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Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep.

Hutchinson DS, Brew N, Vu T, Merlin J, Hale N, Walker DW, Wong FY.

J Appl Physiol (1985). 2018 Aug 23. doi: 10.1152/japplphysiol.00472.2018. [Epub ahead of print]


Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture.

Merlin J, Sato M, Chia LY, Fahey R, Pakzad M, Nowell CJ, Summers RJ, Bengtsson T, Evans BA, Hutchinson DS.

Front Endocrinol (Lausanne). 2018 May 30;9:249. doi: 10.3389/fendo.2018.00249. eCollection 2018.


Oral microbiota reveals signs of acculturation in Mexican American women.

Hoffman KL, Hutchinson DS, Fowler J, Smith DP, Ajami NJ, Zhao H, Scheet P, Chow WH, Petrosino JF, Daniel CR.

PLoS One. 2018 Apr 25;13(4):e0194100. doi: 10.1371/journal.pone.0194100. eCollection 2018.


INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

Ang SY, Evans BA, Poole DP, Bron R, DiCello JJ, Bathgate RAD, Kocan M, Hutchinson DS, Summers RJ.

J Mol Endocrinol. 2018 Apr;60(3):213-224. doi: 10.1530/JME-17-0152.


Peripheral modulation of the endocannabinoid system in metabolic disease.

Shrestha N, Cuffe JSM, Hutchinson DS, Headrick JP, Perkins AV, McAinch AJ, Hryciw DH.

Drug Discov Today. 2018 Mar;23(3):592-604. doi: 10.1016/j.drudis.2018.01.029. Epub 2018 Jan 10. Review.


Mirabegron: potential off target effects and uses beyond the bladder.

Dehvari N, da Silva Junior ED, Bengtsson T, Hutchinson DS.

Br J Pharmacol. 2017 Dec 15. doi: 10.1111/bph.14121. [Epub ahead of print] Review.


α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes.

Sato M, Evans BA, Sandström AL, Chia LY, Mukaida S, Thai BS, Nguyen A, Lim L, Tan CYR, Baltos JA, White PJ, May LT, Hutchinson DS, Summers RJ, Bengtsson T.

Biochem Pharmacol. 2018 Feb;148:27-40. doi: 10.1016/j.bcp.2017.11.016. Epub 2017 Nov 24.


Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.

Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Szczepaniak Sloane R, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Marcelo Riquelme Sanchez E, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, Austin-Breneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA.

Science. 2018 Jan 5;359(6371):97-103. doi: 10.1126/science.aan4236. Epub 2017 Nov 2.


Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance.

Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B.

Cell. 2017 Nov 16;171(5):1015-1028.e13. doi: 10.1016/j.cell.2017.09.016. Epub 2017 Oct 19.


The PPARγ agonist rosiglitazone promotes the induction of brite adipocytes, increasing β-adrenoceptor-mediated mitochondrial function and glucose uptake.

Merlin J, Sato M, Nowell C, Pakzad M, Fahey R, Gao J, Dehvari N, Summers RJ, Bengtsson T, Evans BA, Hutchinson DS.

Cell Signal. 2018 Jan;42:54-66. doi: 10.1016/j.cellsig.2017.09.023. Epub 2017 Sep 29.


Impact of environmental microbiota on human microbiota of workers in academic mouse research facilities: An observational study.

Lai PS, Allen JG, Hutchinson DS, Ajami NJ, Petrosino JF, Winters T, Hug C, Wartenberg GR, Vallarino J, Christiani DC.

PLoS One. 2017 Jul 13;12(7):e0180969. doi: 10.1371/journal.pone.0180969. eCollection 2017.


ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

Kocan M, Sarwar M, Ang SY, Xiao J, Marugan JJ, Hossain MA, Wang C, Hutchinson DS, Samuel CS, Agoulnik AI, Bathgate RAD, Summers RJ.

