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Expanding the Clinical Cytometry Toolbox-Receptor Occupancy by Mass Cytometry.

Huse K.

Cytometry A. 2019 May 2. doi: 10.1002/cyto.a.23784. [Epub ahead of print] No abstract available.


Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma.

Köksal H, Dillard P, Josefsson SE, Maggadottir SM, Pollmann S, Fåne A, Blaker YN, Beiske K, Huse K, Kolstad A, Holte H, Kvalheim G, Smeland EB, Myklebust JH, Inderberg EM, Wälchli S.

Blood Adv. 2019 Apr 23;3(8):1230-1243. doi: 10.1182/bloodadvances.2018029678.


Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response.

Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM.

Cytometry A. 2019 Apr;95(4):442-449. doi: 10.1002/cyto.a.23737. Epub 2019 Mar 5.


TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma.

Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH.

Cancer Immunol Res. 2019 Mar;7(3):355-362. doi: 10.1158/2326-6066.CIR-18-0351. Epub 2019 Jan 18.


The high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) may explain naked mole-rat's distinct methionine metabolite profile compared to mouse.

Olecka M, Huse K, Platzer M.

Geroscience. 2018 Aug;40(4):359-360. doi: 10.1007/s11357-018-0035-x. Epub 2018 Aug 7. No abstract available.


Correction: The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.

Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G.

PLoS One. 2018 Mar 26;13(3):e0195169. doi: 10.1371/journal.pone.0195169. eCollection 2018.


The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.

Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G.

PLoS One. 2017 Dec 27;12(12):e0189514. doi: 10.1371/journal.pone.0189514. eCollection 2017. Erratum in: PLoS One. 2018 Mar 26;13(3):e0195169.


Haplotypes composed of minor frequency single nucleotide polymorphisms of the TNF gene protect from progression into sepsis: A study using the new sepsis classification.

Retsas T, Huse K, Lazaridis LD, Karampela N, Bauer M, Platzer M, Kolonia V, Papageorgiou E, Giamarellos-Bourboulis EJ, Dimopoulos G.

Int J Infect Dis. 2018 Feb;67:102-106. doi: 10.1016/j.ijid.2017.12.008. Epub 2017 Dec 21.


T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling.

Josefsson SE, Huse K, Kolstad A, Beiske K, Pende D, Steen CB, Inderberg EM, Lingjærde OC, Østenstad B, Smeland EB, Levy R, Irish JM, Myklebust JH.

Clin Cancer Res. 2018 Feb 15;24(4):870-881. doi: 10.1158/1078-0432.CCR-17-2337. Epub 2017 Dec 7.


Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin-like growth factor 2 imprinting control region.

Agba OB, Lausser L, Huse K, Bergmeier C, Jahn N, Groth M, Bens M, Sahm A, Gall M, Witte OW, Kestler HA, Schwab M, Platzer M.

Physiol Genomics. 2017 Nov 1;49(11):690-702. doi: 10.1152/physiolgenomics.00009.2017. Epub 2017 Sep 15.


Verification and characterization of an alternative low density lipoprotein receptor-related protein 1 splice variant.

Kolb M, Kurz S, Schäfer A, Huse K, Dietz A, Wichmann G, Birkenmeier G.

PLoS One. 2017 Jun 29;12(6):e0180354. doi: 10.1371/journal.pone.0180354. eCollection 2017.


BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5.

Bollum LK, Huse K, Oksvold MP, Bai B, Hilden VI, Forfang L, Yoon SO, Wälchli S, Smeland EB, Myklebust JH.

PLoS One. 2017 May 10;12(5):e0177188. doi: 10.1371/journal.pone.0177188. eCollection 2017.


Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations.

Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K.

Cytometry B Clin Cytom. 2017 Jan;92(1):79-87. doi: 10.1002/cyto.b.21498.


Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.

Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M.

EBioMedicine. 2016 Oct;12:227-238. doi: 10.1016/j.ebiom.2016.08.037. Epub 2016 Sep 15.


Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms.

Debebe T, Krüger M, Huse K, Kacza J, Mühlberg K, König B, Birkenmeier G.

PLoS One. 2016 Sep 22;11(9):e0162919. doi: 10.1371/journal.pone.0162919. eCollection 2016.


Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat.

