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A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis.

Qin Z, Devine R, Hutchings MI, Wilkinson B.

Nat Commun. 2019 Aug 9;10(1):3611. doi: 10.1038/s41467-019-11538-6.


Sensing and responding to diverse extracellular signals: an updated analysis of the sensor kinases and response regulators of Streptomyces species.

McLean TC, Lo R, Tschowri N, Hoskisson PA, Al Bassam MM, Hutchings MI, Som NF.

Microbiology. 2019 Sep;165(9):929-952. doi: 10.1099/mic.0.000817.


Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis.

McLean TC, Wilkinson B, Hutchings MI, Devine R.

Antibiotics (Basel). 2019 Jun 18;8(2). pii: E83. doi: 10.3390/antibiotics8020083. Review.


Biocontrol of Cereal Crop Diseases Using Streptomycetes.

Newitt JT, Prudence SMM, Hutchings MI, Worsley SF.

Pathogens. 2019 Jun 13;8(2). pii: E78. doi: 10.3390/pathogens8020078. Review.


Defining the regulon of genes controlled by σE , a key regulator of the cell envelope stress response in Streptomyces coelicolor.

Tran NT, Huang X, Hong HJ, Bush MJ, Chandra G, Pinto D, Bibb MJ, Hutchings MI, Mascher T, Buttner MJ.

Mol Microbiol. 2019 Aug;112(2):461-481. doi: 10.1111/mmi.14250. Epub 2019 Apr 29.


Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues.

Volbeda A, Martinez MTP, Crack JC, Amara P, Gigarel O, Munnoch JT, Hutchings MI, Darnault C, Le Brun NE, Fontecilla-Camps JC.

J Am Chem Soc. 2019 Feb 13;141(6):2367-2375. doi: 10.1021/jacs.8b10823. Epub 2019 Feb 1.


Diet, Gut Microbes and Host Mate Choice: Understanding the significance of microbiome effects on host mate choice requires a case by case evaluation.

Leftwich PT, Hutchings MI, Chapman T.

Bioessays. 2018 Dec;40(12):e1800053. doi: 10.1002/bies.201800053. Epub 2018 Oct 12. Review.


Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen.

Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B.

Nat Commun. 2018 Jun 7;9(1):2208. doi: 10.1038/s41467-018-04520-1.


Reply to Obadia et al.: Effect of methyl paraben on host-microbiota interactions in Drosophila melanogaster.

Leftwich PT, Clarke NVE, Hutchings MI, Chapman T.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4549-E4550. doi: 10.1073/pnas.1805499115. Epub 2018 May 7. No abstract available.


Reply to Rosenberg et al.: Diet, gut bacteria, and assortative mating in Drosophila melanogaster.

Leftwich PT, Clarke NVE, Hutchings MI, Chapman T.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2154-E2155. doi: 10.1073/pnas.1721804115. Epub 2018 Feb 20. No abstract available.


Complete genome sequence of Streptomyces formicae KY5, the formicamycin producer.

Holmes NA, Devine R, Qin Z, Seipke RF, Wilkinson B, Hutchings MI.

J Biotechnol. 2018 Jan 10;265:116-118. doi: 10.1016/j.jbiotec.2017.11.011. Epub 2017 Nov 27.


Gut microbiomes and reproductive isolation in Drosophila.

Leftwich PT, Clarke NVE, Hutchings MI, Chapman T.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12767-12772. doi: 10.1073/pnas.1708345114. Epub 2017 Nov 6. Erratum in: Proc Natl Acad Sci U S A. 2018 Feb 20;:.


The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2).

Som NF, Heine D, Holmes N, Knowles F, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B, Hutchings MI.

Microbiology. 2017 Oct;163(10):1415-1419. doi: 10.1099/mic.0.000524. Epub 2017 Sep 8.


The Conserved Actinobacterial Two-Component System MtrAB Coordinates Chloramphenicol Production with Sporulation in Streptomyces venezuelae NRRL B-65442.

Som NF, Heine D, Holmes NA, Munnoch JT, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B, Hutchings MI.

Front Microbiol. 2017 Jun 28;8:1145. doi: 10.3389/fmicb.2017.01145. eCollection 2017.


Chemical ecology of antibiotic production by actinomycetes.

van der Meij A, Worsley SF, Hutchings MI, van Wezel GP.

FEMS Microbiol Rev. 2017 May 1;41(3):392-416. doi: 10.1093/femsre/fux005. Review.


Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants.

Qin Z, Munnoch JT, Devine R, Holmes NA, Seipke RF, Wilkinson KA, Wilkinson B, Hutchings MI.

Chem Sci. 2017 Apr 1;8(4):3218-3227. doi: 10.1039/c6sc04265a. Epub 2017 Feb 13.


Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding.

Volbeda A, Dodd EL, Darnault C, Crack JC, Renoux O, Hutchings MI, Le Brun NE, Fontecilla-Camps JC.

Nat Commun. 2017 Apr 20;8:15052. doi: 10.1038/ncomms15052.


Genome Analysis of Two Pseudonocardia Phylotypes Associated with Acromyrmex Leafcutter Ants Reveals Their Biosynthetic Potential.

