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Prostate Specific Membrane Antigen Targeted Positron Emission Tomography of Primary Prostate Cancer: Assessing Accuracy with Whole Mount Pathology.

Bahler CD, Green M, Hutchins GD, Cheng L, Magers MJ, Fletcher J, Koch MO.

J Urol. 2020 Jan;203(1):92-99. doi: 10.1097/JU.0000000000000501. Epub 2019 Aug 20.


[68Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [68Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence.

Green MA, Hutchins GD, Bahler CD, Tann M, Mathias CJ, Territo W, Sims J, Polson H, Alexoff D, Eckelman WC, Kung HF, Fletcher JW.

Mol Imaging Biol. 2019 Aug 19. doi: 10.1007/s11307-019-01421-7. [Epub ahead of print]


Synthesis and in vitro biological evaluation of new P2X7R radioligands [11C]halo-GSK1482160 analogs.

Gao M, Wang M, Meyer JA, Territo PR, Hutchins GD, Zarrinmayeh H, Zheng QH.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1476-1480. doi: 10.1016/j.bmcl.2019.04.018. Epub 2019 Apr 10.


Synthesis and initial in vitro characterization of a new P2X7R radioligand [18F]IUR-1602.

Gao M, Wang M, Glick-Wilson BE, Meyer JA, Peters JS, Territo PR, Green MA, Hutchins GD, Zarrinmayeh H, Zheng QH.

Appl Radiat Isot. 2019 Feb;144:10-18. doi: 10.1016/j.apradiso.2018.11.006. Epub 2018 Nov 16.


Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection vs. Insulin Alone in Type 2 Diabetes.

Mather KJ, Considine RV, Hamilton L, Patel NA, Mathias C, Territo W, Goodwill AG, Tune JD, Green MA, Hutchins GD.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3456-3465. doi: 10.1210/jc.2018-00712.


Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [18F]IUR-1601.

Gao M, Wang M, Glick-Wilson BE, Meyer JA, Peters JS, Territo PR, Green MA, Hutchins GD, Zarrinmayeh H, Zheng QH.

Bioorg Med Chem Lett. 2018 May 15;28(9):1603-1609. doi: 10.1016/j.bmcl.2018.03.044. Epub 2018 Mar 17.


Olfactory identification in subjective cognitive decline and mild cognitive impairment: Association with tau but not amyloid positron emission tomography.

Risacher SL, Tallman EF, West JD, Yoder KK, Hutchins GD, Fletcher JW, Gao S, Kareken DA, Farlow MR, Apostolova LG, Saykin AJ.

Alzheimers Dement (Amst). 2017 Sep 23;9:57-66. doi: 10.1016/j.dadm.2017.09.001. eCollection 2017.


Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model.

Allen MR, McNerny E, Aref M, Organ JM, Newman CL, McGowan B, Jang T, Burr DB, Brown DM, Hammond M, Territo PR, Lin C, Persohn S, Jiang L, Riley AA, McCarthy BP, Hutchins GD, Wallace JM.

PLoS One. 2017 Aug 9;12(8):e0181750. doi: 10.1371/journal.pone.0181750. eCollection 2017.


Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor.

Wang M, Gao M, Meyer JA, Peters JS, Zarrinmayeh H, Territo PR, Hutchins GD, Zheng QH.

Bioorg Med Chem. 2017 Jul 15;25(14):3835-3844. doi: 10.1016/j.bmc.2017.05.031. Epub 2017 May 18.


Synthesis and preliminary biological evaluation of [11C]methyl (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-yl)-d-leucinate for the fractalkine receptor (CX3CR1).

Gao M, Wang M, Meyer JA, Peters JS, Zarrinmayeh H, Territo PR, Hutchins GD, Zheng QH.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2727-2730. doi: 10.1016/j.bmcl.2017.04.052. Epub 2017 Apr 24.


Development of a novel magnetic resonance imaging acquisition and analysis workflow for the quantification of shock wave lithotripsy-induced renal hemorrhagic injury.

Handa RK, Territo PR, Blomgren PM, Persohn SA, Lin C, Johnson CD, Jiang L, Connors BA, Hutchins GD.

Urolithiasis. 2017 Oct;45(5):507-513. doi: 10.1007/s00240-016-0959-5. Epub 2017 Jan 10.


Estimation of radiation dosimetry for 68Ga-HBED-CC (PSMA-11) in patients with suspected recurrence of prostate cancer.

Green MA, Eitel JA, Fletcher JW, Mathias CJ, Tann MA, Gardner T, Koch MO, Territo W, Polson H, Hutchins GD.

