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Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.

Cheng J, Baßler J, Fischer P, Lau B, Kellner N, Kunze R, Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R, Hurt E.

Mol Cell. 2019 Jul 15. pii: S1097-2765(19)30489-7. doi: 10.1016/j.molcel.2019.06.032. [Epub ahead of print]


Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin-ligand-type complexes.

Ahmed YL, Thoms M, Mitterer V, Sinning I, Hurt E.

Nat Commun. 2019 Jul 11;10(1):3050. doi: 10.1038/s41467-019-10922-6.


Nucleoporin Nup155 is part of the p53 network in liver cancer.

Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S.

Nat Commun. 2019 May 14;10(1):2147. doi: 10.1038/s41467-019-10133-z.


Eukaryotic Ribosome Assembly.

Baßler J, Hurt E.

Annu Rev Biochem. 2019 Jun 20;88:281-306. doi: 10.1146/annurev-biochem-013118-110817. Epub 2018 Dec 19.


Preclinical assessment of an antibody-PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells.

Kinneer K, Flynn M, Thomas SB, Meekin J, Varkey R, Xiao X, Zhong H, Breen S, Hynes PG, Fleming R, Bezabeh B, Chen CT, Wetzel L, Chen R, Dimasi N, Tai YT, Anderson KC, Herbst R, Howard PW, Hurt EM, Tice DA.

Leukemia. 2019 Mar;33(3):766-771. doi: 10.1038/s41375-018-0278-7. Epub 2018 Oct 12. No abstract available.


Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.

Thoms M, Mitterer V, Kater L, Falquet L, Beckmann R, Kressler D, Hurt E.

Nat Commun. 2018 Oct 5;9(1):4094. doi: 10.1038/s41467-018-06660-w.


Assembly Kinetics of Vimentin Tetramers to Unit-Length Filaments: A Stopped-Flow Study.

Mücke N, Kämmerer L, Winheim S, Kirmse R, Krieger J, Mildenberger M, Baßler J, Hurt E, Goldmann WH, Aebi U, Toth K, Langowski J, Herrmann H.

Biophys J. 2018 May 22;114(10):2408-2418. doi: 10.1016/j.bpj.2018.04.032. Epub 2018 May 10.


Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.

Lin H, Wei S, Hurt EM, Green MD, Zhao L, Vatan L, Szeliga W, Herbst R, Harms PW, Fecher LA, Vats P, Chinnaiyan AM, Lao CD, Lawrence TS, Wicha M, Hamanishi J, Mandai M, Kryczek I, Zou W.

J Clin Invest. 2018 Apr 2;128(4):1708. doi: 10.1172/JCI120803. Epub 2018 Apr 2. No abstract available.


Structure of the nuclear exosome captured on a maturing preribosome.

Schuller JM, Falk S, Fromm L, Hurt E, Conti E.

Science. 2018 Apr 13;360(6385):219-222. doi: 10.1126/science.aar5428. Epub 2018 Mar 8.


Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.

Lin H, Wei S, Hurt EM, Green MD, Zhao L, Vatan L, Szeliga W, Herbst R, Harms PW, Fecher LA, Vats P, Chinnaiyan AM, Lao CD, Lawrence TS, Wicha M, Hamanishi J, Mandai M, Kryczek I, Zou W.

J Clin Invest. 2018 Feb 1;128(2):805-815. doi: 10.1172/JCI96113. Epub 2018 Jan 16. Erratum in: J Clin Invest. 2018 Apr 2;128(4):1708.


Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.

Sturm M, Cheng J, Baßler J, Beckmann R, Hurt E.

Nat Commun. 2017 Dec 20;8(1):2213. doi: 10.1038/s41467-017-02199-4.


Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes.

Kater L, Thoms M, Barrio-Garcia C, Cheng J, Ismail S, Ahmed YL, Bange G, Kressler D, Berninghausen O, Sinning I, Hurt E, Beckmann R.

Cell. 2017 Dec 14;171(7):1599-1610.e14. doi: 10.1016/j.cell.2017.11.039.


Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome.

Fromm L, Falk S, Flemming D, Schuller JM, Thoms M, Conti E, Hurt E.

Nat Commun. 2017 Nov 27;8(1):1787. doi: 10.1038/s41467-017-01786-9.


Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.

Heuer A, Thomson E, Schmidt C, Berninghausen O, Becker T, Hurt E, Beckmann R.

Elife. 2017 Nov 20;6. pii: e30189. doi: 10.7554/eLife.30189.


Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control.

Sarkar A, Thoms M, Barrio-Garcia C, Thomson E, Flemming D, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2017 Dec;24(12):1107-1115. doi: 10.1038/nsmb.3495. Epub 2017 Oct 30.


A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex.

Teimer R, Kosinski J, von Appen A, Beck M, Hurt E.

Nat Commun. 2017 Oct 24;8(1):1107. doi: 10.1038/s41467-017-01160-9.


Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.

Dosch J, Ziemke E, Wan S, Luker K, Welling T, Hardiman K, Fearon E, Thomas S, Flynn M, Rios-Doria J, Hollingsworth R, Herbst R, Hurt E, Sebolt-Leopold J.

Oncotarget. 2017 May 10;8(39):65090-65099. doi: 10.18632/oncotarget.17780. eCollection 2017 Sep 12.


3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.

Cheng J, Kellner N, Berninghausen O, Hurt E, Beckmann R.

Nat Struct Mol Biol. 2017 Nov;24(11):954-964. doi: 10.1038/nsmb.3476. Epub 2017 Oct 2.


Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53.

Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E.

RNA. 2017 Dec;23(12):1780-1787. doi: 10.1261/rna.062901.117. Epub 2017 Sep 7.


Eukaryotic ribosome assembly, transport and quality control.

Peña C, Hurt E, Panse VG.

Nat Struct Mol Biol. 2017 Sep 7;24(9):689-699. doi: 10.1038/nsmb.3454. Review.


Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome.

Sá-Moura B, Kornprobst M, Kharde S, Ahmed YL, Stier G, Kunze R, Sinning I, Hurt E.

PLoS One. 2017 Aug 16;12(8):e0183272. doi: 10.1371/journal.pone.0183272. eCollection 2017.


A Puzzle of Life: Crafting Ribosomal Subunits.

Kressler D, Hurt E, Baßler J.

Trends Biochem Sci. 2017 Aug;42(8):640-654. doi: 10.1016/j.tibs.2017.05.005. Epub 2017 Jun 1. Review.


Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis.

Calviño FR, Kornprobst M, Schermann G, Birkle F, Wild K, Fischer T, Hurt E, Ahmed YL, Sinning I.

PLoS One. 2017 Jun 2;12(6):e0178752. doi: 10.1371/journal.pone.0178752. eCollection 2017.


Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.

Harper J, Lloyd C, Dimasi N, Toader D, Marwood R, Lewis L, Bannister D, Jovanovic J, Fleming R, D'Hooge F, Mao S, Marrero AM, Korade M 3rd, Strout P, Xu L, Chen C, Wetzel L, Breen S, van Vlerken-Ysla L, Jalla S, Rebelatto M, Zhong H, Hurt EM, Hinrichs MJ, Huang K, Howard PW, Tice DA, Hollingsworth RE, Herbst R, Kamal A.

Mol Cancer Ther. 2017 Aug;16(8):1576-1587. doi: 10.1158/1535-7163.MCT-16-0825. Epub 2017 May 18.


The nuclear pore complex: understanding its function through structural insight.

Beck M, Hurt E.

Nat Rev Mol Cell Biol. 2017 Feb;18(2):73-89. doi: 10.1038/nrm.2016.147. Epub 2016 Dec 21. Review.


Interaction network of the ribosome assembly machinery from a eukaryotic thermophile.

Baßler J, Ahmed YL, Kallas M, Kornprobst M, Calviño FR, Gnädig M, Thoms M, Stier G, Ismail S, Kharde S, Castillo N, Griesel S, Bastuck S, Bradatsch B, Thomson E, Flemming D, Sinning I, Hurt E.