Holmes NA, Innocent TM, Heine D, Bassam MA, Worsley SF, Trottmann F, Patrick EH, Yu DW, Murrell JC, Schiøtt M, Wilkinson B, Boomsma JJ, Hutchings MI.

Front Microbiol. 2016 Dec 26;7:2073. doi: 10.3389/fmicb.2016.02073. eCollection 2016.


Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes.

Serrano PN, Wang H, Crack JC, Prior C, Hutchings MI, Thomson AJ, Kamali S, Yoda Y, Zhao J, Hu MY, Alp EE, Oganesyan VS, Le Brun NE, Cramer SP.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14575-14579. doi: 10.1002/anie.201607033. Epub 2016 Oct 25.


Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamily.

Munnoch JT, Martinez MT, Svistunenko DA, Crack JC, Le Brun NE, Hutchings MI.

Sci Rep. 2016 Sep 8;6:31597. doi: 10.1038/srep31597.


Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene.

Munnoch JT, Widdick DA, Chandra G, Sutcliffe IC, Palmer T, Hutchings MI.

Sci Rep. 2016 Jul 12;6:29495. doi: 10.1038/srep29495.


Differentiated, Promoter-specific Response of [4Fe-4S] NsrR DNA Binding to Reaction with Nitric Oxide.

Crack JC, Svistunenko DA, Munnoch J, Thomson AJ, Hutchings MI, Le Brun NE.

J Biol Chem. 2016 Apr 15;291(16):8663-72. doi: 10.1074/jbc.M115.693192. Epub 2016 Feb 17.


Biochemical properties of Paracoccus denitrificans FnrP: reactions with molecular oxygen and nitric oxide.

Crack JC, Hutchings MI, Thomson AJ, Le Brun NE.

J Biol Inorg Chem. 2016 Mar;21(1):71-82. doi: 10.1007/s00775-015-1326-7. Epub 2016 Jan 20.


NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function.

Crack JC, Munnoch J, Dodd EL, Knowles F, Al Bassam MM, Kamali S, Holland AA, Cramer SP, Hamilton CJ, Johnson MK, Thomson AJ, Hutchings MI, Le Brun NE.

J Biol Chem. 2015 May 15;290(20):12689-704. doi: 10.1074/jbc.M115.643072. Epub 2015 Mar 14.


Regulation of antimycin biosynthesis by the orphan ECF RNA polymerase sigma factor σ (AntA.).

Seipke RF, Patrick E, Hutchings MI.

PeerJ. 2014 Feb 6;2:e253. doi: 10.7717/peerj.253. eCollection 2014.


The regulation and biosynthesis of antimycins.

Seipke RF, Hutchings MI.

Beilstein J Org Chem. 2013 Nov 19;9:2556-63. doi: 10.3762/bjoc.9.290. Review.


Analysis of the bacterial communities associated with two ant-plant symbioses.

Seipke RF, Barke J, Heavens D, Yu DW, Hutchings MI.

Microbiologyopen. 2013 Apr;2(2):276-83. doi: 10.1002/mbo3.73. Epub 2013 Feb 17.


Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence.

Clark LC, Seipke RF, Prieto P, Willemse J, van Wezel GP, Hutchings MI, Hoskisson PA.

Sci Rep. 2013;3:1109. doi: 10.1038/srep01109. Epub 2013 Jan 23.


Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria.

Moore JM, Bradshaw E, Seipke RF, Hutchings MI, McArthur M.

Methods Enzymol. 2012;517:367-85. doi: 10.1016/B978-0-12-404634-4.00018-8.


Isolating antifungals from fungus-growing ant symbionts using a genome-guided chemistry approach.

Seipke RF, Grüschow S, Goss RJ, Hutchings MI.

Methods Enzymol. 2012;517:47-70. doi: 10.1016/B978-0-12-404634-4.00003-6.


Dynamic localization of Tat protein transport machinery components in Streptomyces coelicolor.

Willemse J, Ruban-Ośmialowska B, Widdick D, Celler K, Hutchings MI, van Wezel GP, Palmer T.

J Bacteriol. 2012 Nov;194(22):6272-81. doi: 10.1128/JB.01425-12. Epub 2012 Sep 21.


A phylum level analysis reveals lipoprotein biosynthesis to be a fundamental property of bacteria.

Sutcliffe IC, Harrington DJ, Hutchings MI.

Protein Cell. 2012 Mar;3(3):163-70. doi: 10.1007/s13238-012-2023-8. Review.


Bacterial iron-sulfur regulatory proteins as biological sensor-switches.

Crack JC, Green J, Hutchings MI, Thomson AJ, Le Brun NE.

Antioxid Redox Signal. 2012 Nov 1;17(9):1215-31. doi: 10.1089/ars.2012.4511. Epub 2012 Mar 6. Review.


Streptomyces as symbionts: an emerging and widespread theme?

Seipke RF, Kaltenpoth M, Hutchings MI.

FEMS Microbiol Rev. 2012 Jul;36(4):862-76. doi: 10.1111/j.1574-6976.2011.00313.x. Epub 2011 Dec 2. Review.


