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Items: 48

1.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.

Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD.

Nat Commun. 2019 Jun 27;10(1):2816. doi: 10.1038/s41467-019-10687-y.

2.

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors.

Jumani RS, Hasan MM, Stebbins EE, Donnelly L, Miller P, Klopfer C, Bessoff K, Teixeira JE, Love MS, McNamara CW, Huston CD.

Nat Commun. 2019 Apr 23;10(1):1862. doi: 10.1038/s41467-019-09880-w.

3.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

4.

Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis.

Lee S, Ginese M, Girouard D, Beamer G, Huston CD, Osbourn D, Griggs DW, Tzipori S.

J Infect Dis. 2019 Jun 19;220(2):285-293. doi: 10.1093/infdis/jiz105.

PMID:
30893435
5.

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.

Buckner FS, Ranade RM, Gillespie JR, Shibata S, Hulverson MA, Zhang Z, Huang W, Choi R, Verlinde CLMJ, Hol WGJ, Ochida A, Akao Y, Choy RKM, Van Voorhis WC, Arnold SLM, Jumani RS, Huston CD, Fan E.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02061-18. doi: 10.1128/AAC.02061-18. Print 2019 Apr.

PMID:
30745384
6.

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.

Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar.

PMID:
30559138
7.

Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium.

Bartelt LA, Bolick DT, Kolling GL, Stebbins E, Huston CD, Guerrant RL, Hoffman PS.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00718-18. doi: 10.1128/AAC.00718-18. Print 2018 Dec.

8.

Invadosome-Mediated Human Extracellular Matrix Degradation by Entamoeba histolytica.

Hasan MM, Teixeira JE, Huston CD.

Infect Immun. 2018 Aug 22;86(9). pii: e00287-18. doi: 10.1128/IAI.00287-18. Print 2018 Sep.

9.

A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box.

Jumani RS, Bessoff K, Love MS, Miller P, Stebbins EE, Teixeira JE, Campbell MA, Meyers MJ, Zambriski JA, Nunez V, Woods AK, McNamara CW, Huston CD.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e01505-17. doi: 10.1128/AAC.01505-17. Print 2018 Apr.

10.

Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model.

Stebbins E, Jumani RS, Klopfer C, Barlow J, Miller P, Campbell MA, Meyers MJ, Griggs DW, Huston CD.

PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0006183. doi: 10.1371/journal.pntd.0006183. eCollection 2018 Jan.

11.

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

Jain V, Yogavel M, Kikuchi H, Oshima Y, Hariguchi N, Matsumoto M, Goel P, Touquet B, Jumani RS, Tacchini-Cottier F, Harlos K, Huston CD, Hakimi MA, Sharma A.

Structure. 2017 Oct 3;25(10):1495-1505.e6. doi: 10.1016/j.str.2017.07.015. Epub 2017 Aug 31.

12.

Susceptibility Testing of Medically Important Parasites.

Genetu Bayih A, Debnath A, Mitre E, Huston CD, Laleu B, Leroy D, Blasco B, Campo B, Wells TNC, Willis PA, Sjö P, Van Voorhis WC, Pillai DR.

Clin Microbiol Rev. 2017 Jul;30(3):647-669. doi: 10.1128/CMR.00111-16. Review.

13.

Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.

Osman KT, Ye J, Shi Z, Toker C, Lovato D, Jumani RS, Zuercher W, Huston CD, Edwards AM, Lautens M, Santhakumar V, Hui R.

Bioorg Med Chem. 2017 Mar 1;25(5):1672-1680. doi: 10.1016/j.bmc.2017.01.036. Epub 2017 Jan 24.

PMID:
28162900
14.

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis.

Love MS, Beasley FC, Jumani RS, Wright TM, Chatterjee AK, Huston CD, Schultz PG, McNamara CW.

PLoS Negl Trop Dis. 2017 Feb 3;11(2):e0005373. doi: 10.1371/journal.pntd.0005373. eCollection 2017 Feb.

15.

Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells.

Sateriale A, Miller P, Huston CD.

Infect Immun. 2016 Mar 24;84(4):1045-1053. doi: 10.1128/IAI.01325-15. Print 2016 Apr.

16.

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments.

Huston CD, Spangenberg T, Burrows J, Willis P, Wells TN, van Voorhis W.

