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Items: 1 to 50 of 151

1.

Corrosion-wear of β-Ti alloy TMZF (Ti-12Mo-6Zr-2Fe) in simulated body fluid.

Yang X, Hutchinson CR.

Acta Biomater. 2016 Sep 15;42:429-439. doi: 10.1016/j.actbio.2016.07.008. Epub 2016 Jul 7.

PMID:
27397494
2.

Quantitative atom probe analysis of nanostructure containing clusters and precipitates with multiple length scales.

Marceau RK, Stephenson LT, Hutchinson CR, Ringer SP.

Ultramicroscopy. 2011 May;111(6):738-42. doi: 10.1016/j.ultramic.2010.12.029. Epub 2010 Dec 29.

PMID:
21215521
3.

Characterization of a large, stable, high-copy-number Streptomyces plasmid that requires stability and transfer functions for heterologous polyketide overproduction.

Fong R, Vroom JA, Hu Z, Hutchinson CR, Huang J, Cohen SN, Kao CM.

Appl Environ Microbiol. 2007 Feb;73(4):1296-307. Epub 2006 Dec 1. Erratum in: Appl Environ Microbiol. 2007 Jun;73(12):4094. Vroom, Jonathan A [added]; Cohen, Stanley [corrected to Cohen, Stanley N]; Kao, Camilla [corrected to Kao, Camilla M].

4.

Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius.

Jiang H, Hutchinson CR.

Res Microbiol. 2006 Sep;157(7):666-74. Epub 2006 Mar 3.

PMID:
16545946
5.

Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.

Wendt-Pienkowski E, Huang Y, Zhang J, Li B, Jiang H, Kwon H, Hutchinson CR, Shen B.

J Am Chem Soc. 2005 Nov 30;127(47):16442-52.

PMID:
16305230
6.

Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.

Rascher A, Hu Z, Buchanan GO, Reid R, Hutchinson CR.

Appl Environ Microbiol. 2005 Aug;71(8):4862-71.

7.

Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta.

Schirmer A, Gadkari R, Reeves CD, Ibrahim F, DeLong EF, Hutchinson CR.

Appl Environ Microbiol. 2005 Aug;71(8):4840-9.

8.

Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation.

Vetcher L, Tian ZQ, McDaniel R, Rascher A, Revill WP, Hutchinson CR, Hu Z.

Appl Environ Microbiol. 2005 Apr;71(4):1829-35.

9.

Genetic approaches to polyketide antibiotics. 1.

McDaniel R, Welch M, Hutchinson CR.

Chem Rev. 2005 Feb;105(2):543-58. Review. No abstract available.

PMID:
15700956
10.

Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.

Patel K, Piagentini M, Rascher A, Tian ZQ, Buchanan GO, Regentin R, Hu Z, Hutchinson CR, McDaniel R.

Chem Biol. 2004 Dec;11(12):1625-33. Erratum in: Chem Biol. 2006 Mar;13(3):341.

11.
12.

Isolation and characterization of novel geldanamycin analogues.

Hu Z, Liu Y, Tian ZQ, Ma W, Starks CM, Regentin R, Licari P, Myles DC, Hutchinson CR.

J Antibiot (Tokyo). 2004 Jul;57(7):421-8.

13.

Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.

Lum AM, Huang J, Hutchinson CR, Kao CM.

Metab Eng. 2004 Jul;6(3):186-96.

PMID:
15256208
14.

Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.

Thompson TB, Katayama K, Watanabe K, Hutchinson CR, Rayment I.

J Biol Chem. 2004 Sep 3;279(36):37956-63. Epub 2004 Jun 30.

15.

Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues.

Desai RP, Leaf T, Hu Z, Hutchinson CR, Hong A, Byng G, Galazzo J, Licari P.

Biotechnol Prog. 2004 Jan-Feb;20(1):38-43.

PMID:
14763821
16.

Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.

Sorensen JL, Auclair K, Kennedy J, Hutchinson CR, Vederas JC.

Org Biomol Chem. 2003 Jan 7;1(1):50-9.

PMID:
12929390
17.

A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases.

Hu Z, Pfeifer BA, Chao E, Murli S, Kealey J, Carney JR, Ashley G, Khosla C, Hutchinson CR.

Microbiology. 2003 Aug;149(Pt 8):2213-25.

PMID:
12904561
18.

Enhanced heterologous polyketide production in Streptomyces by exploiting plasmid co-integration.

Hu Z, Hopwood DA, Hutchinson CR.

J Ind Microbiol Biotechnol. 2003 Aug;30(8):516-22. Epub 2003 Jun 21.

PMID:
12827516
19.

Approaches to stabilization of inter-domain recombination in polyketide synthase gene expression plasmids.

Hu Z, Desai RP, Volchegursky Y, Leaf T, Woo E, Licari P, Santi DV, Hutchinson CR, McDaniel R.

J Ind Microbiol Biotechnol. 2003 Mar;30(3):161-7. Epub 2003 Mar 1.

PMID:
12715253
20.

Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains.

