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Items: 29

1.

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease.

Reisdorf WC, Xie Q, Zeng X, Xie W, Rajpal N, Hoang B, Burgert ME, Kumar V, Hurle MR, Rajpal DK, O'Donnell S, MacDonald TT, Vossenkämper A, Wang L, Reilly M, Votta BJ, Sanchez Y, Agarwal P.

PLoS One. 2019 Apr 19;14(4):e0215033. doi: 10.1371/journal.pone.0215033. eCollection 2019.

2.

Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunities.

Jhamb D, Magid-Slav M, Hurle MR, Agarwal P.

Drug Discov Today. 2019 Jun;24(6):1232-1236. doi: 10.1016/j.drudis.2019.03.024. Epub 2019 Mar 29.

PMID:
30935985
3.

Predicting clinically promising therapeutic hypotheses using tensor factorization.

Yao J, Hurle MR, Nelson MR, Agarwal P.

BMC Bioinformatics. 2019 Feb 8;20(1):69. doi: 10.1186/s12859-019-2664-1.

4.

Systematic interrogation of diverse Omic data reveals interpretable, robust, and generalizable transcriptomic features of clinically successful therapeutic targets.

Rouillard AD, Hurle MR, Agarwal P.

PLoS Comput Biol. 2018 May 21;14(5):e1006142. doi: 10.1371/journal.pcbi.1006142. eCollection 2018 May.

5.

Impact of genetically supported target selection on R&D productivity.

Hurle MR, Nelson MR, Agarwal P, Cardon LR.

Nat Rev Drug Discov. 2016 Sep 12;15(9):596-597. doi: 10.1038/nrd.2016.187.

PMID:
28184040
6.

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues.

Kumar V, Sanseau P, Simola DF, Hurle MR, Agarwal P.

Sci Rep. 2016 Nov 8;6:36205. doi: 10.1038/srep36205.

7.

Trial watch: Impact of genetically supported target selection on R&D productivity.

Hurle MR, Nelson MR, Agarwal P, Cardon LR.

Nat Rev Drug Discov. 2016 Aug 30;15(9):596-597. doi: 10.1038/nrd.2016.164. No abstract available. Erratum in: Nat Rev Drug Discov. 2016 Sep 12;:.

PMID:
27573226
8.

Combined Analysis of Phenotypic and Target-Based Screening in Assay Networks.

Swamidass SJ, Schillebeeckx CN, Matlock M, Hurle MR, Agarwal P.

J Biomol Screen. 2014 Jun;19(5):782-90. doi: 10.1177/1087057114523068. Epub 2014 Feb 21.

PMID:
24563424
9.

Computational drug repositioning: from data to therapeutics.

Hurle MR, Yang L, Xie Q, Rajpal DK, Sanseau P, Agarwal P.

Clin Pharmacol Ther. 2013 Apr;93(4):335-41. doi: 10.1038/clpt.2013.1. Epub 2013 Jan 15. Review.

PMID:
23443757
10.

Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans.

Sarov-Blat L, Morgan JM, Fernandez P, James R, Fang Z, Hurle MR, Baidoo C, Willette RN, Lepore JJ, Jensen SE, Sprecher DL.

Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2256-63. doi: 10.1161/ATVBAHA.110.209205. Epub 2010 Aug 5.

PMID:
20689074
11.

Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.

Sarov-Blat L, Kiss RS, Haidar B, Kavaslar N, Jaye M, Bertiaux M, Steplewski K, Hurle MR, Sprecher D, McPherson R, Marcel YL.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1115-22. Epub 2007 Feb 22.

PMID:
17322100
12.

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.

Chaturvedi P, Sudakin V, Bobiak ML, Fisher PW, Mattern MR, Jablonski SA, Hurle MR, Zhu Y, Yen TJ, Zhou BB.

Cancer Res. 2002 Mar 15;62(6):1797-801.

13.

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.

Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR, Zhang X, Annan RS, Lu Q, Faucette LF, Scott GF, Li X, Carr SA, Johnson RK, Winkler JD, Zhou BB.

Oncogene. 1999 Jul 15;18(28):4047-54.

14.

Selective inhibition of Abeta fibril formation.

Wood SJ, MacKenzie L, Maleeff B, Hurle MR, Wetzel R.

J Biol Chem. 1996 Feb 23;271(8):4086-92.

15.

Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis.

Truneh A, Reddy M, Ryan P, Lyn SD, Eichman C, Couez D, Hurle MR, Sekaly RP, Olive D, Sweet R.

Mol Immunol. 1996 Feb;33(3):321-34.

PMID:
8649453
16.

Prolines and amyloidogenicity in fragments of the Alzheimer's peptide beta/A4.

Wood SJ, Wetzel R, Martin JD, Hurle MR.

Biochemistry. 1995 Jan 24;34(3):724-30.

PMID:
7827029
17.

Protein engineering techniques for antibody humanization.

Hurle MR, Gross M.

Curr Opin Biotechnol. 1994 Aug;5(4):428-33. Review.

PMID:
7765176
18.

A role for destabilizing amino acid replacements in light-chain amyloidosis.

Hurle MR, Helms LR, Li L, Chan W, Wetzel R.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5446-50.

19.

Strong inhibition of fibrinogen binding to platelet receptor alpha IIb beta 3 by RGD sequences installed into a presentation scaffold.

Lee G, Chan W, Hurle MR, DesJarlais RL, Watson F, Sathe GM, Wetzel R.

Protein Eng. 1993 Sep;6(7):745-54.

PMID:
8248098
20.

Comparison of solution structures of mutant bovine pancreatic trypsin inhibitor proteins using two-dimensional nuclear magnetic resonance.

Hurle MR, Eads CD, Pearlman DA, Seibel GL, Thomason J, Kosen PA, Kollman P, Anderson S, Kuntz ID.

Protein Sci. 1992 Jan;1(1):91-106.

21.
22.

Denaturant-dependent folding of bovine pancreatic trypsin inhibitor mutants with two intact disulfide bonds.

Hurle MR, Marks CB, Kosen PA, Anderson S, Kuntz ID.

Biochemistry. 1990 May 8;29(18):4410-9.

PMID:
1693524
23.

Multiple replacements at position 211 in the alpha subunit of tryptophan synthase as a probe of the folding unit association reaction.

Tweedy NB, Hurle MR, Chrunyk BA, Matthews CR.

Biochemistry. 1990 Feb 13;29(6):1539-45.

PMID:
2185841
24.
25.

Mutant sequences as probes of protein folding mechanisms.

Matthews CR, Hurle MR.

Bioessays. 1987 Jun;6(6):254-7. No abstract available.

PMID:
3619886
26.

Prediction of the tertiary structure of the alpha-subunit of tryptophan synthase.

Hurle MR, Matthews CR, Cohen FE, Kuntz ID, Toumadje A, Johnson WC Jr.

Proteins. 1987;2(3):210-24.

PMID:
3328862
27.

Characterization of a slow folding reaction for the alpha subunit of tryptophan synthase.

Hurle MR, Michelotti GA, Crisanti MM, Matthews CR.

Proteins. 1987;2(1):54-63.

PMID:
3328859
28.

Synergism in folding of a double mutant of the alpha subunit of tryptophan synthase.

Hurle MR, Tweedy NB, Matthews CR.

Biochemistry. 1986 Oct 21;25(21):6356-60.

PMID:
3539187

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