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Items: 26

1.

De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.

Vishnepolsky B, Zaalishvili G, Karapetian M, Nasrashvili T, Kuljanishvili N, Gabrielian A, Rosenthal A, Hurt DE, Tartakovsky M, Grigolava M, Pirtskhalava M.

Pharmaceuticals (Basel). 2019 Jun 3;12(2). pii: E82. doi: 10.3390/ph12020082.

2.

TB DEPOT (Data Exploration Portal): A multi-domain tuberculosis data analysis resource.

Gabrielian A, Engle E, Harris M, Wollenberg K, Juarez-Espinosa O, Glogowski A, Long A, Patti L, Hurt DE, Rosenthal A, Tartakovsky M.

PLoS One. 2019 May 23;14(5):e0217410. doi: 10.1371/journal.pone.0217410. eCollection 2019.

3.

Predictive Model of Linear Antimicrobial Peptides Active against Gram-Negative Bacteria.

Vishnepolsky B, Gabrielian A, Rosenthal A, Hurt DE, Tartakovsky M, Managadze G, Grigolava M, Makhatadze GI, Pirtskhalava M.

J Chem Inf Model. 2018 May 29;58(5):1141-1151. doi: 10.1021/acs.jcim.8b00118. Epub 2018 May 11.

PMID:
29716188
4.

Nephele: a cloud platform for simplified, standardized and reproducible microbiome data analysis.

Weber N, Liou D, Dommer J, MacMenamin P, Quiñones M, Misner I, Oler AJ, Wan J, Kim L, Coakley McCarthy M, Ezeji S, Noble K, Hurt DE.

Bioinformatics. 2018 Apr 15;34(8):1411-1413. doi: 10.1093/bioinformatics/btx617.

5.

The TB Portals: an Open-Access, Web-Based Platform for Global Drug-Resistant-Tuberculosis Data Sharing and Analysis.

Rosenthal A, Gabrielian A, Engle E, Hurt DE, Alexandru S, Crudu V, Sergueev E, Kirichenko V, Lapitskii V, Snezhko E, Kovalev V, Astrovko A, Skrahina A, Taaffe J, Harris M, Long A, Wollenberg K, Akhundova I, Ismayilova S, Skrahin A, Mammadbayov E, Gadirova H, Abuzarov R, Seyfaddinova M, Avaliani Z, Strambu I, Zaharia D, Muntean A, Ghita E, Bogdan M, Mindru R, Spinu V, Sora A, Ene C, Vashakidze S, Shubladze N, Nanava U, Tuzikov A, Tartakovsky M.

J Clin Microbiol. 2017 Nov;55(11):3267-3282. doi: 10.1128/JCM.01013-17. Epub 2017 Sep 13.

6.

Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry.

Cimbro R, Peterson FC, Liu Q, Guzzo C, Zhang P, Miao H, Van Ryk D, Ambroggio X, Hurt DE, De Gioia L, Volkman BF, Dolan MA, Lusso P.

EBioMedicine. 2016 Aug;10:45-54. doi: 10.1016/j.ebiom.2016.06.037. Epub 2016 Jun 26.

7.

3D Printing in the Laboratory: Maximize Time and Funds with Customized and Open-Source Labware.

Coakley M, Hurt DE.

J Lab Autom. 2016 Aug;21(4):489-95. doi: 10.1177/2211068216649578. Epub 2016 May 19.

8.

DBAASP v.2: an enhanced database of structure and antimicrobial/cytotoxic activity of natural and synthetic peptides.

Pirtskhalava M, Gabrielian A, Cruz P, Griggs HL, Squires RB, Hurt DE, Grigolava M, Chubinidze M, Gogoladze G, Vishnepolsky B, Alekseyev V, Rosenthal A, Tartakovsky M.

Nucleic Acids Res. 2016 Jul 27;44(13):6503. doi: 10.1093/nar/gkw243. Epub 2016 Apr 8. No abstract available.

9.

Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains.

Hurt DE, Suzuki S, Mayama T, Charmandari E, Kino T.

Mol Endocrinol. 2016 Feb;30(2):173-88. doi: 10.1210/me.2015-1177. Epub 2016 Jan 8.

10.

DBAASP v.2: an enhanced database of structure and antimicrobial/cytotoxic activity of natural and synthetic peptides.

Pirtskhalava M, Gabrielian A, Cruz P, Griggs HL, Squires RB, Hurt DE, Grigolava M, Chubinidze M, Gogoladze G, Vishnepolsky B, Alekseyev V, Rosenthal A, Tartakovsky M.

Nucleic Acids Res. 2016 Jan 4;44(D1):D1104-12. doi: 10.1093/nar/gkv1174. Epub 2015 Nov 17. Erratum in: Nucleic Acids Res. 2016 Jul 27;44(13):6503.

11.

Selectivity in the Use of Gi/o Proteins Is Determined by the DRF Motif in CXCR6 and Is Cell-Type Specific.

Singh SP, Foley JF, Zhang HH, Hurt DE, Richards JL, Smith CS, Liao F, Farber JM.

Mol Pharmacol. 2015 Nov;88(5):894-910. doi: 10.1124/mol.115.099960. Epub 2015 Aug 27.

