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Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing.

Tamzalit F, Tran D, Jin W, Boyko V, Bazzi H, Kepecs A, Kam LC, Anderson KV, Huse M.

Proc Natl Acad Sci U S A. 2020 Feb 10. pii: 201913220. doi: 10.1073/pnas.1913220117. [Epub ahead of print]


Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell-target interactions.

Vorselen D, Wang Y, de Jesus MM, Shah PK, Footer MJ, Huse M, Cai W, Theriot JA.

Nat Commun. 2020 Jan 7;11(1):20. doi: 10.1038/s41467-019-13804-z.


T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces.

Jin W, Tamzalit F, Chaudhuri PK, Black CT, Huse M, Kam LC.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19835-19840. doi: 10.1073/pnas.1906986116. Epub 2019 Sep 16.


Actin clearance promotes polarized dynein accumulation at the immunological synapse.

Sanchez E, Liu X, Huse M.

PLoS One. 2019 Jul 3;14(7):e0210377. doi: 10.1371/journal.pone.0210377. eCollection 2019.


Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells.

Adams NM, Geary CD, Santosa EK, Lumaquin D, Le Luduec JB, Sottile R, van der Ploeg K, Hsu J, Whitlock BM, Jackson BT, Weizman OE, Huse M, Hsu KC, Sun JC.

Immunity. 2019 Jun 18;50(6):1381-1390.e5. doi: 10.1016/j.immuni.2019.04.009. Epub 2019 May 15.


CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape.

Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, Li Z, Cunanan KM, Huse M, Hendrickson RC, Wang X, Rivière I, Sadelain M.

Nature. 2019 Apr;568(7750):112-116. doi: 10.1038/s41586-019-1054-1. Epub 2019 Mar 27.


Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells.

Tamzalit F, Wang MS, Jin W, Tello-Lafoz M, Boyko V, Heddleston JM, Black CT, Kam LC, Huse M.

Sci Immunol. 2019 Mar 22;4(33). pii: eaav5445. doi: 10.1126/sciimmunol.aav5445.


Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist.

Sanchez E, Huse M.

J Vis Exp. 2018 Apr 25;(134). doi: 10.3791/56655.


Mechanical forces in the immune system.

Huse M.

Nat Rev Immunol. 2017 Nov;17(11):679-690. doi: 10.1038/nri.2017.74. Epub 2017 Jul 31. Review.


Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.

Tello-Lafoz M, Martínez-Martínez G, Rodríguez-Rodríguez C, Albar JP, Huse M, Gharbi S, Merida I.

Traffic. 2017 Aug;18(8):491-504. doi: 10.1111/tra.12492. Epub 2017 Jun 29.


A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O.

Immunity. 2017 Apr 18;46(4):609-620. doi: 10.1016/j.immuni.2017.03.011. Epub 2017 Apr 4.


Correction: Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse.

Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M.

J Exp Med. 2017 Apr 3;214(4):1203. doi: 10.1084/jem.2013132403102017c. Epub 2017 Mar 14. No abstract available.


Probing Synaptic Biomechanics Using Micropillar Arrays.

Jin W, Black CT, Kam LC, Huse M.

Methods Mol Biol. 2017;1584:333-346. doi: 10.1007/978-1-4939-6881-7_19.


Mechanical Communication at the Immunological Synapse.

Basu R, Huse M.

Trends Cell Biol. 2017 Apr;27(4):241-254. doi: 10.1016/j.tcb.2016.10.005. Epub 2016 Dec 13. Review.


Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors.

Cheng M, Santich BH, Xu H, Ahmed M, Huse M, Cheung NK.

Oncoimmunology. 2016 May 5;5(6):e1168557. doi: 10.1080/2162402X.2016.1168557. eCollection 2016 Jun.


Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing.

Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M.

Cell. 2016 Mar 24;165(1):100-110. doi: 10.1016/j.cell.2016.01.021. Epub 2016 Feb 25.


Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells.

Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, Toure A, Pritykin Y, Huse M, Leslie CS, Li MO.

Cell. 2016 Jan 28;164(3):365-77. doi: 10.1016/j.cell.2016.01.002. Epub 2016 Jan 21.


A Generalizable Platform for the Photoactivation of Cell Surface Receptors.

Duc TN, Huse M.

ACS Chem Biol. 2015 Nov 20;10(11):2435-40. doi: 10.1021/acschembio.5b00372. Epub 2015 Aug 28.


Retargeting T cells to GD2 pentasaccharide on human tumors using Bispecific humanized antibody.

Xu H, Cheng M, Guo H, Chen Y, Huse M, Cheung NK.

Cancer Immunol Res. 2015 Mar;3(3):266-77. doi: 10.1158/2326-6066.CIR-14-0230-T. Epub 2014 Dec 26.


Lipid-based patterning of the immunological synapse.

Huse M.

Biochem Soc Trans. 2014 Dec;42(6):1506-11. doi: 10.1042/BST20140191. Review.


Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse.

Le Floc'h A, Huse M.

Cell Mol Life Sci. 2015 Feb;72(3):537-556. doi: 10.1007/s00018-014-1760-7. Epub 2014 Oct 30. Review.


Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

Chauveau A, Le Floc'h A, Bantilan NS, Koretzky GA, Huse M.

Sci Signal. 2014 Aug 26;7(340):ra82. doi: 10.1126/scisignal.2005287.


The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse.

Basu R, Chen Y, Quann EJ, Huse M.

PLoS One. 2014 Apr 21;9(4):e95531. doi: 10.1371/journal.pone.0095531. eCollection 2014.


CD28 and CD3 have complementary roles in T-cell traction forces.