Debebe T, Holtze S, Morhart M, Hildebrandt TB, Rodewald S, Huse K, Platzer M, Wyohannes D, Yirga S, Lemma A, Thieme R, König B, Birkenmeier G.

Gut Pathog. 2016 May 28;8:25. doi: 10.1186/s13099-016-0107-3. eCollection 2016.


High Copy Numbers of β-Defensin Cluster on 8p23.1, Confer Genetic Susceptibility, and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa.

Giamarellos-Bourboulis EJ, Platzer M, Karagiannidis I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K.

J Invest Dermatol. 2016 Aug;136(8):1592-1598. doi: 10.1016/j.jid.2016.04.021. Epub 2016 May 7.


Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat.

Dziegelewska M, Holtze S, Vole C, Wachter U, Menzel U, Morhart M, Groth M, Szafranski K, Sahm A, Sponholz C, Dammann P, Huse K, Hildebrandt T, Platzer M.

Redox Biol. 2016 Aug;8:192-8. doi: 10.1016/j.redox.2016.01.008. Epub 2016 Jan 14.


Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis.

Sponholz C, Kramer M, Schöneweck F, Menzel U, Inanloo Rahatloo K, Giamarellos-Bourboulis EJ, Papavassileiou V, Lymberopoulou K, Pavlaki M, Koutelidakis I, Perdios I, Scherag A, Bauer M, Platzer M, Huse K.

Eur J Hum Genet. 2016 Jul;24(7):1041-8. doi: 10.1038/ejhg.2015.231. Epub 2015 Oct 28.


A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.

Buch S, Stickel F, Trépo E, Way M, Herrmann A, Nischalke HD, Brosch M, Rosendahl J, Berg T, Ridinger M, Rietschel M, McQuillin A, Frank J, Kiefer F, Schreiber S, Lieb W, Soyka M, Semmo N, Aigner E, Datz C, Schmelz R, Brückner S, Zeissig S, Stephan AM, Wodarz N, Devière J, Clumeck N, Sarrazin C, Lammert F, Gustot T, Deltenre P, Völzke H, Lerch MM, Mayerle J, Eyer F, Schafmayer C, Cichon S, Nöthen MM, Nothnagel M, Ellinghaus D, Huse K, Franke A, Zopf S, Hellerbrand C, Moreno C, Franchimont D, Morgan MY, Hampe J.

Nat Genet. 2015 Dec;47(12):1443-8. doi: 10.1038/ng.3417. Epub 2015 Oct 19.


Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells.

Polikowsky HG, Wogsland CE, Diggins KE, Huse K, Irish JM.

J Immunol. 2015 Aug 15;195(4):1364-1367. doi: 10.4049/jimmunol.1500904. Epub 2015 Jul 8.


Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma.

Thieme R, Kurz S, Kolb M, Debebe T, Holtze S, Morhart M, Huse K, Szafranski K, Platzer M, Hildebrandt TB, Birkenmeier G.

PLoS One. 2015 Jun 23;10(6):e0130470. doi: 10.1371/journal.pone.0130470. eCollection 2015.


Alternative splicing of SMPD1 in human sepsis.

Kramer M, Quickert S, Sponholz C, Menzel U, Huse K, Platzer M, Bauer M, Claus RA.

PLoS One. 2015 Apr 21;10(4):e0124503. doi: 10.1371/journal.pone.0124503. eCollection 2015.


Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons.

Szafranski K, Fritsch C, Schumann F, Siebel L, Sinha R, Hampe J, Hiller M, Englert C, Huse K, Platzer M.

Nucleic Acids Res. 2014 Aug;42(14):8895-904. doi: 10.1093/nar/gku532. Epub 2014 Jul 16.


Narrowing down the distal border of the copy number variable beta-defensin gene cluster on human 8p23.

Taudien S, Huse K, Groth M, Platzer M.

BMC Res Notes. 2014 Feb 19;7:93. doi: 10.1186/1756-0500-7-93.


8p23 beta-defensin copy number determination by single-locus pseudogene-based paralog ratio tests risk bias due to low-frequency sequence variations.

Zhang X, Müller S, Möller M, Huse K, Taudien S, Book M, Stuber F, Platzer M, Groth M.

BMC Genomics. 2014 Jan 24;15:64. doi: 10.1186/1471-2164-15-64.


Mutation in ST6GALNAC5 identified in family with coronary artery disease.

