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Items: 48

1.

MicroRNA-30c-5p modulates neuropathic pain in rodents.

Tramullas M, Francés R, de la Fuente R, Velategui S, Carcelén M, García R, Llorca J, Hurlé MA.

Sci Transl Med. 2018 Aug 8;10(453). pii: eaao6299. doi: 10.1126/scitranslmed.aao6299.

PMID:
30089634
2.

Experimental modelling of cardiac pressure overload hypertrophy: Modified technique for precise, reproducible, safe and easy aortic arch banding-debanding in mice.

Merino D, Gil A, Gómez J, Ruiz L, Llano M, García R, Hurlé MA, Nistal JF.

Sci Rep. 2018 Feb 16;8(1):3167. doi: 10.1038/s41598-018-21548-x.

3.

Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.

Oller J, Méndez-Barbero N, Ruiz EJ, Villahoz S, Renard M, Canelas LI, Briones AM, Alberca R, Lozano-Vidal N, Hurlé MA, Milewicz D, Evangelista A, Salaices M, Nistal JF, Jiménez-Borreguero LJ, De Backer J, Campanero MR, Redondo JM.

Nat Med. 2017 Feb;23(2):200-212. doi: 10.1038/nm.4266. Epub 2017 Jan 9.

PMID:
28067899
4.

Extracellular heat shock protein 90 binding to TGFβ receptor I participates in TGFβ-mediated collagen production in myocardial fibroblasts.

García R, Merino D, Gómez JM, Nistal JF, Hurlé MA, Cortajarena AL, Villar AV.

Cell Signal. 2016 Oct;28(10):1563-79. doi: 10.1016/j.cellsig.2016.07.003. Epub 2016 Jul 11.

PMID:
27418101
5.

BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery.

Merino D, Villar AV, García R, Tramullas M, Ruiz L, Ribas C, Cabezudo S, Nistal JF, Hurlé MA.

Cardiovasc Res. 2016 Jun 1;110(3):331-45. doi: 10.1093/cvr/cvw076. Epub 2016 Apr 11.

PMID:
27068510
6.

p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling.

García R, Nistal JF, Merino D, Price NL, Fernández-Hernando C, Beaumont J, González A, Hurlé MA, Villar AV.

Biochim Biophys Acta. 2015 Jul;1852(7):1520-30. doi: 10.1016/j.bbadis.2015.04.006. Epub 2015 Apr 15.

7.

TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.

Lantero A, Tramullas M, Pílar-Cuellar F, Valdizán E, Santillán R, Roques BP, Hurlé MA.

J Neurosci. 2014 Apr 9;34(15):5385-95. doi: 10.1523/JNEUROSCI.4405-13.2014.

8.

Circulating levels of miR-133a predict the regression potential of left ventricular hypertrophy after valve replacement surgery in patients with aortic stenosis.

García R, Villar AV, Cobo M, Llano M, Martín-Durán R, Hurlé MA, Nistal JF.

J Am Heart Assoc. 2013 Aug 15;2(4):e000211. doi: 10.1161/JAHA.113.000211.

9.

BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling.

Villar AV, García R, Llano M, Cobo M, Merino D, Lantero A, Tramullas M, Hurlé JM, Hurlé MA, Nistal JF.

Biochim Biophys Acta. 2013 Feb;1832(2):323-35. doi: 10.1016/j.bbadis.2012.11.007. Epub 2012 Nov 17.

10.

Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients.

Villar AV, García R, Merino D, Llano M, Cobo M, Montalvo C, Martín-Durán R, Hurlé MA, Nistal JF.

Int J Cardiol. 2013 Sep 10;167(6):2875-81. doi: 10.1016/j.ijcard.2012.07.021. Epub 2012 Aug 9.

PMID:
22882958
11.

Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase.

Martínez-Laorden E, Hurle MA, Milanés MV, Laorden ML, Almela P.

J Pharmacol Exp Ther. 2012 Sep;342(3):665-75. doi: 10.1124/jpet.112.193581. Epub 2012 May 30. Erratum in: J Pharmacol Exp Ther. 2013 Feb;344(2):542.

12.

Androgens contribute to sex differences in myocardial remodeling under pressure overload by a mechanism involving TGF-β.

Montalvo C, Villar AV, Merino D, García R, Ares M, Llano M, Cobo M, Hurlé MA, Nistal JF.

PLoS One. 2012;7(4):e35635. doi: 10.1371/journal.pone.0035635. Epub 2012 Apr 25.

