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Items: 8


Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.

Ulanet DB, Couto K, Jha A, Choe S, Wang A, Woo HK, Steadman M, DeLaBarre B, Gross S, Driggers E, Dorsch M, Hurov JB.

PLoS One. 2014 Dec 12;9(12):e115144. doi: 10.1371/journal.pone.0115144. eCollection 2014.


Targeting metabolic changes in cancer: novel therapeutic approaches.

Bobrovnikova-Marjon E, Hurov JB.

Annu Rev Med. 2014;65:157-70. doi: 10.1146/annurev-med-092012-112344. Review.


Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC.

Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057.


Full-length human glutaminase in complex with an allosteric inhibitor.

DeLaBarre B, Gross S, Fang C, Gao Y, Jha A, Jiang F, Song J J, Wei W, Hurov JB.

Biochemistry. 2011 Dec 20;50(50):10764-70. doi: 10.1021/bi201613d. Epub 2011 Nov 18.


Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.

Lennerz JK, Hurov JB, White LS, Lewandowski KT, Prior JL, Planer GJ, Gereau RW 4th, Piwnica-Worms D, Schmidt RE, Piwnica-Worms H.

Mol Cell Biol. 2010 Nov;30(21):5043-56. doi: 10.1128/MCB.01472-09. Epub 2010 Aug 23.


Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.

Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5680-5. Epub 2007 Mar 19.


Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

Hurov JB, Watkins JL, Piwnica-Worms H.

Curr Biol. 2004 Apr 20;14(8):736-41.


Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase.

Hurov JB, Stappenbeck TS, Zmasek CM, White LS, Ranganath SH, Russell JH, Chan AC, Murphy KM, Piwnica-Worms H.

Mol Cell Biol. 2001 May;21(9):3206-19.

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