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A derived Polymorphic Amplified Cleaved Sequence assay for detecting the Δ210 PPX2L codon deletion conferring target-site resistance to protoporphyrinogen oxidase-inhibiting herbicides.

Kaundun SS, Hutchings SJ, Marchegiani E, Rauser R, Jackson LV.

Pest Manag Sci. 2019 Aug 10. doi: 10.1002/ps.5581. [Epub ahead of print]


Derived Polymorphic Amplified Cleaved Sequence (dPACS): A Novel PCR-RFLP Procedure for Detecting Known Single Nucleotide and Deletion-Insertion Polymorphisms.

Kaundun SS, Marchegiani E, Hutchings SJ, Baker K.

Int J Mol Sci. 2019 Jun 29;20(13). pii: E3193. doi: 10.3390/ijms20133193.


The occupations at increased risk of COPD: analysis of lifetime job-histories in the population-based UK Biobank Cohort.

De Matteis S, Jarvis D, Darnton A, Hutchings S, Sadhra S, Fishwick D, Rushton L, Cullinan P.

Eur Respir J. 2019 Jul 18;54(1). pii: 1900186. doi: 10.1183/13993003.00186-2019. Print 2019 Jul.


Comparative Bioavailability Study of a New Orodispersible Formulation of Ibuprofen Versus Two Existing Oral Tablet Formulations in Healthy Male and Female Volunteers.

Sugár D, Francombe D, da Silva T, Hanid S, Hutchings S.

Clin Ther. 2019 Aug;41(8):1486-1498. doi: 10.1016/j.clinthera.2019.04.040. Epub 2019 Jun 12.


Bioequivalence of 2 Naproxen Sodium Tablet Formulations in Healthy Male and Female Volunteers.

Sugár D, Francombe D, da Silva T, Adams R, Hutchings S.

Curr Ther Res Clin Exp. 2019 Jan 18;90:33-38. doi: 10.1016/j.curtheres.2019.01.004. eCollection 2019.


The acceptability of fluoride varnish and fissure sealant treatments in children aged 6-9 delivered in a school setting.

Morgan-Trimmer S, Chadwick BL, Hutchings S, Scoble C, Lisles C, Drew CJ, Murphy S, Pickles T, Hood K, Chestnutt IG.

Community Dent Health. 2019 Feb 25;36(1):33-38. doi: 10.1922/CDH_4263Morgan-Trimmer06.


Incorporation of bioactive dairy hydrolysate influences the stability and digestion behaviour of milk protein stabilised emulsions.

McIntyre I, Carolan A, O'Sullivan M, Jacquier JC, Hutchings S, Murray B, O'Riordan D.

Food Funct. 2018 Nov 14;9(11):5813-5823. doi: 10.1039/c8fo00912k.


Cancers in France in 2015 attributable to occupational exposures.

Marant Micallef C, Shield KD, Vignat J, Baldi I, Charbotel B, Fervers B, Gilg Soit Ilg A, Guénel P, Olsson A, Rushton L, Hutchings SJ, Cléro E, Laurier D, Scanff P, Bray F, Straif K, Soerjomataram I.

Int J Hyg Environ Health. 2019 Jan;222(1):22-29. doi: 10.1016/j.ijheh.2018.07.015. Epub 2018 Aug 30.


Novel techniques to understand consumer responses towards food products: A review with a focus on meat.

Torrico DD, Hutchings SC, Ha M, Bittner EP, Fuentes S, Warner RD, Dunshea FR.

Meat Sci. 2018 Oct;144:30-42. doi: 10.1016/j.meatsci.2018.06.006. Epub 2018 Jun 8. Review.


Microcirculatory Impairment Is Associated With Multiple Organ Dysfunction Following Traumatic Hemorrhagic Shock: The MICROSHOCK Study.

Hutchings SD, Naumann DN, Hopkins P, Mellis C, Riozzi P, Sartini S, Mamuza J, Harris T, Midwinter MJ, Wendon J.

Crit Care Med. 2018 Sep;46(9):e889-e896. doi: 10.1097/CCM.0000000000003275.


Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study.

Naumann DN, Hazeldine J, Bishop J, Midwinter MJ, Harrison P, Nash G, Hutchings SD.

Clin Hemorheol Microcirc. 2019;71(1):71-82. doi: 10.3233/CH-180397.