13.

Transforming growth factor-β in normal nociceptive processing and pathological pain models.

Lantero A, Tramullas M, Díaz A, Hurlé MA.

Mol Neurobiol. 2012 Feb;45(1):76-86. doi: 10.1007/s12035-011-8221-1. Epub 2011 Nov 29. Review.

PMID:
22125199
14.

Chronic treatment with the opioid antagonist naltrexone favours the coupling of spinal cord μ-opioid receptors to Gαz protein subunits.

Valdizán EM, Díaz A, Pilar-Cuéllar F, Lantero A, Mostany R, Villar AV, Laorden ML, Hurlé MA.

Neuropharmacology. 2012 Feb;62(2):757-64. doi: 10.1016/j.neuropharm.2011.08.029. Epub 2011 Aug 31.

PMID:
21903117
15.

Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis.

Villar AV, Merino D, Wenner M, Llano M, Cobo M, Montalvo C, García R, Martín-Durán R, Hurlé JM, Hurlé MA, Nistal JF.

Heart. 2011 Jul;97(14):1132-7. doi: 10.1136/hrt.2010.220418. Epub 2011 May 17.

PMID:
21586423
16.

BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.

Tramullas M, Lantero A, Díaz A, Morchón N, Merino D, Villar A, Buscher D, Merino R, Hurlé JM, Izpisúa-Belmonte JC, Hurlé MA.

J Neurosci. 2010 Jan 27;30(4):1502-11. doi: 10.1523/JNEUROSCI.2584-09.2010.

17.

Plasma levels of transforming growth factor-beta1 reflect left ventricular remodeling in aortic stenosis.

Villar AV, Cobo M, Llano M, Montalvo C, González-Vílchez F, Martín-Durán R, Hurlé MA, Nistal JF.

PLoS One. 2009 Dec 30;4(12):e8476. doi: 10.1371/journal.pone.0008476.

18.

Gender differences of echocardiographic and gene expression patterns in human pressure overload left ventricular hypertrophy.

Villar AV, Llano M, Cobo M, Expósito V, Merino R, Martín-Durán R, Hurlé MA, Nistal JF.

J Mol Cell Cardiol. 2009 Apr;46(4):526-35.

PMID:
19639678
19.

Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.

Mostany R, Díaz A, Valdizán EM, Rodríguez-Muñoz M, Garzón J, Hurlé MA.

Neuropharmacology. 2008 May;54(6):989-97. doi: 10.1016/j.neuropharm.2008.02.004. Epub 2008 Feb 16.

PMID:
18384820
20.

Facilitation of avoidance behaviour in mice chronically treated with heroin or methadone.

Tramullas M, Martínez-Cué C, Hurlé MA.

Behav Brain Res. 2008 Jun 3;189(2):332-40. doi: 10.1016/j.bbr.2008.01.013. Epub 2008 Feb 5.

PMID:
18336928
21.

Chronic administration of heroin to mice produces up-regulation of brain apoptosis-related proteins and impairs spatial learning and memory.

Tramullas M, Martínez-Cué C, Hurlé MA.

Neuropharmacology. 2008 Mar;54(4):640-52. doi: 10.1016/j.neuropharm.2007.11.018. Epub 2007 Dec 8.

PMID:
18201731
22.

Chronic methadone treatment and repeated withdrawal impair cognition and increase the expression of apoptosis-related proteins in mouse brain.

Tramullas M, Martínez-Cué C, Hurlé MA.

Psychopharmacology (Berl). 2007 Jul;193(1):107-20. Epub 2007 Mar 24.

PMID:
17384938
23.

Modulation of brain apoptosis-related proteins by the opioid antagonist naltrexone in mice.

San-Emeterio EP, Hurlé MA.

Neurosci Lett. 2006 Aug 7;403(3):276-9. Epub 2006 May 22.

PMID:
16716514
24.

Modulation of apoptosis in the mouse brain after morphine treatments and morphine withdrawal.

Emeterio EP, Tramullas M, Hurlé MA.

J Neurosci Res. 2006 May 15;83(7):1352-61.

PMID:
16496378
25.

Regulation of mu-opioid receptors, G-protein-coupled receptor kinases and beta-arrestin 2 in the rat brain after chronic opioid receptor antagonism.

Díaz A, Pazos A, Flórez J, Ayesta FJ, Santana V, Hurlé MA.

Neuroscience. 2002;112(2):345-53.

PMID:
12044452
27.

