;27(9):2023-2028. doi: 10.1016/j.bmcl.2017.02.078. Epub 2017 Mar 9.

PMID:
28336141
6.

Reply: Surgical Lung Biopsy: The Role of Better Surgery.

Hutchinson JP, Fogarty AW, McKeever TM, Hubbard RB.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1303. No abstract available.

PMID:
27845587
7.

Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008.

Hutchinson JP, McKeever TM, Fogarty AW, Navaratnam V, Hubbard RB.

Eur Respir J. 2016 Nov;48(5):1453-1461. doi: 10.1183/13993003.00378-2016. Epub 2016 Sep 22.

8.

Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase.

Batt SM, Cacho Izquierdo M, Castro Pichel J, Stubbs CJ, Vela-Glez Del Peral L, Pérez-Herrán E, Dhar N, Mouzon B, Rees M, Hutchinson JP, Young RJ, McKinney JD, Barros Aguirre D, Ballell L, Besra GS, Argyrou A.

ACS Infect Dis. 2015 Dec 11;1(12):615-26. doi: 10.1021/acsinfecdis.5b00065. Epub 2015 Aug 25.

PMID:
27623058
9.

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP.

Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.

10.

In-Hospital Mortality after Surgical Lung Biopsy for Interstitial Lung Disease in the United States. 2000 to 2011.

Hutchinson JP, Fogarty AW, McKeever TM, Hubbard RB.

Am J Respir Crit Care Med. 2016 May 15;193(10):1161-7. doi: 10.1164/rccm.201508-1632OC.

PMID:
26646481
11.

Micellar electrokinetic chromatography of organic and peroxide-based explosives.

Johns C, Hutchinson JP, Guijt RM, Hilder EF, Haddad PR, Macka M, Nesterenko PN, Gaudry AJ, Dicinoski GW, Breadmore MC.

Anal Chim Acta. 2015 May 30;876:91-7. doi: 10.1016/j.aca.2015.02.070. Epub 2015 Mar 30.

PMID:
25998463
12.

Seropositivity to Toxoplasma infection in sheep samples submitted to Animal and Plant Health Agency laboratories between 2005 and 2012.

Hutchinson JP, Smith RP.

Vet Rec. 2015 May 30;176(22):573. doi: 10.1136/vr.102114. Epub 2015 Apr 17.

PMID:
25888604
13.

Cross-sectional survey of antibiotic resistance in Escherichia coli isolated from diseased farm livestock in England and Wales.

Cheney TE, Smith RP, Hutchinson JP, Brunton LA, Pritchard G, Teale CJ.

Epidemiol Infect. 2015 Sep;143(12):2653-9. doi: 10.1017/S0950268814003963. Epub 2015 Jan 23.

PMID:
25613078
14.

Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century.

Hutchinson JP, McKeever TM, Fogarty AW, Navaratnam V, Hubbard RB.

Ann Am Thorac Soc. 2014 Oct;11(8):1176-85. doi: 10.1513/AnnalsATS.201404-145OC.

PMID:
25165873
15.

Lead discovery for human kynurenine 3-monooxygenase by high-throughput RapidFire mass spectrometry.

Lowe DM, Gee M, Haslam C, Leavens B, Christodoulou E, Hissey P, Hardwicke P, Argyrou A, Webster SP, Mole DJ, Wilson K, Binnie M, Yard BA, Dean T, Liddle J, Uings I, Hutchinson JP.

J Biomol Screen. 2014 Apr;19(4):508-15. doi: 10.1177/1087057113518069. Epub 2013 Dec 31.

PMID:
24381207
16.

Effects of eluent temperature and elution bandwidth on detection response for aerosol-based detectors.

Khandagale MM, Hutchinson JP, Dicinoski GW, Haddad PR.

J Chromatogr A. 2013 Sep 20;1308:96-103. doi: 10.1016/j.chroma.2013.07.111. Epub 2013 Aug 6.

PMID:
23953611
17.

Ion exchange chromatographic separation and isolation of oligosaccharides of intact low-molecular-weight heparin for the determination of their anticoagulant and anti-inflammatory properties.

Shastri MD, Johns C, Hutchinson JP, Khandagale M, Patel RP.

Anal Bioanal Chem. 2013 Jul;405(18):6043-52. doi: 10.1007/s00216-013-6996-9. Epub 2013 May 28.

PMID:
23712644
18.

On-line simultaneous and rapid separation of anions and cations from a single sample using dual-capillary sequential injection-capillary electrophoresis.

Gaudry AJ, Guijt RM, Macka M, Hutchinson JP, Johns C, Hilder EF, Dicinoski GW, Nesterenko PN, Haddad PR, Breadmore MC.

Anal Chim Acta. 2013 Jun 5;781:80-7. doi: 10.1016/j.aca.2013.03.027. Epub 2013 Mar 26.

PMID:
23684468
19.

