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UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb.

Sanchez-Fernandez C, Lorda-Diez CI, García-Porrero JA, Montero JA, Hurlé JM.

Cell Death Dis. 2019 Apr 25;10(5):347. doi: 10.1038/s41419-019-1575-4.


TGFβ2-induced senescence during early inner ear development.

Gibaja A, Aburto MR, Pulido S, Collado M, Hurle JM, Varela-Nieto I, Magariños M.

Sci Rep. 2019 Apr 11;9(1):5912. doi: 10.1038/s41598-019-42040-0.


Cell senescence, apoptosis and DNA damage cooperate in the remodeling processes accounting for heart morphogenesis.

Lorda-Diez CI, Solis-Mancilla ME, Sanchez-Fernandez C, Garcia-Porrero JA, Hurle JM, Montero JA.

J Anat. 2019 Jun;234(6):815-829. doi: 10.1111/joa.12972. Epub 2019 Mar 15.


Four and a half domain 2 (FHL2) scaffolding protein is a marker of connective tissues of developing digits and regulates fibrogenic differentiation of limb mesodermal progenitors.

Lorda-Diez CI, Montero JA, Sanchez-Fernandez C, Garcia-Porrero JA, Chimal-Monroy J, Hurle JM.

J Tissue Eng Regen Med. 2018 Apr;12(4):e2062-e2072. doi: 10.1002/term.2637. Epub 2018 Feb 7.


Interdigital tissue remodelling in the embryonic limb involves dynamic regulation of the miRNA profiles.

Garcia-Riart B, Lorda-Diez CI, Marin-Llera JC, Garcia-Porrero JA, Hurle JM, Montero JA.

J Anat. 2017 Aug;231(2):275-286. doi: 10.1111/joa.12629. Epub 2017 May 24.


Sox9 Expression in Amniotes: Species-Specific Differences in the Formation of Digits.

Montero JA, Lorda-Diez CI, Francisco-Morcillo J, Chimal-Monroy J, Garcia-Porrero JA, Hurle JM.

Front Cell Dev Biol. 2017 Mar 23;5:23. doi: 10.3389/fcell.2017.00023. eCollection 2017.


DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos.

Montero JA, Sanchez-Fernandez C, Lorda-Diez CI, Garcia-Porrero JA, Hurle JM.

Sci Rep. 2016 Oct 18;6:35478. doi: 10.1038/srep35478.


Autophagy resolves early retinal inflammation in Igf1-deficient mice.

Arroba AI, Rodríguez-de la Rosa L, Murillo-Cuesta S, Vaquero-Villanueva L, Hurlé JM, Varela-Nieto I, Valverde ÁM.

Dis Model Mech. 2016 Sep 1;9(9):965-74. doi: 10.1242/dmm.026344. Epub 2016 Jul 21.


The tumor suppressor BTG1 is expressed in the developing digits and regulates skeletogenic differentiation of limb mesodermal progenitors in high density cultures.

Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM.

Cell Tissue Res. 2016 May;364(2):299-308. doi: 10.1007/s00441-015-2331-4. Epub 2015 Dec 11.


Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.

Lorda-Diez CI, Garcia-Riart B, Montero JA, Rodriguez-León J, Garcia-Porrero JA, Hurle JM.

Aging (Albany NY). 2015 Nov;7(11):974-85.


Interdigital tissue regression in the developing limb of vertebrates.

Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM.

Int J Dev Biol. 2015;59(1-3):55-62. doi: 10.1387/ijdb.150065jh. Review.


Regenerative versus destructive cell death in developing systems and tissue homeostasis (retrospective on DOI 10.1002/bies.201200018).

Hurle JM.

Bioessays. 2014 Nov;36(11):1020. doi: 10.1002/bies.201400149. Epub 2014 Sep 25. No abstract available.


The retinal pigment epithelium utilizes fatty acids for ketogenesis.

Adijanto J, Du J, Moffat C, Seifert EL, Hurle JB, Philp NJ.

J Biol Chem. 2014 Jul 25;289(30):20570-82.


Decorin gene expression in the differentiation of the skeletal connective tissues of the developing limb.

Lorda-Diez CI, García-Porrero JA, Hurlé JM, Montero JA.

Gene Expr Patterns. 2014 May;15(1):52-60. doi: 10.1016/j.gep.2014.04.003. Epub 2014 Apr 24.


Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors.

Diaz-Mendoza MJ, Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM.

J Cell Physiol. 2014 Oct;229(10):1397-404. doi: 10.1002/jcp.24576.


Divergent differentiation of skeletal progenitors into cartilage and tendon: lessons from the embryonic limb.

Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM.

ACS Chem Biol. 2014 Jan 17;9(1):72-9. doi: 10.1021/cb400713v. Epub 2013 Nov 20. Review.


Comparative transcriptional analysis of three human ligaments with distinct biomechanical properties.

Lorda-Diez CI, Canga-Villegas A, Cerezal L, Plaza S, Hurlé JM, García-Porrero JA, Montero JA.

J Anat. 2013 Dec;223(6):593-602. doi: 10.1111/joa.12124. Epub 2013 Oct 16.


Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.

Lorda-Diez CI, Montero JA, Choe S, Garcia-Porrero JA, Hurle JM.

J Bone Miner Res. 2014 Mar;29(3):735-48. doi: 10.1002/jbmr.2077.


Interdigital cell death in the embryonic limb is associated with depletion of Reelin in the extracellular matrix.

Díaz-Mendoza MJ, Lorda-Diez CI, Montero JA, García-Porrero JA, Hurlé JM.

Cell Death Dis. 2013 Sep 12;4:e800. doi: 10.1038/cddis.2013.322.


Expression and functional study of extracellular BMP antagonists during the morphogenesis of the digits and their associated connective tissues.

Lorda-Diez CI, Montero JA, Rodriguez-Leon J, Garcia-Porrero JA, Hurle JM.

PLoS One. 2013;8(4):e60423. doi: 10.1371/journal.pone.0060423. Epub 2013 Apr 3.


BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling.

Villar AV, García R, Llano M, Cobo M, Merino D, Lantero A, Tramullas M, Hurlé JM, Hurlé MA, Nistal JF.

Biochim Biophys Acta. 2013 Feb;1832(2):323-35. doi: 10.1016/j.bbadis.2012.11.007. Epub 2012 Nov 17.


Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation.

Aburto MR, Sánchez-Calderón H, Hurlé JM, Varela-Nieto I, Magariños M.

Cell Death Dis. 2012 Oct 4;3:e394. doi: 10.1038/cddis.2012.132.


βig-h3 potentiates the profibrogenic effect of TGFβ signaling on connective tissue progenitor cells through the negative regulation of master chondrogenic genes.

Lorda-Diez CI, Montero JA, Diaz-Mendoza MJ, Garcia-Porrero JA, Hurle JM.

Tissue Eng Part A. 2013 Feb;19(3-4):448-57. doi: 10.1089/ten.TEA.2012.0188. Epub 2012 Oct 24.


Autophagy during vertebrate development.

Aburto MR, Hurlé JM, Varela-Nieto I, Magariños M.

Cells. 2012 Aug 2;1(3):428-48. doi: 10.3390/cells1030428.


Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.

Lorda-Diez CI, Montero JA, Diaz-Mendoza MJ, Garcia-Porrero JA, Hurle JM.

PLoS One. 2011;6(9):e24546. doi: 10.1371/journal.pone.0024546. Epub 2011 Sep 13.


Regenerative medicine and connective tissues: cartilage versus tendon.

Montero JA, Lorda-Diez CI, Hurlé JM.

J Tissue Eng Regen Med. 2012 May;6(5):337-47. doi: 10.1002/term.436. Epub 2011 Jun 28. Review.


Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis.

Villar AV, Merino D, Wenner M, Llano M, Cobo M, Montalvo C, García R, Martín-Durán R, Hurlé JM, Hurlé MA, Nistal JF.

Heart. 2011 Jul;97(14):1132-7. doi: 10.1136/hrt.2010.220418. Epub 2011 May 17.


Coordinated and sequential activation of neutral and acidic DNases during interdigital cell death in the embryonic limb.

Montero JA, Lorda-Diez CI, Certal AC, Moreno N, Rodriguez-Leon J, Torriglia A, Hurle JM.

Apoptosis. 2010 Oct;15(10):1197-210. doi: 10.1007/s10495-010-0523-7.


Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.

Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM.

BMC Dev Biol. 2010 Jun 21;10:69. doi: 10.1186/1471-213X-10-69.


BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.

Tramullas M, Lantero A, Díaz A, Morchón N, Merino D, Villar A, Buscher D, Merino R, Hurlé JM, Izpisúa-Belmonte JC, Hurlé MA.

J Neurosci. 2010 Jan 27;30(4):1502-11. doi: 10.1523/JNEUROSCI.2584-09.2010.


Sculpturing digit shape by cell death.

Montero JA, Hurlé JM.

Apoptosis. 2010 Mar;15(3):365-75. doi: 10.1007/s10495-009-0444-5. Review.


Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme.