PLoS Negl Trop Dis. 2015 Oct 8;9(10):e0003987. doi: 10.1371/journal.pntd.0003987. eCollection 2015 Oct. No abstract available.

17.

Immunization with the Entamoeba histolytica surface metalloprotease EhMSP-1 protects hamsters from amebic liver abscess.

Roncolato EC, Teixeira JE, Barbosa JE, Zambelli Ramalho LN, Huston CD.

Infect Immun. 2015 Feb;83(2):713-20. doi: 10.1128/IAI.02490-14. Epub 2014 Dec 1.

18.

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.

Checkley W, White AC Jr, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA Jr, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER.

Lancet Infect Dis. 2015 Jan;15(1):85-94. doi: 10.1016/S1473-3099(14)70772-8. Epub 2014 Sep 29. Review.

19.

Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box.

Bessoff K, Spangenberg T, Foderaro JE, Jumani RS, Ward GE, Huston CD.

Antimicrob Agents Chemother. 2014 May;58(5):2731-9. doi: 10.1128/AAC.02641-13. Epub 2014 Feb 24.

20.

SNAP-tag technology optimized for use in Entamoeba histolytica.

Sateriale A, Roy NH, Huston CD.

PLoS One. 2013 Dec 31;8(12):e83997. doi: 10.1371/journal.pone.0083997. eCollection 2013.

21.

Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds.

Sateriale A, Bessoff K, Sarkar IN, Huston CD.

J Am Med Inform Assoc. 2014 Mar-Apr;21(2):238-44. doi: 10.1136/amiajnl-2013-001700. Epub 2013 Jun 11.

22.

Drug repurposing screen reveals FDA-approved inhibitors of human HMG-CoA reductase and isoprenoid synthesis that block Cryptosporidium parvum growth.

Bessoff K, Sateriale A, Lee KK, Huston CD.

Antimicrob Agents Chemother. 2013 Apr;57(4):1804-14. doi: 10.1128/AAC.02460-12. Epub 2013 Feb 4.

23.

Feed-forward regulation of phagocytosis by Entamoeba histolytica.

Sateriale A, Vaithilingam A, Donnelly L, Miller P, Huston CD.

Infect Immun. 2012 Dec;80(12):4456-62. doi: 10.1128/IAI.00671-12. Epub 2012 Oct 8.

24.

Entamoeba histolytica cell surface calreticulin binds human c1q and functions in amebic phagocytosis of host cells.

Vaithilingam A, Teixeira JE, Miller PJ, Heron BT, Huston CD.

Infect Immun. 2012 Jun;80(6):2008-18. doi: 10.1128/IAI.06287-11. Epub 2012 Apr 2.

25.

Control of Entamoeba histolytica adherence involves metallosurface protease 1, an M8 family surface metalloprotease with homology to leishmanolysin.

Teixeira JE, Sateriale A, Bessoff KE, Huston CD.

Infect Immun. 2012 Jun;80(6):2165-76. doi: 10.1128/IAI.06389-11. Epub 2012 Mar 26.

26.

A Sequential Model of Host Cell Killing and Phagocytosis by Entamoeba histolytica.

Sateriale A, Huston CD.

J Parasitol Res. 2011;2011:926706. doi: 10.1155/2011/926706. Epub 2011 Jan 20.

27.

Evidence for a novel Entamoeba histolytica lectin activity that recognises carbohydrates present on ovalbumin.

Heron BT, Sateriale A, Teixeira JE, Huston CD.

Int J Parasitol. 2011 Feb;41(2):137-44. doi: 10.1016/j.ijpara.2010.07.011. Epub 2010 Aug 31.

28.
29.

C1q- and collectin-dependent phagocytosis of apoptotic host cells by the intestinal protozoan Entamoeba histolytica.

Teixeira JE, Heron BT, Huston CD.

J Infect Dis. 2008 Oct 1;198(7):1062-70. doi: 10.1086/591628.

30.

Evidence of a continuous endoplasmic reticulum in the protozoan parasite Entamoeba histolytica.

Teixeira JE, Huston CD.

Eukaryot Cell. 2008 Jul;7(7):1222-6. doi: 10.1128/EC.00007-08. Epub 2008 Feb 15.

31.

Entamoeba histolytica phagocytosis of human erythrocytes involves PATMK, a member of the transmembrane kinase family.