Sci Rep. 2017 Jun 7;7(1):2968. doi: 10.1038/s41598-017-02916-5.


Factors influencing biased agonism in recombinant cells expressing the human α1A -adrenoceptor.

da Silva Junior ED, Sato M, Merlin J, Broxton N, Hutchinson DS, Ventura S, Evans BA, Summers RJ.

Br J Pharmacol. 2017 Jul;174(14):2318-2333. doi: 10.1111/bph.13837. Epub 2017 Jun 10.


Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing.

Zhang H, Zhao F, Hutchinson DS, Sun W, Ajami NJ, Lai S, Wong MC, Petrosino JF, Fang J, Jiang J, Chen W, Reinach PS, Qu J, Zeng C, Zhang D, Zhou X.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):128-136. doi: 10.1167/iovs.16-20231.


Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2.

Mukaida S, Evans BA, Bengtsson T, Hutchinson DS, Sato M.

Pharmacol Res. 2017 Feb;116:87-92. doi: 10.1016/j.phrs.2016.12.022. Epub 2016 Dec 23. Review.


The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.

Ang SY, Hutchinson DS, Evans BA, Hossain MA, Patil N, Bathgate RA, Kocan M, Summers RJ.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):105-111. doi: 10.1007/s00210-016-1321-8. Epub 2016 Nov 26.


Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population.

Santos-Cortez RL, Reyes-Quintos MR, Tantoco ML, Abbe I, Llanes EG, Ajami NJ, Hutchinson DS, Petrosino JF, Padilla CD, Villarta RL Jr, Gloria-Cruz TL, Chan AL, Cutiongco-de la Paz EM, Chiong CM, Leal SM, Abes GT.

Otolaryngol Head Neck Surg. 2016 Nov;155(5):856-862. Epub 2016 Aug 2.


Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene.

Santos-Cortez RL, Hutchinson DS, Ajami NJ, Reyes-Quintos MR, Tantoco ML, Labra PJ, Lagrana SM, Pedro M, Llanes EG, Gloria-Cruz TL, Chan AL, Cutiongco-de la Paz EM, Belmont JW, Chonmaitree T, Abes GT, Petrosino JF, Leal SM, Chiong CM.

Infect Dis Poverty. 2016 Nov 1;5(1):97.


Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.

Ang SY, Hutchinson DS, Patil N, Evans BA, Bathgate RAD, Halls ML, Hossain MA, Summers RJ, Kocan M.

Br J Pharmacol. 2017 May;174(10):1077-1089. doi: 10.1111/bph.13522. Epub 2016 Jul 13. Erratum in: Br J Pharmacol. 2017 Dec;174(24):4836.


CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, Burns CJ, Carotta S, Gray DH, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND.

Nat Immunol. 2016 Jul;17(7):816-24. doi: 10.1038/ni.3470. Epub 2016 May 23.


Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome.

de Paiva CS, Jones DB, Stern ME, Bian F, Moore QL, Corbiere S, Streckfus CF, Hutchinson DS, Ajami NJ, Petrosino JF, Pflugfelder SC.

Sci Rep. 2016 Apr 18;6:23561. doi: 10.1038/srep23561.


The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Delconte RB, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, Kolesnik TB, Rankin LC, Mielke LA, Zhang JG, Busslinger M, Smyth MJ, Hutchinson DS, Nutt SL, Nicholson SE, Alexander WS, Corcoran LM, Vivier E, Belz GT, Carotta S, Huntington ND.

Immunity. 2016 Jan 19;44(1):103-115. doi: 10.1016/j.immuni.2015.12.007. Epub 2016 Jan 12.


G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction.

Rajaraman G, Simcocks A, Hryciw DH, Hutchinson DS, McAinch AJ.

Mol Nutr Food Res. 2016 Jan;60(1):92-102. doi: 10.1002/mnfr.201500449. Epub 2015 Sep 22. Review.


Promise and Pragmatism in Clinical Microbiome Research.

