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HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia.

Huot JR, Novinger LJ, Pin F, Bonetto A.

Dis Model Mech. 2020 Jan 24;13(1). pii: dmm043166. doi: 10.1242/dmm.043166.


Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice.

Essex AL, Pin F, Huot JR, Bonewald LF, Plotkin LI, Bonetto A.

Front Endocrinol (Lausanne). 2019 Nov 19;10:809. doi: 10.3389/fendo.2019.00809. eCollection 2019.


Mechanochemistry of Metal Hydrides: Recent Advances.

Huot J, Cuevas F, Deledda S, Edalati K, Filinchuk Y, Grosdidier T, Hauback BC, Heere M, Jensen TR, Latroche M, Sartori S.

Materials (Basel). 2019 Aug 29;12(17). pii: E2778. doi: 10.3390/ma12172778. Review.


Inducible orthogonal aminoacylation demonstrates that charging is required for mitochondrial tRNA import in Trypanosoma brucei.

Huot JL, Shikha S, Schneider A.

Sci Rep. 2019 Jul 25;9(1):10836. doi: 10.1038/s41598-019-47268-4.


Chronic Treatment with Multi-Kinase Inhibitors Causes Differential Toxicities on Skeletal and Cardiac Muscles.

Huot JR, Essex AL, Gutierrez M, Barreto R, Wang M, Waning DL, Plotkin LI, Bonetto A.

Cancers (Basel). 2019 Apr 23;11(4). pii: E571. doi: 10.3390/cancers11040571.


PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia.

Pin F, Novinger LJ, Huot JR, Harris RA, Couch ME, O'Connell TM, Bonetto A.

FASEB J. 2019 Jun;33(6):7778-7790. doi: 10.1096/fj.201802799R. Epub 2019 Mar 20.


Microstructure Optimization of Mg-Alloys by the ECAP Process Including Numerical Simulation, SPD Treatments, Characterization, and Hydrogen Sorption Properties.

Skryabina N, Aptukov V, Romanov P, Fruchart D, de Rango P, Girard G, Grandini C, Sandim H, Huot J, Lang J, Cantelli R, Leardini F.

Molecules. 2018 Dec 27;24(1). pii: E89. doi: 10.3390/molecules24010089.


Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation.

Zhong L, Simard MJ, Huot J.

FASEB J. 2018 Aug;32(8):4070-4084. doi: 10.1096/fj.201701536R. Epub 2018 Mar 22. Review.


Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle.

Peck B, Huot J, Renzi T, Arthur S, Turner MJ, Marino JS.

Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R468-R477. doi: 10.1152/ajpregu.00521.2016. Epub 2017 Nov 29.


The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells.

Corre I, Paris F, Huot J.

Oncotarget. 2017 May 29;8(33):55684-55714. doi: 10.18632/oncotarget.18264. eCollection 2017 Aug 15. Review.


Corrigendum: The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins.

Harsman A, Oeljeklaus S, Wenger C, Huot JL, Warscheid B, Schneider A.

Nat Commun. 2017 Jun 30;8:16123. doi: 10.1038/ncomms16123.


The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins.

Harsman A, Oeljeklaus S, Wenger C, Huot JL, Warscheid B, Schneider A.

Nat Commun. 2016 Dec 19;7:13707. doi: 10.1038/ncomms13707. Erratum in: Nat Commun. 2017 Jun 30;8:16123.


p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription.

Zhong L, Simoneau B, Huot J, Simard MJ.

Oncotarget. 2017 Jan 3;8(1):1678-1687. doi: 10.18632/oncotarget.13779.


Oxidative stress disassembles the p38/NPM/PP2A complex, which leads to modulation of nucleophosmin-mediated signaling to DNA damage response.

Guillonneau M, Paris F, Dutoit S, Estephan H, Bénéteau E, Huot J, Corre I.

FASEB J. 2016 Aug;30(8):2899-914. doi: 10.1096/fj.201500194R. Epub 2016 May 3.


Altered left ventricular performance in aging physically active mice with an ankle sprain injury.

Turner MJ, Guderian S, Wikstrom EA, Huot JR, Peck BD, Arthur ST, Marino JS, Hubbard-Turner T.

Age (Dordr). 2016 Feb;38(1):15. doi: 10.1007/s11357-016-9877-2. Epub 2016 Jan 23.


Hydrogenation Properties of TiFe Doped with Zirconium.

Gosselin C, Huot J.

Materials (Basel). 2015 Nov 20;8(11):7864-7872. doi: 10.3390/ma8115423.


Enhancement of the initial hydrogenation of Mg by ball milling with alkali metal amides MNH2 (M = Li or Na).

Chu H, Qiu S, Sun L, Huot J.

Dalton Trans. 2015 Oct 14;44(38):16694-7. doi: 10.1039/c5dt01847a. Epub 2015 Sep 9.


