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miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells.

Brinkmann K, Ng AP, de Graaf CA, Di Rago L, Hyland CD, Morelli E, Rautela J, Huntington ND, Strasser A, Alexander WS, Herold MJ.

Cell Death Differ. 2019 Oct 7. doi: 10.1038/s41418-019-0430-6. [Epub ahead of print]


Therapeutic blockade of activin-A improves NK cell function and antitumor immunity.

Rautela J, Dagley LF, de Oliveira CC, Schuster IS, Hediyeh-Zadeh S, Delconte RB, Cursons J, Hennessy R, Hutchinson DS, Harrison C, Kita B, Vivier E, Webb AI, Degli-Esposti MA, Davis MJ, Huntington ND, Souza-Fonseca-Guimaraes F.

Sci Signal. 2019 Aug 27;12(596). pii: eaat7527. doi: 10.1126/scisignal.aat7527.


Impact of Tumor and Immunological Heterogeneity on the Anti-Cancer Immune Response.

Shembrey C, Huntington ND, Hollande F.

Cancers (Basel). 2019 Aug 21;11(9). pii: E1217. doi: 10.3390/cancers11091217. Review.


Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection.

Sheikh AA, Cooper L, Feng M, Souza-Fonseca-Guimaraes F, Lafouresse F, Duckworth BC, Huntington ND, Moon JJ, Pellegrini M, Nutt SL, Belz GT, Good-Jacobson KL, Groom JR.

Cell Rep. 2019 Aug 13;28(7):1758-1772.e4. doi: 10.1016/j.celrep.2019.07.034.


IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.

Eissmann MF, Dijkstra C, Jarnicki A, Phesse T, Brunnberg J, Poh AR, Etemadi N, Tsantikos E, Thiem S, Huntington ND, Hibbs ML, Boussioutas A, Grimbaldeston MA, Buchert M, O'Donoghue RJJ, Masson F, Ernst M.

Nat Commun. 2019 Jun 21;10(1):2735. doi: 10.1038/s41467-019-10676-1.


Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF-β.

Healy LP, Rossi GR, Rautela J, Slade CA, Huntington ND, Winship IM, Souza-Fonseca-Guimaraes F.

Front Immunol. 2019 May 1;10:904. doi: 10.3389/fimmu.2019.00904. eCollection 2019.


A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients.

Cursons J, Souza-Fonseca-Guimaraes F, Foroutan M, Anderson A, Hollande F, Hediyeh-Zadeh S, Behren A, Huntington ND, Davis MJ.

Cancer Immunol Res. 2019 Jul;7(7):1162-1174. doi: 10.1158/2326-6066.CIR-18-0500. Epub 2019 May 14.


Quantifying NK cell growth and survival changes in response to cytokines and regulatory checkpoint blockade helps identify optimal culture and expansion conditions.

Hennessy RJ, Pham K, Delconte R, Rautela J, Hodgkin PD, Huntington ND.

J Leukoc Biol. 2019 Jun;105(6):1341-1354. doi: 10.1002/JLB.MA0718-296R. Epub 2019 May 12.


Author Correction: Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin.

Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T.

Nature. 2019 Feb;566(7745):E10. doi: 10.1038/s41586-019-0958-0.


The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy.

Souza-Fonseca-Guimaraes F, Cursons J, Huntington ND.

Trends Immunol. 2019 Feb;40(2):142-158. doi: 10.1016/ Epub 2019 Jan 10. Review.


Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin.

Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T.

Nature. 2019 Jan;565(7739):366-371. doi: 10.1038/s41586-018-0812-9. Epub 2018 Dec 31. Erratum in: Nature. 2019 Feb;566(7745):E10.


Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes.

Jiao Y, Davis JE, Rautela J, Carrington EM, Ludford-Menting MJ, Goh W, Delconte RB, Souza-Fonseca-Guimaraes F, Koldej R, Gray D, Huang D, Kile BT, Lew AM, Ritchie DS, Huntington ND.

Cell Death Differ. 2019 Aug;26(8):1516-1530. doi: 10.1038/s41418-018-0228-y. Epub 2018 Nov 12.


Bone marrow transplantation generates T cell-dependent control of myeloma in mice.

Vuckovic S, Minnie SA, Smith D, Gartlan KH, Watkins TS, Markey KA, Mukhopadhyay P, Guillerey C, Kuns RD, Locke KR, Pritchard AL, Johansson PA, Varelias A, Zhang P, Huntington ND, Waddell N, Chesi M, Miles JJ, Smyth MJ, Hill GR.

