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The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.

Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL.

Immunity. 2018 Nov 20;49(5):829-841.e6. doi: 10.1016/j.immuni.2018.09.007. Epub 2018 Oct 30.


Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands.

Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL.

J Biol Chem. 2016 Dec 2;291(49):25292-25305. Epub 2016 Oct 5.


Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.

Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8373-8. doi: 10.1073/pnas.1504971112. Epub 2015 Jun 8.


Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1517-22. doi: 10.1073/pnas.1424829112. Epub 2015 Jan 20.


Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes.

Reche PA, Keskin DB, Hussey RE, Ancuta P, Gabuzda D, Reinherz EL.

Med Immunol. 2006 May 18;5:1. doi: 10.1186/1476-9433-5-1.


Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies.

Kim M, Yang H, Kim SK, Reche PA, Tirabassi RS, Hussey RE, Chishti Y, Rheinwald JG, Morehead TJ, Zech T, Damon IK, Welsh RM, Reinherz EL.

J Biol Chem. 2004 Jun 11;279(24):25838-48. Epub 2004 Apr 7.


Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.

Fiorini E, Schmitz I, Marissen WE, Osborn SL, Touma M, Sasada T, Reche PA, Tibaldi EV, Hussey RE, Kruisbeek AM, Reinherz EL, Clayton LK.

Mol Cell. 2002 Mar;9(3):637-48.


The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments.

Kim M, Chen B, Hussey RE, Chishti Y, Montefiori D, Hoxie JA, Byron O, Campbell G, Harrison SC, Reinherz EL.

J Biol Chem. 2001 Nov 16;276(46):42667-76. Epub 2001 Sep 5.


A critical role for p59(fyn) in CD2-based signal transduction.

Fukai I, Hussey RE, Sunder-Plassmann R, Reinherz EL.

Eur J Immunol. 2000 Dec;30(12):3507-15.


Expression, purification, and characterization of gp160e, the soluble, trimeric ectodomain of the simian immunodeficiency virus envelope glycoprotein, gp160.

Chen B, Zhou G, Kim M, Chishti Y, Hussey RE, Ely B, Skehel JJ, Reinherz EL, Harrison SC, Wiley DC.

J Biol Chem. 2000 Nov 10;275(45):34946-53.


The crystal structure of a T cell receptor in complex with peptide and MHC class II.

Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, Wang J.

Science. 1999 Dec 3;286(5446):1913-21.


Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers.

Kern P, Hussey RE, Spoerl R, Reinherz EL, Chang HC.

J Biol Chem. 1999 Sep 17;274(38):27237-43.


A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.

Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL.

EMBO J. 1998 Dec 15;17(24):7320-36.


Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.

Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH.

Immunity. 1998 Oct;9(4):519-30.


Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes.

Teng MK, Smolyar A, Tse AG, Liu JH, Liu J, Hussey RE, Nathenson SG, Chang HC, Reinherz EL, Wang JH.

Curr Biol. 1998 Mar 26;8(7):409-12.


Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.

Wang J, Lim K, Smolyar A, Teng M, Liu J, Tse AG, Liu J, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang HC, Sacchettini JC, Reinherz EL.

EMBO J. 1998 Jan 2;17(1):10-26.


Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection.

Ghendler Y, Hussey RE, Witte T, Mizoguchi E, Clayton LK, Bhan AK, Koyasu S, Chang HC, Reinherz EL.

Eur J Immunol. 1997 Sep;27(9):2279-89.


Crystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment.

Liu J, Tse AG, Chang HC, Liu Jh, Wang J, Hussey RE, Chishti Y, Rheinhold B, Spoerl R, Nathenson SG, Sacchettini JC, Reinherz EL.

J Biol Chem. 1996 Dec 27;271(52):33639-46.


Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.

Koyasu S, Tse AG, Moingeon P, Hussey RE, Mildonian A, Hannisian J, Clayton LK, Reinherz EL.

Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6693-7.


Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.

Koyasu S, Hussey RE, Clayton LK, Lerner A, Pedersen R, Delany-Heiken P, Chau F, Reinherz EL.

EMBO J. 1994 Feb 15;13(4):784-97.


Overexpression of CD3 eta during thymic development does not alter the negative selection process.

Hussey RE, Clayton LK, Diener A, McConkey DJ, Howard FD, Rodewald HR, D'Adamio L, Dallenbach F, Stein H, Schmidt EV, et al.

J Immunol. 1993 Feb 15;150(4):1183-94.


T-cell-receptor isoforms.

Clayton LK, Lerner A, Diener AC, Hussey RE, Koyasu S, Reinherz EL.

Int J Cancer Suppl. 1992;7:1-5. Review.


A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties.

Novotny J, Ganju RK, Smiley ST, Hussey RE, Luther MA, Recny MA, Siliciano RF, Reinherz EL.

Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8646-50.


CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development.

Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL.

Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5202-6.


Structural and binding analysis of a two domain extracellular CD2 molecule.

Sayre PH, Hussey RE, Chang HC, Ciardelli TL, Reinherz EL.

J Exp Med. 1989 Mar 1;169(3):995-1009.


Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding.

Clayton LK, Hussey RE, Steinbrich R, Ramachandran H, Husain Y, Reinherz EL.

Nature. 1988 Sep 22;335(6188):363-6.


Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain.

Richardson NE, Brown NR, Hussey RE, Vaid A, Matthews TJ, Bolognesi DP, Reinherz EL.

Proc Natl Acad Sci U S A. 1988 Aug;85(16):6102-6.


Adhesion domain of human T11 (CD2) is encoded by a single exon.

Richardson NE, Chang HC, Brown NR, Hussey RE, Sayre PH, Reinherz EL.

Proc Natl Acad Sci U S A. 1988 Jul;85(14):5176-80.


A soluble CD4 protein selectively inhibits HIV replication and syncytium formation.

Hussey RE, Richardson NE, Kowalski M, Brown NR, Chang HC, Siliciano RF, Dorfman T, Walker B, Sodroski J, Reinherz EL.

Nature. 1988 Jan 7;331(6151):78-81.


Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.

Sayre PH, Chang HC, Hussey RE, Brown NR, Richardson NE, Spagnoli G, Clayton LK, Reinherz EL.

Proc Natl Acad Sci U S A. 1987 May;84(9):2941-5.


Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.

Ritz J, Campen TJ, Schmidt RE, Royer HD, Hercend T, Hussey RE, Reinherz EL.

Science. 1985 Jun 28;228(4707):1540-3.


Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

Fox DA, Hussey RE, Fitzgerald KA, Bensussan A, Daley JF, Schlossman SF, Reinherz EL.

J Immunol. 1985 Jan;134(1):330-5.


T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2.

Bensussan A, Acuto O, Hussey RE, Milanese C, Reinherz EL.

Nature. 1984 Oct 11-17;311(5986):565-7.


Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.

Fox DA, Hussey RE, Fitzgerald KA, Acuto O, Poole C, Palley L, Daley JF, Schlossman SF, Reinherz EL.

J Immunol. 1984 Sep;133(3):1250-6.


An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.

Meuer SC, Hussey RE, Fabbi M, Fox D, Acuto O, Fitzgerald KA, Hodgdon JC, Protentis JP, Schlossman SF, Reinherz EL.

Cell. 1984 Apr;36(4):897-906.


Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

Meuer SC, Hussey RE, Cantrell DA, Hodgdon JC, Schlossman SF, Smith KA, Reinherz EL.

Proc Natl Acad Sci U S A. 1984 Mar;81(5):1509-13.


Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes.

Meuer SC, Cooper DA, Hodgdon JC, Hussey RE, Fitzgerald KA, Schlossman SF, Reinherz EL.

Science. 1983 Dec 16;222(4629):1239-42.


The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors.

Acuto O, Hussey RE, Fitzgerald KA, Protentis JP, Meuer SC, Schlossman SF, Reinherz EL.

Cell. 1983 Oct;34(3):717-26.


Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

Meuer SC, Hodgdon JC, Hussey RE, Protentis JP, Schlossman SF, Reinherz EL.

J Exp Med. 1983 Sep 1;158(3):988-93.


Immunoregulatory human T lymphocytes triggered as a consequence of viral infection: clonal analysis of helper, suppressor inducer and suppressor effector cell populations.

Meuer SC, Cooper DA, Hodgdon JC, Hussey RE, Morimoto C, Schlossman SF, Reinherz EL.

J Immunol. 1983 Sep;131(3):1167-72.


Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

Reinherz EL, Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Acuto O, Schlossman SF.

Proc Natl Acad Sci U S A. 1983 Jul;80(13):4104-8.


Human cytotoxic T cell clones directed at autologous virus-transformed targets: further evidence for linkage of genetic restriction to T4 and T8 surface glycoproteins.

Meuer SC, Hodgdon JC, Cooper DA, Hussey RE, Fitzgerald KA, Schlossman SF, Reinherz EL.

J Immunol. 1983 Jul;131(1):186-90.


Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor.

Meuer SC, Acuto O, Hussey RE, Hodgdon JC, Fitzgerald KA, Schlossman SF, Reinherz EL.

Nature. 1983 Jun 30;303(5920):808-10.


Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Schlossman SF, Reinherz EL.

J Exp Med. 1983 Feb 1;157(2):705-19.


Surface structures involved in target recognition by human cytotoxic T lymphocytes.

Meuer SC, Hussey RE, Hodgdon JC, Hercend T, Schlossman SF, Reinherz EL.

Science. 1982 Oct 29;218(4571):471-3.


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