Lorda-Diez CI, Montero JA, Martinez-Cue C, Garcia-Porrero JA, Hurle JM.

J Biol Chem. 2009 Oct 23;284(43):29988-96. doi: 10.1074/jbc.M109.014811. Epub 2009 Aug 28.


Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits.

Lorda-Diez CI, Torre-Pérez N, García-Porrero JA, Hurle JM, Montero JA.

Int J Dev Biol. 2009;53(8-10):1495-502. doi: 10.1387/ijdb.072415cl.


Activin/TGFbeta and BMP crosstalk determines digit chondrogenesis.

Montero JA, Lorda-Diez CI, Gañan Y, Macias D, Hurle JM.

Dev Biol. 2008 Sep 15;321(2):343-56. doi: 10.1016/j.ydbio.2008.06.022. Epub 2008 Jun 21.


Migration and differentiation of human umbilical cord stem cells after heart injury in chicken embryos.

Torre-Pérez N, Montero JA, Zuzarte-Luis V, García-Porrero JA, Rubio N, Blanco J, Nistal JF, Hurlé JM.

Stem Cells Dev. 2009 Jan-Feb;18(1):27-36. doi: 10.1089/scd.2007.0239.


Deconstructing digit chondrogenesis.

Montero JA, Hurlé JM.

Bioessays. 2007 Aug;29(8):725-37. Review.


Cathepsin D gene expression outlines the areas of physiological cell death during embryonic development.

Zuzarte-Luis V, Montero JA, Torre-Perez N, Garcia-Porrero JA, Hurle JM.

Dev Dyn. 2007 Mar;236(3):880-5.


Role of RhoC in digit morphogenesis during limb development.

Montero JA, Zuzarte-Luis V, Garcia-Martinez V, Hurle JM.

Dev Biol. 2007 Mar 1;303(1):325-35. Epub 2006 Nov 16.


Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling.

Rodriguez-Guzman M, Montero JA, Santesteban E, Gañan Y, Macias D, Hurle JM.

Dev Biol. 2007 Feb 1;302(1):267-80. Epub 2006 Sep 26.


Lysosomal cathepsins in embryonic programmed cell death.

Zuzarte-Luis V, Montero JA, Kawakami Y, Izpisua-Belmonte JC, Hurle JM.

Dev Biol. 2007 Jan 1;301(1):205-17. Epub 2006 Aug 12.


Caspase redundancy and release of mitochondrial apoptotic factors characterize interdigital apoptosis.

Zuzarte-Luis V, Berciano MT, Lafarga M, Hurlé JM.

Apoptosis. 2006 May;11(5):701-15.


Experimental models for cardiac regeneration.

Sánchez A, Fernández ME, Rodríguez A, Fernández J, Torre-Pérez N, Hurlé JM, García-Sancho J.

Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S29-32.


Programmed cell death in the embryonic vertebrate limb.

Zuzarte-Luis V, Hurle JM.

Semin Cell Dev Biol. 2005 Apr;16(2):261-9. Epub 2005 Jan 16. Review.


A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways.

Zuzarte-Luís V, Montero JA, Rodriguez-León J, Merino R, Rodríguez-Rey JC, Hurlé JM.

Dev Biol. 2004 Aug 1;272(1):39-52.


The molecular basis of retinoid action in tumors.

Merino R, Hurlé JM.

Trends Mol Med. 2003 Dec;9(12):509-11. Review. No abstract available.


Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling.

Chimal-Monroy J, Rodriguez-Leon J, Montero JA, Gañan Y, Macias D, Merino R, Hurle JM.

Dev Biol. 2003 May 15;257(2):292-301.


Programmed cell death in the developing limb.

Zuzarte-Luís V, Hurlé JM.

Int J Dev Biol. 2002;46(7):871-6. Review.


Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart.

Montero JA, Giron B, Arrechedera H, Cheng YC, Scotting P, Chimal-Monroy J, Garcia-Porrero JA, Hurle JM.

Mech Dev. 2002 Oct;118(1-2):199-202.


Comparative analysis of the expression and regulation of Wnt5a, Fz4, and Frzb1 during digit formation and in micromass cultures.

Chimal-Monroy J, Montero JA, Gañan Y, Macias D, Garcia-Porrero JA, Hurle JM.

Dev Dyn. 2002 Jul;224(3):314-20.


Role of FGFs in the control of programmed cell death during limb development.

Montero JA, Gañan Y, Macias D, Rodriguez-Leon J, Sanz-Ezquerro JJ, Merino R, Chimal-Monroy J, Nieto MA, Hurle JM.

Development. 2001 Jun;128(11):2075-84.

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