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CD200R1 regulates eosinophilia during pulmonary fungal infection in mice.

Salek-Ardakani S, Bell T, Jagger CP, Snelgrove RJ, Hussell T.

Eur J Immunol. 2019 Jul 31. doi: 10.1002/eji.201847861. [Epub ahead of print]


Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

Fujino N, Brand OJ, Morgan DJ, Fujimori T, Grabiec AM, Jagger CP, Maciewicz RA, Yamada M, Itakura K, Sugiura H, Ichinose M, Hussell T.

J Exp Med. 2019 Jul 9. pii: jem.20171978. doi: 10.1084/jem.20171978. [Epub ahead of print]


CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality.

Casulli J, Fife ME, Houston SA, Rossi S, Dow J, Williamson ED, Clark GC, Hussell T, D'Elia RV, Travis MA.

Nat Commun. 2019 May 9;10(1):2121. doi: 10.1038/s41467-019-10156-6.


The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.

Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS.

Nat Immunol. 2019 May;20(5):571-580. doi: 10.1038/s41590-019-0352-y. Epub 2019 Apr 1.


Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.

Zhang Z, Hunter L, Wu G, Maidstone R, Mizoro Y, Vonslow R, Fife M, Hopwood T, Begley N, Saer B, Wang P, Cunningham P, Baxter M, Durrington H, Blaikley JF, Hussell T, Rattray M, Hogenesch JB, Gibbs J, Ray DW, Loudon ASI.

FASEB J. 2019 May;33(5):6226-6238. doi: 10.1096/fj.201801682R. Epub 2019 Feb 22.


Endothelin-1 mediates Aspergillus fumigatus-induced airway inflammation and remodelling.

Labram B, Namvar S, Hussell T, Herrick SE.

Clin Exp Allergy. 2019 Jun;49(6):861-873. doi: 10.1111/cea.13367. Epub 2019 Mar 18.


Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia.

Morgan DJ, Casulli J, Chew C, Connolly E, Lui S, Brand OJ, Rahman R, Jagger C, Hussell T.

Front Immunol. 2018 Dec 14;9:2943. doi: 10.3389/fimmu.2018.02943. eCollection 2018. Review.


Mycobacterium tuberculosis Joyrides Alveolar Macrophages into the Pulmonary Interstitium.

Goenka A, Casulli J, Hussell T.

Cell Host Microbe. 2018 Sep 12;24(3):331-333. doi: 10.1016/j.chom.2018.08.011.


An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.


The consequence of matrix dysfunction on lung immunity and the microbiome in COPD.

Hussell T, Lui S, Jagger C, Morgan D, Brand O.

Eur Respir Rev. 2018 Jun 27;27(148). pii: 180032. doi: 10.1183/16000617.0032-2018. Print 2018 Jun 30.


Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis.

Bell TJ, Brand OJ, Morgan DJ, Salek-Ardakani S, Jagger C, Fujimori T, Cholewa L, Tilakaratna V, Östling J, Thomas M, Day AJ, Snelgrove RJ, Hussell T.

Matrix Biol. 2019 Jul;80:14-28. doi: 10.1016/j.matbio.2018.06.006. Epub 2018 Jun 20.


VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy.

Fletcher HA, Chatterjee M, Cooper A, Hussell T, Kaye PM, Prior J, Reljic R, Vermaak S, Vordermeier M, Williams A, McShane H.

F1000Res. 2018 Apr 23;7:485. doi: 10.12688/f1000research.14386.1. eCollection 2018.


Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways.

Villeneuve DL, Landesmann B, Allavena P, Ashley N, Bal-Price A, Corsini E, Halappanavar S, Hussell T, Laskin D, Lawrence T, Nikolic-Paterson D, Pallardy M, Paini A, Pieters R, Roth R, Tschudi-Monnet F.

Toxicol Sci. 2018 Jun 1;163(2):346-352. doi: 10.1093/toxsci/kfy047. Review.


Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers.

Grabiec AM, Goenka A, Fife ME, Fujimori T, Hussell T.

Eur J Immunol. 2018 May;48(5):855-860. doi: 10.1002/eji.201747283. Epub 2018 Feb 22.


Progress and prospects of early detection in lung cancer.

Blandin Knight S, Crosbie PA, Balata H, Chudziak J, Hussell T, Dive C.

Open Biol. 2017 Sep;7(9). pii: 170070. doi: 10.1098/rsob.170070. Review.


Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Grabiec AM, Denny N, Doherty JA, Happonen KE, Hankinson J, Connolly E, Fife ME, Fujimori T, Fujino N, Goenka A, Holden S, Tavernier G, Shah R, Cook PC, MacDonald AS, Niven RM, Dahlbäck B, Fowler SJ, Simpson A, Hussell T.

