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Items: 1 to 50 of 163

1.

Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons.

Miller ML, Chadwick B, Dickstein DL, Purushothaman I, Egervari G, Rahman T, Tessereau C, Hof PR, Roussos P, Shen L, Baxter MG, Hurd YL.

Mol Psychiatry. 2018 Oct 3. doi: 10.1038/s41380-018-0243-x. [Epub ahead of print]

PMID:
30283037
2.

A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons.

Kozlenkov A, Li J, Apontes P, Hurd YL, Byne WM, Koonin EV, Wegner M, Mukamel EA, Dracheva S.

Sci Adv. 2018 Sep 26;4(9):eaau6190. doi: 10.1126/sciadv.aau6190. eCollection 2018 Sep.

3.

Molecular Genetics and New Medication Strategies for Opioid Addiction.

Hurd YL, O'Brien CP.

Am J Psychiatry. 2018 Oct 1;175(10):935-942. doi: 10.1176/appi.ajp.2018.18030352. Epub 2018 Aug 2.

PMID:
30068261
4.

Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity.

Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang GJ, Volkow ND, Hurd YL.

Mol Psychiatry. 2018 Jun 28. doi: 10.1038/s41380-018-0120-7. [Epub ahead of print]

5.

Molecular windows into the human brain for psychiatric disorders.

Egervari G, Kozlenkov A, Dracheva S, Hurd YL.

Mol Psychiatry. 2018 Jun 28. doi: 10.1038/s41380-018-0125-2. [Epub ahead of print] Review.

6.

An atlas of chromatin accessibility in the adult human brain.

Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P.

Genome Res. 2018 Aug;28(8):1243-1252. doi: 10.1101/gr.232488.117. Epub 2018 Jun 26.

PMID:
29945882
7.

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures.

McKenzie AT, Wang M, Hauberg ME, Fullard JF, Kozlenkov A, Keenan A, Hurd YL, Dracheva S, Casaccia P, Roussos P, Zhang B.

Sci Rep. 2018 Jun 11;8(1):8868. doi: 10.1038/s41598-018-27293-5.

8.

THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders.

Guennewig B, Bitar M, Obiorah I, Hanks J, O'Brien EA, Kaczorowski DC, Hurd YL, Roussos P, Brennand KJ, Barry G.

Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.

9.

Can a Framework Be Established for the Safe Use of Ketamine?

Freedman R, Brown AS, Cannon TD, Druss BG, Earls FJ, Escobar J, Hurd YL, Lewis DA, López-Jaramillo C, Luby J, Mayberg HS, Moffitt TE, Oquendo M, Perlis RH, Pine DS, Rush AJ, Tamminga CA, Tohen M, Vieta E, Wisner KL, Xin Y.

Am J Psychiatry. 2018 Jul 1;175(7):587-589. doi: 10.1176/appi.ajp.2018.18030290. Epub 2018 Apr 16. No abstract available.

PMID:
29656666
10.

Cannabidiol, an Adjunct Player in the Antipsychosis Arsenal.

Bassir Nia A, Hurd YL.

Am J Psychiatry. 2018 Mar 1;175(3):197-198. doi: 10.1176/appi.ajp.2017.17121295. No abstract available.

PMID:
29490489
11.

Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.

Calipari ES, Godino A, Peck EG, Salery M, Mervosh NL, Landry JA, Russo SJ, Hurd YL, Nestler EJ, Kiraly DD.

Nat Commun. 2018 Jan 16;9(1):9. doi: 10.1038/s41467-017-01881-x.

12.

Perioperative Patient Beliefs Regarding Potential Effectiveness of Marijuana (Cannabinoids) for Treatment of Pain: A Prospective Population Survey.

Khelemsky Y, Goldberg AT, Hurd YL, Winkel G, Ninh A, Qian L, Oprescu A, Ciccone J, Katz DJ.

Reg Anesth Pain Med. 2017 Sep/Oct;42(5):652-659. doi: 10.1097/AAP.0000000000000654.

PMID:
28796754
13.

A new dawn in cannabinoid neurobiology: The road from molecules to therapeutic discoveries.

Cheer JF, Hurd YL.