Occupational exposures and cancer: a review of agents and relative risk estimates.

Marant Micallef C, Shield KD, Baldi I, Charbotel B, Fervers B, Gilg Soit Ilg A, Guénel P, Olsson A, Rushton L, Hutchings SJ, Straif K, Soerjomataram I.

Occup Environ Med. 2018 Aug;75(8):604-614. doi: 10.1136/oemed-2017-104858. Epub 2018 May 7.


Predicting rapid analgesic onset of ibuprofen salts compared with ibuprofen acid: Tlag, Tlow, Tmed, and a novel parameter, TCmaxRef.

Miles L, Hall J, Jenner B, Addis R, Hutchings S.

Curr Med Res Opin. 2018 Aug;34(8):1483-1490. doi: 10.1080/03007995.2018.1466697. Epub 2018 Apr 27.


Sugar reduction without compromising sensory perception. An impossible dream?

Hutchings SC, Low JYQ, Keast RSJ.

Crit Rev Food Sci Nutr. 2019;59(14):2287-2307. doi: 10.1080/10408398.2018.1450214. Epub 2018 Mar 30.


Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine.

Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro NI, Duranteau J, Pinsky MR, Artigas A, Teboul JL, Reiss IKM, Aldecoa C, Hutchings SD, Donati A, Maggiorini M, Taccone FS, Hernandez G, Payen D, Tibboel D, Martin DS, Zarbock A, Monnet X, Dubin A, Bakker J, Vincent JL, Scheeren TWL; Cardiovascular Dynamics Section of the ESICM.

Intensive Care Med. 2018 Mar;44(3):281-299. doi: 10.1007/s00134-018-5070-7. Epub 2018 Feb 6.


Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study.

Naumann DN, Hazeldine J, Dinsdale RJ, Bishop JR, Midwinter MJ, Harrison P, Hutchings SD, Lord JM.

PLoS One. 2017 Dec 19;12(12):e0189870. doi: 10.1371/journal.pone.0189870. eCollection 2017.


Evaluating the feasibility of conducting a trial using a patient decision aid in implantable cardioverter defibrillator candidates: a randomized controlled feasibility trial.

Carroll SL, Stacey D, McGillion M, Healey JS, Foster G, Hutchings S, Arthur HM, Browne G, Thabane L.

Pilot Feasibility Stud. 2017 Nov 21;3:49. doi: 10.1186/s40814-017-0189-9. eCollection 2017.


Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding after traumatic hemorrhagic shock.

Naumann DN, Hazeldine J, Midwinter MJ, Hutchings SD, Harrison P.

J Trauma Acute Care Surg. 2018 Jan;84(1):81-88. doi: 10.1097/TA.0000000000001695.


Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial.

Vasseur B, Dufour A, Houdas L, Goodwin H, Harries K, Emul NY, Hutchings S.

Adv Ther. 2017 Aug;34(8):2022-2032. doi: 10.1007/s12325-017-0585-9. Epub 2017 Jul 19.


Mechanism of resistance to mesotrione in an Amaranthus tuberculatus population from Nebraska, USA.

Kaundun SS, Hutchings SJ, Dale RP, Howell A, Morris JA, Kramer VC, Shivrain VK, Mcindoe E.

PLoS One. 2017 Jun 29;12(6):e0180095. doi: 10.1371/journal.pone.0180095. eCollection 2017.


Seal or Varnish? A randomised controlled trial to determine the relative cost and effectiveness of pit and fissure sealant and fluoride varnish in preventing dental decay.

Chestnutt IG, Hutchings S, Playle R, Morgan-Trimmer S, Fitzsimmons D, Aawar N, Angel L, Derrick S, Drew C, Hoddell C, Hood K, Humphreys I, Kirby N, Lau TMM, Lisles C, Morgan MZ, Murphy S, Nuttall J, Onishchenko K, Phillips C, Pickles T, Scoble C, Townson J, Withers B, Chadwick BL.

Health Technol Assess. 2017 Apr;21(21):1-256. doi: 10.3310/hta21210.


Prioritising action on occupational carcinogens in Europe: a socioeconomic and health impact assessment.

Cherrie JW, Hutchings S, Gorman Ng M, Mistry R, Corden C, Lamb J, Sánchez Jiménez A, Shafrir A, Sobey M, van Tongeren M, Rushton L.