Bashour KT, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2241-6. doi: 10.1073/pnas.1315606111. Epub 2014 Jan 27.


Inhibitory receptor signaling destabilizes immunological synapse formation in primary NK cells.

Abeyweera TP, Kaissar M, Huse M.

Front Immunol. 2013 Nov 27;4:410. doi: 10.3389/fimmu.2013.00410. eCollection 2013.


Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse.

Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M.

J Exp Med. 2013 Nov 18;210(12):2721-37. doi: 10.1084/jem.20131324. Epub 2013 Nov 4. Erratum in: J Exp Med. 2017 Apr 3;214(4):1203.


From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells.

Huse M, Le Floc'h A, Liu X.

Immunol Rev. 2013 Nov;256(1):95-106. doi: 10.1111/imr.12116. Review.


Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II.

Liu X, Kapoor TM, Chen JK, Huse M.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11976-81. doi: 10.1073/pnas.1306180110. Epub 2013 Jul 1.


IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.

Gasteiger G, Hemmers S, Firth MA, Le Floc'h A, Huse M, Sun JC, Rudensky AY.

J Exp Med. 2013 Jun 3;210(6):1167-78. doi: 10.1084/jem.20122462. Epub 2013 May 6.


NK cell tolerance of self-specific activating receptor KIR2DS1 in individuals with cognate HLA-C2 ligand.

Pittari G, Liu XR, Selvakumar A, Zhao Z, Merino E, Huse M, Chewning JH, Hsu KC, Dupont B.

J Immunol. 2013 May 1;190(9):4650-60. doi: 10.4049/jimmunol.1202120. Epub 2013 Apr 3.


Board task performance: An exploration of micro- and macro-level determinants of board effectiveness.

Minichilli A, Zattoni A, Nielsen S, Huse M.

J Organ Behav. 2012 Feb;33(2):193-215. Epub 2011 Jan 4.


Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells.

Huse M, Catherine Milanoski S, Abeyweera TP.

Immunol Rev. 2013 Jan;251(1):143-53. doi: 10.1111/imr.12014. Review.


Novel Foxo1-dependent transcriptional programs control T(reg) cell function.

Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, Li MO.

Nature. 2012 Nov 22;491(7425):554-9. doi: 10.1038/nature11581. Epub 2012 Nov 7.


Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells.

Merino E, Abeyweera TP, Firth MA, Zawislak CL, Basu R, Liu X, Sun JC, Huse M.

J Immunol. 2012 Nov 15;189(10):4859-69. doi: 10.4049/jimmunol.1200825. Epub 2012 Oct 17.


Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond.

Huse M.

Front Immunol. 2012 Jul 31;3:235. doi: 10.3389/fimmu.2012.00235. eCollection 2012.


Lymphocyte polarity, the immunological synapse and the scope of biological analogy.

Huse M.

Bioarchitecture. 2011 Jul;1(4):180-185. Epub 2011 Jul 1.


A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

Quann EJ, Liu X, Altan-Bonnet G, Huse M.

Nat Immunol. 2011 May 22;12(7):647-54. doi: 10.1038/ni.2033.


Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells.

Abeyweera TP, Merino E, Huse M.

J Cell Biol. 2011 Feb 21;192(4):675-90. doi: 10.1083/jcb.201009135.


Photochemical approaches to T-cell activation.

Huse M.

Immunology. 2010 Jun;130(2):151-7. doi: 10.1111/j.1365-2567.2010.03267.x. Epub 2010 Apr 6. Review.


Evidence for a functional sidedness to the alphabetaTCR.

Kuhns MS, Girvin AT, Klein LO, Chen R, Jensen KD, Newell EW, Huppa JB, Lillemeier BF, Huse M, Chien YH, Garcia KC, Davis MM.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5094-9. doi: 10.1073/pnas.1000925107. Epub 2010 Mar 2.


Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells.

Quann EJ, Merino E, Furuta T, Huse M.

Nat Immunol. 2009 Jun;10(6):627-35. doi: 10.1038/ni.1734.


The T-cell-receptor signaling network.

Huse M.

J Cell Sci. 2009 May 1;122(Pt 9):1269-73. doi: 10.1242/jcs.042762. No abstract available.


Shouts, whispers and the kiss of death: directional secretion in T cells.

Huse M, Quann EJ, Davis MM.

Nat Immunol. 2008 Oct;9(10):1105-11. doi: 10.1038/ni.f.215. Review.


Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.

Huse M, Klein LO, Girvin AT, Faraj JM, Li QJ, Kuhns MS, Davis MM.

Immunity. 2007 Jul;27(1):76-88. Epub 2007 Jul 12.


T cells as a self-referential, sensory organ.

Davis MM, Krogsgaard M, Huse M, Huppa J, Lillemeier BF, Li QJ.

Annu Rev Immunol. 2007;25:681-95. Review.


T cells use two directionally distinct pathways for cytokine secretion.

Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM.

Nat Immunol. 2006 Mar;7(3):247-55. Epub 2006 Jan 29.


Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.

Krogsgaard M, Li QJ, Sumen C, Huppa JB, Huse M, Davis MM.

Nature. 2005 Mar 10;434(7030):238-43. Epub 2005 Feb 20.


Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase.

Ottesen JJ, Huse M, Sekedat MD, Muir TW.

Biochemistry. 2004 May 18;43(19):5698-706.


The conformational plasticity of protein kinases.

Huse M, Kuriyan J.

Cell. 2002 May 3;109(3):275-82. Review.


Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor.

Flavell RR, Huse M, Goger M, Trester-Zedlitz M, Kuriyan J, Muir TW.

Org Lett. 2002 Jan 24;4(2):165-8.


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