Neuropharmacology. 2017 Sep 15;124:1-2. doi: 10.1016/j.neuropharm.2017.07.004. Epub 2017 Jul 8. No abstract available.

PMID:
28694099
14.

Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement.

Michaelides M, Miller ML, DiNieri JA, Gomez JL, Schwartz E, Egervari G, Wang GJ, Mobbs CV, Volkow ND, Hurd YL.

Neuropsychopharmacology. 2017 Nov;42(12):2365-2376. doi: 10.1038/npp.2017.112. Epub 2017 Jun 5.

15.

Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms.

Egervari G, Ciccocioppo R, Jentsch JD, Hurd YL.

Neurosci Biobehav Rev. 2018 Feb;85:117-125. doi: 10.1016/j.neubiorev.2017.05.019. Epub 2017 May 29. Review.

PMID:
28571877
16.

The endocannabinoid system as a target for addiction treatment: Trials and tribulations.

Sloan ME, Gowin JL, Ramchandani VA, Hurd YL, Le Foll B.

Neuropharmacology. 2017 Sep 15;124:73-83. doi: 10.1016/j.neuropharm.2017.05.031. Epub 2017 May 28. Review.

PMID:
28564576
17.

DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age.

Kozlenkov A, Jaffe AE, Timashpolsky A, Apontes P, Rudchenko S, Barbu M, Byne W, Hurd YL, Horvath S, Dracheva S.

Genes (Basel). 2017 May 30;8(6). pii: E152. doi: 10.3390/genes8060152.

18.

High times for cannabis: Epigenetic imprint and its legacy on brain and behavior.

Szutorisz H, Hurd YL.

Neurosci Biobehav Rev. 2018 Feb;85:93-101. doi: 10.1016/j.neubiorev.2017.05.011. Epub 2017 May 12. Review.

PMID:
28506926
19.

Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability.

Miller ML, Ren Y, Szutorisz H, Warren NA, Tessereau C, Egervari G, Mlodnicka A, Kapoor M, Chaarani B, Morris CV, Schumann G, Garavan H, Goate AM, Bannon MJ; IMAGEN Consortium, Halperin JM, Hurd YL.

Mol Psychiatry. 2018 May;23(5):1328-1335. doi: 10.1038/mp.2017.80. Epub 2017 Apr 25.

20.

Cannabidiol: Swinging the Marijuana Pendulum From 'Weed' to Medication to Treat the Opioid Epidemic.

Hurd YL.

Trends Neurosci. 2017 Mar;40(3):124-127. doi: 10.1016/j.tins.2016.12.006. Epub 2017 Feb 2.

PMID:
28162799
21.

Testing the Gateway Hypothesis.

Miller ML, Hurd YL.

Neuropsychopharmacology. 2017 Apr;42(5):985-986. doi: 10.1038/npp.2016.279. Epub 2017 Jan 18. No abstract available.

22.

Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior.

Mazzone CM, Pati D, Michaelides M, DiBerto J, Fox JH, Tipton G, Anderson C, Duffy K, McKlveen JM, Hardaway JA, Magness ST, Falls WA, Hammack SE, McElligott ZA, Hurd YL, Kash TL.

Mol Psychiatry. 2018 Jan;23(1):143-153. doi: 10.1038/mp.2016.218. Epub 2016 Dec 13.

23.

Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target.

Egervari G, Landry J, Callens J, Fullard JF, Roussos P, Keller E, Hurd YL.

Biol Psychiatry. 2017 Apr 1;81(7):585-594. doi: 10.1016/j.biopsych.2016.09.015. Epub 2016 Sep 28.

24.

Feeding the Developing Brain: The Persistent Epigenetic Effects of Early Life Malnutrition.

Szutorisz H, Hurd YL.

Biol Psychiatry. 2016 Nov 15;80(10):730-732. doi: 10.1016/j.biopsych.2016.08.032. No abstract available.

PMID:
27765157
25.

Histone arginine methylation in cocaine action in the nucleus accumbens.

Damez-Werno DM, Sun H, Scobie KN, Shao N, Rabkin J, Dias C, Calipari ES, Maze I, Pena CJ, Walker DM, Cahill ME, Chandra R, Gancarz A, Mouzon E, Landry JA, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Neve RL, Hurd YL, Shen L, Nestler EJ.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.