Rodriguez E, Hu Z, Ou S, Volchegursky Y, Hutchinson CR, McDaniel R.

J Ind Microbiol Biotechnol. 2003 Aug;30(8):480-8. Epub 2003 Apr 16.

PMID:
12698320
21.

Polyketide and non-ribosomal peptide synthases: falling together by coming apart.

Hutchinson CR.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3010-2. Epub 2003 Mar 11. No abstract available.

22.

Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

Rascher A, Hu Z, Viswanathan N, Schirmer A, Reid R, Nierman WC, Lewis M, Hutchinson CR.

FEMS Microbiol Lett. 2003 Jan 28;218(2):223-30.

23.

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.

Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R.

Biochemistry. 2003 Jan 14;42(1):72-9.

PMID:
12515540
24.

A comparison of EDS microanalysis in FIB-prepared and electropolished TEM thin foils.

Hutchinson CR, Hackenberg RE, Shiflet GJ.

Ultramicroscopy. 2003 Jan;94(1):37-48.

PMID:
12489594
25.
26.

Combinatorial biosynthesis in microorganisms as a route to new antimicrobial, antitumor and neuroregenerative drugs.

Hutchinson CR, McDaniel R.

Curr Opin Investig Drugs. 2001 Dec;2(12):1681-90. Review.

PMID:
11892929
27.

Biosynthetic Studies of Daunorubicin and Tetracenomycin C.

Hutchinson CR.

Chem Rev. 1997 Nov 10;97(7):2525-2536. No abstract available.

PMID:
11851469
28.

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

Reeves CD, Murli S, Ashley GW, Piagentini M, Hutchinson CR, McDaniel R.

Biochemistry. 2001 Dec 25;40(51):15464-70.

PMID:
11747421
29.
30.

Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.

Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR.

Chem Biol. 2001 Jul;8(7):681-700.

31.

Conversion of cyclic nonaketides to lovastatin and compactin by a lovC deficient mutant of Aspergillus terreus.

Auclair K, Kennedy J, Hutchinson CR, Vederas JC.

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1527-31.

PMID:
11412974
32.

Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases.

Hutchinson CR, Kennedy J, Park C, Kendrew S, Auclair K, Vederas J.

Antonie Van Leeuwenhoek. 2000 Dec;78(3-4):287-95. Review.

PMID:
11386351
33.
34.

Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699.

Doi-Katayama Y, Yoon YJ, Choi CY, Yu TW, Floss HG, Hutchinson CR.

J Antibiot (Tokyo). 2000 May;53(5):484-95.

36.

An acyl-coenzyme A carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230.

Han L, Yang K, Kulowski K, Wendt-Pienkowski E, Hutchinson CR, Vining LC.

Microbiology. 2000 Apr;146 ( Pt 4):903-10.

PMID:
10784049
37.

A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D.

Olano C, Lomovskaya N, Fonstein L, Roll JT, Hutchinson CR.

Chem Biol. 1999 Dec;6(12):845-55.

38.

A multiplasmid approach to preparing large libraries of polyketides.

Xue Q, Ashley G, Hutchinson CR, Santi DV.

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11740-5.

39.

A host-vector system for analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei.

Hu Z, Hunziker D, Hutchinson CR, Khosla C.

Microbiology. 1999 Sep;145 ( Pt 9):2335-41.

PMID:
10517586
40.

Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production.

Zhang YX, Denoya CD, Skinner DD, Fedechko RW, McArthur HA, Morgenstern MR, Davies RA, Lobo S, Reynolds KA, Hutchinson CR.

Microbiology. 1999 Sep;145 ( Pt 9):2323-34.

PMID:
10517585
41.

Genetic engineering of doxorubicin production in Streptomyces peucetius: a review.

Hutchinson CR, Colombo AL.

J Ind Microbiol Biotechnol. 1999 Jul;23(1):647-52. Review.

PMID:
10455495
43.

The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide.

Bao W, Sheldon PJ, Wendt-Pienkowski E, Hutchinson CR.

J Bacteriol. 1999 Aug;181(15):4690-5.

44.

Nurturing nature: engineering new antibiotics.

Kennedy J, Hutchinson CR.

Nat Biotechnol. 1999 Jun;17(6):538-9. No abstract available. Erratum in: Nat Biotechnol 1999 Jul;17(7):621.

PMID:
10385314
45.

Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR.

Science. 1999 May 21;284(5418):1368-72.

46.

DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme.

Kendrew SG, Katayama K, Deutsch E, Madduri K, Hutchinson CR.

Biochemistry. 1999 Apr 13;38(15):4794-9.

PMID:
10200167
47.

Microbial polyketide synthases: more and more prolific.

Hutchinson CR.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3336-8. Review. No abstract available.

48.

Combinatorial biosynthesis for new drug discovery.

Hutchinson CR.

Curr Opin Microbiol. 1998 Jun;1(3):319-29. Review.

PMID:
10066498
49.

Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.

Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR.

J Bacteriol. 1999 Jan;181(1):305-18.

50.

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