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Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase.

Tang HYH, Shin DS, Hura GL, Yang Y, Hu X, Lightstone FC, McGee MD, Padgett HS, Yannone SM, Tainer JA.

Biochemistry. 2018 Dec 4;57(48):6688-6700. doi: 10.1021/acs.biochem.8b00963. Epub 2018 Nov 15.


From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.

Ramadan AM, Daguindau E, Rech JC, Chinnaswamy K, Zhang J, Hura GL, Griesenauer B, Bolten Z, Robida A, Larsen M, Stuckey JA, Yang CY, Paczesny S.

JCI Insight. 2018 Jul 26;3(14). pii: 99208. doi: 10.1172/jci.insight.99208. eCollection 2018 Jul 26.


A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function.

Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL Jr.

Neuron. 2018 Feb 21;97(4):836-852.e6. doi: 10.1016/j.neuron.2018.01.035. Epub 2018 Feb 8.


Small angle X-ray scattering and cross-linking for data assisted protein structure prediction in CASP 12 with prospects for improved accuracy.

Ogorzalek TL, Hura GL, Belsom A, Burnett KH, Kryshtafovych A, Tainer JA, Rappsilber J, Tsutakawa SE, Fidelis K.

Proteins. 2018 Mar;86 Suppl 1:202-214. doi: 10.1002/prot.25452. Epub 2018 Feb 7.


High Resolution Distance Distributions Determined by X-Ray and Neutron Scattering.

Tang HYH, Tainer JA, Hura GL.

Adv Exp Med Biol. 2017;1009:167-181. doi: 10.1007/978-981-10-6038-0_10. Review.


Coiled coils unspring protein origami.

Hura GL, Tainer JA.

Nat Biotechnol. 2017 Nov 9;35(11):1044-1045. doi: 10.1038/nbt.4003. No abstract available.


2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update.

Trewhella J, Duff AP, Durand D, Gabel F, Guss JM, Hendrickson WA, Hura GL, Jacques DA, Kirby NM, Kwan AH, Pérez J, Pollack L, Ryan TM, Sali A, Schneidman-Duhovny D, Schwede T, Svergun DI, Sugiyama M, Tainer JA, Vachette P, Westbrook J, Whitten AE.

Acta Crystallogr D Struct Biol. 2017 Sep 1;73(Pt 9):710-728. doi: 10.1107/S2059798317011597. Epub 2017 Aug 18.


Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.

Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny D, Tripathi SM, Takahashi JS, Partch CL.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1560-1565. doi: 10.1073/pnas.1615310114. Epub 2017 Jan 31.


Designing and defining dynamic protein cage nanoassemblies in solution.

Lai YT, Hura GL, Dyer KN, Tang HY, Tainer JA, Yeates TO.

Sci Adv. 2016 Dec 14;2(12):e1501855. eCollection 2016 Dec.


Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.

Brosey CA, Ho C, Long WZ, Singh S, Burnett K, Hura GL, Nix JC, Bowman GR, Ellenberger T, Tainer JA.

Structure. 2016 Dec 6;24(12):2067-2079. doi: 10.1016/j.str.2016.09.012. Epub 2016 Nov 3.


Lipid Cross-Linking of Nanolipoprotein Particles Substantially Enhances Serum Stability and Cellular Uptake.

Gilmore SF, Blanchette CD, Scharadin TM, Hura GL, Rasley A, Corzett M, Pan CX, Fischer NO, Henderson PT.

ACS Appl Mater Interfaces. 2016 Aug 17;8(32):20549-57. doi: 10.1021/acsami.6b04609. Epub 2016 Aug 4.


Finding Our Way in the Dark Proteome.

Bhowmick A, Brookes DH, Yost SR, Dyson HJ, Forman-Kay JD, Gunter D, Head-Gordon M, Hura GL, Pande VS, Wemmer DE, Wright PE, Head-Gordon T.

J Am Chem Soc. 2016 Aug 10;138(31):9730-42. doi: 10.1021/jacs.6b06543. Epub 2016 Jul 19.


RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.

Hodge CD, Ismail IH, Edwards RA, Hura GL, Xiao AT, Tainer JA, Hendzel MJ, Glover JN.

J Biol Chem. 2016 Apr 29;291(18):9396-410. doi: 10.1074/jbc.M116.715698. Epub 2016 Feb 22.


Exploring the repeat protein universe through computational protein design.

Brunette TJ, Parmeggiani F, Huang PS, Bhabha G, Ekiert DC, Tsutakawa SE, Hura GL, Tainer JA, Baker D.

Nature. 2015 Dec 24;528(7583):580-4. doi: 10.1038/nature16162. Epub 2015 Dec 16.


Cell-free expression of functional receptor tyrosine kinases.

He W, Scharadin TM, Saldana M, Gellner C, Hoang-Phou S, Takanishi C, Hura GL, Tainer JA, Carraway KL 3rd, Henderson PT, Coleman MA.

Sci Rep. 2015 Aug 14;5:12896. doi: 10.1038/srep12896.


Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.

Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T.

Nucleic Acids Res. 2015 Aug 18;43(14):7021-31. doi: 10.1093/nar/gkv652. Epub 2015 Jun 29.


Structure of a designed protein cage that self-assembles into a highly porous cube.

Lai YT, Reading E, Hura GL, Tsai KL, Laganowsky A, Asturias FJ, Tainer JA, Robinson CV, Yeates TO.

Nat Chem. 2014 Dec;6(12):1065-71. doi: 10.1038/nchem.2107. Epub 2014 Nov 10.


Nanoparticle imaging. Electron microscopy of gold nanoparticles at atomic resolution.

Azubel M, Koivisto J, Malola S, Bushnell D, Hura GL, Koh AL, Tsunoyama H, Tsukuda T, Pettersson M, Häkkinen H, Kornberg RD.

Science. 2014 Aug 22;345(6199):909-12. doi: 10.1126/science.1251959.


Intact functional fourteen-subunit respiratory membrane-bound [NiFe]-hydrogenase complex of the hyperthermophilic archaeon Pyrococcus furiosus.

McTernan PM, Chandrayan SK, Wu CH, Vaccaro BJ, Lancaster WA, Yang Q, Fu D, Hura GL, Tainer JA, Adams MW.

J Biol Chem. 2014 Jul 11;289(28):19364-72. doi: 10.1074/jbc.M114.567255. Epub 2014 May 23.


High-throughput SAXS for the characterization of biomolecules in solution: a practical approach.

Dyer KN, Hammel M, Rambo RP, Tsutakawa SE, Rodic I, Classen S, Tainer JA, Hura GL.

Methods Mol Biol. 2014;1091:245-58. doi: 10.1007/978-1-62703-691-7_18.


DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals.

Hura GL, Tsai CL, Claridge SA, Mendillo ML, Smith JM, Williams GJ, Mastroianni AJ, Alivisatos AP, Putnam CD, Kolodner RD, Tainer JA.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17308-13. doi: 10.1073/pnas.1308595110. Epub 2013 Oct 7.


Structure, dynamics, and specificity of endoglucanase D from Clostridium cellulovorans.

Bianchetti CM, Brumm P, Smith RW, Dyer K, Hura GL, Rutkoski TJ, Phillips GN Jr.

J Mol Biol. 2013 Nov 15;425(22):4267-85. doi: 10.1016/j.jmb.2013.05.030. Epub 2013 Jun 8.


Structural and functional characterization of CalS11, a TDP-rhamnose 3'-O-methyltransferase involved in calicheamicin biosynthesis.

Singh S, Chang A, Helmich KE, Bingman CA, Wrobel RL, Beebe ET, Makino S, Aceti DJ, Dyer K, Hura GL, Sunkara M, Morris AJ, Phillips GN Jr, Thorson JS.

ACS Chem Biol. 2013 Jul 19;8(7):1632-9. doi: 10.1021/cb400068k. Epub 2013 May 23.


Fusion of dioxygenase and lignin-binding domains in a novel secreted enzyme from cellulolytic Streptomyces sp. SirexAA-E.

Bianchetti CM, Harmann CH, Takasuka TE, Hura GL, Dyer K, Fox BG.

J Biol Chem. 2013 Jun 21;288(25):18574-87. doi: 10.1074/jbc.M113.475848. Epub 2013 May 7.


Comprehensive macromolecular conformations mapped by quantitative SAXS analyses.

Hura GL, Budworth H, Dyer KN, Rambo RP, Hammel M, McMurray CT, Tainer JA.

Nat Methods. 2013 Jun;10(6):453-4. doi: 10.1038/nmeth.2453. No abstract available.


Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.

Classen S, Hura GL, Holton JM, Rambo RP, Rodic I, McGuire PJ, Dyer K, Hammel M, Meigs G, Frankel KA, Tainer JA.

J Appl Crystallogr. 2013 Feb 1;46(Pt 1):1-13. Epub 2013 Jan 17.


The positional specificity of EXXK motifs within an amphipathic α-helix dictates preferential lysine modification by acrolein: implications for the design of high-density lipoprotein mimetic peptides.

Zheng Y, Kim SH, Patel AB, Narayanaswami V, Iavarone AT, Hura GL, Bielicki JK.

Biochemistry. 2012 Aug 14;51(32):6400-12. Epub 2012 Aug 2.


Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.

Burke JR, Hura GL, Rubin SM.

Genes Dev. 2012 Jun 1;26(11):1156-66. doi: 10.1101/gad.189837.112. Epub 2012 May 8.


Small-angle X-ray scattering studies of the oligomeric state and quaternary structure of the trifunctional proline utilization A (PutA) flavoprotein from Escherichia coli.

Singh RK, Larson JD, Zhu W, Rambo RP, Hura GL, Becker DF, Tanner JJ.

J Biol Chem. 2011 Dec 16;286(50):43144-53. doi: 10.1074/jbc.M111.292474. Epub 2011 Oct 19.


Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops.

Lang WH, Coats JE, Majka J, Hura GL, Lin Y, Rasnik I, McMurray CT.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E837-44. doi: 10.1073/pnas.1105461108. Epub 2011 Sep 29.


Crystal structure of the unliganded retinoblastoma protein pocket domain.

Balog ER, Burke JR, Hura GL, Rubin SM.

Proteins. 2011 Jun;79(6):2010-4. doi: 10.1002/prot.23007. Epub 2011 Apr 12. No abstract available.


HDL mimetic peptide ATI-5261 forms an oligomeric assembly in solution that dissociates to monomers upon dilution.

Zheng Y, Patel AB, Narayanaswami V, Hura GL, Hang B, Bielicki JK.

Biochemistry. 2011 May 17;50(19):4068-76. doi: 10.1021/bi2002955. Epub 2011 Apr 20.


Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system.

Classen S, Rodic I, Holton J, Hura GL, Hammel M, Tainer JA.

J Synchrotron Radiat. 2010 Nov;17(6):774-81. doi: 10.1107/S0909049510028566. Epub 2010 Sep 3.


Small-angle scattering and the structure of ambient liquid water.

Clark GN, Hura GL, Teixeira J, Soper AK, Head-Gordon T.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14003-7. doi: 10.1073/pnas.1006599107. Epub 2010 Jul 20.


Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum.

Srivastava D, Schuermann JP, White TA, Krishnan N, Sanyal N, Hura GL, Tan A, Henzl MT, Becker DF, Tanner JJ.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2878-83. doi: 10.1073/pnas.0906101107. Epub 2010 Feb 1.


Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.

Aleshin AE, Gramatikova S, Hura GL, Bobkov A, Strongin AY, Stec B, Tainer JA, Liddington RC, Smith JW.

Structure. 2009 Nov 11;17(11):1465-75. doi: 10.1016/j.str.2009.09.009.


Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.

Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA.

J Biol Chem. 2010 Jan 8;285(2):1414-23. doi: 10.1074/jbc.M109.065615. Epub 2009 Nov 5.


The structure and conformation of Lys63-linked tetraubiquitin.

Datta AB, Hura GL, Wolberger C.

J Mol Biol. 2009 Oct 9;392(5):1117-24. doi: 10.1016/j.jmb.2009.07.090. Epub 2009 Aug 4. Erratum in: J Mol Biol. 2014 Jan 23;426(2):499.


Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS).

Hura GL, Menon AL, Hammel M, Rambo RP, Poole FL 2nd, Tsutakawa SE, Jenney FE Jr, Classen S, Frankel KA, Hopkins RC, Yang SJ, Scott JW, Dillard BD, Adams MW, Tainer JA.

Nat Methods. 2009 Aug;6(8):606-12. doi: 10.1038/nmeth.1353. Epub 2009 Jul 20.


Structure and flexibility within proteins as identified through small angle X-ray scattering.

Pelikan M, Hura GL, Hammel M.

Gen Physiol Biophys. 2009 Jun;28(2):174-89.


Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72.

Kozlov G, Määttänen P, Schrag JD, Hura GL, Gabrielli L, Cygler M, Thomas DY, Gehring K.

Structure. 2009 May 13;17(5):651-9. doi: 10.1016/j.str.2009.02.016.


Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.

Shin DS, Didonato M, Barondeau DP, Hura GL, Hitomi C, Berglund JA, Getzoff ED, Cary SC, Tainer JA.

J Mol Biol. 2009 Feb 6;385(5):1534-55. doi: 10.1016/j.jmb.2008.11.031. Epub 2008 Nov 25.


Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.

Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, Bokoch GM, Tainer JA, Weckbecker G, Kuhn P.

J Mol Biol. 2008 Jul 25;380(5):828-43. doi: 10.1016/j.jmb.2008.05.024. Epub 2008 May 17.


The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair.

Iyer RR, Pohlhaus TJ, Chen S, Hura GL, Dzantiev L, Beese LS, Modrich P.

J Biol Chem. 2008 May 9;283(19):13310-9. doi: 10.1074/jbc.M800606200. Epub 2008 Mar 7.


Effects of hydration water on protein methyl group dynamics in solution.

Russo D, Hura GL, Copley JR.

Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Apr;75(4 Pt 1):040902. Epub 2007 Apr 30.


Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography.

Tsutakawa SE, Hura GL, Frankel KA, Cooper PK, Tainer JA.

J Struct Biol. 2007 May;158(2):214-23. Epub 2006 Oct 27.


Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.

Pioletti M, Findeisen F, Hura GL, Minor DL Jr.

Nat Struct Mol Biol. 2006 Nov;13(11):987-95. Epub 2006 Oct 22.


A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T.

Mol Cell. 2006 Oct 20;24(2):279-91.


Crosstalk between primase subunits can act to regulate primer synthesis in trans.

Corn JE, Pease PJ, Hura GL, Berger JM.

Mol Cell. 2005 Nov 11;20(3):391-401.

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