Br J Cancer. 2017 Jul 11;117(2):274-281. doi: 10.1038/bjc.2017.161. Epub 2017 Jun 13.


Estimating the burden of occupational cancer: assessing bias and uncertainty.

Hutchings S, Rushton L.

Occup Environ Med. 2017 Aug;74(8):604-611. doi: 10.1136/oemed-2016-103810. Epub 2017 Apr 17.


Fissure Seal or Fluoride Varnish? A Randomized Trial of Relative Effectiveness.

Chestnutt IG, Playle R, Hutchings S, Morgan-Trimmer S, Fitzsimmons D, Aawar N, Angel L, Derrick S, Drew C, Hoddell C, Hood K, Humphreys I, Kirby N, Lau TMM, Lisles C, Morgan MZ, Murphy S, Nuttall J, Onishchenko K, Phillips C, Pickles T, Scoble C, Townson J, Withers B, Chadwick BL.

J Dent Res. 2017 Jul;96(7):754-761. doi: 10.1177/0022034517702094. Epub 2017 Apr 10. Review.


The future excess fraction of occupational cancer among those exposed to carcinogens at work in Australia in 2012.

Carey RN, Hutchings SJ, Rushton L, Driscoll TR, Reid A, Glass DC, Darcey E, Si S, Peters S, Benke G, Fritschi L.

Cancer Epidemiol. 2017 Apr;47:1-6. doi: 10.1016/j.canep.2016.12.009. Epub 2017 Jan 9.


Safety and feasibility of sublingual microcirculation assessment in the emergency department for civilian and military patients with traumatic haemorrhagic shock: a prospective cohort study.

Naumann DN, Mellis C, Smith IM, Mamuza J, Skene I, Harris T, Midwinter MJ, Hutchings SD.

BMJ Open. 2016 Dec 21;6(12):e014162. doi: 10.1136/bmjopen-2016-014162.


Modification of aftertaste with a menthol mouthwash reduces food wanting, liking, and ad libitum intake of potato crisps.

Hutchings SC, Horner KM, Dible VA, Grigor JMV, O'Riordan D.

Appetite. 2017 Jan 1;108:57-67. doi: 10.1016/j.appet.2016.09.022. Epub 2016 Sep 20.


Real-time point of care microcirculatory assessment of shock: design, rationale and application of the point of care microcirculation (POEM) tool.

Naumann DN, Mellis C, Husheer SL, Hopkins P, Bishop J, Midwinter MJ, Hutchings SD.

Crit Care. 2016 Sep 30;20(1):310.


Molecular and Cellular Responses to Interleukin-4 Treatment in a Rat Model of Transient Ischemia.

Lively S, Hutchings S, Schlichter LC.

J Neuropathol Exp Neurol. 2016 Sep 15. pii: nlw081. [Epub ahead of print]


Searching For the Optimal Fluid to Restore Microcirculatory Flow Dynamics After Haemorrhagic Shock: A Systematic Review of Preclinical Studies.

Naumann DN, Beaven A, Dretzke J, Hutchings S, Midwinter MJ.

Shock. 2016 Dec;46(6):609-622. Review.


Microcirculatory perfusion shows wide inter-individual variation and is important in determining shock reversal during resuscitation in a porcine experimental model of complex traumatic hemorrhagic shock.

Hutchings SD, Naumann DN, Watts S, Wilson C, Burton C, Wendon J, Kirkman E.

Intensive Care Med Exp. 2016 Dec;4(1):17. doi: 10.1186/s40635-016-0088-z. Epub 2016 Jun 24.


The future excess fraction model for calculating burden of disease.

Fritschi L, Chan J, Hutchings SJ, Driscoll TR, Wong AY, Carey RN.

BMC Public Health. 2016 May 11;16:386. doi: 10.1186/s12889-016-3066-1.


Occupations associated with COPD risk in the large population-based UK Biobank cohort study.

De Matteis S, Jarvis D, Hutchings S, Darnton A, Fishwick D, Sadhra S, Rushton L, Cullinan P.

Occup Environ Med. 2016 Jun;73(6):378-84. doi: 10.1136/oemed-2015-103406. Epub 2016 Mar 21.


Observational study of the effects of traumatic injury, haemorrhagic shock and resuscitation on the microcirculation: a protocol for the MICROSHOCK study.