Ajami NJ, Hutchinson DS, Petrosino JF.

Mini Rev Med Chem. 2015;16(3):222-4. Review.


Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.

Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS.

Mol Nutr Food Res. 2016 Jan;60(1):18-42. doi: 10.1002/mnfr.201500251. Epub 2015 Aug 27. Review.


DNAM-1 expression marks an alternative program of NK cell maturation.

Martinet L, Ferrari De Andrade L, Guillerey C, Lee JS, Liu J, Souza-Fonseca-Guimaraes F, Hutchinson DS, Kolesnik TB, Nicholson SE, Huntington ND, Smyth MJ.

Cell Rep. 2015 Apr 7;11(1):85-97. doi: 10.1016/j.celrep.2015.03.006. Epub 2015 Mar 26.


Response to Comment on Sato et al. Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle. Diabetes 2014;63:4115-4129.

Sato M, Dehvari N, Oberg AI, Summers RJ, Hutchinson DS, Bengtsson T.

Diabetes. 2014 Dec;63(12):e22-3. doi: 10.2337/db14-1283. No abstract available.


Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation.

Olsen JM, Sato M, Dallner OS, Sandström AL, Pisani DF, Chambard JC, Amri EZ, Hutchinson DS, Bengtsson T.

J Cell Biol. 2014 Nov 10;207(3):365-74. doi: 10.1083/jcb.201403080.


Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle.

Sato M, Dehvari N, Oberg AI, Dallner OS, Sandström AL, Olsen JM, Csikasz RI, Summers RJ, Hutchinson DS, Bengtsson T.

Diabetes. 2014 Dec;63(12):4115-29. doi: 10.2337/db13-1860. Epub 2014 Jul 9.


Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor.

Maïga A, Merlin J, Marcon E, Rouget C, Larregola M, Gilquin B, Fruchart-Gaillard C, Lajeunesse E, Marchetti C, Lorphelin A, Bellanger L, Summers RJ, Hutchinson DS, Evans BA, Servent D, Gilles N.

PLoS One. 2013 Jul 25;8(7):e68841. doi: 10.1371/journal.pone.0068841. Print 2013.


β2-Adrenoceptor-mediated regulation of glucose uptake in skeletal muscle--ligand-directed signalling or a reflection of system complexity?

Evans BA, Hutchinson DS, Summers RJ.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Sep;386(9):757-60. doi: 10.1007/s00210-013-0879-7. Epub 2013 May 9.


Rapid turnover of glycogen in memory formation.

Gibbs ME, Hutchinson DS.

Neurochem Res. 2012 Nov;37(11):2456-63. doi: 10.1007/s11064-012-0805-2. Epub 2012 Jun 5.


Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.

Sato M, Hutchinson DS, Halls ML, Furness SG, Bengtsson T, Evans BA, Summers RJ.

J Biol Chem. 2012 Jun 8;287(24):20674-88. doi: 10.1074/jbc.M111.280651. Epub 2012 Apr 25.


β(2)-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail.

Dehvari N, Hutchinson DS, Nevzorova J, Dallner OS, Sato M, Kocan M, Merlin J, Evans BA, Summers RJ, Bengtsson T.

Br J Pharmacol. 2012 Mar;165(5):1442-56. doi: 10.1111/j.1476-5381.2011.01647.x.


β₁-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β₃-adrenergic receptor-knockout mice via nonshivering thermogenesis.

Mattsson CL, Csikasz RI, Chernogubova E, Yamamoto DL, Hogberg HT, Amri EZ, Hutchinson DS, Bengtsson T.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1108-18. doi: 10.1152/ajpendo.00085.2011. Epub 2011 Aug 30.


Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats.

Öberg AI, Yassin K, Csikasz RI, Dehvari N, Shabalina IG, Hutchinson DS, Wilcke M, Östenson CG, Bengtsson T.

PLoS One. 2011;6(7):e22510. doi: 10.1371/journal.pone.0022510. Epub 2011 Jul 26.