Acute Sodium Ingestion Before Exercise Increases Voluntary Water Consumption Resulting In Preexercise Hyperhydration and Improvement in Exercise Performance in the Heat.

Morris DM, Huot JR, Jetton AM, Collier SR, Utter AC.

Int J Sport Nutr Exerc Metab. 2015 Oct;25(5):456-62. doi: 10.1123/ijsnem.2014-0212. Epub 2015 Mar 26.


MicroRNA-196a promotes an oncogenic effect in head and neck cancer cells by suppressing annexin A1 and enhancing radioresistance.

Suh YE, Raulf N, Gäken J, Lawler K, Urbano TG, Bullenkamp J, Gobeil S, Huot J, Odell E, Tavassoli M.

Int J Cancer. 2015 Sep 1;137(5):1021-34. doi: 10.1002/ijc.29397. Epub 2015 Jan 12.


Exploring the evolutionary diversity and assembly modes of multi-aminoacyl-tRNA synthetase complexes: lessons from unicellular organisms.

Laporte D, Huot JL, Bader G, Enkler L, Senger B, Becker HD.

FEBS Lett. 2014 Nov 28;588(23):4268-78. doi: 10.1016/j.febslet.2014.10.007. Epub 2014 Oct 12. Review.


Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases.

Araiso Y, Huot JL, Sekiguchi T, Frechin M, Fischer F, Enkler L, Senger B, Ishitani R, Becker HD, Nureki O.

Nucleic Acids Res. 2014 May;42(9):6052-63. doi: 10.1093/nar/gku234. Epub 2014 Apr 1.


Idiosyncrasies in decoding mitochondrial genomes.

Huot JL, Enkler L, Megel C, Karim L, Laporte D, Becker HD, Duchêne AM, Sissler M, Maréchal-Drouard L.

Biochimie. 2014 May;100:95-106. doi: 10.1016/j.biochi.2014.01.004. Epub 2014 Jan 16. Review.


In-Vitro and Ex-Vivo Investigations of the Microtubule Binding Drug Targetin on Angiogenesis.

Ajeawung NF, Mononen L, Thorn A, Pin AL, Joshi HC, Huot J, Kamnasaran D.

J Pediatr Oncol. 2013;1:41-47.


Regulation of endothelial permeability and transendothelial migration of cancer cells by tropomyosin-1 phosphorylation.

Simoneau B, Houle F, Huot J.

Vasc Cell. 2012 Nov 17;4(1):18. doi: 10.1186/2045-824X-4-18.


Development of a tridimensional microvascularized human skin substitute to study melanoma biology.

Gibot L, Galbraith T, Huot J, Auger FA.

Clin Exp Metastasis. 2013 Jan;30(1):83-90. doi: 10.1007/s10585-012-9511-3. Epub 2012 Jul 13.


Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.

Pin AL, Houle F, Fournier P, Guillonneau M, Paquet ÉR, Simard MJ, Royal I, Huot J.

J Biol Chem. 2012 Aug 31;287(36):30541-51. doi: 10.1074/jbc.M112.393561. Epub 2012 Jul 6.


miR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF.

Pin AL, Houle F, Guillonneau M, Paquet ER, Simard MJ, Huot J.

Angiogenesis. 2012 Dec;15(4):593-608. doi: 10.1007/s10456-012-9283-z. Epub 2012 Jun 14.


17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration.

Aka JA, Zerradi M, Houle F, Huot J, Lin SX.

Breast Cancer Res. 2012 Jun 12;14(3):R92.


The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code.

Fischer F, Huot JL, Lorber B, Diss G, Hendrickson TL, Becker HD, Lapointe J, Kern D.

Nucleic Acids Res. 2012 Jun;40(11):4965-76. doi: 10.1093/nar/gks167. Epub 2012 Feb 22.


Gln-tRNAGln synthesis in a dynamic transamidosome from Helicobacter pylori, where GluRS2 hydrolyzes excess Glu-tRNAGln.

Huot JL, Fischer F, Corbeil J, Madore E, Lorber B, Diss G, Hendrickson TL, Kern D, Lapointe J.

Nucleic Acids Res. 2011 Nov;39(21):9306-15. doi: 10.1093/nar/gkr619. Epub 2011 Aug 3.


Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3.

Porquet N, Poirier A, Houle F, Pin AL, Gout S, Tremblay PL, Paquet ER, Klinck R, Auger FA, Huot J.

BMC Cancer. 2011 Jul 1;11:285. doi: 10.1186/1471-2407-11-285.


Recent advances in colorectal cancer research: the microenvironment impact.

Pin AL, Houle F, Huot J.

Cancer Microenviron. 2011 Aug;4(2):127-31. doi: 10.1007/s12307-011-0070-y. No abstract available.


The effect of radiation dose on the tensile and impact toughness of highly cross-linked and remelted ultrahigh-molecular weight polyethylenes.

