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Resistance to change: AMR gene dynamics on a commercial pig farm with high antimicrobial usage.

Pollock J, Muwonge A, Hutchings MR, Mainda G, Bronsvoort BM, Gally DL, Corbishley A.

Sci Rep. 2020 Feb 3;10(1):1708. doi: 10.1038/s41598-020-58659-3.


Bond-Order Time Series Analysis for Detecting Reaction Events in Ab Initio Molecular Dynamics Simulations.

Hutchings M, Liu J, Qiu Y, Song C, Wang LP.

J Chem Theory Comput. 2020 Feb 13. doi: 10.1021/acs.jctc.9b01039. [Epub ahead of print]


Brentuximab vedotin with chemotherapy for Stage III/IV classical Hodgkin lymphoma: 3-year update of the ECHELON-1 study.

Straus DJ, Długosz-Danecka M, Alekseev S, Illes A, Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Connors JM, Radford J, Munoz J, Kim WS, Advani R, Ansell SM, Younes A, Miao H, Liu R, Fenton K, Forero A, Gallamini A.

Blood. 2020 Jan 16. pii: blood.2019003127. doi: 10.1182/blood.2019003127. [Epub ahead of print]


Editorial overview: Antimicrobials: Tackling AMR in the 21st century.

Hutchings MI, Truman AW, Wilkinson B.

Curr Opin Microbiol. 2019 Oct;51:iii-v. doi: 10.1016/j.mib.2019.11.004. No abstract available.


Antibiotics: past, present and future.

Hutchings MI, Truman AW, Wilkinson B.

Curr Opin Microbiol. 2019 Oct;51:72-80. doi: 10.1016/j.mib.2019.10.008. Epub 2019 Nov 13. Review.


In Situ Activation and Heterologous Production of a Cryptic Lantibiotic from an African Plant Ant-Derived Saccharopolyspora Species.

Vikeli E, Widdick DA, Batey SFD, Heine D, Holmes NA, Bibb MJ, Martins DJ, Pierce NE, Hutchings MI, Wilkinson B.

Appl Environ Microbiol. 2020 Jan 21;86(3). pii: e01876-19. doi: 10.1128/AEM.01876-19. Print 2020 Jan 21.


PET-adapted treatment of Hodgkin lymphoma.

Hutchings M.

Blood. 2019 Oct 10;134(15):1200-1201. doi: 10.1182/blood.2019002420. No abstract available.


Multi-host disease management: the why and the how to include wildlife.

Portier J, Ryser-Degiorgis MP, Hutchings MR, Monchâtre-Leroy E, Richomme C, Larrat S, van der Poel WHM, Dominguez M, Linden A, Santos PT, Warns-Petit E, Chollet JY, Cavalerie L, Grandmontagne C, Boadella M, Bonbon E, Artois M.

BMC Vet Res. 2019 Aug 14;15(1):295. doi: 10.1186/s12917-019-2030-6.


A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis.

Qin Z, Devine R, Hutchings MI, Wilkinson B.

Nat Commun. 2019 Aug 9;10(1):3611. doi: 10.1038/s41467-019-11538-6.


Sensing and responding to diverse extracellular signals: an updated analysis of the sensor kinases and response regulators of Streptomyces species.

McLean TC, Lo R, Tschowri N, Hoskisson PA, Al Bassam MM, Hutchings MI, Som NF.

Microbiology. 2019 Sep;165(9):929-952. doi: 10.1099/mic.0.000817.


Changes in the Ileal, but Not Fecal, Microbiome in Response to Increased Dietary Protein Level and Enterotoxigenic Escherichia coli Exposure in Pigs.

Pollock J, Hutchings MR, Hutchings KEK, Gally DL, Houdijk JGM.

Appl Environ Microbiol. 2019 Sep 17;85(19). pii: e01252-19. doi: 10.1128/AEM.01252-19. Print 2019 Oct 1.


When Is Forgetting Not Forgetting? A Discursive Analysis of Differences in Forgetting Talk Between Adults With Cystic Fibrosis With Different Levels of Adherence to Nebulizer Treatments.

Drabble SJ, O'Cathain A, Arden MA, Hutchings M, Beever D, Wildman M.

Qual Health Res. 2019 Dec;29(14):2119-2131. doi: 10.1177/1049732319856580. Epub 2019 Jul 13.


Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis.

McLean TC, Wilkinson B, Hutchings MI, Devine R.

Antibiotics (Basel). 2019 Jun 18;8(2). pii: E83. doi: 10.3390/antibiotics8020083. Review.


Biocontrol of Cereal Crop Diseases Using Streptomycetes.

Newitt JT, Prudence SMM, Hutchings MI, Worsley SF.