The recovery education center: an integrated health promotion and wellness program.

Hutchinson DS.

Psychiatr Rehabil J. 2011 Spring;34(4):321-3. doi: 10.2975/34.4.2011.321.323.


α₂-Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes.

Hutchinson DS, Catus SL, Merlin J, Summers RJ, Gibbs ME.

J Neurochem. 2011 Jun;117(5):915-26. doi: 10.1111/j.1471-4159.2011.07261.x. Epub 2011 Apr 26.


Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.

Catus SL, Gibbs ME, Sato M, Summers RJ, Hutchinson DS.

Br J Pharmacol. 2011 Apr;162(8):1700-15. doi: 10.1111/j.1476-5381.2010.01153.x.


Quantification of functional selectivity at the human α(1A)-adrenoceptor.

Evans BA, Broxton N, Merlin J, Sato M, Hutchinson DS, Christopoulos A, Summers RJ.

Mol Pharmacol. 2011 Feb;79(2):298-307. doi: 10.1124/mol.110.067454. Epub 2010 Oct 26. Erratum in: Mol Pharmacol. 2011 Mar;79(3):627.


Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for α- and β-adrenergic receptors.

Gibbs ME, Hutchinson DS, Summers RJ.

Neuroscience. 2010 Nov 10;170(4):1209-22. doi: 10.1016/j.neuroscience.2010.07.052. Epub 2010 Aug 13.


The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism.

Merlin J, Evans BA, Csikasz RI, Bengtsson T, Summers RJ, Hutchinson DS.

Cell Signal. 2010 Jul;22(7):1104-13. doi: 10.1016/j.cellsig.2010.03.004. Epub 2010 Mar 4.


Ligand-directed signalling at beta-adrenoceptors.

Evans BA, Sato M, Sarwar M, Hutchinson DS, Summers RJ.

Br J Pharmacol. 2010 Mar;159(5):1022-38. doi: 10.1111/j.1476-5381.2009.00602.x. Epub 2010 Feb 2. Review.


Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick.

Gibbs ME, Rodricks CL, Hutchinson DS, Summers RJ, Miller SL.

Int J Dev Neurosci. 2009 Feb;27(1):27-35. doi: 10.1016/j.ijdevneu.2008.10.005. Epub 2008 Nov 5.


Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease.

Hutchinson DS, Summers RJ, Bengtsson T.

Pharmacol Ther. 2008 Sep;119(3):291-310. doi: 10.1016/j.pharmthera.2008.05.008. Epub 2008 Jun 17. Review.


Results of an innovative university-based recovery education program for adults with psychiatric disabilities.

Dunn EC, Sally Rogers E, Hutchinson DS, Lyass A, MacDonald Wilson KL, Wallace LR, Furlong-Norman K.

Adm Policy Ment Health. 2008 Sep;35(5):357-69. doi: 10.1007/s10488-008-0176-9. Epub 2008 Jun 14.


Energy metabolism and memory processing: role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken.

Hutchinson DS, Summers RJ, Gibbs ME.

Brain Res Bull. 2008 Jun 15;76(3):224-34. doi: 10.1016/j.brainresbull.2008.02.019. Epub 2008 Mar 6. Review.


Memory processing in the avian hippocampus involves interactions between beta-adrenoceptors, glutamate receptors, and metabolism.

Gibbs ME, Bowser DN, Hutchinson DS, Loiacono RE, Summers RJ.

Neuropsychopharmacology. 2008 Nov;33(12):2831-46. doi: 10.1038/npp.2008.5. Epub 2008 Feb 6.


Role of beta-adrenoceptors in memory consolidation: beta3-adrenoceptors act on glucose uptake and beta2-adrenoceptors on glycogenolysis.

Gibbs ME, Hutchinson DS, Summers RJ.

Neuropsychopharmacology. 2008 Sep;33(10):2384-97. Epub 2007 Nov 28.

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