Nucl Med Biol. 2017 Mar;46:32-35. doi: 10.1016/j.nucmedbio.2016.11.002. Epub 2016 Nov 4.


Measurement of cardiovascular function using a novel view-sharing PET reconstruction method and tracer kinetic analysis.

Territo PR, Riley AA, McCarthy BP, Hutchins GD.

EJNMMI Phys. 2016 Dec;3(1):24. Epub 2016 Oct 20.


Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation.

Territo PR, Meyer JA, Peters JS, Riley AA, McCarthy BP, Gao M, Wang M, Green MA, Zheng QH, Hutchins GD.

J Nucl Med. 2017 Mar;58(3):458-465. doi: 10.2967/jnumed.116.181354. Epub 2016 Oct 20.


Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney.

Hato T, Friedman AN, Mang H, Plotkin Z, Dube S, Hutchins GD, Territo PR, McCarthy BP, Riley AA, Pichumani K, Malloy CR, Harris RA, Dagher PC, Sutton TA.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F717-F725. doi: 10.1152/ajprenal.00535.2015. Epub 2016 Jan 13.


Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer.

Mather KJ, Hutchins GD, Perry K, Territo W, Chisholm R, Acton A, Glick-Wilson B, Considine RV, Moberly S, DeGrado TR.

Am J Physiol Endocrinol Metab. 2016 Mar 15;310(6):E452-60. doi: 10.1152/ajpendo.00437.2015. Epub 2016 Jan 5.


Differential dopamine function in fibromyalgia.

Albrecht DS, MacKie PJ, Kareken DA, Hutchins GD, Chumin EJ, Christian BT, Yoder KK.

Brain Imaging Behav. 2016 Sep;10(3):829-39. doi: 10.1007/s11682-015-9459-4.


GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

Ramanan VK, Risacher SL, Nho K, Kim S, Shen L, McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S, Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, Jagust WJ, Weiner MW, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Brain. 2015 Oct;138(Pt 10):3076-88. doi: 10.1093/brain/awv231. Epub 2015 Aug 11.


Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor.

Gao M, Wang M, Green MA, Hutchins GD, Zheng QH.

Bioorg Med Chem Lett. 2015 May 1;25(9):1965-70. doi: 10.1016/j.bmcl.2015.03.021. Epub 2015 Mar 14.


In Vivo UTE-MRI Reveals Positive Effects of Raloxifene on Skeletal-Bound Water in Skeletally Mature Beagle Dogs.

Allen MR, Territo PR, Lin C, Persohn S, Jiang L, Riley AA, McCarthy BP, Newman CL, Burr DB, Hutchins GD.

J Bone Miner Res. 2015 Aug;30(8):1441-4. doi: 10.1002/jbmr.2470. Epub 2015 May 21.


Cerebral hypometabolism and grey matter density in MAPT intron 10 +3 mutation carriers.

Deters KD, Risacher SL, Farlow MR, Unverzagt FW, Kareken DA, Hutchins GD, Yoder KK, Murrell JR, Spina S, Epperson F, Gao S, Saykin AJ, Ghetti B.

Am J Neurodegener Dis. 2014 Dec 5;3(3):103-14. eCollection 2014.


Whole-body PET/CT evaluation of tumor perfusion using generator-based 62Cu-ethylglyoxal bis(thiosemicarbazonato)copper(II): validation by direct comparison to 15O-water in metastatic renal cell carcinoma.

Fletcher JW, Logan TF, Eitel JA, Mathias CJ, Ng Y, Lacy JL, Hutchins GD, Green MA.

J Nucl Med. 2015 Jan;56(1):56-62. doi: 10.2967/jnumed.114.148106. Epub 2014 Dec 18.


Comparison of standardized uptake values with volume of distribution for quantitation of [(11)C]PBR28 brain uptake.

Yoder KK, Territo PR, Hutchins GD, Hannestad J, Morris ED, Gallezot JD, Normandin MD, Cosgrove KP.

Nucl Med Biol. 2015 Mar;42(3):305-8. doi: 10.1016/j.nucmedbio.2014.11.003. Epub 2014 Nov 15.


The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation.

Weber DJ, Gracon AS, Ripsch MS, Fisher AJ, Cheon BM, Pandya PH, Vittal R, Capitano ML, Kim Y, Allette YM, Riley AA, McCarthy BP, Territo PR, Hutchins GD, Broxmeyer HE, Sandusky GE, White FA, Wilkes DS.

Sci Transl Med. 2014 Sep 3;6(252):252ra124. doi: 10.1126/scitranslmed.3009443. Retraction in: Sci Transl Med. 2018 Dec 12;10(471):.