Investigation of polar organic solvents compatible with Corona Charged Aerosol Detection and their use for the determination of sugars by hydrophilic interaction liquid chromatography.

Hutchinson JP, Remenyi T, Nesterenko P, Farrell W, Groeber E, Szucs R, Dicinoski G, Haddad PR.

Anal Chim Acta. 2012 Oct 31;750:199-206. doi: 10.1016/j.aca.2012.04.002. Epub 2012 Apr 11.

PMID:
23062441
20.

Determination of pharmaceutically related compounds by suppressed ion chromatography: IV. Interfacing ion chromatography with universal detectors.

Karu N, Hutchinson JP, Dicinoski GW, Hanna-Brown M, Srinivasan K, Pohl CA, Haddad PR.

J Chromatogr A. 2012 Aug 31;1253:44-51. doi: 10.1016/j.chroma.2012.06.101. Epub 2012 Jul 16.

PMID:
22840819
21.

Survey to determine the seroprevalence of Toxoplasma gondii infection in British sheep flocks.

Hutchinson JP, Wear AR, Lambton SL, Smith RP, Pritchard GC.

Vet Rec. 2011 Nov 26;169(22):582. doi: 10.1136/vr.d5764. Epub 2011 Sep 27.

PMID:
21957115
22.

Verocytotoxin-producing and attaching and effacing activity of Escherichia coli isolated from diseased farm livestock.

Hutchinson JP, Cheney TE, Smith RP, Lynch K, Pritchard GC.

Vet Rec. 2011 May 21;168(20):536. doi: 10.1136/vr.d915. Epub 2011 May 5.

PMID:
21546408
23.

Comparison of the response of four aerosol detectors used with ultra high pressure liquid chromatography.

Hutchinson JP, Li J, Farrell W, Groeber E, Szucs R, Dicinoski G, Haddad PR.

J Chromatogr A. 2011 Mar 25;1218(12):1646-55. doi: 10.1016/j.chroma.2011.01.062. Epub 2011 Jan 27.

PMID:
21315361
24.

Universal response model for a corona charged aerosol detector.

Hutchinson JP, Li J, Farrell W, Groeber E, Szucs R, Dicinoski G, Haddad PR.

J Chromatogr A. 2010 Nov 19;1217(47):7418-27. doi: 10.1016/j.chroma.2010.09.056. Epub 2010 Sep 29.

PMID:
20961549
25.

Glycan profiling of monoclonal antibodies using zwitterionic-type hydrophilic interaction chromatography coupled with electrospray ionization mass spectrometry detection.

Mauko L, Nordborg A, Hutchinson JP, Lacher NA, Hilder EF, Haddad PR.

Anal Biochem. 2011 Jan 15;408(2):235-41. doi: 10.1016/j.ab.2010.09.035. Epub 2010 Sep 29.

PMID:
20887707
26.

Predator attacks on sheep in Northumberland.

Hutchinson JP, Carson AJ, Proctor P.

Vet Rec. 2009 Jun 27;164(26):820. No abstract available.

PMID:
19561356
27.

Silica nanoparticle-templated methacrylic acid monoliths for in-line solid-phase extraction-capillary electrophoresis of basic analytes.

Thabano JR, Breadmore MC, Hutchinson JP, Johns C, Haddad PR.

J Chromatogr A. 2009 Jun 19;1216(25):4933-40. doi: 10.1016/j.chroma.2009.04.012. Epub 2009 Apr 9.

PMID:
19446825
28.

Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm.

Hassan NJ, Gul S, Flett F, Hollingsworth E, Dunne AA, Emmons AJ, Hutchinson JP, Hibbs MJ, Dyos S, Kitson JD, Hiley E, Rüdiger M, Tew DG, Powell DJ, Morse MA.

Biochem J. 2009 Apr 1;419(1):65-73. doi: 10.1042/BJ20081646.

PMID:
19061480
29.

Identification of inorganic ions in post-blast explosive residues using portable CE instrumentation and capacitively coupled contactless conductivity detection.

Hutchinson JP, Johns C, Breadmore MC, Hilder EF, Guijt RM, Lennard C, Dicinoski G, Haddad PR.

Electrophoresis. 2008 Nov;29(22):4593-602. doi: 10.1002/elps.200800226.

PMID:
19035395
30.

Selective extraction and elution of weak bases by in-line solid-phase extraction capillary electrophoresis using a pH step gradient and a weak cation-exchange monolith.

Thabano JR, Breadmore MC, Hutchinson JP, Johns C, Haddad PR.

Analyst. 2008 Oct;133(10):1380-7. doi: 10.1039/b804805c. Epub 2008 Jul 14.

PMID:
18810286
31.

Indirect photometric detection of anions in nonaqueous capillary electrophoresis employing Orange G as probe and a light-emitting diode-based detector.

Heras GA, Breadmore MC, Johns C, Hutchinson JP, Hilder EF, López-Mahía P, Haddad PR.