12.

The NIH 3D Print Exchange: A Public Resource for Bioscientific and Biomedical 3D Prints.

Coakley MF, Hurt DE, Weber N, Mtingwa M, Fincher EC, Alekseyev V, Chen DT, Yun A, Gizaw M, Swan J, Yoo TS, Huyen Y.

3D Print Addit Manuf. 2014 Sep 1;1(3):137-140. doi: 10.1089/3dp.2014.1503.

13.

Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity.

Cimbro R, Gallant TR, Dolan MA, Guzzo C, Zhang P, Lin Y, Miao H, Van Ryk D, Arthos J, Gorshkova I, Brown PH, Hurt DE, Lusso P.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3152-7. doi: 10.1073/pnas.1314718111. Epub 2014 Feb 3.

14.

A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities.

Nicolaides NC, Roberts ML, Kino T, Braatvedt G, Hurt DE, Katsantoni E, Sertedaki A, Chrousos GP, Charmandari E.

J Clin Endocrinol Metab. 2014 May;99(5):E902-7. doi: 10.1210/jc.2013-3005. Epub 2014 Jan 31.

15.

HASP server: a database and structural visualization platform for comparative models of influenza A hemagglutinin proteins.

Ambroggio XI, Dommer J, Gopalan V, Dunham EJ, Taubenberger JK, Hurt DE.

BMC Bioinformatics. 2013 Jun 18;14:197. doi: 10.1186/1471-2105-14-197.

16.

A novel point mutation in the DNA-binding domain (DBD) of the human glucocorticoid receptor causes primary generalized glucocorticoid resistance by disrupting the hydrophobic structure of its DBD.

Roberts ML, Kino T, Nicolaides NC, Hurt DE, Katsantoni E, Sertedaki A, Komianou F, Kassiou K, Chrousos GP, Charmandari E.

J Clin Endocrinol Metab. 2013 Apr;98(4):E790-5. doi: 10.1210/jc.2012-3549. Epub 2013 Feb 20.

17.

A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension.

Charmandari E, Sertedaki A, Kino T, Merakou C, Hoffman DA, Hatch MM, Hurt DE, Lin L, Xekouki P, Stratakis CA, Chrousos GP.

J Clin Endocrinol Metab. 2012 Aug;97(8):E1532-9. doi: 10.1210/jc.2012-1334. Epub 2012 May 24.

18.

Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP.

Uchime O, Herrera R, Reiter K, Kotova S, Shimp RL Jr, Miura K, Jones D, Lebowitz J, Ambroggio X, Hurt DE, Jin AJ, Long C, Miller LH, Narum DL.

Eukaryot Cell. 2012 May;11(5):615-25. doi: 10.1128/EC.00039-12. Epub 2012 Mar 30.

19.

Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.

Meyerson JR, White TA, Bliss D, Moran A, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Schauder D, Hartnell LM, Nandwani R, Dawood M, Kim B, Kim JH, Sununu J, Yang L, Bhatia S, Subramaniam C, Hurt DE, Gaudreault L, Subramaniam S.

J Vis Exp. 2011 Dec 1;(58). pii: 2770. doi: 10.3791/2770.

20.

Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain.

Das SR, Puigbò P, Hensley SE, Hurt DE, Bennink JR, Yewdell JW.

PLoS Pathog. 2010 Nov 24;6(11):e1001211. doi: 10.1371/journal.ppat.1001211.

21.

A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.

Nader N, Bachrach BE, Hurt DE, Gajula S, Pittman A, Lescher R, Kino T.

J Clin Endocrinol Metab. 2010 May;95(5):2281-5. doi: 10.1210/jc.2009-2463. Epub 2010 Mar 24.

22.

Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor.

Kino T, Hurt DE, Ichijo T, Nader N, Chrousos GP.

Sci Signal. 2010 Feb 2;3(107):ra8. doi: 10.1126/scisignal.2000568.

23.

Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate.

Plassmeyer ML, Reiter K, Shimp RL Jr, Kotova S, Smith PD, Hurt DE, House B, Zou X, Zhang Y, Hickman M, Uchime O, Herrera R, Nguyen V, Glen J, Lebowitz J, Jin AJ, Miller LH, MacDonald NJ, Wu Y, Narum DL.

J Biol Chem. 2009 Sep 25;284(39):26951-63. doi: 10.1074/jbc.M109.013706. Epub 2009 Jul 24.

24.

Characterization of a protective Escherichia coli-expressed Plasmodium falciparum merozoite surface protein 3 indicates a non-linear, multi-domain structure.

Tsai CW, Duggan PF, Jin AJ, Macdonald NJ, Kotova S, Lebowitz J, Hurt DE, Shimp RL Jr, Lambert L, Miller LH, Long CA, Saul A, Narum DL.

Mol Biochem Parasitol. 2009 Mar;164(1):45-56. doi: 10.1016/j.molbiopara.2008.11.006. Epub 2008 Nov 27.

25.

Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.

Hurt DE, Widom J, Clardy J.

Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):312-23. Epub 2006 Feb 22.

PMID:
16510978
26.

Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.

Hurt DE, Sutton AE, Clardy J.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1610-5. Epub 2006 Jan 10.

PMID:
16406782

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