Pathogens. 2019 Jun 13;8(2). pii: E78. doi: 10.3390/pathogens8020078. Review.


Publisher Correction: Contrasting latitudinal patterns in phylogenetic diversity between woody and herbaceous communities.

Massante JC, Götzenberger L, Takkis K, Hallikma T, Kaasik A, Laanisto L, Hutchings MJ, Gerhold P.

Sci Rep. 2019 May 22;9(1):7917. doi: 10.1038/s41598-019-44332-x.


Considering appropriate replication in the design of animal social network studies.

Smith LA, Swain DL, Innocent GT, Nevison I, Hutchings MR.

Sci Rep. 2019 May 10;9(1):7208. doi: 10.1038/s41598-019-43764-9.


Contrasting latitudinal patterns in phylogenetic diversity between woody and herbaceous communities.

Massante JC, Götzenberger L, Takkis K, Hallikma T, Kaasik A, Laanisto L, Hutchings MJ, Gerhold P.

Sci Rep. 2019 Apr 23;9(1):6443. doi: 10.1038/s41598-019-42827-1. Erratum in: Sci Rep. 2019 May 22;9(1):7917.


Supporting medication adherence for adults with cystic fibrosis: a randomised feasibility study.

Hind D, Drabble SJ, Arden MA, Mandefield L, Waterhouse S, Maguire C, Cantrill H, Robinson L, Beever D, Scott AJ, Keating S, Hutchings M, Bradley J, Nightingale J, Allenby MI, Dewar J, Whelan P, Ainsworth J, Walters SJ, O'Cathain A, Wildman MJ.

BMC Pulm Med. 2019 Apr 11;19(1):77. doi: 10.1186/s12890-019-0834-6.


Defining the regulon of genes controlled by σE , a key regulator of the cell envelope stress response in Streptomyces coelicolor.

Tran NT, Huang X, Hong HJ, Bush MJ, Chandra G, Pinto D, Bibb MJ, Hutchings MI, Mascher T, Buttner MJ.

Mol Microbiol. 2019 Aug;112(2):461-481. doi: 10.1111/mmi.14250. Epub 2019 Apr 29.


Effect of the Serious Illness Care Program in Outpatient Oncology: A Cluster Randomized Clinical Trial.

Bernacki R, Paladino J, Neville BA, Hutchings M, Kavanagh J, Geerse OP, Lakin J, Sanders JJ, Miller K, Lipsitz S, Gawande AA, Block SD.

JAMA Intern Med. 2019 Jun 1;179(6):751-759. doi: 10.1001/jamainternmed.2019.0077.


When to kill a cull: factors affecting the success of culling wildlife for disease control.

Prentice JC, Fox NJ, Hutchings MR, White PCL, Davidson RS, Marion G.

J R Soc Interface. 2019 Mar 29;16(152):20180901. doi: 10.1098/rsif.2018.0901.


Adherence to medication in adults with Cystic Fibrosis: An investigation using objective adherence data and the Theoretical Domains Framework.

Arden MA, Drabble S, O'Cathain A, Hutchings M, Wildman M.

Br J Health Psychol. 2019 May;24(2):357-380. doi: 10.1111/bjhp.12357. Epub 2019 Mar 1.


Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues.

Volbeda A, Martinez MTP, Crack JC, Amara P, Gigarel O, Munnoch JT, Hutchings MI, Darnault C, Le Brun NE, Fontecilla-Camps JC.

J Am Chem Soc. 2019 Feb 13;141(6):2367-2375. doi: 10.1021/jacs.8b10823. Epub 2019 Feb 1.


123I-MIBG for detection of subacute doxorubicin-induced cardiotoxicity in patients with malignant lymphoma.

Laursen AH, Ripa RS, Hasbak P, Kjær A, Elming MB, Køber L, Hutchings M, Thune JJ.

J Nucl Cardiol. 2018 Dec 19. doi: 10.1007/s12350-018-01566-y. [Epub ahead of print]


A small change makes a big difference in Hodgkin lymphoma.

Hutchings M.

Blood. 2018 Nov 22;132(21):2214-2215. doi: 10.1182/blood-2018-09-873596. No abstract available.


Phase I dose-escalation study of brentuximab-vedotin combined with dexamethasone, high-dose cytarabine and cisplatin, as salvage treatment in relapsed/refractory classical Hodgkin lymphoma: The HOVON/LLPC Transplant BRaVE study.

Hagenbeek A, Mooij H, Zijlstra J, Lugtenburg P, van Imhoff G, Nijland M, Tonino S, Hutchings M, Spiering M, Liu R, van Tinteren H, Kersten MJ.

Haematologica. 2019 Apr;104(4):e151-e153. doi: 10.3324/haematol.2018.196899. Epub 2018 Oct 31. No abstract available.


