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The structure and metal binding properties of Chlamydia trachomatis YtgA.

Luo Z, Neville SL, Campbell R, Morey JR, Menon S, Thomas M, Eijkelkamp BA, Ween MP, Huston WM, Kobe B, McDevitt CA.

J Bacteriol. 2019 Oct 14. pii: JB.00580-19. doi: 10.1128/JB.00580-19. [Epub ahead of print]


Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development.

Christensen S, Halili MA, Strange N, Petit GA, Huston WM, Martin JL, McMahon RM.

PLoS One. 2019 Sep 19;14(9):e0222595. doi: 10.1371/journal.pone.0222595. eCollection 2019.


Structure-activity analysis of peptidic Chlamydia HtrA inhibitors.

Agbowuro AA, Hwang J, Peel E, Mazraani R, Springwald A, Marsh JW, McCaughey L, Gamble AB, Huston WM, Tyndall JDA.

Bioorg Med Chem. 2019 Sep 15;27(18):4185-4199. doi: 10.1016/j.bmc.2019.07.049. Epub 2019 Jul 30.


Evaluation of a PGP3 ELISA for surveillance of the burden of Chlamydia infection in women from Australia and Samoa.

Mazraani R, Timms P, Hill PC, Suaalii-Sauni T, Niupulusu T, Temese SVA, Iosefa-Siitia L, Auvaa L, Tapelu SA, Motu MF, Righarts A, Walsh MS, Rombauts L, Allan JA, Horner P, Huston WM.

Pathog Dis. 2019 Apr 1;77(3). pii: ftz031. doi: 10.1093/femspd/ftz031.


Fresh faces and new approaches at Pathogens and Disease.

Huston WM, Coers J, Garzino-Demo A.

Pathog Dis. 2019 Feb 1;77(1). pii: ftz010. doi: 10.1093/femspd/ftz010. No abstract available.


A sponsorship action plan for increasing diversity in STEMM.

Huston WM, Cranfield CG, Forbes SL, Leigh A.

Ecol Evol. 2019 Feb 10;9(5):2340-2345. doi: 10.1002/ece3.4962. eCollection 2019 Mar.


High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response.

Ziklo N, Huston WM, Taing K, Timms P.

BMC Infect Dis. 2019 Mar 4;19(1):218. doi: 10.1186/s12879-019-3843-4.


Life inside and out: making and breaking protein disulfide bonds in Chlamydia.

Christensen S, McMahon RM, Martin JL, Huston WM.

Crit Rev Microbiol. 2019 Feb;45(1):33-50. doi: 10.1080/1040841X.2018.1538933. Epub 2019 Jan 21. Review.


A laboratory competency examination in microbiology.

Wang JTH, Huston WM, Johanesen P, Lloyd M, Waller KL.

FEMS Microbiol Lett. 2018 Oct 1;365(20). doi: 10.1093/femsle/fny224.


Detection of Chlamydia trachomatis mRNA using digital PCR as a more accurate marker of viable organism.

Phillips S, Vodstrcil LA, Huston WM, Lawerence A, Timms P, Chen MY, Worthington K, McIver R, Bradshaw CS, Garland SM, Tabrizi SN, Hocking JS.

Eur J Clin Microbiol Infect Dis. 2018 Nov;37(11):2117-2122. doi: 10.1007/s10096-018-3347-y. Epub 2018 Aug 14.


Cervicovaginal microbiota, women's health, and reproductive outcomes.

Kroon SJ, Ravel J, Huston WM.

Fertil Steril. 2018 Aug;110(3):327-336. doi: 10.1016/j.fertnstert.2018.06.036. Review.


Cloacal and Ocular Microbiota of the Endangered Australian Northern Quoll.

Burke C, Burnard D, Polkinghorne A, Webb J, Huston WM.

Microorganisms. 2018 Jul 12;6(3). pii: E68. doi: 10.3390/microorganisms6030068.


Advancing the public health applications of Chlamydia trachomatis serology.

