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Items: 1 to 50 of 84

1.

Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation.

Dalton WB, Helmenstine E, Walsh N, Gondek LP, Kelkar DS, Read A, Natrajan R, Christenson ES, Roman B, Das S, Zhao L, Leone RD, Shinn D, Groginski T, Madugundu AK, Patil A, Zabransky DJ, Medford A, Lee J, Cole AJ, Rosen M, Thakar M, Ambinder A, Donaldson J, DeZern AE, Cravero K, Chu D, Madero-Marroquin R, Pandey A, Hurley PJ, Lauring J, Park B.

J Clin Invest. 2019 Aug 8;130. pii: 125022. doi: 10.1172/JCI125022.

2.

Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer.

Torquato S, Pallavajjala A, Goldstein A, Toro PV, Silberstein JL, Lee J, Nakazawa M, Waters I, Chu D, Shinn D, Groginski T, Hughes RM, Simons BW, Khan H, Feng Z, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Eisenberger MA, Antonarakis ES, Trock BJ, Park BH, Hurley PJ.

JCO Precis Oncol. 2019;3. doi: 10.1200/PO.18.00227. Epub 2019 Apr 3.

3.

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ.

Cancer Res. 2019 Jul 15;79(14):3636-3650. doi: 10.1158/0008-5472.CAN-18-2931. Epub 2019 May 23.

PMID:
31123087
4.

Combining immune check-point blockade and cryoablation in an immunocompetent hormone sensitive murine model of prostate cancer.

Benzon B, Glavaris SA, Simons BW, Hughes RM, Ghabili K, Mullane P, Miller R, Nugent K, Shinder B, Tosoian J, Fuchs EJ, Tran PT, Hurley PJ, Vuica-Ross M, Schaeffer EM, Drake CG, Ross AE.

Prostate Cancer Prostatic Dis. 2018 Apr;21(1):126-136. doi: 10.1038/s41391-018-0035-z. Epub 2018 Mar 20.

5.

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy.

Ross AE, Hughes RM, Glavaris S, Ghabili K, He P, Anders NM, Harb R, Tosoian JJ, Marchionni L, Schaeffer EM, Partin AW, Allaf ME, Bivalacqua TJ, Chapman C, O'Neal T, DeMarzo AM, Hurley PJ, Rudek MA, Antonarakis ES.

Oncotarget. 2017 Oct 26;8(61):104182-104192. doi: 10.18632/oncotarget.22115. eCollection 2017 Nov 28.

6.

A Murine Orthotopic Allograft to Model Prostate Cancer Growth and Metastasis.

Hughes RM, Simons BW, Hurley PJ.

Bio Protoc. 2017 Feb 20;7(4). pii: e2137. doi: 10.21769/BioProtoc.2137.

7.

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination.

Haffner MC, Esopi DM, Chaux A, G├╝rel M, Ghosh S, Vaghasia AM, Tsai H, Kim K, Castagna N, Lam H, Hicks J, Wyhs N, Biswal Shinohara D, Hurley PJ, Simons BW, Schaeffer EM, Lotan TL, Isaacs WB, Netto GJ, De Marzo AM, Nelson WG, An SS, Yegnasubramanian S.

Nat Commun. 2017 Jul 26;8(1):142. doi: 10.1038/s41467-017-00084-8.

8.

TWIST1-WDR5-Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis.

Malek R, Gajula RP, Williams RD, Nghiem B, Simons BW, Nugent K, Wang H, Taparra K, Lemtiri-Chlieh G, Yoon AR, True L, An SS, DeWeese TL, Ross AE, Schaeffer EM, Pienta KJ, Hurley PJ, Morrissey C, Tran PT.

Cancer Res. 2017 Jun 15;77(12):3181-3193. doi: 10.1158/0008-5472.CAN-16-2797. Epub 2017 May 8.

9.

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity.

Croessmann S, Wong HY, Zabransky DJ, Chu D, Rosen DM, Cidado J, Cochran RL, Dalton WB, Erlanger B, Cravero K, Button B, Kyker-Snowman K, Hurley PJ, Lauring J, Park BH.

Breast Cancer Res Treat. 2017 Apr;162(3):451-464. doi: 10.1007/s10549-017-4147-2. Epub 2017 Feb 11.

10.

