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Items: 28

1.

Evaluation of a noncanonical Cys40-Cys55 disulfide linkage for stabilization of single-domain antibodies.

Kim DY, Kandalaft H, Hussack G, Raphael S, Ding W, Kelly JF, Henry KA, Tanha J.

Protein Sci. 2019 May;28(5):881-888. doi: 10.1002/pro.3595. Epub 2019 Mar 14.

PMID:
30803088
2.

Modulating antibody-dependent cellular cytotoxicity of epidermal growth factor receptor-specific heavy-chain antibodies through hinge engineering.

D'Eall C, Pon RA, Rossotti MA, Krahn N, Spearman M, Callaghan D, van Faassen H, Hussack G, Stetefeld J, Butler M, Durocher Y, Zhang J, Henry KA, Tanha J.

Immunol Cell Biol. 2019 Jan 25. doi: 10.1111/imcb.12238. [Epub ahead of print]

PMID:
30680791
3.

Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains.

Hussack G, Ryan S, van Faassen H, Rossotti M, MacKenzie CR, Tanha J.

PLoS One. 2018 Dec 12;13(12):e0208978. doi: 10.1371/journal.pone.0208978. eCollection 2018.

4.

Isolation and characterization of camelid single-domain antibodies against HER2.

Hussack G, Raphael S, Lowden MJ, Henry KA.

BMC Res Notes. 2018 Dec 5;11(1):866. doi: 10.1186/s13104-018-3955-8.

5.

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling.

Rossotti MA, Henry KA, van Faassen H, Tanha J, Callaghan D, Hussack G, Arbabi-Ghahroudi M, MacKenzie CR.

Biochem J. 2019 Jan 7;476(1):39-50. doi: 10.1042/BCJ20180795.

PMID:
30455372
6.

Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody.

Sulea T, Hussack G, Ryan S, Tanha J, Purisima EO.

Sci Rep. 2018 Feb 2;8(1):2260. doi: 10.1038/s41598-018-20599-4.

7.

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries.

Henry KA, Kim DY, Kandalaft H, Lowden MJ, Yang Q, Schrag JD, Hussack G, MacKenzie CR, Tanha J.

Front Immunol. 2017 Dec 12;8:1759. doi: 10.3389/fimmu.2017.01759. eCollection 2017.

8.

A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display.

Hussack G, Baral TN, Baardsnes J, van Faassen H, Raphael S, Henry KA, Zhang J, MacKenzie CR.

Front Immunol. 2017 Oct 30;8:1406. doi: 10.3389/fimmu.2017.01406. eCollection 2017.

9.

A disulfide-stabilized human VL single-domain antibody library is a source of soluble and highly thermostable binders.

Henry KA, Kandalaft H, Lowden MJ, Rossotti MA, van Faassen H, Hussack G, Durocher Y, Kim DY, Tanha J.

Mol Immunol. 2017 Oct;90:190-196. doi: 10.1016/j.molimm.2017.07.006. Epub 2017 Aug 15.

PMID:
28820969
10.

A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies.

Henry KA, Sulea T, van Faassen H, Hussack G, Purisima EO, MacKenzie CR, Arbabi-Ghahroudi M.

PLoS One. 2016 Sep 15;11(9):e0163113. doi: 10.1371/journal.pone.0163113. eCollection 2016.

11.

Isolation of TGF-β-neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing.

Henry KA, Hussack G, Collins C, Zwaagstra JC, Tanha J, MacKenzie CR.

Protein Eng Des Sel. 2016 Oct;29(10):439-443. doi: 10.1093/protein/gzw043. Epub 2016 Sep 8.

PMID:
27613412
12.

An update on antibody-based immunotherapies for Clostridium difficile infection.

Hussack G, Tanha J.

Clin Exp Gastroenterol. 2016 Aug 1;9:209-24. doi: 10.2147/CEG.S84017. eCollection 2016. Review.

13.

Identification of cross-reactive single-domain antibodies against serum albumin using next-generation DNA sequencing.

Henry KA, Tanha J, Hussack G.

Protein Eng Des Sel. 2015 Oct;28(10):379-83. doi: 10.1093/protein/gzv039. Epub 2015 Aug 27.

PMID:
26319004
14.

Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease.

Kandalaft H, Hussack G, Aubry A, van Faassen H, Guan Y, Arbabi-Ghahroudi M, MacKenzie R, Logan SM, Tanha J.