Diet, Gut Microbes and Host Mate Choice: Understanding the significance of microbiome effects on host mate choice requires a case by case evaluation.

Leftwich PT, Hutchings MI, Chapman T.

Bioessays. 2018 Dec;40(12):e1800053. doi: 10.1002/bies.201800053. Epub 2018 Oct 12. Review.


Rubidium-82 positron emission tomography for detection of acute doxorubicin-induced cardiac effects in lymphoma patients.

Laursen AH, Elming MB, Ripa RS, Hasbak P, Kjær A, Køber L, Marott JL, Thune JJ, Hutchings M.

J Nucl Cardiol. 2018 Oct 8. doi: 10.1007/s12350-018-1458-6. [Epub ahead of print]


Improvements in Imaging of Hodgkin Lymphoma: Positron Emission Tomography.

Hutchings M.

Cancer J. 2018 Sep/Oct;24(5):215-222. doi: 10.1097/PPO.0000000000000336. Review.


Ubiquitous parasites drive a 33% increase in methane yield from livestock.

Fox NJ, Smith LA, Houdijk JGM, Athanasiadou S, Hutchings MR.

Int J Parasitol. 2018 Nov;48(13):1017-1021. doi: 10.1016/j.ijpara.2018.06.001. Epub 2018 Aug 11.


Analysis of temporal fecal microbiota dynamics in weaner pigs with and without exposure to enterotoxigenic Escherichia coli1,2.

Pollock J, Gally DL, Glendinning L, Tiwari R, Hutchings MR, Houdijk JGM.

J Anim Sci. 2018 Sep 7;96(9):3777-3790. doi: 10.1093/jas/sky260.


ESMO Consensus Conference on malignant lymphoma: management of 'ultra-high-risk' patients.

Hutchings M, Ladetto M, Buske C, de Nully Brown P, Ferreri AJM, Pfreundschuh M, Schmitz N, Balari AS, van Imhoff G, Walewski J; ESMO Lymphoma Consensus Conference Panel Members.

Ann Oncol. 2018 Aug 1;29(8):1687-1700. doi: 10.1093/annonc/mdy167.


Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen.

Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B.

Nat Commun. 2018 Jun 7;9(1):2208. doi: 10.1038/s41467-018-04520-1.


Hodgkin lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Eichenauer DA, Aleman BMP, André M, Federico M, Hutchings M, Illidge T, Engert A, Ladetto M; ESMO Guidelines Committee.

Ann Oncol. 2018 Oct 1;29(Suppl 4):iv19-iv29. doi: 10.1093/annonc/mdy080. No abstract available.


Reply to Obadia et al.: Effect of methyl paraben on host-microbiota interactions in Drosophila melanogaster.

Leftwich PT, Clarke NVE, Hutchings MI, Chapman T.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4549-E4550. doi: 10.1073/pnas.1805499115. Epub 2018 May 7. No abstract available.


Quantum chemical studies of redox properties and conformational changes of a four-center iron CO2 reduction electrocatalyst.

Jang H, Qiu Y, Hutchings ME, Nguyen M, Berben LA, Wang LP.

Chem Sci. 2018 Jan 29;9(10):2645-2654. doi: 10.1039/c7sc04342b. eCollection 2018 Mar 14.


Survival of Mycobacterium avium subspecies paratuberculosis in retail pasteurised milk.

Gerrard ZE, Swift BMC, Botsaris G, Davidson RS, Hutchings MR, Huxley JN, Rees CED.

Food Microbiol. 2018 Sep;74:57-63. doi: 10.1016/ Epub 2018 Mar 9.


Drivers of vegetative dormancy across herbaceous perennial plant species.

Shefferson RP, Kull T, Hutchings MJ, Selosse MA, Jacquemyn H, Kellett KM, Menges ES, Primack RB, Tuomi J, Alahuhta K, Hurskainen S, Alexander HM, Anderson DS, Brys R, Brzosko E, Dostálik S, Gregg K, Ipser Z, Jäkäläniemi A, Jersáková J, Dean Kettle W, McCormick MK, Mendoza A, Miller MT, Moen A, Øien DI, Püttsepp Ü, Roy M, Sather N, Sletvold N, Štípková Z, Tali K, Warren RJ 2nd, Whigham DF.

Ecol Lett. 2018 May;21(5):724-733. doi: 10.1111/ele.12940. Epub 2018 Mar 25.


Treatment strategies, outcomes and prognostic factors in 291 patients with secondary CNS involvement by diffuse large B-cell lymphoma.