Microsphere localization and dose quantification using positron emission tomography/CT following hepatic intraarterial radioembolization with yttrium-90 in patients with advanced hepatocellular carcinoma.

Lea WB, Tapp KN, Tann M, Hutchins GD, Fletcher JW, Johnson MS.

J Vasc Interv Radiol. 2014 Oct;25(10):1595-603. doi: 10.1016/j.jvir.2014.06.028. Epub 2014 Aug 23.


The impact of image reconstruction bias on PET/CT 90Y dosimetry after radioembolization.

Tapp KN, Lea WB, Johnson MS, Tann M, Fletcher JW, Hutchins GD.

J Nucl Med. 2014 Sep;55(9):1452-8. doi: 10.2967/jnumed.113.133629. Epub 2014 Jun 30.


Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus.

Moberly SP, Mather KJ, Berwick ZC, Owen MK, Goodwill AG, Casalini ED, Hutchins GD, Green MA, Ng Y, Considine RV, Perry KM, Chisholm RL, Tune JD.

Basic Res Cardiol. 2013 Jul;108(4):365. doi: 10.1007/s00395-013-0365-x. Epub 2013 Jun 14.


Equivalence of arterial and venous blood for [11C]CO2-metabolite analysis following intravenous administration of 1-[11C]acetate and 1-[11C]palmitate.

Ng Y, Moberly SP, Mather KJ, Brown-Proctor C, Hutchins GD, Green MA.

Nucl Med Biol. 2013 Apr;40(3):361-5. doi: 10.1016/j.nucmedbio.2012.11.011. Epub 2013 Jan 8.


PARP1 gene variation and microglial activity on [11C]PBR28 PET in older adults at risk for Alzheimer's disease.

Kim S, Nho K, Risacher SL, Inlow M, Swaminathan S, Yoder KK, Shen L, West JD, McDonald BC, Tallman EF, Hutchins GD, Fletcher JW, Farlow MR, Ghetti B, Saykin AJ.

Multimodal Brain Image Anal (2013). 2013;8159:150-158.


Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial.

Robertson KA, Nalepa G, Yang FC, Bowers DC, Ho CY, Hutchins GD, Croop JM, Vik TA, Denne SC, Parada LF, Hingtgen CM, Walsh LE, Yu M, Pradhan KR, Edwards-Brown MK, Cohen MD, Fletcher JW, Travers JB, Staser KW, Lee MW, Sherman MR, Davis CJ, Miller LC, Ingram DA, Clapp DW.

Lancet Oncol. 2012 Dec;13(12):1218-24. doi: 10.1016/S1470-2045(12)70414-X. Epub 2012 Oct 23.


A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor.

Wang M, Gao M, Steele BL, Glick-Wilson BE, Brown-Proctor C, Shekhar A, Hutchins GD, Zheng QH.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4713-8. doi: 10.1016/j.bmcl.2012.05.076. Epub 2012 May 26.


Striatal dopamine transporter availability in unmedicated bipolar disorder.

Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng QH, Hutchins GD, Normandin MD, Yoder KK.

Bipolar Disord. 2011 Jun;13(4):406-13. doi: 10.1111/j.1399-5618.2011.00936.x.


Positron emission tomography (PET) assessment of renal perfusion.

Green MA, Hutchins GD.

Semin Nephrol. 2011 May;31(3):291-9. doi: 10.1016/j.semnephrol.2011.05.008.


Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia.

Murphy MP, Lawson JH, Rapp BM, Dalsing MC, Klein J, Wilson MG, Hutchins GD, March KL.

J Vasc Surg. 2011 Jun;53(6):1565-74.e1. doi: 10.1016/j.jvs.2011.01.074. Epub 2011 Apr 22.


Synthesis of carbon-11-labeled bivalent β-carbolines as new PET agents for imaging of cholinesterase in Alzheimer's disease.

Wang M, Zheng DX, Gao M, Hutchins GD, Zheng QH.

Appl Radiat Isot. 2011 Apr;69(4):678-85. doi: 10.1016/j.apradiso.2011.01.004. Epub 2011 Jan 8.


Assessment of i.p. injection of [18F]fallypride for behavioral neuroimaging in rats.

Yoder KK, Mock BH, Zheng QH, McCarthy BP, Riley AA, Hutchins GD.

J Neurosci Methods. 2011 Mar 15;196(1):70-5. doi: 10.1016/j.jneumeth.2010.12.027. Epub 2011 Jan 8.


The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3).