Woodhall SC, Gorwitz RJ, Migchelsen SJ, Gottlieb SL, Horner PJ, Geisler WM, Winstanley C, Hufnagel K, Waterboer T, Martin DL, Huston WM, Gaydos CA, Deal C, Unemo M, Dunbar JK, Bernstein K.

Lancet Infect Dis. 2018 Dec;18(12):e399-e407. doi: 10.1016/S1473-3099(18)30159-2. Epub 2018 Jul 5. Review.


CtGEM typing: Discrimination of Chlamydia trachomatis ocular and urogenital strains and major evolutionary lineages by high resolution melting analysis of two amplified DNA fragments.

Giffard PM, Andersson P, Wilson J, Buckley C, Lilliebridge R, Harris TM, Kleinecke M, O'Grady KF, Huston WM, Lambert SB, Whiley DM, Holt DC.

PLoS One. 2018 Apr 10;13(4):e0195454. doi: 10.1371/journal.pone.0195454. eCollection 2018.


Turning microplastics into nanoplastics through digestive fragmentation by Antarctic krill.

Dawson AL, Kawaguchi S, King CK, Townsend KA, King R, Huston WM, Bengtson Nash SM.

Nat Commun. 2018 Mar 8;9(1):1001. doi: 10.1038/s41467-018-03465-9.


Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections.

Ziklo N, Vidgen ME, Taing K, Huston WM, Timms P.

Front Cell Infect Microbiol. 2018 Jan 18;8:1. doi: 10.3389/fcimb.2018.00001. eCollection 2018.


Characterization of the In Vitro Chlamydia pecorum Response to Gamma Interferon.

Islam MM, Jelocnik M, Huston WM, Timms P, Polkinghorne A.

Infect Immun. 2018 Mar 22;86(4). pii: e00714-17. doi: 10.1128/IAI.00714-17. Print 2018 Apr.


A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women.

Wee BA, Thomas M, Sweeney EL, Frentiu FD, Samios M, Ravel J, Gajer P, Myers G, Timms P, Allan JA, Huston WM.

Aust N Z J Obstet Gynaecol. 2018 Jun;58(3):341-348. doi: 10.1111/ajo.12754. Epub 2017 Dec 26.


Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?

Donnelly S, Huston WM, Johnson M, Tiberti N, Saunders B, O'Brien B, Burke C, Labbate M, Combes V.

Parasit Vectors. 2017 Nov 21;10(1):581. doi: 10.1186/s13071-017-2528-3. Review.


Proteases and protease inhibitors in infectious diseases.

Agbowuro AA, Huston WM, Gamble AB, Tyndall JDA.

Med Res Rev. 2018 Jul;38(4):1295-1331. doi: 10.1002/med.21475. Epub 2017 Nov 17. Review.


Systemic antibody response to Chlamydia Trachomatis infection in patients either infected or reinfected with different Chlamydia serovars.

Gupta VK, Waugh CA, Ziklo N, Huston WM, Hocking JS, Timms P.

Indian J Med Microbiol. 2017 Jul-Sep;35(3):394-401. doi: 10.4103/ijmm.IJMM_17_1.


Molecular evidence of Chlamydia pecorum and arthropod-associated Chlamydiae in an expanded range of marsupials.

Burnard D, Huston WM, Webb JK, Jelocnik M, Reiss A, Gillett A, Fitzgibbon S, Carver S, Carrucan J, Flanagan C, Timms P, Polkinghorne A.

Sci Rep. 2017 Oct 9;7(1):12844. doi: 10.1038/s41598-017-13164-y.


Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.

Marsh JW, Djoko KY, McEwan AG, Huston WM.

Pathog Dis. 2017 Sep 29;75(7). doi: 10.1093/femspd/ftx084.


CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.

Marsh JW, Ong VA, Lott WB, Timms P, Tyndall JD, Huston WM.

Future Microbiol. 2017 Jul;12:817-829. doi: 10.2217/fmb-2017-0017. Epub 2017 Jun 8. Review.


Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS).

Vodstrcil LA, Rupasinghe TWT, Kong FYS, Tull D, Worthington K, Chen MY, Huston WM, Timms P, McConville MJ, Fairley CK, Bradshaw CS, Tabrizi SN, Hocking JS.

PLoS One. 2017 May 12;12(5):e0177615. doi: 10.1371/journal.pone.0177615. eCollection 2017.


Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.

Kerr MC, Gomez GA, Ferguson C, Tanzer MC, Murphy JM, Yap AS, Parton RG, Huston WM, Teasdale RD.

Nat Commun. 2017 Mar 10;8:14729. doi: 10.1038/ncomms14729.


Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis.

Paul B, Kim HS, Kerr MC, Huston WM, Teasdale RD, Collins BM.

Elife. 2017 Feb 22;6. pii: e22311. doi: 10.7554/eLife.22311.


Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase.

Christensen S, Grøftehauge MK, Byriel K, Huston WM, Furlong E, Heras B, Martin JL, McMahon RM.

PLoS One. 2016 Dec 28;11(12):e0168485. doi: 10.1371/journal.pone.0168485. eCollection 2016.


Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.

Lawrence A, Fraser T, Gillett A, Tyndall JD, Timms P, Polkinghorne A, Huston WM.

Sci Rep. 2016 Aug 17;6:31466. doi: 10.1038/srep31466.


Development and evaluation of a multi-antigen peptide ELISA for the diagnosis of Chlamydia trachomatis-related infertility in women.

Menon S, Stansfield SH, Logan B, Hocking JS, Timms P, Rombauts L, Allan JA, Huston WM.

J Med Microbiol. 2016 Sep;65(9):915-922. doi: 10.1099/jmm.0.000311. Epub 2016 Jul 17.


Chlamydia trachomatis Genital Tract Infections: When Host Immune Response and the Microbiome Collide.

Ziklo N, Huston WM, Hocking JS, Timms P.

Trends Microbiol. 2016 Sep;24(9):750-765. doi: 10.1016/j.tim.2016.05.007. Epub 2016 Jun 16. Review.


Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women.

Menon S, Stansfield SH, Walsh M, Hope E, Isaia L, Righarts AA, Niupulusu T, Temese SV, Iosefa-Siitia L, Auvaa L, Tapelu SA, Motu MF, Suaalii-Sauni T, Timms P, Hill PC, Huston WM.

BMC Infect Dis. 2016 Apr 21;16:175. doi: 10.1186/s12879-016-1508-0.


Sortilin is associated with the chlamydial inclusion and is modulated during infection.

Teo WX, Kerr MC, Huston WM, Teasdale RD.

Biol Open. 2016 Apr 15;5(4):429-35. doi: 10.1242/bio.016485.


Cyclic-di-AMP synthesis by the diadenylate cyclase CdaA is modulated by the peptidoglycan biosynthesis enzyme GlmM in Lactococcus lactis.

Zhu Y, Pham TH, Nhiep TH, Vu NM, Marcellin E, Chakrabortti A, Wang Y, Waanders J, Lo R, Huston WM, Bansal N, Nielsen LK, Liang ZX, Turner MS.

Mol Microbiol. 2016 Mar;99(6):1015-27. doi: 10.1111/mmi.13281. Epub 2015 Dec 15.


CXCL10, CXCL11, HLA-A and IL-1β are induced in peripheral blood mononuclear cells from women with Chlamydia trachomatis related infertility.

Menon S, Alexander K, Timms P, Allan JA, Huston WM.

Pathog Dis. 2016 Feb;74(1):ftv099. doi: 10.1093/femspd/ftv099. Epub 2015 Oct 27.


A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.

Marsh JW, Wee BA, Tyndall JD, Lott WB, Bastidas RJ, Caldwell HD, Valdivia RH, Kari L, Huston WM.

BMC Microbiol. 2015 Sep 30;15:194. doi: 10.1186/s12866-015-0533-2.