Electrophoresis. 2008 Jul;29(14):3032-7. doi: 10.1002/elps.200800116.

PMID:
18655039
32.

Identification of homemade inorganic explosives by ion chromatographic analysis of post-blast residues.

Johns C, Shellie RA, Potter OG, O'Reilly JW, Hutchinson JP, Guijt RM, Breadmore MC, Hilder EF, Dicinoski GW, Haddad PR.

J Chromatogr A. 2008 Feb 29;1182(2):205-14. doi: 10.1016/j.chroma.2008.01.014. Epub 2008 Jan 11.

PMID:
18221942
33.

A simple capillary electrophoresis method for the rapid separation and determination of intact low molecular weight and unfractionated heparins.

Patel RP, Narkowicz C, Hutchinson JP, Hilder EF, Jacobson GA.

J Pharm Biomed Anal. 2008 Jan 7;46(1):30-5. Epub 2007 Oct 13.

PMID:
18024047
34.
35.

Identification of inorganic improvised explosive devices by analysis of postblast residues using portable capillary electrophoresis instrumentation and indirect photometric detection with a light-emitting diode.

Hutchinson JP, Evenhuis CJ, Johns C, Kazarian AA, Breadmore MC, Macka M, Hilder EF, Guijt RM, Dicinoski GW, Haddad PR.

Anal Chem. 2007 Sep 15;79(18):7005-13. Epub 2007 Aug 18.

PMID:
17705451
36.

Copper poisoning in sheep associated with clover.

Millar M, Errington H, Hutchinson JP, Norton A.

Vet Rec. 2007 Jul 21;161(3):108. No abstract available.

PMID:
17652441
37.

Clostridium perfringens type D enterotoxaemia in neonatal lambs.

Scholes SF, Welchman Dde B, Hutchinson JP, Edwards GT, Mitchell ES.

Vet Rec. 2007 Jun 9;160(23):811-2. No abstract available.

PMID:
17558035
38.

Subacute symmetrical necrotising encephalopathy in young lambs.

Scholes SF, Higgins RJ, Holliman A, Watson PJ, Hutchinson JP, Daniel R.

Vet Rec. 2007 Jun 2;160(22):775. No abstract available.

PMID:
17545651
39.

Automation of solid-phase microextraction on a 96-well plate format.

Hutchinson JP, Setkova L, Pawliszyn J.

J Chromatogr A. 2007 May 18;1149(2):127-37. Epub 2007 Mar 16.

PMID:
17418854
40.

Preparation and characterisation of anion-exchange latex-coated silica monoliths for capillary electrochromatography.

Hutchinson JP, Hilder EF, Macka M, Avdalovic N, Haddad PR.

J Chromatogr A. 2006 Mar 17;1109(1):10-8. Epub 2005 Sep 8.

PMID:
16517242
41.

On-line preconcentration of organic anions in capillary electrophoresis by solid-phase extraction using latex-coated monolithic stationary phases.

Hutchinson JP, Macka M, Avdalovic N, Haddad PR.

J Chromatogr A. 2006 Feb 17;1106(1-2):43-51. Epub 2005 Sep 1.

PMID:
16443451
42.

Towards high capacity latex-coated porous polymer monoliths as ion-exchange stationary phases.

Hutchinson JP, Hilder EF, Shellie RA, Smith JA, Haddad PR.

Analyst. 2006 Feb;131(2):215-21. Epub 2005 Nov 21.

PMID:
16440085
43.

Fluorescence-based assays.

Eccleston JF, Hutchinson JP, Jameson DM.

Prog Med Chem. 2005;43:19-48. Review. No abstract available.

PMID:
15850822
44.

Latex-coated polymeric monolithic ion-exchange stationary phases. 2. Micro-ion chromatography.

Zakaria P, Hutchinson JP, Avdalovic N, Liu Y, Haddad PR.

Anal Chem. 2005 Jan 15;77(2):417-23.

PMID:
15649036
45.
47.

A modular, fully integrated ultra-high-throughput screening system based on confocal fluorescence analysis techniques.

Jäger S, Garbow N, Kirsch A, Preckel H, Gandenberger FU, Herrenknecht K, Rüdiger M, Hutchinson JP, Bingham RP, Ramon F, Bardera A, Martin J.

J Biomol Screen. 2003 Dec;8(6):648-59.

PMID:
14711390
48.

Purification and characterization of guanine nucleotide dissociation stimulator protein.

Hutchinson JP, Rittinger K, Eccleston JF.

Methods Enzymol. 2000;325:71-82. No abstract available.

PMID:
11036593
49.

Mechanism of nucleotide release from Rho by the GDP dissociation stimulator protein.

Hutchinson JP, Eccleston JF.

Biochemistry. 2000 Sep 19;39(37):11348-59.

PMID:
10985780
50.

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