Hutchings S, Naumann DN, Harris T, Wendon J, Midwinter MJ.

BMJ Open. 2016 Mar 4;6(3):e010893. doi: 10.1136/bmjopen-2015-010893.


A change in the trend in dosulepin usage following the introduction of a prescribing indicator but not after two national safety warnings.

Deslandes PN, Jenkins KS, Haines KE, Hutchings S, Cannings-John R, Lewis TL, Bracchi RC, Routledge PA.

J Clin Pharm Ther. 2016 Apr;41(2):224-8. doi: 10.1111/jcpt.12376. Epub 2016 Mar 2.


Venous-to-arterial CO2 differences and the quest for bedside point-of-care monitoring to assess the microcirculation during shock.

Naumann DN, Midwinter MJ, Hutchings S.

Ann Transl Med. 2016 Jan;4(2):37. doi: 10.3978/j.issn.2305-5839.2015.12.61.


Nurse-delivered focused echocardiography to determine intravascular volume status in a deployed maritime critical care unit.

Hutchings S, Bisset L, Cantillon L, Keating-Brown P, Jeffreys S, Muzvidziwa C, Richmond E, Rees P.

J R Nav Med Serv. 2015;101(2):124-8.


The Cytocam video microscope. A new method for visualising the microcirculation using Incident Dark Field technology.

Hutchings S, Watts S, Kirkman E.

Clin Hemorheol Microcirc. 2016;62(3):261-71. doi: 10.3233/CH-152013.


Protocol for a systematic review of the impact of resuscitation fluids on the microcirculation after haemorrhagic shock in animal models.

Naumann DN, Dretzke J, Hutchings S, Midwinter MJ.

Syst Rev. 2015 Oct 5;4:135. doi: 10.1186/s13643-015-0113-4.


Development of the New Zealand strategy for local eradication of tuberculosis from wildlife and livestock.

Livingstone PG, Hancox N, Nugent G, Mackereth G, Hutchings SA.

N Z Vet J. 2015 Jun;63 Suppl 1:98-107. doi: 10.1080/00480169.2015.1013581. Epub 2015 Apr 2. Review.


The proportion of cancer attributable to occupational exposures.

Purdue MP, Hutchings SJ, Rushton L, Silverman DT.

Ann Epidemiol. 2015 Mar;25(3):188-92. doi: 10.1016/j.annepidem.2014.11.009. Epub 2014 Nov 13. Review.


Epidemiology, diagnostics, and management of tuberculosis in domestic cattle and deer in New Zealand in the face of a wildlife reservoir.

Buddle BM, de Lisle GW, Griffin JF, Hutchings SA.

N Z Vet J. 2015 Jun;63 Suppl 1:19-27. doi: 10.1080/00480169.2014.929518. Epub 2015 Feb 3. Review.


Deployed research.

Nordmann G, Woolley T, Doughty H, Dalle Lucca J, Hutchings S, Kirkman E.

J R Army Med Corps. 2014 Jun;160(2):92-8. doi: 10.1136/jramc-2014-000272. Epub 2014 Apr 30.


Conducting clinical research in the deployed intensive care unit: challenges and solutions.

Hutchings SD, Howarth G, Rees P, Midwinter M.

J R Nav Med Serv. 2013;99(3):151-3.


The cytokine and endocannabinoid systems are co-regulated by NF-κB p65/RelA in cell culture and transgenic mouse models of Huntington's disease and in striatal tissue from Huntington's disease patients.

Laprairie RB, Warford JR, Hutchings S, Robertson GS, Kelly ME, Denovan-Wright EM.

J Neuroimmunol. 2014 Feb 15;267(1-2):61-72. doi: 10.1016/j.jneuroim.2013.12.008. Epub 2013 Dec 12.


A strategic approach to eradication of bovine TB from wildlife in New Zealand.

Hutchings SA, Hancox N, Livingstone PG.

Transbound Emerg Dis. 2013 Nov;60 Suppl 1:85-91. doi: 10.1111/tbed.12079.


Role of a novel I1781T mutation and other mechanisms in conferring resistance to acetyl-CoA carboxylase inhibiting herbicides in a black-grass population.

Kaundun SS, Hutchings SJ, Dale RP, McIndoe E.

PLoS One. 2013 Jul 25;8(7):e69568. doi: 10.1371/journal.pone.0069568. Print 2013.

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