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Items: 1 to 50 of 103


A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ.

Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032.


ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.

Sarvi S, Crispin R, Lu Y, Zeng L, Hurley TD, Houston DR, von Kriegsheim A, Chen CH, Mochly-Rosen D, Ranzani M, Mathers ME, Xu X, Xu W, Adams DJ, Carragher NO, Fujita M, Schuchter L, Unciti-Broceta A, Brunton VG, Patton EE.

Cell Chem Biol. 2018 Dec 20;25(12):1456-1469.e6. doi: 10.1016/j.chembiol.2018.09.005. Epub 2018 Oct 4.


Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.

Huddle BC, Grimley E, Buchman CD, Chtcherbinine M, Debnath B, Mehta P, Yang K, Morgan CA, Li S, Felton J, Sun D, Mehta G, Neamati N, Buckanovich RJ, Hurley TD, Larsen SD.

J Med Chem. 2018 Oct 11;61(19):8754-8773. doi: 10.1021/acs.jmedchem.8b00930. Epub 2018 Sep 28.


Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.

Buchman CD, Hurley TD.

J Med Chem. 2017 Mar 23;60(6):2439-2455. doi: 10.1021/acs.jmedchem.6b01825. Epub 2017 Mar 6.


Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.

Li J, Condello S, Thomes-Pepin J, Ma X, Xia Y, Hurley TD, Matei D, Cheng JX.

Cell Stem Cell. 2017 Mar 2;20(3):303-314.e5. doi: 10.1016/j.stem.2016.11.004. Epub 2016 Dec 29.


Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.

Mahalingan KK, Baskaran S, DePaoli-Roach AA, Roach PJ, Hurley TD.

Biochemistry. 2017 Jan 10;56(1):179-188. doi: 10.1021/acs.biochem.6b00884. Epub 2016 Dec 20.


A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.

Maile CA, Hingst JR, Mahalingan KK, O'Reilly AO, Cleasby ME, Mickelson JR, McCue ME, Anderson SM, Hurley TD, Wojtaszewski JFP, Piercy RJ.

Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3388-3398. doi: 10.1016/j.bbagen.2016.08.021. Epub 2016 Aug 31.


Incorporation of phosphate into glycogen by glycogen synthase.

Contreras CJ, Segvich DM, Mahalingan K, Chikwana VM, Kirley TL, Hurley TD, DePaoli-Roach AA, Roach PJ.

Arch Biochem Biophys. 2016 May 1;597:21-9. doi: 10.1016/ Epub 2016 Mar 29.


Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.

Buchman CD, Mahalingan KK, Hurley TD.

Chem Biol Interact. 2015 Jun 5;234:38-44. doi: 10.1016/j.cbi.2014.12.038. Epub 2015 Jan 29.


Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.

Morgan CA, Hurley TD.

J Med Chem. 2015 Feb 26;58(4):1964-75. doi: 10.1021/jm501900s. Epub 2015 Feb 10.


N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

Morgan CA, Parajuli B, Buchman CD, Dria K, Hurley TD.

Chem Biol Interact. 2015 Jun 5;234:18-28. doi: 10.1016/j.cbi.2014.12.008. Epub 2014 Dec 12.


Hominids adapted to metabolize ethanol long before human-directed fermentation.

Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, Benner SA.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):458-63. doi: 10.1073/pnas.1404167111. Epub 2014 Dec 1.


Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.

Morgan CA, Hurley TD.

Chem Biol Interact. 2015 Jun 5;234:29-37. doi: 10.1016/j.cbi.2014.10.028. Epub 2014 Nov 4.


β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.

Condello S, Morgan CA, Nagdas S, Cao L, Turek J, Hurley TD, Matei D.

Oncogene. 2015 Apr 30;34(18):2297-308. doi: 10.1038/onc.2014.178. Epub 2014 Jun 23.


Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2.

Wang B, Buchman CD, Li L, Hurley TD, Meroueh SO.

J Chem Inf Model. 2014 Jul 28;54(7):2105-16. doi: 10.1021/ci5002026. Epub 2014 Jun 30.


Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.

Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD.

J Med Chem. 2014 Feb 13;57(3):714-22. doi: 10.1021/jm401377v. Epub 2014 Jan 31.


Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.

Parajuli B, Fishel ML, Hurley TD.

J Med Chem. 2014 Jan 23;57(2):449-61. doi: 10.1021/jm401508p. Epub 2014 Jan 10.


Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase.

Chikwana VM, Khanna M, Baskaran S, Tagliabracci VS, Contreras CJ, DePaoli-Roach A, Roach PJ, Hurley TD.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20976-81. doi: 10.1073/pnas.1310106111. Epub 2013 Dec 9. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2264.


Molecular recognition in a diverse set of protein-ligand interactions studied with molecular dynamics simulations and end-point free energy calculations.

Wang B, Li L, Hurley TD, Meroueh SO.

J Chem Inf Model. 2013 Oct 28;53(10):2659-70. doi: 10.1021/ci400312v. Epub 2013 Oct 8.


The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum.

Akin BL, Hurley TD, Chen Z, Jones LR.

J Biol Chem. 2013 Oct 18;288(42):30181-91. doi: 10.1074/jbc.M113.501585. Epub 2013 Aug 31.


Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells.

Khanna M, Imasaki T, Chikwana VM, Perez-Miller S, Hunter GO, Mosley A, Takagi Y, Hurley TD.

Protein Expr Purif. 2013 Aug;90(2):78-83. doi: 10.1016/j.pep.2013.05.007. Epub 2013 May 24.


Catalytic contribution of threonine 244 in human ALDH2.