Spectroscopic analysis of protein Fe-NO complexes.

Bellota-Antón C, Munnoch J, Robb K, Adamczyk K, Candelaresi M, Parker AW, Dixon R, Hutchings MI, Hunt NT, Tucker NP.

Biochem Soc Trans. 2011 Oct;39(5):1293-8. doi: 10.1042/BST0391293. Review.


A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus.

Seipke RF, Barke J, Brearley C, Hill L, Yu DW, Goss RJ, Hutchings MI.

PLoS One. 2011;6(8):e22028. doi: 10.1371/journal.pone.0022028. Epub 2011 Aug 3.


Fungus-growing Allomerus ants are associated with antibiotic-producing actinobacteria.

Seipke RF, Barke J, Ruiz-Gonzalez MX, Orivel J, Yu DW, Hutchings MI.

Antonie Van Leeuwenhoek. 2012 Feb;101(2):443-7. doi: 10.1007/s10482-011-9621-y. Epub 2011 Jul 12.


Draft genome sequence of Streptomyces strain S4, a symbiont of the leaf-cutting ant Acromyrmex octospinosus.

Seipke RF, Crossman L, Drou N, Heavens D, Bibb MJ, Caccamo M, Hutchings MI.

J Bacteriol. 2011 Aug;193(16):4270-1. doi: 10.1128/JB.05275-11. Epub 2011 Jun 17.


A mutualistic microbiome: How do fungus-growing ants select their antibiotic-producing bacteria?

Barke J, Seipke RF, Yu DW, Hutchings MI.

Commun Integr Biol. 2011 Jan;4(1):41-3. doi: 10.4161/cib.4.1.13552.


Dissecting the complete lipoprotein biogenesis pathway in Streptomyces scabies.

Widdick DA, Hicks MG, Thompson BJ, Tschumi A, Chandra G, Sutcliffe IC, Brülle JK, Sander P, Palmer T, Hutchings MI.

Mol Microbiol. 2011 Jun;80(5):1395-412. doi: 10.1111/j.1365-2958.2011.07656.x. Epub 2011 May 2.


A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus.

Barke J, Seipke RF, Grüschow S, Heavens D, Drou N, Bibb MJ, Goss RJ, Yu DW, Hutchings MI.

BMC Biol. 2010 Aug 26;8:109. doi: 10.1186/1741-7007-8-109.


Investigating lipoprotein biogenesis and function in the model Gram-positive bacterium Streptomyces coelicolor.

Thompson BJ, Widdick DA, Hicks MG, Chandra G, Sutcliffe IC, Palmer T, Hutchings MI.

Mol Microbiol. 2010 Aug;77(4):943-57. doi: 10.1111/j.1365-2958.2010.07261.x. Epub 2010 Jun 21.


The twin arginine protein transport pathway exports multiple virulence proteins in the plant pathogen Streptomyces scabies.

Joshi MV, Mann SG, Antelmann H, Widdick DA, Fyans JK, Chandra G, Hutchings MI, Toth I, Hecker M, Loria R, Palmer T.

Mol Microbiol. 2010 Jul 1;77(1):252-71. doi: 10.1111/j.1365-2958.2010.07206.x. Epub 2010 May 12.


There's NO stopping NsrR, a global regulator of the bacterial NO stress response.

Tucker NP, Le Brun NE, Dixon R, Hutchings MI.

Trends Microbiol. 2010 Apr;18(4):149-56. doi: 10.1016/j.tim.2009.12.009. Epub 2010 Feb 16. Review.


Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em.

Hutchings MI, Palmer T, Harrington DJ, Sutcliffe IC.

Trends Microbiol. 2009 Jan;17(1):13-21. doi: 10.1016/j.tim.2008.10.001. Epub 2008 Dec 6. Review.


The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster.

Tucker NP, Hicks MG, Clarke TA, Crack JC, Chandra G, Le Brun NE, Dixon R, Hutchings MI.

PLoS One. 2008;3(11):e3623. doi: 10.1371/journal.pone.0003623. Epub 2008 Nov 7.


Vancomycin resistance VanS/VanR two-component systems.

Hong HJ, Hutchings MI, Buttner MJ; Biotechnology and Biological Sciences Research Council, UK.

Adv Exp Med Biol. 2008;631:200-13. Review.


Cell envelope stress response in Gram-positive bacteria.

Jordan S, Hutchings MI, Mascher T.

FEMS Microbiol Rev. 2008 Jan;32(1):107-46. doi: 10.1111/j.1574-6976.2007.00091.x. Review.


RsmA is an anti-sigma factor that modulates its activity through a [2Fe-2S] cluster cofactor.

Gaskell AA, Crack JC, Kelemen GH, Hutchings MI, Le Brun NE.

J Biol Chem. 2007 Oct 26;282(43):31812-20. Epub 2007 Aug 31.


Unusual two-component signal transduction pathways in the actinobacteria.

Hutchings MI.

Adv Appl Microbiol. 2007;61:1-26. Review. No abstract available.


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