InanlooRahatloo K, Parsa AF, Huse K, Rasooli P, Davaran S, Platzer M, Kramer M, Fan JB, Turk C, Amini S, Steemers F, Gunderson K, Ronaghi M, Elahi E.

Sci Rep. 2014 Jan 8;4:3595. doi: 10.1038/srep03595.


Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma.

Brodtkorb M, Lingjærde OC, Huse K, Trøen G, Hystad M, Hilden VI, Myklebust JH, Leich E, Rosenwald A, Delabie J, Holte H, Smeland EB.

Blood. 2014 Feb 13;123(7):1051-4. doi: 10.1182/blood-2013-07-512392. Epub 2013 Dec 19.


Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1.

Kramer M, Sponholz C, Slaba M, Wissuwa B, Claus RA, Menzel U, Huse K, Platzer M, Bauer M.

PLoS One. 2013 Oct 2;8(10):e77224. doi: 10.1371/journal.pone.0077224. eCollection 2013.


Mutation in CYP27A1 identified in family with coronary artery disease.

Inanloorahatloo K, Zand Parsa AF, Huse K, Rasooli P, Davaran S, Platzer M, Fan JB, Amini S, Steemers F, Elahi E.

Eur J Med Genet. 2013 Dec;56(12):655-60. doi: 10.1016/j.ejmg.2013.09.008. Epub 2013 Sep 28.


Haplotypes of IL-12Rβ1 impact on the clinical phenotype of hidradenitis suppurativa.

Giatrakos S, Huse K, Kanni T, Tzanetakou V, Kramer M, Grech I, Papadavid E, Katoulis A, Stavrianeas N, Nothnagel M, Platzer M, Bauer M, Giamarellos-Bourboulis EJ.

Cytokine. 2013 May;62(2):297-301. doi: 10.1016/j.cyto.2013.03.008. Epub 2013 Apr 2.


Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.

Taudien S, Gäbel G, Kuss O, Groth M, Grützmann R, Huse K, Kluttig A, Wolf A, Nothnagel M, Rosenstiel P, Greiser KH, Werdan K, Krawczak M, Pilarsky C, Platzer M.

BMC Res Notes. 2012 Nov 13;5:629. doi: 10.1186/1756-0500-5-629.


Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.

Huse K, Bakkebø M, Wälchli S, Oksvold MP, Hilden VI, Forfang L, Bredahl ML, Liestøl K, Alizadeh AA, Smeland EB, Myklebust JH.

PLoS One. 2012;7(10):e46117. doi: 10.1371/journal.pone.0046117. Epub 2012 Oct 1.


Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.

Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, Kern A, Engel C, Kuhnt E, Kiehntopf M, Routsi C, Mylona V, Tsangaris I, Heinemann SH, Reinhart K, Platzer M, Bauer M.

Shock. 2012 Nov;38(5):459-65. doi: 10.1097/SHK.0b013e31826ae951. Erratum in: Shock. 2013 Jan;39(1):115.


Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus.

von Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, Erhart W, von Schönfels W, Egberts J, Seeger M, Arlt A, Balschun T, Franke A, Lerch MM, Mayerle J, Kratzer W, Boehm BO, Huse K, Schniewind B, Tiemann K, Jiang ZY, Han TQ, Mittal B, Srivastava A, Fenger M, Jørgensen T, Schirin-Sokhan R, Tönjes A, Wittenburg H, Stumvoll M, Kalthoff H, Lammert F, Tepel J, Puschel K, Becker T, Schreiber S, Platzer M, Völzke H, Krawczak M, Miquel JF, Schafmayer C, Hampe J.

Hepatology. 2013 Jun;57(6):2407-17. doi: 10.1002/hep.26009. Epub 2013 Jan 25.


Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting.

Fritsch C, Herrmann A, Nothnagel M, Szafranski K, Huse K, Schumann F, Schreiber S, Platzer M, Krawczak M, Hampe J, Brosch M.

Genome Res. 2012 Nov;22(11):2208-18. doi: 10.1101/gr.139568.112. Epub 2012 Aug 9.


SARA is dispensable for functional TGF-β signaling.

Bakkebø M, Huse K, Hilden VI, Forfang L, Myklebust JH, Smeland EB, Oksvold MP.