Appl Microbiol Biotechnol. 2015 Oct;99(20):8549-62. doi: 10.1007/s00253-015-6594-1. Epub 2015 May 5.

15.

Mutational approaches to improve the biophysical properties of human single-domain antibodies.

Kim DY, Hussack G, Kandalaft H, Tanha J.

Biochim Biophys Acta. 2014 Nov;1844(11):1983-2001. doi: 10.1016/j.bbapap.2014.07.008. Epub 2014 Jul 24. Review.

PMID:
25065345
16.

Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility.

Hussack G, Riazi A, Ryan S, van Faassen H, MacKenzie R, Tanha J, Arbabi-Ghahroudi M.

Protein Eng Des Sel. 2014 Jun;27(6):191-8. doi: 10.1093/protein/gzu011. Epub 2014 Apr 16.

PMID:
24742504
17.

Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile.

Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK.

J Biol Chem. 2014 Jan 24;289(4):2331-43. doi: 10.1074/jbc.M113.505917. Epub 2013 Dec 5.

18.

Characterization of single-domain antibodies with an engineered disulfide bond.

Hussack G, Mackenzie CR, Tanha J.

Methods Mol Biol. 2012;911:417-29. doi: 10.1007/978-1-61779-968-6_25.

PMID:
22886266
19.

Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies.

Hussack G, Arbabi-Ghahroudi M, Mackenzie CR, Tanha J.

Methods Mol Biol. 2012;911:211-39. doi: 10.1007/978-1-61779-968-6_14.

PMID:
22886255
20.

Modulation of toxin production by the flagellar regulon in Clostridium difficile.

Aubry A, Hussack G, Chen W, KuoLee R, Twine SM, Fulton KM, Foote S, Carrillo CD, Tanha J, Logan SM.

Infect Immun. 2012 Oct;80(10):3521-32. doi: 10.1128/IAI.00224-12. Epub 2012 Jul 30.

21.

A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders.

Hussack G, Keklikian A, Alsughayyir J, Hanifi-Moghaddam P, Arbabi-Ghahroudi M, van Faassen H, Hou ST, Sad S, MacKenzie R, Tanha J.

Protein Eng Des Sel. 2012 Jun;25(6):313-8. doi: 10.1093/protein/gzs014. Epub 2012 Apr 6.

PMID:
22490957
22.

Engineered single-domain antibodies with high protease resistance and thermal stability.

Hussack G, Hirama T, Ding W, Mackenzie R, Tanha J.

PLoS One. 2011;6(11):e28218. doi: 10.1371/journal.pone.0028218. Epub 2011 Nov 30.

23.

Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain.

Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, MacKenzie R, Tanha J.

J Biol Chem. 2011 Mar 18;286(11):8961-76. doi: 10.1074/jbc.M110.198754. Epub 2011 Jan 7.

24.

Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives.

Hussack G, Tanha J.

Toxins (Basel). 2010 May;2(5):998-1018. doi: 10.3390/toxins2050998. Epub 2010 May 7. Review.

25.

Purification of plant-derived antibodies through direct immobilization of affinity ligands on cellulose.

Hussack G, Grohs BM, Almquist KC, McLean MD, Ghosh R, Hall JC.

J Agric Food Chem. 2010 Mar 24;58(6):3451-9. doi: 10.1021/jf9040657.

PMID:
20170183
26.

Intracellular expression of a single domain antibody reduces cytotoxicity of 15-acetyldeoxynivalenol in yeast.

Doyle PJ, Saeed H, Hermans A, Gleddie SC, Hussack G, Arbabi-Ghahroudi M, Seguin C, Savard ME, Mackenzie CR, Hall JC.

J Biol Chem. 2009 Dec 11;284(50):35029-39. doi: 10.1074/jbc.M109.045047. Epub 2009 Sep 25.

27.

Multivalent anchoring and oriented display of single-domain antibodies on cellulose.

Hussack G, Luo Y, Veldhuis L, Hall JC, Tanha J, Mackenzie R.

Sensors (Basel). 2009;9(7):5351-67. doi: 10.3390/s90705351. Epub 2009 Jul 7.

28.

Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases.

Komatsu N, Saijoh K, Toyama T, Ohka R, Otsuki N, Hussack G, Takehara K, Diamandis EP.

Br J Dermatol. 2005 Aug;153(2):274-81.

PMID:
16086736

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