26.

Psychiatric comorbidity associated with synthetic cannabinoid use compared to cannabis.

Bassir Nia A, Medrano B, Perkel C, Galynker I, Hurd YL.

J Psychopharmacol. 2016 Dec;30(12):1321-1330. Epub 2016 Jul 26.

PMID:
27462088
27.

Cross-generational THC exposure alters the developmental sensitivity of ventral and dorsal striatal gene expression in male and female offspring.

Szutorisz H, Egervári G, Sperry J, Carter JM, Hurd YL.

Neurotoxicol Teratol. 2016 Nov - Dec;58:107-114. doi: 10.1016/j.ntt.2016.05.005. Epub 2016 May 21. Review.

28.

A Functional 3'UTR Polymorphism (rs2235749) of Prodynorphin Alters microRNA-365 Binding in Ventral Striatonigral Neurons to Influence Novelty Seeking and Positive Reward Traits.

Egervari G, Jutras-Aswad D, Landry J, Miller ML, Anderson SA, Michaelides M, Jacobs MM, Peter C, Yiannoulos G, Liu X, Hurd YL.

Neuropsychopharmacology. 2016 Sep;41(10):2512-20. doi: 10.1038/npp.2016.53. Epub 2016 Apr 14.

29.

Sex and age specific effects of delta-9-tetrahydrocannabinol during the periadolescent period in the rat: The unique susceptibility of the prepubescent animal.

Silva L, Black R, Michaelides M, Hurd YL, Dow-Edwards D.

Neurotoxicol Teratol. 2016 Nov - Dec;58:88-100. doi: 10.1016/j.ntt.2016.02.005. Epub 2016 Feb 16. Review.

PMID:
26898326
30.

Substantial DNA methylation differences between two major neuronal subtypes in human brain.

Kozlenkov A, Wang M, Roussos P, Rudchenko S, Barbu M, Bibikova M, Klotzle B, Dwork AJ, Zhang B, Hurd YL, Koonin EV, Wegner M, Dracheva S.

Nucleic Acids Res. 2016 Apr 7;44(6):2593-612. doi: 10.1093/nar/gkv1304. Epub 2015 Nov 26.

31.

Epigenetic Effects of Cannabis Exposure.

Szutorisz H, Hurd YL.

Biol Psychiatry. 2016 Apr 1;79(7):586-94. doi: 10.1016/j.biopsych.2015.09.014. Epub 2015 Nov 3. Review.

32.

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.

Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL.

Neuropsychopharmacology. 2016 Apr;41(5):1404-15. doi: 10.1038/npp.2015.293. Epub 2015 Sep 18.

33.

Endocannabinoid signalling in reward and addiction.

Parsons LH, Hurd YL.

Nat Rev Neurosci. 2015 Oct;16(10):579-94. doi: 10.1038/nrn4004. Epub 2015 Sep 16. Review.

34.

Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage.

Hurd YL, Yoon M, Manini AF, Hernandez S, Olmedo R, Ostman M, Jutras-Aswad D.

Neurotherapeutics. 2015 Oct;12(4):807-15. doi: 10.1007/s13311-015-0373-7. Review.

35.

Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions.

Kovacs GG, Horvath MC, Majtenyi K, Lutz MI, Hurd YL, Keller E.

Neurobiol Aging. 2015 Nov;36(11):3100-3107. doi: 10.1016/j.neurobiolaging.2015.07.018. Epub 2015 Jul 17.

36.

Effects of an opioid (proenkephalin) polymorphism on neural response to errors in health and cocaine use disorder.

Moeller SJ, Beebe-Wang N, Schneider KE, Konova AB, Parvaz MA, Alia-Klein N, Hurd YL, Goldstein RZ.

Behav Brain Res. 2015 Oct 15;293:18-26. doi: 10.1016/j.bbr.2015.07.004. Epub 2015 Jul 8.

37.

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.

Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR, Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD.

Neuron. 2015 Jul 1;87(1):77-94. doi: 10.1016/j.neuron.2015.06.014.

38.