FEBS Lett. 2012 Sep 21;586(19):3367-72. doi: 10.1016/j.febslet.2012.07.027. Epub 2012 Jul 20.


Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.

Huse K, Bakkebø M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH.

Eur J Immunol. 2011 Nov;41(11):3135-45. doi: 10.1002/eji.201141558. Epub 2011 Oct 18.


Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1.

Stepanow S, Reichwald K, Huse K, Gausmann U, Nebel A, Rosenstiel P, Wabitsch M, Fischer-Posovszky P, Platzer M.

PLoS One. 2011;6(5):e17711. doi: 10.1371/journal.pone.0017711. Epub 2011 May 26.


Comprehensive assessment of sequence variation within the copy number variable defensin cluster on 8p23 by target enriched in-depth 454 sequencing.

Taudien S, Szafranski K, Felder M, Groth M, Huse K, Raffaelli F, Petzold A, Zhang X, Rosenstiel P, Hampe J, Schreiber S, Platzer M.

BMC Genomics. 2011 May 18;12(1):243. doi: 10.1186/1471-2164-12-243.


Polymorphisms in the 3'-untranslated region of the CDH1 gene are a risk factor for primary gastric diffuse large B-cell lymphoma.

Jacobs G, Hellmig S, Huse K, Titz A, Franke A, Kwiatkowski R, Ott S, Kosmahl M, Fischbach W, Lucius R, Klapper W, Fölsch UR, Hampe J, Schreiber S, Rosenstiel P.

Haematologica. 2011 Jul;96(7):987-95. doi: 10.3324/haematol.2010.033126. Epub 2011 Apr 1.


Constant splice-isoform ratios in human lymphoblastoid cells support the concept of a splico-stat.

Kramer M, Huse K, Menzel U, Backhaus O, Rosenstiel P, Schreiber S, Hampe J, Platzer M.

Genetics. 2011 Mar;187(3):761-70. doi: 10.1534/genetics.110.125096. Epub 2011 Jan 10.


Statistical inference of allelic imbalance from transcriptome data.

Nothnagel M, Wolf A, Herrmann A, Szafranski K, Vater I, Brosch M, Huse K, Siebert R, Platzer M, Hampe J, Krawczak M.

Hum Mutat. 2011 Jan;32(1):98-106. doi: 10.1002/humu.21396.


TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK.

Bakkebø M, Huse K, Hilden VI, Smeland EB, Oksvold MP.

BMC Immunol. 2010 Nov 23;11:57. doi: 10.1186/1471-2172-11-57.


NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner.

Kramer M, Boeck J, Reichenbach D, Kaether C, Schreiber S, Platzer M, Rosenstiel P, Huse K.

BMC Res Notes. 2010 Aug 10;3:224. doi: 10.1186/1756-0500-3-224.


Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation.

Birkenmeier G, Stegemann C, Hoffmann R, Günther R, Huse K, Birkemeyer C.

PLoS One. 2010 Apr 29;5(4):e10399. doi: 10.1371/journal.pone.0010399.


Both copy number and sequence variations affect expression of human DEFB4.

Groth M, Wiegand C, Szafranski K, Huse K, Kramer M, Rosenstiel P, Schreiber S, Norgauer J, Platzer M.

Genes Immun. 2010 Sep;11(6):458-66. doi: 10.1038/gene.2010.19. Epub 2010 May 6.


TassDB2 - A comprehensive database of subtle alternative splicing events.

Sinha R, Lenser T, Jahn N, Gausmann U, Friedel S, Szafranski K, Huse K, Rosenstiel P, Hampe J, Schuster S, Hiller M, Backofen R, Platzer M.

BMC Bioinformatics. 2010 Apr 29;11:216. doi: 10.1186/1471-2105-11-216.


Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing.

Taudien S, Groth M, Huse K, Petzold A, Szafranski K, Hampe J, Rosenstiel P, Schreiber S, Platzer M.

BMC Genomics. 2010 Apr 19;11:252. doi: 10.1186/1471-2164-11-252.


Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.

Kramer M, Backhaus O, Rosenstiel P, Horn D, Klopocki E, Birkenmeier G, Schreiber S, Platzer M, Hampe J, Huse K.

Gene. 2010 May 1;455(1-2):1-7. doi: 10.1016/j.gene.2010.01.005. Epub 2010 Feb 4.


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