Protein Sci. 2017 Feb;26(2):327-342. doi: 10.1002/pro.3085. Epub 2017 Jan 14.


5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma.

Kerk SA, Finkel KA, Pearson AT, Warner KA, Zhang Z, Nör F, Wagner VP, Vargas PA, Wicha MS, Hurt EM, Hollingsworth RE, Tice DA, Nör JE.

Clin Cancer Res. 2017 May 15;23(10):2516-2527. doi: 10.1158/1078-0432.CCR-16-1834. Epub 2016 Oct 25.


Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.

Sarkar A, Pech M, Thoms M, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2016 Dec;23(12):1074-1082. doi: 10.1038/nsmb.3312. Epub 2016 Oct 24.


Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations.

Ladd B, Mazzola AM, Bihani T, Lai Z, Bradford J, Collins M, Barry E, Goeppert AU, Weir HM, Hearne K, Renshaw JG, Mohseni M, Hurt E, Jalla S, Bao H, Hollingsworth R, Reimer C, Zinda M, Fawell S, D'Cruz CM.

Oncotarget. 2016 Aug 23;7(34):54120-54136. doi: 10.18632/oncotarget.10852.


Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome.

Kornprobst M, Turk M, Kellner N, Cheng J, Flemming D, Koš-Braun I, Koš M, Thoms M, Berninghausen O, Beckmann R, Hurt E.

Cell. 2016 Jul 14;166(2):380-393. doi: 10.1016/j.cell.2016.06.014.


Therapeutic Efficacy of Cancer Stem Cell Vaccines in the Adjuvant Setting.

Hu Y, Lu L, Xia Y, Chen X, Chang AE, Hollingsworth RE, Hurt E, Owen J, Moyer JS, Prince ME, Dai F, Bao Y, Wang Y, Whitfield J, Xia JC, Huang S, Wicha MS, Li Q.

Cancer Res. 2016 Aug 15;76(16):4661-72. doi: 10.1158/0008-5472.CAN-15-2664. Epub 2016 Jun 20.


IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence.

Finkel KA, Warner KA, Kerk S, Bradford CR, McLean SA, Prince ME, Zhong H, Hurt EM, Hollingsworth RE, Wicha MS, Tice DA, Nör JE.

Neoplasia. 2016 May;18(5):273-281. doi: 10.1016/j.neo.2016.03.004. Epub 2016 Apr 15.


Molecular architecture of the inner ring scaffold of the human nuclear pore complex.

Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M.

Science. 2016 Apr 15;352(6283):363-5. doi: 10.1126/science.aaf0643.


Developing genetic tools to exploit Chaetomium thermophilum for biochemical analyses of eukaryotic macromolecular assemblies.

Kellner N, Schwarz J, Sturm M, Fernandez-Martinez J, Griesel S, Zhang W, Chait BT, Rout MP, Kück U, Hurt E.

Sci Rep. 2016 Feb 11;6:20937. doi: 10.1038/srep20937.


The K⁺-dependent GTPase Nug1 is implicated in the association of the helicase Dbp10 to the immature peptidyl transferase centre during ribosome maturation.

Manikas RG, Thomson E, Thoms M, Hurt E.

Nucleic Acids Res. 2016 Feb 29;44(4):1800-12. doi: 10.1093/nar/gkw045. Epub 2016 Jan 28.


A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors.

Zhong H, Davis A, Ouzounova M, Carrasco RA, Chen C, Breen S, Chang YS, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice DA, Clouthier SG, Xiao Z, Wicha MS, Korkaya H, Hollingsworth RE.

Cancer Res. 2016 Jan 15;76(2):480-90. doi: 10.1158/0008-5472.CAN-15-0883. Epub 2016 Jan 7.


Will cancer stem cells provide more effective biomarkers?

Hurt EM.

Front Biosci (Elite Ed). 2016 Jan 1;8:181-8. Review.


