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Items: 11

3.

Target-Mediated Drug Disposition Population Pharmacokinetics Model of Alirocumab in Healthy Volunteers and Patients: Pooled Analysis of Randomized Phase I/II/III Studies.

Djebli N, Martinez JM, Lohan L, Khier S, Brunet A, Hurbin F, Fabre D.

Clin Pharmacokinet. 2017 Oct;56(10):1155-1171. doi: 10.1007/s40262-016-0505-1.

4.

Physiologically based pharmacokinetic modeling for sequential metabolism: effect of CYP2C19 genetic polymorphism on clopidogrel and clopidogrel active metabolite pharmacokinetics.

Djebli N, Fabre D, Boulenc X, Fabre G, Sultan E, Hurbin F.

Drug Metab Dispos. 2015 Apr;43(4):510-22. doi: 10.1124/dmd.114.062596. Epub 2015 Jan 21.

PMID:
25609219
5.

Clopidogrel pharmacodynamics and pharmacokinetics in the fed and fasted state: a randomized crossover study of healthy men.

Hurbin F, Boulenc X, Daskalakis N, Farenc C, Taylor T, Bonneau D, Lacreta F, Cheng S, Sultan E.

J Clin Pharmacol. 2012 Oct;52(10):1506-15. Epub 2011 Nov 29.

PMID:
22128201
6.

Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite.

Boulenc X, Djebli N, Shi J, Perrin L, Brian W, Van Horn R, Hurbin F.

Drug Metab Dispos. 2012 Jan;40(1):187-97. doi: 10.1124/dmd.111.040394. Epub 2011 Oct 17.

PMID:
22004687
7.

Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects.

Simon T, Bhatt DL, Bergougnan L, Farenc C, Pearson K, Perrin L, Vicaut E, Lacreta F, Hurbin F, Dubar M.

Clin Pharmacol Ther. 2011 Aug;90(2):287-95. doi: 10.1038/clpt.2011.127. Epub 2011 Jun 29.

PMID:
21716274
8.

An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma.

Tuffal G, Roy S, Lavisse M, Brasseur D, Schofield J, Delesque Touchard N, Savi P, Bremond N, Rouchon MC, Hurbin F, Sultan E.

Thromb Haemost. 2011 Apr;105(4):696-705. doi: 10.1160/TH10-09-0582. Epub 2011 Feb 8.

PMID:
21301779
9.

Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies.

Angiolillo DJ, Gibson CM, Cheng S, Ollier C, Nicolas O, Bergougnan L, Perrin L, LaCreta FP, Hurbin F, Dubar M.

Clin Pharmacol Ther. 2011 Jan;89(1):65-74. doi: 10.1038/clpt.2010.219. Epub 2010 Sep 15.

PMID:
20844485
10.

Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers.

Ubeaud G, Schiller CD, Hurbin F, Jaeck D, Coassolo P.

Eur J Drug Metab Pharmacokinet. 2001 Jan-Jun;26(1-2):37-45.

PMID:
11554432
11.

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