Wang M, Gao M, Miller KD, Sledge GW, Hutchins GD, Zheng QH.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):245-9. doi: 10.1016/j.bmcl.2010.11.026. Epub 2010 Nov 11.


The first design and synthesis of [11C]MKC-1 ([11C]Ro 31-7453), a new potential PET cancer imaging agent.

Wang M, Gao M, Miller KD, Sledge GW, Hutchins GD, Zheng QH.

Nucl Med Biol. 2010 Oct;37(7):763-75. doi: 10.1016/j.nucmedbio.2010.04.186.


Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T.

Wang Y, Saykin AJ, Pfeuffer J, Lin C, Mosier KM, Shen L, Kim S, Hutchins GD.

Neuroimage. 2011 Jan 15;54(2):1188-95. doi: 10.1016/j.neuroimage.2010.08.043. Epub 2010 Aug 25.


Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer.

Wang M, Gao M, Miller KD, Sledge GW, Hutchins GD, Zheng QH.

Steroids. 2010 Dec;75(12):967-73. doi: 10.1016/j.steroids.2010.06.004. Epub 2010 Jun 15.


Pancreatic cancer: utility of dynamic contrast-enhanced MR imaging in assessment of antiangiogenic therapy.

Akisik MF, Sandrasegaran K, Bu G, Lin C, Hutchins GD, Chiorean EG.

Radiology. 2010 Aug;256(2):441-9. doi: 10.1148/radiol.10091733. Epub 2010 Jun 1.


Synthesis of carbon-11-labeled tricyclic necroptosis inhibitors as new potential PET agents for imaging of tumor necrosis factor alpha (TNF-alpha).

Gao M, Lola CM, Wang M, Miller KD, Sledge GW, Hutchins GD, Zheng QH.

Appl Radiat Isot. 2010 Oct;68(10):1950-8. doi: 10.1016/j.apradiso.2010.04.030. Epub 2010 May 5.


Facile synthesis of carbon-11-labeled cholesterol-based cationic lipids as new potential PET probes for imaging of gene delivery in cancer.

Gao M, Wang M, Miller KD, Sledge GW, Hutchins GD, Zheng QH.

Steroids. 2010 Oct;75(10):715-20. doi: 10.1016/j.steroids.2010.04.009. Epub 2010 May 6.


[(11)C]Dimebon, radiosynthesis and lipophilicity of a new potential PET agent for imaging of Alzheimer's disease and Huntington's disease.

Gao M, Wang M, Hutchins GD, Zheng QH.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2529-32. doi: 10.1016/j.bmcl.2010.02.094. Epub 2010 Mar 3.


Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging.

Gao M, Wang M, Miller KD, Hutchins GD, Zheng QH.

Bioorg Med Chem. 2010 Mar 15;18(6):2099-2106. doi: 10.1016/j.bmc.2010.02.011. Epub 2010 Feb 10.


Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2).

Wang M, Zheng DX, Luo MB, Gao M, Miller KD, Hutchins GD, Zheng QH.

Appl Radiat Isot. 2010 Jun;68(6):1098-103. doi: 10.1016/j.apradiso.2010.02.008. Epub 2010 Feb 13.


An improved synthesis of dopamine D2/D3 receptor radioligands [11C]fallypride and [18F]fallypride.

Gao M, Wang M, Mock BH, Glick-Wilson BE, Yoder KK, Hutchins GD, Zheng QH.

Appl Radiat Isot. 2010 Jun;68(6):1079-86. doi: 10.1016/j.apradiso.2009.09.071. Epub 2010 Jan 25.


Synthesis of carbon-11-labeled piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as new selective PET sigma1 receptor probes.

Gao M, Wang M, Hutchins GD, Zheng QH.

Appl Radiat Isot. 2010 Mar;68(3):459-65. doi: 10.1016/j.apradiso.2009.12.035. Epub 2009 Dec 22.


Cerebral metabolism in dogs assessed by (18)F-FDG PET: a pilot study to understand physiological changes in behavioral disorders in dogs.

Irimajiri M, Miller MA, Green MA, Jaeger CB, Luescher AU, Hutchins GD.

J Vet Med Sci. 2010 Jan;72(1):1-6. Epub 2009 Oct 28.


Synthesis of carbon-11-labeled 4-aryl-4H-chromens as new PET agents for imaging of apoptosis in cancer.

Gao M, Wang M, Miller KD, Hutchins GD, Zheng QH.

Appl Radiat Isot. 2010 Jan;68(1):110-6. doi: 10.1016/j.apradiso.2009.09.067. Epub 2009 Sep 26.


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