Autoradiographic mapping of mu-opioid receptors during opiate tolerance and supersensitivity in the rat central nervous system.

Díaz A, Pazos A, Flórez J, Hurlé MA.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Aug;362(2):101-9.

PMID:
10961371
29.
30.

Effects of kappa- and mu-opioid receptor agonists on Ca2+ channels in neuroblastoma cells: involvement of the orphan opioid receptor.

Hurlé MA, Sánchez A, García-Sancho J.

Eur J Pharmacol. 1999 Aug 27;379(2-3):191-8.

PMID:
10497906
31.

Nimodipine-enhanced opiate analgesia in cancer patients requiring morphine dose escalation: a double-blind, placebo-controlled study.

Santillán R, Hurlé MA, Armijo JA, de los Mozos R, Flórez J.

Pain. 1998 May;76(1-2):17-26.

PMID:
9696455
32.

Mu-opioid receptor regulation during opioid tolerance and supersensitivity in rat central nervous system.

Diaz A, Ruiz F, Flórez J, Hurlé MA, Pazos A.

J Pharmacol Exp Ther. 1995 Sep;274(3):1545-51.

PMID:
7562532
33.

Regulation of dihydropyridine-sensitive Ca++ channels during opioid tolerance and supersensitivity in rats.

Díaz A, Ruíz F, Flórez J, Pazos A, Hurlé MA.

J Pharmacol Exp Ther. 1995 Sep;274(3):1538-44.

PMID:
7562531
34.
35.
36.

Potentiation of acute opioid-induced respiratory depression and reversal of tolerance by the calcium antagonist nimodipine in awake rats.

Ruiz F, Dierssen M, Flórez J, Hurlé MA.

Naunyn Schmiedebergs Arch Pharmacol. 1993 Dec;348(6):633-7.

PMID:
8133906
37.

The Ca2+ channel agonist Bay K 8644 induces central respiratory depression in cats, an effect blocked by naloxone.

Ruiz F, Dierssen M, Flórez J, Hurlé MA.

Eur J Pharmacol. 1993 Aug 24;240(2-3):155-61.

PMID:
7694855
38.

Ca2+ channel modulation by dihydropyridines modifies sufentanil-induced respiratory depression in cats.

Dierssen M, Ruiz F, Flórez J, Hurlé MA.

Eur J Pharmacol. 1991 Jun 6;198(2-3):149-55.

PMID:
1713849
39.

Calcium channel modulation by dihydropyridines modifies sufentanil-induced antinociception in acute and tolerant conditions.

Dierssen M, Flórez J, Hurlé MA.

Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):559-65.

PMID:
1708855
40.

Opiate analgesia and calcium channels modulation by dihydropyridines under acute and tolerant conditions.

Flórez J, Dierssen M, Hurlé MA.

Prog Clin Biol Res. 1990;328:461-4. No abstract available.

PMID:
1689496
41.

Lack of interaction between cholecystokinin and opioid systems in the central control of breathing.

Dierssen M, Flórez J, Hurlé MA.

Rev Esp Fisiol. 1989;45 Suppl:185-90.

PMID:
2641818
42.

Respiratory actions induced by cholecystokinin at the brainstem level.

Hurlé MA, Dierssen MM, Morin-Surun MP, Oceja C, Flórez J.

Peptides. 1988 Jul-Aug;9(4):809-15.

PMID:
3226957
43.

Mechanism of the respiratory action of pentobarbital at the medullary and pontine levels.

Hurlé MA, Dierssen MM, Flórez J.

Eur J Pharmacol. 1986 Jun 17;125(2):225-32.

PMID:
3017725
44.

Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats.

Hurlé MA, Mediavilla A, Flórez J.

Neuropharmacology. 1985 Jul;24(7):597-606.

PMID:
3927184
45.

The effects of cholecystokinin-8 in the nucleus tractus solitarius.

Denavit-Saubié M, Hurlé MA, Morin-Surun MP, Foutz AS, Champagnat J.

Ann N Y Acad Sci. 1985;448:375-84. No abstract available.

PMID:
3861125
46.

Participation of pontine structures in the respiratory action of opioids.

Hurlé MA, Mediavilla A, Flórez J.

Life Sci. 1983;33 Suppl 1:571-4.

PMID:
6363854
47.

Respiratory responses to opiates applied to the medullary ventral surface.

Flórez J, Hurlé MA, Mediavilla A.

Life Sci. 1982 Nov 15-22;31(20-21):2189-92.

PMID:
6819420
48.

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