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Correction for Mir et al., "Mycobacterial Gene cuvA Is Required for Optimal Nutrient Utilization and Virulence".

Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN.

Infect Immun. 2019 Jul 23;87(8). pii: e00414-19. doi: 10.1128/IAI.00414-19. Print 2019 Aug. No abstract available.


Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome.

Barth VC, Zeng JM, Vvedenskaya IO, Ouyang M, Husson RN, Woychik NA.

Nat Commun. 2019 Jul 10;10(1):3035. doi: 10.1038/s41467-019-10869-8.


Accurate target identification for Mycobacterium tuberculosis endoribonuclease toxins requires expression in their native host.

CintrĂ³n M, Zeng JM, Barth VC, Cruz JW, Husson RN, Woychik NA.

Sci Rep. 2019 Apr 11;9(1):5949. doi: 10.1038/s41598-019-41548-9.


Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface.

Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri LP, Moody CS, Zeng J, Prisic S, Paulson JN, Muntel J, Madduri AVR, Velarde J, Mayfield JA, Locher C, Wang T, Quackenbush J, Rhee KY, Moody DB, Steen H, Husson RN.

MBio. 2018 Mar 6;9(2). pii: e02333-17. doi: 10.1128/mBio.02333-17.


A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB.

Wang Q, Marchetti R, Prisic S, Ishii K, Arai Y, Ohta I, Inuki S, Uchiyama S, Silipo A, Molinaro A, Husson RN, Fukase K, Fujimoto Y.

Chembiochem. 2017 Nov 2;18(21):2094-2098. doi: 10.1002/cbic.201700385. Epub 2017 Sep 14.


Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system.

Singh AK, Carette X, Potluri LP, Sharp JD, Xu R, Prisic S, Husson RN.

Nucleic Acids Res. 2016 Oct 14;44(18):e143. Epub 2016 Jul 12.


Comprehensive Definition of the SigH Regulon of Mycobacterium tuberculosis Reveals Transcriptional Control of Diverse Stress Responses.

Sharp JD, Singh AK, Park ST, Lyubetskaya A, Peterson MW, Gomes AL, Potluri LP, Raman S, Galagan JE, Husson RN.

PLoS One. 2016 Mar 22;11(3):e0152145. doi: 10.1371/journal.pone.0152145. eCollection 2016.


tRNA is a new target for cleavage by a MazF toxin.

Schifano JM, Cruz JW, Vvedenskaya IO, Edifor R, Ouyang M, Husson RN, Nickels BE, Woychik NA.

Nucleic Acids Res. 2016 Feb 18;44(3):1256-70. doi: 10.1093/nar/gkv1370. Epub 2016 Jan 5.


Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase.

Cruz JW, Sharp JD, Hoffer ED, Maehigashi T, Vvedenskaya IO, Konkimalla A, Husson RN, Nickels BE, Dunham CM, Woychik NA.

Nat Commun. 2015 Jul 9;6:7480. doi: 10.1038/ncomms8480.


Zinc regulates a switch between primary and alternative S18 ribosomal proteins in Mycobacterium tuberculosis.

Prisic S, Hwang H, Dow A, Barnaby O, Pan TS, Lonzanida JA, Chazin WJ, Steen H, Husson RN.

Mol Microbiol. 2015 Jul;97(2):263-80. doi: 10.1111/mmi.13022. Epub 2015 May 15.


Mycobacterium tuberculosis Serine/Threonine Protein Kinases.

Prisic S, Husson RN.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.MGM2-0006-2013. Review.


Phosphorylation regulates mycobacterial proteasome.

Anandan T, Han J, Baun H, Nyayapathy S, Brown JT, Dial RL, Moltalvo JA, Kim MS, Yang SH, Ronning DR, Husson RN, Suh J, Kang CM.

J Microbiol. 2014 Sep;52(9):743-54. doi: 10.1007/s12275-014-4416-2. Epub 2014 Sep 2.


Mycobacterial gene cuvA is required for optimal nutrient utilization and virulence.

Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN.

Infect Immun. 2014 Oct;82(10):4104-17. doi: 10.1128/IAI.02207-14. Epub 2014 Jul 21. Erratum in: Infect Immun. 2019 Jul 23;87(8):.


Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site.

Schifano JM, Edifor R, Sharp JD, Ouyang M, Konkimalla A, Husson RN, Woychik NA.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8501-6. doi: 10.1073/pnas.1222031110. Epub 2013 May 6.


Using bacteria to determine protein kinase specificity and predict target substrates.

Chou MF, Prisic S, Lubner JM, Church GM, Husson RN, Schwartz D.

PLoS One. 2012;7(12):e52747. doi: 10.1371/journal.pone.0052747. Epub 2012 Dec 26.


A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity.

Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI.

PLoS One. 2012;7(2):e31307. doi: 10.1371/journal.pone.0031307. Epub 2012 Feb 16. Erratum in: PLoS One. 2012;7(4): doi/10.1371/annotation/06010c3b-61a1-4c46-864a-15f64403ec55. PLoS One. 2012;7(4): doi/10.1371/annotation/7efd3085-dd48-4210-9b7a-9ddb1acaa608.


Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin.

Sharp JD, Cruz JW, Raman S, Inouye M, Husson RN, Woychik NA.

J Biol Chem. 2012 Apr 13;287(16):12835-47. doi: 10.1074/jbc.M112.340109. Epub 2012 Feb 21.


Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis.

Peters JM, Madhavan VL, Kazacos KR, Husson RN, Dangoudoubiyam S, Soul JS.

Pediatrics. 2012 Mar;129(3):e806-11. doi: 10.1542/peds.2011-2078. Epub 2012 Feb 6.


The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization.

Mir M, Asong J, Li X, Cardot J, Boons GJ, Husson RN.

PLoS Pathog. 2011 Jul;7(7):e1002182. doi: 10.1371/journal.ppat.1002182. Epub 2011 Jul 28.


A modified immunoblot method to identify substrates of protein kinases.

Kang CM, Jahng WJ, Husson RN, Lee SH.

J Microbiol. 2011 Jun;49(3):499-501. doi: 10.1007/s12275-011-0465-y. Epub 2011 Jun 30.


Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.

Prisic S, Dankwa S, Schwartz D, Chou MF, Locasale JW, Kang CM, Bemis G, Church GM, Steen H, Husson RN.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7521-6. doi: 10.1073/pnas.0913482107. Epub 2010 Apr 5.


Nitrile-inducible gene expression in mycobacteria.

Pandey AK, Raman S, Proff R, Joshi S, Kang CM, Rubin EJ, Husson RN, Sassetti CM.

Tuberculosis (Edinb). 2009 Jan;89(1):12-6. doi: 10.1016/ Epub 2008 Sep 17.


Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.

Park ST, Kang CM, Husson RN.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13105-10. doi: 10.1073/pnas.0801143105. Epub 2008 Aug 26.


The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA.

Zhu L, Phadtare S, Nariya H, Ouyang M, Husson RN, Inouye M.

Mol Microbiol. 2008 Aug;69(3):559-69. doi: 10.1111/j.1365-2958.2008.06284.x. Epub 2008 Jun 28.


Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria.

Kang CM, Nyayapathy S, Lee JY, Suh JW, Husson RN.

Microbiology. 2008 Mar;154(Pt 3):725-35. doi: 10.1099/mic.0.2007/014076-0. Erratum in: Microbiology. 2008 Jul;154(Pt 7):2168.


Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE and SigH.

Song T, Song SE, Raman S, Anaya M, Husson RN.

J Bacteriol. 2008 Mar;190(6):2227-30. doi: 10.1128/JB.01642-07. Epub 2008 Jan 11.


The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.

Kang CM, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN.

Genes Dev. 2005 Jul 15;19(14):1692-704. Epub 2005 Jun 28.


Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life.

Kovacs A, Cowles MK, Britto P, Capparelli E, Fowler MG, Moye J, McIntosh K, Rathore MH, Pitt J, Husson RN.