González-Segura L, Ho KK, Perez-Miller S, Weiner H, Hurley TD.

Chem Biol Interact. 2013 Feb 25;202(1-3):32-40. doi: 10.1016/j.cbi.2012.12.009. Epub 2013 Jan 4.


Genes encoding enzymes involved in ethanol metabolism.

Hurley TD, Edenberg HJ.

Alcohol Res. 2012;34(3):339-44.


The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion.

Carrigan MA, Uryasev O, Davis RP, Zhai L, Hurley TD, Benner SA.

PLoS One. 2012;7(7):e41175. doi: 10.1371/journal.pone.0041175. Epub 2012 Jul 31.


Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application.

Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V.

Pharmacol Rev. 2012 Jul;64(3):520-39. doi: 10.1124/pr.111.005538. Epub 2012 Apr 27. Review.


Glycogen and its metabolism: some new developments and old themes.

Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS.

Biochem J. 2012 Feb 1;441(3):763-87. doi: 10.1042/BJ20111416. Review.


Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.

Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD.

J Biol Chem. 2011 Dec 16;286(50):43486-94. doi: 10.1074/jbc.M111.293597. Epub 2011 Oct 21.


Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen.

Baskaran S, Chikwana VM, Contreras CJ, Davis KD, Wilson WA, DePaoli-Roach AA, Roach PJ, Hurley TD.

J Biol Chem. 2011 Sep 30;286(39):33999-4006. doi: 10.1074/jbc.M111.264531. Epub 2011 Aug 11.


A new crystal form of mouse thiamin pyrophosphokinase.

Liu JY, Hurley TD.

Int J Biochem Mol Biol. 2011;2(2):111-8.


Phosphate incorporation during glycogen synthesis and Lafora disease.

Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ.

Cell Metab. 2011 Mar 2;13(3):274-82. doi: 10.1016/j.cmet.2011.01.017.


Discovery of novel regulators of aldehyde dehydrogenase isoenzymes.

Parajuli B, Kimble-Hill AC, Khanna M, Ivanova Y, Meroueh S, Hurley TD.

Chem Biol Interact. 2011 May 30;191(1-3):153-8. doi: 10.1016/j.cbi.2011.02.018. Epub 2011 Feb 22.


Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition.

Allen EM, Anderson DG, Florang VR, Khanna M, Hurley TD, Doorn JA.

Chem Res Toxicol. 2010 Nov 15;23(11):1843-50. doi: 10.1021/tx100317q. Epub 2010 Oct 18.


Structural basis for glucose-6-phosphate activation of glycogen synthase.

Baskaran S, Roach PJ, DePaoli-Roach AA, Hurley TD.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17563-8. doi: 10.1073/pnas.1006340107. Epub 2010 Sep 27.


High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones.

Perez-Miller S, Zou Q, Novotny MV, Hurley TD.

Protein Sci. 2010 Aug;19(8):1469-79. doi: 10.1002/pro.426.


Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD.

Nat Struct Mol Biol. 2010 Feb;17(2):159-64. doi: 10.1038/nsmb.1737. Epub 2010 Jan 10.


Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.

Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R.

J Biol Chem. 2010 Jan 15;285(3):1950-6. doi: 10.1074/jbc.M109.042986. Epub 2009 Nov 18.


Alcohol dehydrogenase-catalyzed in vitro oxidation of anandamide to N-arachidonoyl glycine, a lipid mediator: synthesis of N-acyl glycinals.

Aneetha H, O'Dell DK, Tan B, Walker JM, Hurley TD.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):237-41. doi: 10.1016/j.bmcl.2008.10.087. Epub 2008 Nov 1.


Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.

Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D.

Science. 2008 Sep 12;321(5895):1493-5. doi: 10.1126/science.1158554.


Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.

Wang WL, Chai SC, Huang M, He HZ, Hurley TD, Ye QZ.

J Med Chem. 2008 Oct 9;51(19):6110-20. doi: 10.1021/jm8005788. Epub 2008 Sep 12.


Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase.

González-Segura L, Witte JF, McClard RW, Hurley TD.

Biochemistry. 2007 Dec 11;46(49):14075-86. Epub 2007 Nov 20.


A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme.

Janecki DJ, Bemis KG, Tegeler TJ, Sanghani PC, Zhai L, Hurley TD, Bosron WF, Wang M.

Anal Biochem. 2007 Oct 1;369(1):18-26. Epub 2007 Jul 6.


Structural basis for regulation of protein phosphatase 1 by inhibitor-2.

Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK, DePaoli-Roach AA.

J Biol Chem. 2007 Sep 28;282(39):28874-83. Epub 2007 Jul 18.


Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487.

Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD.

J Biol Chem. 2007 Apr 27;282(17):12940-50. Epub 2007 Feb 27.


Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.

Bateman RL, Ashworth J, Witte JF, Baker LJ, Bhanumoorthy P, Timm DE, Hurley TD, Grompe M, McClard RW.

Biochem J. 2007 Mar 1;402(2):251-60.


Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal.

Florang VR, Rees JN, Brogden NK, Anderson DG, Hurley TD, Doorn JA.

Neurotoxicology. 2007 Jan;28(1):76-82. Epub 2006 Aug 1.


Direct detection of glycogenin reaction products during glycogen initiation.

Hurley TD, Walls C, Bennett JR, Roach PJ, Wang M.

Biochem Biophys Res Commun. 2006 Sep 22;348(2):374-8. Epub 2006 Jul 28.


Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal.

Doorn JA, Hurley TD, Petersen DR.

Chem Res Toxicol. 2006 Jan;19(1):102-10.


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