Detection fidelity of AR mutations in plasma derived cell-free DNA.

Goldstein A, Toro PV, Lee J, Silberstein JL, Nakazawa M, Waters I, Cravero K, Chu D, Cochran RL, Kim M, Shinn D, Torquato S, Hughes RM, Pallavajjala A, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Trock BJ, Eisenberger MA, Antonarakis ES, Park BH, Hurley PJ.

Oncotarget. 2017 Feb 28;8(9):15651-15662. doi: 10.18632/oncotarget.14926.

11.

Early-stage Type 2 Diabetes Mellitus Impairs Erectile Function and Neurite Outgrowth From the Major Pelvic Ganglion and Downregulates the Gene Expression of Neurotrophic Factors.

Matsui H, Musicki B, Sopko NA, Liu X, Hurley PJ, Burnett AL, Bivalacqua TJ, Hannan JL.

Urology. 2017 Jan;99:287.e1-287.e7. doi: 10.1016/j.urology.2016.08.045. Epub 2016 Sep 14.

12.

Ki-67 is required for maintenance of cancer stem cells but not cell proliferation.

Cidado J, Wong HY, Rosen DM, Cimino-Mathews A, Garay JP, Fessler AG, Rasheed ZA, Hicks J, Cochran RL, Croessmann S, Zabransky DJ, Mohseni M, Beaver JA, Chu D, Cravero K, Christenson ES, Medford A, Mattox A, De Marzo AM, Argani P, Chawla A, Hurley PJ, Lauring J, Park BH.

Oncotarget. 2016 Feb 2;7(5):6281-93. doi: 10.18632/oncotarget.7057.

13.

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.

Wong HY, Wang GM, Croessmann S, Zabransky DJ, Chu D, Garay JP, Cidado J, Cochran RL, Beaver JA, Aggarwal A, Liu ML, Argani P, Meeker A, Hurley PJ, Lauring J, Park BH.

Oncotarget. 2015 Dec 29;6(42):44927-40. doi: 10.18632/oncotarget.6743.

14.

Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.

Hurley PJ, Sundi D, Shinder B, Simons BW, Hughes RM, Miller RM, Benzon B, Faraj SF, Netto GJ, Vergara IA, Erho N, Davicioni E, Karnes RJ, Yan G, Ewing C, Isaacs SD, Berman DM, Rider JR, Jordahl KM, Mucci LA, Huang J, An SS, Park BH, Isaacs WB, Marchionni L, Ross AE, Schaeffer EM.

Clin Cancer Res. 2016 Jan 15;22(2):448-58. doi: 10.1158/1078-0432.CCR-15-0256. Epub 2015 Oct 7.

15.

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability.

Croessmann S, Wong HY, Zabransky DJ, Chu D, Mendonca J, Sharma A, Mohseni M, Rosen DM, Scharpf RB, Cidado J, Cochran RL, Parsons HA, Dalton WB, Erlanger B, Button B, Cravero K, Kyker-Snowman K, Beaver JA, Kachhap S, Hurley PJ, Lauring J, Park BH.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11583-8. doi: 10.1073/pnas.1503683112. Epub 2015 Aug 31.

16.

Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression.

Hurley PJ, Hughes RM, Simons BW, Huang J, Miller RM, Shinder B, Haffner MC, Esopi D, Kimura Y, Jabbari J, Ross AE, Erho N, Vergara IA, Faraj SF, Davicioni E, Netto GJ, Yegnasubramanian S, An SS, Schaeffer EM.

Cancer Res. 2015 Oct 15;75(20):4322-34. doi: 10.1158/0008-5472.CAN-15-0024. Epub 2015 Aug 20.

17.

ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients.

Chu D, Paoletti C, Gersch C, VanDenBerg DA, Zabransky DJ, Cochran RL, Wong HY, Toro PV, Cidado J, Croessmann S, Erlanger B, Cravero K, Kyker-Snowman K, Button B, Parsons HA, Dalton WB, Gillani R, Medford A, Aung K, Tokudome N, Chinnaiyan AM, Schott A, Robinson D, Jacks KS, Lauring J, Hurley PJ, Hayes DF, Rae JM, Park BH.

Clin Cancer Res. 2016 Feb 15;22(4):993-9. doi: 10.1158/1078-0432.CCR-15-0943. Epub 2015 Aug 10.