Boettner DR, Huston CD, Linford AS, Buss SN, Houpt E, Sherman NE, Petri WA Jr.

PLoS Pathog. 2008 Jan;4(1):e8. doi: 10.1371/journal.ppat.0040008.

32.
33.

Emerging and reemerging intestinal protozoa.

Huston CD, Petri WA Jr.

Curr Opin Gastroenterol. 2001 Jan;17(1):17-23.

PMID:
17031144
34.

Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children.

Kirkpatrick BD, Huston CD, Wagner D, Noel F, Rouzier P, Pape JW, Bois G, Larsson CJ, Alston WK, Tenney K, Powden C, O'Neill JP, Sears CL.

Clin Infect Dis. 2006 Aug 1;43(3):289-94. Epub 2006 Jun 22.

PMID:
16804841
35.

Identification and characterization of EhABC A1, an Entamoeba histolytica Group A ABC transporter with similarity to Ced-7.

Huston CD, Miller-Sims VC, Teixeira JE.

Mol Biochem Parasitol. 2006 Apr;146(2):272-6. Epub 2006 Jan 17. No abstract available.

PMID:
16442643
36.

Kinetics and strain variation of phagosome proteins of Entamoeba histolytica by proteomic analysis.

Okada M, Huston CD, Oue M, Mann BJ, Petri WA Jr, Kita K, Nozaki T.

Mol Biochem Parasitol. 2006 Feb;145(2):171-83. Epub 2005 Oct 19.

PMID:
16290089
37.
38.

Proteomic analysis of phagocytosis in the enteric protozoan parasite Entamoeba histolytica.

Okada M, Huston CD, Mann BJ, Petri WA Jr, Kita K, Nozaki T.

Eukaryot Cell. 2005 Apr;4(4):827-31.

39.

Molecular-based diagnosis of Entamoeba histolytica infection.

Huston CD, Haque R, Petri WA Jr.

Expert Rev Mol Med. 1999 Mar 22;1999:1-11. doi: 10.1017/S1462399499000599. No abstract available.

PMID:
14987356
40.

Parasite and host contributions to the pathogenesis of amebic colitis.

Huston CD.

Trends Parasitol. 2004 Jan;20(1):23-6. Review. No abstract available.

PMID:
14700586
41.

Amebiasis.

Haque R, Huston CD, Hughes M, Houpt E, Petri WA Jr.

N Engl J Med. 2003 Apr 17;348(16):1565-73. Review. No abstract available.

PMID:
12700377
42.

Apoptotic killing and phagocytosis of host cells by the parasite Entamoeba histolytica.

Huston CD, Boettner DR, Miller-Sims V, Petri WA Jr.

Infect Immun. 2003 Feb;71(2):964-72.

43.

Intermediate subunit of the Gal/GalNAc lectin of Entamoeba histolytica is a member of a gene family containing multiple CXXC sequence motifs.

Cheng XJ, Hughes MA, Huston CD, Loftus B, Gilchrist CA, Lockhart LA, Ghosh S, Miller-Sims V, Mann BJ, Petri WA Jr, Tachibana H.

Infect Immun. 2001 Sep;69(9):5892-8.

44.

Caspase 3-dependent killing of host cells by the parasite Entamoeba histolytica.

Huston CD, Houpt ER, Mann BJ, Hahn CS, Petri WA Jr.

Cell Microbiol. 2000 Dec;2(6):617-25.

PMID:
11207613
45.

Amebiasis: Clinical Implications of the Recognition of Entamoeba dispar.

Huston CD, Petri WA.

Curr Infect Dis Rep. 1999 Dec;1(5):441-447.

PMID:
11095821
46.

Role of host caspases in cell killing by Entamoeba histolytica.

Huston CD, Mann BJ, Hahn CS, Petri WA.

Arch Med Res. 2000 Jul-Aug;31(4 Suppl):S216-7. No abstract available.

PMID:
11070290
47.

Host-pathogen interaction in amebiasis and progress in vaccine development.

Huston CD, Petri WA Jr.

Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):601-14. Review.

PMID:
9832261
48.

Lyme arthritis synovial gamma delta T cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides.

Vincent MS, Roessner K, Sellati T, Huston CD, Sigal LH, Behar SM, Radolf JD, Budd RC.

J Immunol. 1998 Nov 15;161(10):5762-71.

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