El-Galaly TC, Cheah CY, Bendtsen MD, Nowakowski GS, Kansara R, Savage KJ, Connors JM, Sehn LH, Goldschmidt N, Shaulov A, Farooq U, Link BK, Ferreri AJM, Calimeri T, Cecchetti C, Dann EJ, Thompson CA, Inbar T, Maurer MJ, Gade IL, Juul MB, Hansen JW, Holmberg S, Larsen TS, Cordua S, Mikhaeel NG, Hutchings M, Seymour JF, Clausen MR, Smith D, Opat S, Gilbertson M, Thanarajasingam G, Villa D.

Eur J Cancer. 2018 Apr;93:57-68. doi: 10.1016/j.ejca.2018.01.073. Epub 2018 Feb 21.


Reply to Rosenberg et al.: Diet, gut bacteria, and assortative mating in Drosophila melanogaster.

Leftwich PT, Clarke NVE, Hutchings MI, Chapman T.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2154-E2155. doi: 10.1073/pnas.1721804115. Epub 2018 Feb 20. No abstract available.


Counterintuitive increase in observed Mycobacterium avium subspecies paratuberculosis prevalence in sympatric rabbits following the introduction of paratuberculosis control measures in cattle.

Fox NJ, Caldow GL, Liebeschuetz H, Stevenson K, Hutchings MR.

Vet Rec. 2018 Jun 2;182(22):634. doi: 10.1136/vr.104638. Epub 2018 Feb 14.


Prognostic value of baseline metabolic tumor volume in early-stage Hodgkin lymphoma in the standard arm of the H10 trial.

Cottereau AS, Versari A, Loft A, Casasnovas O, Bellei M, Ricci R, Bardet S, Castagnoli A, Brice P, Raemaekers J, Deau B, Fortpied C, Raveloarivahy T, Van Zele E, Chartier L, Vander Borght T, Federico M, Hutchings M, Ricardi U, Andre M, Meignan M.

Blood. 2018 Mar 29;131(13):1456-1463. doi: 10.1182/blood-2017-07-795476. Epub 2018 Feb 1.


Ibrutinib, lenalidomide, and rituximab in relapsed or refractory mantle cell lymphoma (PHILEMON): a multicentre, open-label, single-arm, phase 2 trial.

Jerkeman M, Eskelund CW, Hutchings M, Räty R, Wader KF, Laurell A, Toldbod H, Pedersen LB, Niemann CU, Dahl C, Kuitunen H, Geisler CH, Grønbæk K, Kolstad A.

Lancet Haematol. 2018 Mar;5(3):e109-e116. doi: 10.1016/S2352-3026(18)30018-8. Epub 2018 Jan 29.


PET/CT for Staging; Past, Present, and Future.

El-Galaly TC, Gormsen LC, Hutchings M.

Semin Nucl Med. 2018 Jan;48(1):4-16. doi: 10.1053/j.semnuclmed.2017.09.001. Epub 2017 Sep 21. Review.


ESMO Consensus Conference on malignant lymphoma: general perspectives and recommendations for the clinical management of the elderly patient with malignant lymphoma.

Buske C, Hutchings M, Ladetto M, Goede V, Mey U, Soubeyran P, Spina M, Stauder R, Trnený M, Wedding U, Fields P; ESMO Lymphoma Consensus Conference Panel Members.

Ann Oncol. 2018 Mar 1;29(3):544-562. doi: 10.1093/annonc/mdx413.


Complete genome sequence of Streptomyces formicae KY5, the formicamycin producer.

Holmes NA, Devine R, Qin Z, Seipke RF, Wilkinson B, Hutchings MI.

J Biotechnol. 2018 Jan 10;265:116-118. doi: 10.1016/j.jbiotec.2017.11.011. Epub 2017 Nov 27.


Gut microbiomes and reproductive isolation in Drosophila.

Leftwich PT, Clarke NVE, Hutchings MI, Chapman T.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12767-12772. doi: 10.1073/pnas.1708345114. Epub 2017 Nov 6. Erratum in: Proc Natl Acad Sci U S A. 2018 Feb 20;:.


The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2).

Som NF, Heine D, Holmes N, Knowles F, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B, Hutchings MI.

Microbiology. 2017 Oct;163(10):1415-1419. doi: 10.1099/mic.0.000524. Epub 2017 Sep 8.


Predictive Value of PET Response Combined with Baseline Metabolic Tumor Volume in Peripheral T-Cell Lymphoma Patients.

Cottereau AS, El-Galaly TC, Becker S, Broussais F, Petersen LJ, Bonnet C, Prior JO, Tilly H, Hutchings M, Casasnovas O, Meignan M.

J Nucl Med. 2018 Apr;59(4):589-595. doi: 10.2967/jnumed.117.193946. Epub 2017 Sep 1.

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