18.

Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA.

Toro PV, Erlanger B, Beaver JA, Cochran RL, VanDenBerg DA, Yakim E, Cravero K, Chu D, Zabransky DJ, Wong HY, Croessmann S, Parsons H, Hurley PJ, Lauring J, Park BH.

Clin Biochem. 2015 Oct;48(15):993-8. doi: 10.1016/j.clinbiochem.2015.07.097. Epub 2015 Jul 31.

19.

MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.

Mohseni M, Cidado J, Croessmann S, Cravero K, Cimino-Mathews A, Wong HY, Scharpf R, Zabransky DJ, Abukhdeir AM, Garay JP, Wang GM, Beaver JA, Cochran RL, Blair BG, Rosen DM, Erlanger B, Argani P, Hurley PJ, Lauring J, Park BH.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17606-11. doi: 10.1073/pnas.1408650111. Epub 2014 Nov 24.

20.

A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression.

Simons BW, Durham NM, Bruno TC, Grosso JF, Schaeffer AJ, Ross AE, Hurley PJ, Berman DM, Drake CG, Thumbikat P, Schaeffer EM.

J Pathol. 2015 Feb;235(3):478-89. doi: 10.1002/path.4472.

21.

Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction.

Li J, Ma W, Wang PY, Hurley PJ, Bunz F, Hwang PM.

Free Radic Biol Med. 2014 Aug;73:270-7. doi: 10.1016/j.freeradbiomed.2014.05.022. Epub 2014 Jun 2.

22.

Detection of cancer DNA in plasma of patients with early-stage breast cancer.

Beaver JA, Jelovac D, Balukrishna S, Cochran R, Croessmann S, Zabransky DJ, Wong HY, Toro PV, Cidado J, Blair BG, Chu D, Burns T, Higgins MJ, Stearns V, Jacobs L, Habibi M, Lange J, Hurley PJ, Lauring J, VanDenBerg D, Kessler J, Jeter S, Samuels ML, Maar D, Cope L, Cimino-Mathews A, Argani P, Wolff AC, Park BH.

Clin Cancer Res. 2014 May 15;20(10):2643-2650. doi: 10.1158/1078-0432.CCR-13-2933. Epub 2014 Feb 6.

23.

Young men's attitudes and behaviour in relation to mental health and technology: implications for the development of online mental health services.

Ellis LA, Collin P, Hurley PJ, Davenport TA, Burns JM, Hickie IB.

BMC Psychiatry. 2013 Apr 20;13:119. doi: 10.1186/1471-244X-13-119.

24.

Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates.

Wakeman DR, Weiss S, Sladek JR, Elsworth JD, Bauereis B, Leranth C, Hurley PJ, Roth RH, Redmond DE.

Cell Transplant. 2014;23(8):981-94. doi: 10.3727/096368913X664865. Epub 2013 Apr 2.

PMID:
23562290
25.

Young men, mental health, and technology: implications for service design and delivery in the digital age.

Ellis LA, Collin P, Davenport TA, Hurley PJ, Burns JM, Hickie IB.

J Med Internet Res. 2012 Nov 22;14(6):e160. doi: 10.2196/jmir.2291.

26.

Wnt signaling though beta-catenin is required for prostate lineage specification.

Simons BW, Hurley PJ, Huang Z, Ross AE, Miller R, Marchionni L, Berman DM, Schaeffer EM.

Dev Biol. 2012 Nov 15;371(2):246-55. doi: 10.1016/j.ydbio.2012.08.016. Epub 2012 Aug 30.

27.

Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome.

Hurley PJ, Marchionni L, Simons BW, Ross AE, Peskoe SB, Miller RM, Erho N, Vergara IA, Ghadessi M, Huang Z, Gurel B, Park BH, Davicioni E, Jenkins RB, Platz EA, Berman DM, Schaeffer EM.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14977-82. doi: 10.1073/pnas.1203525109. Epub 2012 Aug 27.

28.

Sox9 is required for prostate development and prostate cancer initiation.

Huang Z, Hurley PJ, Simons BW, Marchionni L, Berman DM, Ross AE, Schaeffer EM.

Oncotarget. 2012 Jun;3(6):651-63.

29.

Aged monkeys as a partial model for Parkinson's disease.