Genome-Wide DNA Methylation Profiling Reveals Epigenetic Changes in the Rat Nucleus Accumbens Associated With Cross-Generational Effects of Adolescent THC Exposure.

Watson CT, Szutorisz H, Garg P, Martin Q, Landry JA, Sharp AJ, Hurd YL.

Neuropsychopharmacology. 2015 Dec;40(13):2993-3005. doi: 10.1038/npp.2015.155. Epub 2015 Jun 5.

39.

Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans.

Manini AF, Yiannoulos G, Bergamaschi MM, Hernandez S, Olmedo R, Barnes AJ, Winkel G, Sinha R, Jutras-Aswad D, Huestis MA, Hurd YL.

J Addict Med. 2015 May-Jun;9(3):204-10. doi: 10.1097/ADM.0000000000000118.

40.

Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area.

Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Peña CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonté B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ.

Nat Neurosci. 2015 Mar;18(3):415-22. doi: 10.1038/nn.3932. Epub 2015 Feb 2.

41.

DREAMM: a biobehavioral imaging methodology for dynamic in vivo whole-brain mapping of cell type-specific functional networks.

Michaelides M, Hurd YL.

Neuropsychopharmacology. 2015 Jan;40(1):239-40. doi: 10.1038/npp.2014.233. Review. No abstract available.

42.

A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions.

Xu J, Lu Z, Xu M, Pan L, Deng Y, Xie X, Liu H, Ding S, Hurd YL, Pasternak GW, Klein RJ, Cartegni L, Zhou W, Pan YX.

J Neurosci. 2014 Aug 13;34(33):11048-66. doi: 10.1523/JNEUROSCI.3986-13.2014.

43.

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.

Alpár A, Tortoriello G, Calvigioni D, Niphakis MJ, Milenkovic I, Bakker J, Cameron GA, Hanics J, Morris CV, Fuzik J, Kovacs GG, Cravatt BF, Parnavelas JG, Andrews WD, Hurd YL, Keimpema E, Harkany T.

Nat Commun. 2014 Jul 17;5:4421. doi: 10.1038/ncomms5421.

44.

Neuronal substrates and functional consequences of prenatal cannabis exposure.

Calvigioni D, Hurd YL, Harkany T, Keimpema E.

Eur Child Adolesc Psychiatry. 2014 Oct;23(10):931-41. doi: 10.1007/s00787-014-0550-y. Epub 2014 May 3. Review.

45.

G9a influences neuronal subtype specification in striatum.

Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ.

Nat Neurosci. 2014 Apr;17(4):533-9. doi: 10.1038/nn.3670. Epub 2014 Mar 2.

46.

Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.

Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, Keimpema E, Botting CH, Reinecke K, Herdegen T, Courtney M, Hurd YL, Harkany T.

EMBO J. 2014 Apr 1;33(7):668-85. doi: 10.1002/embj.201386035. Epub 2014 Jan 27.

47.

Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development.

Trampush JW, Jacobs MM, Hurd YL, Newcorn JH, Halperin JM.

Dev Sci. 2014 Jul;17(4):584-95. doi: 10.1111/desc.12131. Epub 2014 Jan 11.

48.

Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.

Szutorisz H, DiNieri JA, Sweet E, Egervari G, Michaelides M, Carter JM, Ren Y, Miller ML, Blitzer RD, Hurd YL.

Neuropsychopharmacology. 2014 May;39(6):1315-23. doi: 10.1038/npp.2013.352. Epub 2014 Jan 2.

49.

ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli.

Lobo MK, Zaman S, Damez-Werno DM, Koo JW, Bagot RC, DiNieri JA, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer JF, Han MH, Dietz DM, Self DW, Hurd YL, Vialou V, Nestler EJ.

J Neurosci. 2013 Nov 20;33(47):18381-95. doi: 10.1523/JNEUROSCI.1875-13.2013.

50.

Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks.

Michaelides M, Anderson SA, Ananth M, Smirnov D, Thanos PK, Neumaier JF, Wang GJ, Volkow ND, Hurd YL.

J Clin Invest. 2013 Dec;123(12):5342-50. doi: 10.1172/JCI72117. Epub 2013 Nov 15.

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