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Items: 1 to 50 of 129


Singlet oxygen-activatable Paclitaxel prodrugs via intermolecular activation for combined PDT and chemotherapy.

Bio M, Rahman KMM, Lim I, Rajaputra P, Hurst RE, You Y.

Bioorg Med Chem Lett. 2019 Jun 15;29(12):1537-1540. doi: 10.1016/j.bmcl.2019.03.053. Epub 2019 Apr 2.


Transcriptome profiling of bovine ovarian theca cells treated with fibroblast growth factor 9.

Sch├╝tz LF, Hurst RE, Schreiber NB, Spicer LJ.

Domest Anim Endocrinol. 2018 Apr;63:48-58. doi: 10.1016/j.domaniend.2017.12.002. Epub 2018 Jan 4.


Phosphatidylserine targeted single-walled carbon nanotubes for photothermal ablation of bladder cancer.

Virani NA, Davis C, McKernan P, Hauser P, Hurst RE, Slaton J, Silvy RP, Resasco DE, Harrison RG.

Nanotechnology. 2018 Jan 19;29(3):035101. doi: 10.1088/1361-6528/aa9c0c.


Reduced urothelial regeneration in rat bladders augmented with permeable porcine small intestinal submucosa assessed by magnetic resonance imaging.

Yang Q, Xia D, Towner RA, Smith N, Saunders D, Fung KM, Aston CE, Greenwood-Van Meerveld B, Hurst RE, Madihally SV, Kropp BP, Lin HK.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1778-1787. doi: 10.1002/jbm.b.33985. Epub 2017 Sep 13.


Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria.

Bio M, Rajaputra P, Lim I, Thapa P, Tienabeso B, Hurst RE, You Y.

Chem Commun (Camb). 2017 Feb 7;53(11):1884-1887. doi: 10.1039/c6cc09994g. Epub 2017 Jan 23.


Targeting dormant micrometastases: rationale, evidence to date and clinical implications.

Hurst RE, Bastian A, Bailey-Downs L, Ihnat MA.

Ther Adv Med Oncol. 2016 Mar;8(2):126-37. doi: 10.1177/1758834015624277. Review.


In the absence of overt urothelial damage, chondroitinase ABC digestion of the GAG layer increases bladder permeability in ovariectomized female rats.

Hurst RE, Van Gordon S, Tyler K, Kropp B, Towner R, Lin H, Marentette JO, McHowat J, Mohammedi E, Greenwood-Van Meerveld B.

Am J Physiol Renal Physiol. 2016 May 1;310(10):F1074-80. doi: 10.1152/ajprenal.00566.2015. Epub 2016 Feb 24.


Increased bladder permeability in interstitial cystitis/painful bladder syndrome.

Hurst RE, Greenwood-Van Meerveld B, Wisniewski AB, VanGordon S, Lin H, Kropp BP, Towner RA.

Transl Androl Urol. 2015 Oct;4(5):563-571.


A Feasibility Study to Determine Whether Clinical Contrast Enhanced Magnetic Resonance Imaging can Detect Increased Bladder Permeability in Patients with Interstitial Cystitis.

Towner RA, Wisniewski AB, Wu DH, Van Gordon SB, Smith N, North JC, McElhaney R, Aston CE, Shobeiri SA, Kropp BP, Greenwood-Van Meerveld B, Hurst RE.

J Urol. 2016 Mar;195(3):631-8. doi: 10.1016/j.juro.2015.08.077. Epub 2015 Aug 22.


Assessment of colon and bladder crosstalk in an experimental colitis model using contrast-enhanced magnetic resonance imaging.

Towner RA, Smith N, Saunders D, Van Gordon SB, Tyler KR, Wisniewski AB, Greenwood-Van Meerveld B, Hurst RE.

Neurogastroenterol Motil. 2015 Nov;27(11):1571-9. doi: 10.1111/nmo.12654. Epub 2015 Aug 24.


Identification of novel drugs to target dormant micrometastases.

Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA.

BMC Cancer. 2015 May 14;15:404. doi: 10.1186/s12885-015-1409-4.


Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis.

Hauser PJ, VanGordon SB, Seavey J, Sofinowski TM, Ramadan M, Abdullah S, Buffington CA, Hurst RE.

J Urol. 2015 Aug;194(2):571-7. doi: 10.1016/j.juro.2015.01.090. Epub 2015 Jan 28.


Contrast enhanced magnetic resonance imaging as a diagnostic tool to assess bladder permeability and associated colon cross talk: preclinical studies in a rat model.

Towner RA, Smith N, Saunders D, Van Gordon SB, Wisniewski AB, Tyler KR, Greenwood-Van Meerveld B, Hurst RE.