Pediatr Infect Dis J. 2005 Jun;24(6):503-9.


Development of a model of focal pneumococcal pneumonia in young rats.

Malley R, Stack AM, Husson RN, Thompson CM, Fleisher GR, Saladino RA.

J Immune Based Ther Vaccines. 2004 Jan 23;2(1):2.


The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis.

Raman S, Song T, Puyang X, Bardarov S, Jacobs WR Jr, Husson RN.

J Bacteriol. 2001 Oct;183(20):6119-25.


Novel mycobacterium related to Mycobacterium triplex as a cause of cervical lymphadenitis.

Hazra R, Floyd MM, Sloutsky A, Husson RN.

J Clin Microbiol. 2001 Apr;39(4):1227-30.


Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis.

Hazra R, Lee SH, Maslow JN, Husson RN.

J Infect Dis. 2000 Apr;181(4):1298-303. Epub 2000 Apr 7.


Nontuberculous mycobacterial infection of the head and neck in immunocompetent children: CT and MR findings.

Robson CD, Hazra R, Barnes PD, Robertson RL, Jones D, Husson RN.

AJNR Am J Neuroradiol. 1999 Nov-Dec;20(10):1829-35.


Multidrug-resistant tuberculosis meningitis: clinical problems and concentrations of second-line antituberculous medications.

DeVincenzo JP, Berning SE, Peloquin CA, Husson RN.

Ann Pharmacother. 1999 Nov;33(11):1184-8.


A mycobacterial extracytoplasmic sigma factor involved in survival following heat shock and oxidative stress.

Fernandes ND, Wu QL, Kong D, Puyang X, Garg S, Husson RN.

J Bacteriol. 1999 Jul;181(14):4266-74. Erratum in: J Bacteriol 1999 Oct;181(19):6222.


Lymphadenitis due to nontuberculous mycobacteria in children: presentation and response to therapy.

Hazra R, Robson CD, Perez-Atayde AR, Husson RN.

Clin Infect Dis. 1999 Jan;28(1):123-9. Review.


In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria.

Rubin EJ, Akerley BJ, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1645-50.


Homologous recombination in Mycobacterium smegmatis. Screening methods for detection of gene replacement.

Husson RN.

Methods Mol Biol. 1998;101:199-206. No abstract available.


Vertical transmission of human immunodeficiency virus type 1: autologous neutralizing antibody, virus load, and virus phenotype.

Husson RN, Lan Y, Kojima E, Venzon D, Mitsuya H, McIntosh K.

J Pediatr. 1995 Jun;126(6):865-71.


Clinical and pharmacokinetic evaluation of long-term therapy with didanosine in children with HIV infection.

Mueller BU, Butler KM, Stocker VL, Balis FM, Brouwers P, Jarosinski P, Husson RN, Lewis LL, Venzon D, Pizzo PA.

Pediatrics. 1994 Nov;94(5):724-31.


Pharmacokinetic evaluation of the combination of zidovudine and didanosine in children with human immunodeficiency virus infection.

Mueller BU, Pizzo PA, Farley M, Husson RN, Goldsmith J, Kovacs A, Woods L, Ono J, Church JA, Brouwers P, et al.

J Pediatr. 1994 Jul;125(1):142-6.


Orally administered clarithromycin for the treatment of systemic Mycobacterium avium complex infection in children with acquired immunodeficiency syndrome.

Husson RN, Ross LA, Sandelli S, Inderlied CB, Venzon D, Lewis LL, Woods L, Conville PS, Witebsky FG, Pizzo PA.

J Pediatr. 1994 May;124(5 Pt 1):807-14.


Zidovudine and didanosine combination therapy in children with human immunodeficiency virus infection.

Husson RN, Mueller BU, Farley M, Woods L, Kovacs A, Goldsmith JC, Ono J, Lewis LL, Balis FM, Brouwers P, et al.

Pediatrics. 1994 Feb;93(2):316-22.


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