Huot JC, Van Citters DW, Currier JH, Collier JP.

J Biomed Mater Res B Appl Biomater. 2011 May;97(2):327-33. doi: 10.1002/jbm.b.31818. Epub 2011 Mar 10.


Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by chloramphenicol analogs.

Balg C, De Mieri M, Huot JL, Blais SP, Lapointe J, Chênevert R.

Bioorg Med Chem. 2010 Nov 15;18(22):7868-72. doi: 10.1016/j.bmc.2010.09.045. Epub 2010 Oct 1.


Evaluating the suitability of highly cross-linked and remelted materials for use in posterior stabilized knees.

Huot JC, Van Citters DW, Currier JH, Currier BH, Mayor MB, Collier JP.

J Biomed Mater Res B Appl Biomater. 2010 Nov;95(2):298-307. doi: 10.1002/jbm.b.31714.


A preexisting microvascular network benefits in vivo revascularization of a microvascularized tissue-engineered skin substitute.

Gibot L, Galbraith T, Huot J, Auger FA.

Tissue Eng Part A. 2010 Oct;16(10):3199-206. doi: 10.1089/ten.TEA.2010.0189.


β5 integrin orchestrates epithelial mesenchymal transition in breast cancer: comment on: Bianchi A, et al. Cell Cycle 2010; 9:1647-59.

Pin AL, Huot J.

Cell Cycle. 2010 May 15;9(10):1873. Epub 2010 May 15. No abstract available.


IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation.

Roussel L, Houle F, Chan C, Yao Y, Bérubé J, Olivenstein R, Martin JG, Huot J, Hamid Q, Ferri L, Rousseau S.

J Immunol. 2010 Apr 15;184(8):4531-7. doi: 10.4049/jimmunol.0903162. Epub 2010 Mar 12.


Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1.

Côté MC, Lavoie JR, Houle F, Poirier A, Rousseau S, Huot J.

J Biol Chem. 2010 Mar 12;285(11):8013-21. doi: 10.1074/jbc.M109.098665. Epub 2010 Jan 8.


A C-truncated glutamyl-tRNA synthetase specific for tRNA(Glu) is stimulated by its free complementary distal domain: mechanistic and evolutionary implications.

Dubois DY, Blais SP, Huot JL, Lapointe J.

Biochemistry. 2009 Jun 30;48(25):6012-21. doi: 10.1021/bi801690f. Erratum in: Biochemistry. 2009 Aug 4;48(30):7352.


Role of cancer microenvironment in metastasis: focus on colon cancer.

Gout S, Huot J.

Cancer Microenviron. 2008 Dec;1(1):69-83. doi: 10.1007/s12307-008-0007-2. Epub 2008 Mar 14.


Streptococci and lactococci synthesize large amounts of HPr(Ser-P)(His~P).

Roy DJ, Casabon I, Vaillancourt K, Huot JL, Vadeboncoeur C.

Can J Microbiol. 2008 Nov;54(11):941-9. doi: 10.1139/w08-085.


Mechanisms by which E-selectin regulates diapedesis of colon cancer cells under flow conditions.

Tremblay PL, Huot J, Auger FA.

Cancer Res. 2008 Jul 1;68(13):5167-76. doi: 10.1158/0008-5472.CAN-08-1229.


False memory in aging: effects of emotional valence on word recognition accuracy.

Piguet O, Connally E, Krendl AC, Huot JR, Corkin S.

Psychol Aging. 2008 Jun;23(2):307-14. doi: 10.1037/0882-7974.23.2.307.


Feedback effects of chronic browsing on life-history traits of a large herbivore.

Anouk Simard M, Côté SD, Weladji RB, Huot J.

J Anim Ecol. 2008 Jul;77(4):678-86. doi: 10.1111/j.1365-2656.2008.01374.x. Epub 2008 Feb 27.


Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by puromycin analogues.

Balg C, Huot JL, Lapointe J, Chênevert R.

J Am Chem Soc. 2008 Mar 19;130(11):3264-5. doi: 10.1021/ja7100714. Epub 2008 Feb 23. No abstract available.


Impact of degradation products of sulfamethoxazole on mammalian cultured cells.

Yargeau V, Huot JC, Rodayan A, Rouleau L, Roy R, Leask RL.

Environ Toxicol. 2008 Aug;23(4):492-8. doi: 10.1002/tox.20368.


Mechanism of a GatCAB amidotransferase: aspartyl-tRNA synthetase increases its affinity for Asp-tRNA(Asn) and novel aminoacyl-tRNA analogues are competitive inhibitors.

Huot JL, Balg C, Jahn D, Moser J, Emond A, Blais SP, Chênevert R, Lapointe J.

Biochemistry. 2007 Nov 13;46(45):13190-8. Epub 2007 Oct 11.


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