J Urol. 2015 Apr;193(4):1394-400. doi: 10.1016/j.juro.2014.10.120. Epub 2014 Nov 14.


Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model.

Mondalek FG, Fung KM, Yang Q, Wu W, Lu W, Palmer BW, Frimberger DC, Greenwood-Van Meerveld B, Hurst RE, Kropp BP, Lin HK.

World J Urol. 2015 Aug;33(8):1119-28. doi: 10.1007/s00345-014-1403-5. Epub 2014 Sep 25.


Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression.

Bailey-Downs LC, Thorpe JE, Disch BC, Bastian A, Hauser PJ, Farasyn T, Berry WL, Hurst RE, Ihnat MA.

PLoS One. 2014 May 30;9(5):e98624. doi: 10.1371/journal.pone.0098624. eCollection 2014.


Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase.

Marentette JO, Hauser PJ, Hurst RE, Klumpp DJ, Rickard A, McHowat J.

PLoS One. 2013 Jul 29;8(7):e69948. doi: 10.1371/journal.pone.0069948. Print 2013.


Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy".

Hurst RE, Hauser PJ, Kyker KD, Heinlen JE, Hodde JP, Hiles MC, Kosanke SD, Dozmorov M, Ihnat MA.

PLoS One. 2013 May 24;8(5):e64181. doi: 10.1371/journal.pone.0064181. Print 2013.


Intravesical chondroitin sulfate inhibits recruitment of inflammatory cells in an acute acid damage "leaky bladder" model of cystitis.

Engles CD, Hauser PJ, Abdullah SN, Culkin DJ, Hurst RE.

Urology. 2012 Feb;79(2):483.e13-7. doi: 10.1016/j.urology.2011.10.010. Epub 2011 Dec 2.


VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG.

Saban MR, Davis CA, Avelino A, Cruz F, Maier J, Bjorling DE, Sferra TJ, Hurst RE, Saban R.

BMC Physiol. 2011 Nov 7;11:16. doi: 10.1186/1472-6793-11-16.


System level changes in gene expression in maturing bladder mucosa.

Dozmorov M, Stone R 2nd, Clifford JL, Sabichi AL, Engles CD, Hauser PJ, Culkin DJ, Hurst RE.

J Urol. 2011 May;185(5):1952-8. doi: 10.1016/j.juro.2010.12.101. Epub 2011 Mar 21.


Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression.

Dozmorov MG, Azzarello JT, Wren JD, Fung KM, Yang Q, Davis JS, Hurst RE, Culkin DJ, Penning TM, Lin HK.

BMC Cancer. 2010 Dec 6;10:672. doi: 10.1186/1471-2407-10-672.


Dual sources of vitronectin in the human lower urinary tract: synthesis by urothelium vs. extravasation from the bloodstream.

Zhang D, Hudson AE, Delostrinos CF, Carmean N, Eastman R Jr, Hicks B, Hurst RE, Bassuk JA.

Am J Physiol Renal Physiol. 2011 Feb;300(2):F475-87. doi: 10.1152/ajprenal.00407.2010. Epub 2010 Nov 3.


A comprehensive and universal method for assessing the performance of differential gene expression analyses.

Dozmorov MG, Guthridge JM, Hurst RE, Dozmorov IM.

PLoS One. 2010 Sep 9;5(9). pii: e12657. doi: 10.1371/journal.pone.0012657.


Restoring barrier function to acid damaged bladder by intravesical chondroitin sulfate.

Hauser PJ, Buethe DA, Califano J, Sofinowski TM, Culkin DJ, Hurst RE.

J Urol. 2009 Nov;182(5):2477-82. doi: 10.1016/j.juro.2009.07.013. Epub 2009 Sep 17.


Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen.

Dozmorov M, Wu W, Chakrabarty K, Booth JL, Hurst RE, Coggeshall KM, Metcalf JP.

BMC Infect Dis. 2009 Sep 10;9:152. doi: 10.1186/1471-2334-9-152.


Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells.

Dozmorov MG, Hurst RE, Culkin DJ, Kropp BP, Frank MB, Osban J, Penning TM, Lin HK.

Prostate. 2009 Jul 1;69(10):1077-90. doi: 10.1002/pros.20960.


Does the biomarker search paradigm need re-booting?

Hurst RE.

BMC Urol. 2009 Feb 27;9:1. doi: 10.1186/1471-2490-9-1.


5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling.

Dozmorov MG, Yang Q, Matwalli A, Hurst RE, Culkin DJ, Kropp BP, Lin HK.

Genomic Med. 2007;1(3-4):139-46. doi: 10.1007/s11568-008-9018-9. Epub 2008 Feb 27.


Urothelial expression of neuropilins and VEGF receptors in control and interstitial cystitis patients.