In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146.

Ong VA, Lawrence A, Timms P, Vodstrcil LA, Tabrizi SN, Beagley KW, Allan JA, Hocking JS, Huston WM.

Microbes Infect. 2015 Nov-Dec;17(11-12):738-44. doi: 10.1016/j.micinf.2015.09.004. Epub 2015 Sep 11.


Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women.

Menon S, Timms P, Allan JA, Alexander K, Rombauts L, Horner P, Keltz M, Hocking J, Huston WM.

Clin Microbiol Rev. 2015 Oct;28(4):969-85. doi: 10.1128/CMR.00035-15. Review.


Prevalence of Chlamydia trachomatis infection in Samoan women aged 18 to 29 and assessment of possible risk factors: a community-based study.

Walsh MS, Hope E, Isaia L, Righarts A, Niupulusu T, Temese SV, Iosefa-Siitia L, Auvaa L, Tapelu SA, Motu MF, Edwards C, Wernick M, Huston WM, Suaalii-Sauni T, Hill PC.

Trans R Soc Trop Med Hyg. 2015 Apr;109(4):245-51. doi: 10.1093/trstmh/trv014. Epub 2015 Mar 1.


Human Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not.

Chacko A, Beagley KW, Timms P, Huston WM.

FEMS Microbiol Lett. 2015 Mar;362(6). pii: fnv015. doi: 10.1093/femsle/fnv015. Epub 2015 Feb 5.


The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis.

Kong FY, Tabrizi SN, Fairley CK, Vodstrcil LA, Huston WM, Chen M, Bradshaw C, Hocking JS.

J Antimicrob Chemother. 2015 May;70(5):1290-7. doi: 10.1093/jac/dku574. Epub 2015 Jan 29. Review.


The Epidemiology of Chlamydia trachomatis Organism Load During Genital Infection: A Systematic Review.

Vodstrcil LA, McIver R, Huston WM, Tabrizi SN, Timms P, Hocking JS.

J Infect Dis. 2015 May 15;211(10):1628-45. doi: 10.1093/infdis/jiu670. Epub 2014 Dec 9. Review.


Treatment of rectal chlamydia infection may be more complicated than we originally thought.

Hocking JS, Kong FY, Timms P, Huston WM, Tabrizi SN.

J Antimicrob Chemother. 2015 Apr;70(4):961-4. doi: 10.1093/jac/dku493. Epub 2014 Dec 4. Review.


Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle.

Patel P, De Boer L, Timms P, Huston WM.

Microbes Infect. 2014 Aug;16(8):690-4. doi: 10.1016/j.micinf.2014.07.003. Epub 2014 Jul 25.


Increased sensitivity to tryptophan bioavailability is a positive adaptation by the human strains of Chlamydia pneumoniae.

Chacko A, Barker CJ, Beagley KW, Hodson MP, Plan MR, Timms P, Huston WM.

Mol Microbiol. 2014 Aug;93(4):797-813. doi: 10.1111/mmi.12701. Epub 2014 Jul 22.


Evolution to a chronic disease niche correlates with increased sensitivity to tryptophan availability for the obligate intracellular bacterium Chlamydia pneumoniae.

Huston WM, Barker CJ, Chacko A, Timms P.

J Bacteriol. 2014 Jun;196(11):1915-24. doi: 10.1128/JB.01476-14. Epub 2014 Mar 28. Review.


The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence.

Ong VA, Marsh JW, Lawrence A, Allan JA, Timms P, Huston WM.

Front Cell Infect Microbiol. 2013 Dec 18;3:100. doi: 10.3389/fcimb.2013.00100. eCollection 2013.


A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol.

Hocking JS, Vodstrcil LA, Huston WM, Timms P, Chen MY, Worthington K, McIver R, Tabrizi SN; Australian Chlamydia Treatment Study (ACTS) investigators.

BMC Infect Dis. 2013 Aug 17;13:379. doi: 10.1186/1471-2334-13-379.

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