Concerted removal of the Erb1-Ytm1 complex in ribosome biogenesis relies on an elaborate interface.

Thoms M, Ahmed YL, Maddi K, Hurt E, Sinning I.

Nucleic Acids Res. 2016 Jan 29;44(2):926-39. doi: 10.1093/nar/gkv1365. Epub 2015 Dec 10.


Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities.

Gasse L, Flemming D, Hurt E.

Mol Cell. 2015 Dec 3;60(5):808-815. doi: 10.1016/j.molcel.2015.10.021.


Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.

Barrio-Garcia C, Thoms M, Flemming D, Kater L, Berninghausen O, Baßler J, Beckmann R, Hurt E.

Nat Struct Mol Biol. 2016 Jan;23(1):37-44. doi: 10.1038/nsmb.3132. Epub 2015 Nov 30.


Atomoxetine, Parent Training, and Their Combination in Children With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder.

Handen BL, Aman MG, Arnold LE, Hyman SL, Tumuluru RV, Lecavalier L, Corbett-Dick P, Pan X, Hollway JA, Buchan-Page KA, Silverman LB, Brown NV, Rice RR Jr, Hellings J, Mruzek DW, McAuliffe-Bellin S, Hurt EA, Ryan MM, Levato L, Smith T.

J Am Acad Child Adolesc Psychiatry. 2015 Nov;54(11):905-15. doi: 10.1016/j.jaac.2015.08.013. Epub 2015 Sep 3.


Direct and high throughput (HT) interactions on the ribosomal surface by iRIA.

Pesce E, Minici C, Baβler J, Hurt E, Degano M, Calamita P, Biffo S.

Sci Rep. 2015 Oct 21;5:15401. doi: 10.1038/srep15401.


Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel.

Fischer J, Teimer R, Amlacher S, Kunze R, Hurt E.

Nat Struct Mol Biol. 2015 Oct;22(10):774-81. doi: 10.1038/nsmb.3084. Epub 2015 Sep 7.


The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins.

Thoms M, Thomson E, Baßler J, Gnädig M, Griesel S, Hurt E.

Cell. 2015 Aug 27;162(5):1029-38. doi: 10.1016/j.cell.2015.07.060.


Architecture of the fungal nuclear pore inner ring complex.

Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A.

Science. 2015 Oct 2;350(6256):56-64. doi: 10.1126/science.aac9176. Epub 2015 Aug 27.


Effect of ceramic membrane channel geometry and uniform transmembrane pressure on limiting flux and serum protein removal during skim milk microfiltration.

Adams MC, Hurt EE, Barbano DM.

J Dairy Sci. 2015 Nov;98(11):7527-43. doi: 10.3168/jds.2015-9753. Epub 2015 Aug 20.


Effect of soluble calcium and lactose on limiting flux and serum protein removal during skim milk microfiltration.

Adams MC, Hurt EE, Barbano DM.

J Dairy Sci. 2015 Nov;98(11):7483-97. doi: 10.3168/jds.2015-9474. Epub 2015 Aug 20.


A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.

Baßler J, Paternoga H, Holdermann I, Thoms M, Granneman S, Barrio-Garcia C, Nyarko A, Lee W, Stier G, Clark SA, Schraivogel D, Kallas M, Beckmann R, Tollervey D, Barbar E, Sinning I, Hurt E.

J Cell Biol. 2015 Jul 6;210(1):169-70. doi: 10.1083/jcb.20140811106112015c. No abstract available.


Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.

Aibara S, Valkov E, Lamers MH, Dimitrova L, Hurt E, Stewart M.

Acta Crystallogr F Struct Biol Commun. 2015 Jul;71(Pt 7):876-88. doi: 10.1107/S2053230X15008766. Epub 2015 Jun 27.


Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones.

Pausch P, Singh U, Ahmed YL, Pillet B, Murat G, Altegoer F, Stier G, Thoms M, Hurt E, Sinning I, Bange G, Kressler D.

Nat Commun. 2015 Jun 26;6:7494. doi: 10.1038/ncomms8494.

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