Saban R, Saban MR, Maier J, Fowler B, Tengowski M, Davis CA, Wu XR, Culkin DJ, Hauser P, Backer J, Hurst RE.

Am J Physiol Renal Physiol. 2008 Dec;295(6):F1613-23. doi: 10.1152/ajprenal.90344.2008. Epub 2008 Sep 24.


From microarray to biology: an integrated experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells.

Dozmorov MG, Kyker KD, Hauser PJ, Saban R, Buethe DD, Dozmorov I, Centola MB, Culkin DJ, Hurst RE.

BMC Bioinformatics. 2008 Aug 12;9 Suppl 9:S4. doi: 10.1186/1471-2105-9-S9-S4.


VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation.

Saban MR, Backer JM, Backer MV, Maier J, Fowler B, Davis CA, Simpson C, Wu XR, Birder L, Freeman MR, Soker S, Hurst RE, Saban R.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F60-72. doi: 10.1152/ajprenal.00618.2007. Epub 2008 May 7.


Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha.

Saban MR, O'Donnell MA, Hurst RE, Wu XR, Simpson C, Dozmorov I, Davis C, Saban R.

BMC Immunol. 2008 Feb 11;9:4. doi: 10.1186/1471-2172-9-4.


Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis.

Hauser PJ, Dozmorov MG, Bane BL, Slobodov G, Culkin DJ, Hurst RE.

J Urol. 2008 Feb;179(2):764-9. Epub 2007 Dec 20.


Systems biology approach for mapping the response of human urothelial cells to infection by Enterococcus faecalis.

Dozmorov MG, Kyker KD, Saban R, Shankar N, Baghdayan AS, Centola MB, Hurst RE.

BMC Bioinformatics. 2007 Nov 1;8 Suppl 7:S2.


Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation.

Saban R, Simpson C, Davis CA, Dozmorov I, Maier J, Fowler B, Ihnat MA, Hurst RE, Wershil BK, Saban MR.

BMC Immunol. 2007 Aug 17;8:17.


Differentially expressed gene networks in cultured smooth muscle cells from normal and neuropathic bladder.

Dozmorov MG, Kropp BP, Hurst RE, Cheng EY, Lin HK.

J Smooth Muscle Res. 2007 Apr;43(2):55-72.


Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix.

Hauser PJ, Han Z, Sindhwani P, Hurst RE.

Anticancer Res. 2007 Mar-Apr;27(2):737-40.


Bladder defense molecules, urothelial differentiation, urinary biomarkers, and interstitial cystitis.

Hurst RE, Moldwin RM, Mulholland SG.

Urology. 2007 Apr;69(4 Suppl):17-23.


Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation.

Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Davis CA, Simpson C, Saban MR.

BMC Physiol. 2007 Mar 30;7:4.


Regulatory network of inflammation downstream of proteinase-activated receptors.

Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Simpson C, Saban MR.

BMC Physiol. 2007 Mar 30;7:3.


Template-driven gene selection procedure.

Knowlton N, Dozmorov I, Kyker KD, Saban R, Cadwell C, Centola MB, Hurst RE.

Syst Biol (Stevenage). 2006 Jan;153(1):4-12.


Proteome-level display by 2-dimensional chromatography of extracellular matrix-dependent modulation of the phenotype of bladder cancer cells.

Hurst RE, Kyker KD, Dozmorov MG, Takemori N, Singh A, Matsumoto H, Saban R, Betgovargez E, Simonian MH.

Proteome Sci. 2006 Jun 2;4:13.


The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa.

Saban MR, Hellmich HL, Turner M, Nguyen NB, Vadigepalli R, Dyer DW, Hurst RE, Centola M, Saban R.

BMC Physiol. 2006 Jan 18;6:1.


Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells.

Dozmorov MG, Kyker KD, Saban R, Knowlton N, Dozmorov I, Centola MB, Hurst RE.

BMC Cancer. 2006 Jan 13;6:12.


A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel.

Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA.

Cancer Lett. 2005 Jan 20;217(2):171-80.


Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis.

Slobodov G, Feloney M, Gran C, Kyker KD, Hurst RE, Culkin DJ.

J Urol. 2004 Apr;171(4):1554-8.


A model for 3-dimensional growth of bladder cancers to investigate cell-matrix interactions.

Kyker KD, Culkin DJ, Hurst RE.

Urol Oncol. 2003 Jul-Aug;21(4):255-61.


Matrix-dependent plasticity of the malignant phenotype of bladder cancer cells.

Hurst RE, Kyker KD, Bonner RB, Bowditch RD, Hemstreet GP 3rd.

Anticancer Res. 2003 Jul-Aug;23(4):3119-28.

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