Hurley PJ, Elsworth JD, Whittaker MC, Roth RH, Redmond DE Jr.

Pharmacol Biochem Behav. 2011 Sep;99(3):324-32. doi: 10.1016/j.pbb.2011.05.007. Epub 2011 May 18.

30.

Molecular effects of genistein on male urethral development.

Ross AE, Marchionni L, Phillips TM, Miller RM, Hurley PJ, Simons BW, Salmasi AH, Schaeffer AJ, Gearhart JP, Schaeffer EM.

J Urol. 2011 May;185(5):1894-8. doi: 10.1016/j.juro.2010.12.095. Epub 2011 Mar 21.

31.

Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity.

Ross AE, Emadi A, Marchionni L, Hurley PJ, Simons BW, Schaeffer EM, Vuica-Ross M.

BJU Int. 2011 Aug;108(3):447-54. doi: 10.1111/j.1464-410X.2010.09907.x. Epub 2010 Dec 22.

32.

Existing technologies to reduce specific toxicant emissions in cigarette smoke.

O'Connor RJ, Hurley PJ.

Tob Control. 2008 Sep;17 Suppl 1:i39-48. doi: 10.1136/tc.2007.023689. Review.

33.

ATM and ATR: components of an integrated circuit.

Hurley PJ, Bunz F.

Cell Cycle. 2007 Feb 15;6(4):414-7. Epub 2007 Feb 19. Review.

PMID:
17312392
34.

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation.

Hurley PJ, Wilsker D, Bunz F.

Oncogene. 2007 Apr 19;26(18):2535-42. Epub 2006 Oct 16.

PMID:
17043640
35.

An approach for estimating exposure to ambient concentrations.

Physick WL, Cope ME, Lee S, Hurley PJ.

J Expo Sci Environ Epidemiol. 2007 Jan;17(1):76-83. Epub 2006 Aug 16.

PMID:
16912695
36.

p53 regulates mitochondrial respiration.

Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM.

Science. 2006 Jun 16;312(5780):1650-3. Epub 2006 May 25.

37.

Improved methods for the generation of human gene knockout and knockin cell lines.

Topaloglu O, Hurley PJ, Yildirim O, Civin CI, Bunz F.

Nucleic Acids Res. 2005 Oct 7;33(18):e158.

38.
39.
40.

Orientation averaging of electron backscattered diffraction data.

Humphreys FJ, Bate PS, Hurley PJ.

J Microsc. 2001 Jan;201(Pt 1):50-8.

42.

Illegal dental practice.

Hurley PJ.

Br Dent J. 1982 Feb 2;152(3):75. No abstract available.

PMID:
6949598
43.

99Tcm-diphosphonate scanning as an aid to diagnosis of infection in total hip joint replacements.

Williams ED, Tregonning RJ, Hurley PJ.

Br J Radiol. 1977 Aug;50(596):562-6.

PMID:
890230
44.

Serum digoxin levels in neonates, infants and children with heart disease.

Neutze JM, Rutherford JD, Hurley PJ.

N Z Med J. 1977 Jul 13;86(591):7-10.

PMID:
271873
45.

Isotopes in general practice.

Hurley PJ.

N Z Med J. 1977 Jun 22;85(590):532-5. No abstract available.

PMID:
272514
46.

The effect of verapamil on experimental myocardial ischaemia with a particular reference to regional myocardial blood flow and metabolism.

Smith HJ, Singh BN, Norris RM, Nisbet HD, John MB, Hurley PJ.

Aust N Z J Med. 1977 Apr;7(2):114-21.

PMID:
268165
47.

Distribution of yttrium 90 ferric hydroxide colloid and gold 198 colloid after injection into knee.

Williams ED, Caughey DE, Hurley PJ, John MB.

Ann Rheum Dis. 1976 Dec;35(6):516-20.

48.

The effects of isoprenaline on epicardial ST-segment elevation, lactate production, and myocardial blood flow following coronary artery ligation.

Norris RM, Smith HJ, Singh BN, Nisbet H, John MB, Hurley PJ.

Cardiovasc Res. 1975 Nov;9(6):770-8.

PMID:
1203916
49.

Effects of amiodarone on thyroid function in patients with ischaemic heart disease.

Pritchard DA, Singh BN, Hurley PJ.

Br Heart J. 1975 Aug;37(8):856-60.

50.

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