J Allergy Clin Immunol. 2017 Oct;140(4):1144-1146.e4. doi: 10.1016/j.jaci.2017.03.024. Epub 2017 Apr 12. No abstract available.


Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors.

Weiss G, Lai C, Fife ME, Grabiec AM, Tildy B, Snelgrove RJ, Xin G, Lloyd CM, Hussell T.

Mucosal Immunol. 2017 Jul;10(4):1021-1030. doi: 10.1038/mi.2016.104. Epub 2016 Dec 14.


Immunopathology of lung diseases: introduction for the special issue.

Hussell T, Grabiec AM.

Semin Immunopathol. 2016 Jul;38(4):407-8. doi: 10.1007/s00281-016-0572-2. Epub 2016 May 19. No abstract available.


Heterologous immunity meets tissue-specific training.

Hussell T.

Nat Rev Immunol. 2016 May;16(5):275. doi: 10.1038/nri.2016.41. Epub 2016 Apr 4. No abstract available.


The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation.

Grabiec AM, Hussell T.

Semin Immunopathol. 2016 Jul;38(4):409-23. doi: 10.1007/s00281-016-0555-3. Epub 2016 Mar 8. Review.


TLR vaccine adjuvants: closing the stable door before novel influenza strains bolt?

Hussell T, Goenka A.

Immunol Cell Biol. 2016 Jan;94(1):1-2. doi: 10.1038/icb.2015.92. Epub 2015 Nov 17. No abstract available.


Macrophage adaptation in airway inflammatory resolution.

Kaur M, Bell T, Salek-Ardakani S, Hussell T.

Eur Respir Rev. 2015 Sep;24(137):510-5. doi: 10.1183/16000617.0030-2015. Review.


Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection.

Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T.

J Neuroimmunol. 2015 May 15;282:97-103. doi: 10.1016/j.jneuroim.2015.04.001. Epub 2015 Apr 2.


CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.

Stack G, Jones E, Marsden M, Stacey MA, Snelgrove RJ, Lacaze P, Jacques LC, Cuff SM, Stanton RJ, Gallimore AM, Hussell T, Wilkinson GW, Ghazal P, Taylor PR, Humphreys IR.

PLoS Pathog. 2015 Feb 5;11(2):e1004641. doi: 10.1371/journal.ppat.1004641. eCollection 2015 Feb.


The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

Fujimori T, Grabiec AM, Kaur M, Bell TJ, Fujino N, Cook PC, Svedberg FR, MacDonald AS, Maciewicz RA, Singh D, Hussell T.

Mucosal Immunol. 2015 Sep;8(5):1021-1030. doi: 10.1038/mi.2014.129. Epub 2015 Jan 21.


Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.

Jolly L, Stavrou A, Vanderstoken G, Meliopoulos VA, Habgood A, Tatler AL, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli MR, Schultz-Cherry S, Jenkins G.

J Biol Chem. 2014 Dec 19;289(51):35246-63. doi: 10.1074/jbc.M114.582262. Epub 2014 Oct 22.


Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

Elderfield RA, Watson SJ, Godlee A, Adamson WE, Thompson CI, Dunning J, Fernandez-Alonso M, Blumenkrantz D, Hussell T; MOSAIC Investigators, Zambon M, Openshaw P, Kellam P, Barclay WS.

J Virol. 2014 Nov;88(22):13269-83. doi: 10.1128/JVI.01636-14. Epub 2014 Sep 10.


An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.

Gibbs J, Ince L, Matthews L, Mei J, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud M, Farrow S, DeMayo F, Hussell T, Worthen GS, Ray D, Loudon A.

Nat Med. 2014 Aug;20(8):919-26. doi: 10.1038/nm.3599. Epub 2014 Jul 27.


OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

Gwyer Findlay E, Danks L, Madden J, Cavanagh MM, McNamee K, McCann F, Snelgrove RJ, Shaw S, Feldmann M, Taylor PC, Horwood NJ, Hussell T.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2289-94. doi: 10.1073/pnas.1321071111. Epub 2014 Jan 27.


Alveolar macrophages: plasticity in a tissue-specific context.

Hussell T, Bell TJ.

Nat Rev Immunol. 2014 Feb;14(2):81-93. doi: 10.1038/nri3600. Epub 2014 Jan 21. Review.


Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

Van Maele L, Fougeron D, Janot L, Didierlaurent A, Cayet D, Tabareau J, Rumbo M, Corvo-Chamaillard S, Boulenouar S, Jeffs S, Vande Walle L, Lamkanfi M, Lemoine Y, Erard F, Hot D, Hussell T, Ryffel B, Benecke AG, Sirard JC.

Mucosal Immunol. 2014 May;7(3):489-500. doi: 10.1038/mi.2013.66. Epub 2013 Sep 25.


Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice.

Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T.

Crit Care Med. 2013 Jul;41(7):1627-36. doi: 10.1097/CCM.0b013e31827c0c8d.


Bacterial superinfection following lung inflammatory disorders.

Habibzay M, Weiss G, Hussell T.

Future Microbiol. 2013 Feb;8(2):247-56. doi: 10.2217/fmb.12.143. Review.


Macrophage-mediated inflammation and disease: a focus on the lung.

Gwyer Findlay E, Hussell T.

Mediators Inflamm. 2012;2012:140937. doi: 10.1155/2012/140937. Epub 2012 Dec 12. Review.


Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice.

Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T.

Influenza Other Respir Viruses. 2013 Nov;7(6):895-9. doi: 10.1111/irv.12066. Epub 2012 Dec 24.


Respiratory viral infections: knowledge based therapeutics.

Hussell T, Godlee A, Salek-Ardakani S, Snelgrove RJ.

Curr Opin Immunol. 2012 Aug;24(4):438-43. doi: 10.1016/j.coi.2012.06.001. Epub 2012 Jul 5. Review.


The microbiology of asthma.

Edwards MR, Bartlett NW, Hussell T, Openshaw P, Johnston SL.

Nat Rev Microbiol. 2012 Jun 6;10(7):459-71. doi: 10.1038/nrmicro2801. Review.


Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung.

Habibzay M, Saldana JI, Goulding J, Lloyd CM, Hussell T.

Mucosal Immunol. 2012 Sep;5(5):524-34. doi: 10.1038/mi.2012.28. Epub 2012 May 2.


Immune modulatory strategies: a playground with a swing and a seesaw.

Hussell T.

Expert Rev Anti Infect Ther. 2012 Mar;10(3):249-51. doi: 10.1586/eri.12.12. No abstract available.


OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection.

Snelgrove RJ, Cornere MM, Edwards L, Dagg B, Keeble J, Rodgers A, Lyonga DE, Stewart GR, Young DB, Walker B, Hussell T.

J Infect Dis. 2012 Mar 15;205(6):975-83. doi: 10.1093/infdis/jir868. Epub 2012 Feb 7.


Epidemiological isolation causing variable mortality in Island populations during the 1918-1920 influenza pandemic.

Shanks GD, Hussell T, Brundage JF.

Influenza Other Respir Viruses. 2012 Nov;6(6):417-23. doi: 10.1111/j.1750-2659.2011.00332.x. Epub 2012 Jan 6.


Sedation & immunomodulation.

Sanders RD, Hussell T, Maze M.

Anesthesiol Clin. 2011 Dec;29(4):687-706. doi: 10.1016/j.anclin.2011.09.008.


IL-17 boosts proinflammatory outcome of antiviral response in human cells.

Ryzhakov G, Lai CC, Blazek K, To KW, Hussell T, Udalova I.

J Immunol. 2011 Nov 15;187(10):5357-62. doi: 10.4049/jimmunol.1100917. Epub 2011 Sep 30.


Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection.

Goulding J, Godlee A, Vekaria S, Hilty M, Snelgrove R, Hussell T.

J Infect Dis. 2011 Oct 1;204(7):1086-94. doi: 10.1093/infdis/jir467.


Airway immune homeostasis and implications for influenza-induced inflammation.

Snelgrove RJ, Godlee A, Hussell T.

Trends Immunol. 2011 Jul;32(7):328-34. doi: 10.1016/ Epub 2011 May 24. Review.


IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M, Udalova IA.

Nat Immunol. 2011 Mar;12(3):231-8. doi: 10.1038/ni.1990. Epub 2011 Jan 16.


A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.

Snelgrove RJ, Jackson PL, Hardison MT, Noerager BD, Kinloch A, Gaggar A, Shastry S, Rowe SM, Shim YM, Hussell T, Blalock JE.

Science. 2010 Oct 1;330(6000):90-4. doi: 10.1126/science.1190594. Epub 2010 Sep 2.


Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.

Peirce MJ, Brook M, Morrice N, Snelgrove R, Begum S, Lanfrancotti A, Notley C, Hussell T, Cope AP, Wait R.

PLoS One. 2010 Jul 13;5(7):e11465. doi: 10.1371/journal.pone.0011465.


Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.

Drexler SK, Wales J, Andreakos E, Kong P, Davis A, Garlanda C, Mantovani A, Hussell T, Feldmann M, Foxwell BM.

Scand J Immunol. 2010 Jun;71(6):393-402. doi: 10.1111/j.1365-3083.2010.02392.x.


Structured regulation of inflammation during respiratory viral infection.

Hussell T, Goulding J.

Lancet Infect Dis. 2010 May;10(5):360-6. doi: 10.1016/S1473-3099(10)70067-0.


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