J Clin Invest. 2019 Jan 2;129(1):106-121. doi: 10.1172/JCI98888. Epub 2018 Nov 19.


A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets.

Almeida FF, Tognarelli S, Marçais A, Kueh AJ, Friede ME, Liao Y, Willis SN, Luong K, Faure F, Mercier FE, Galluso J, Firth M, Narni-Mancinelli E, Rais B, Scadden DT, Spallotta F, Weil S, Giannattasio A, Kalensee F, Zöller T, Huntington ND, Schleicher U, Chiocchetti AG, Ugolini S, Herold MJ, Shi W, Koch J, Steinle A, Vivier E, Walzer T, Belz GT, Ullrich E.

Oncoimmunology. 2018 Aug 15;7(10):e1475875. doi: 10.1080/2162402X.2018.1475875. eCollection 2018.


IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos.

Fedele PL, Willis SN, Liao Y, Low MS, Rautela J, Segal DH, Gong JN, Huntington ND, Shi W, Huang DCS, Grigoriadis G, Tellier J, Nutt SL.

Blood. 2018 Nov 15;132(20):2166-2178. doi: 10.1182/blood-2018-05-850727. Epub 2018 Sep 18.


GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function.

Sun L, Rautela J, Delconte RB, Souza-Fonseca-Guimaraes F, Carrington EM, Schenk RL, Herold MJ, Huntington ND, Lew AM, Xu Y, Zhan Y.

Front Immunol. 2018 Aug 28;9:1922. doi: 10.3389/fimmu.2018.01922. eCollection 2018.


Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells.

Rautela J, Dagley LF, Kratina T, Anthony A, Goh W, Surgenor E, Delconte RB, Webb AI, Elwood N, Groom JR, Souza-Fonseca-Guimaraes F, Corcoran L, Huntington ND.

Mol Immunol. 2018 Aug 23. pii: S0161-5890(18)30681-3. doi: 10.1016/j.molimm.2018.08.017. [Epub ahead of print]


Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

Baell JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, Bergamasco MI, May RE, Davey BK, Morgan KJ, Sealey AJ, Wang B, Zamudio N, Wilcox S, Garnham AL, Sheikh BN, Aubrey BJ, Doggett K, Chung MC, de Silva M, Bentley J, Pilling P, Hattarki M, Dolezal O, Dennis ML, Falk H, Ren B, Charman SA, White KL, Rautela J, Newbold A, Hawkins ED, Johnstone RW, Huntington ND, Peat TS, Heath JK, Strasser A, Parker MW, Smyth GK, Street IP, Monahan BJ, Voss AK, Thomas T.

Nature. 2018 Aug;560(7717):253-257. doi: 10.1038/s41586-018-0387-5. Epub 2018 Aug 1.


PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors.

Pang SHM, de Graaf CA, Hilton DJ, Huntington ND, Carotta S, Wu L, Nutt SL.

Front Immunol. 2018 Jun 11;9:1264. doi: 10.3389/fimmu.2018.01264. eCollection 2018.


Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner.

Zhang Y, Maksimovic J, Huang B, De Souza DP, Naselli G, Chen H, Zhang L, Weng K, Liang H, Xu Y, Wentworth JM, Huntington ND, Oshlack A, Gong S, Kallies A, Vuillermin P, Yang M, Harrison LC.

Front Immunol. 2018 Apr 25;9:879. doi: 10.3389/fimmu.2018.00879. eCollection 2018.


Immune homeostasis in health and disease.

Huntington ND, Gray DH.

Immunol Cell Biol. 2018 May;96(5):451-452. doi: 10.1111/imcb.12043. No abstract available.


Molecular insight into targeting the NK cell immune response to cancer.

Rautela J, Souza-Fonseca-Guimaraes F, Hediyeh-Zadeh S, Delconte RB, Davis MJ, Huntington ND.

Immunol Cell Biol. 2018 May;96(5):477-484. doi: 10.1111/imcb.12045. Epub 2018 Apr 17. Review.


Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection.

Ng SS, Souza-Fonseca-Guimaraes F, Rivera FL, Amante FH, Kumar R, Gao Y, Sheel M, Beattie L, Montes de Oca M, Guillerey C, Edwards CL, Faleiro RJ, Frame T, Bunn PT, Vivier E, Godfrey DI, Pellicci DG, Lopez JA, Andrews KT, Huntington ND, Smyth MJ, McCarthy J, Engwerda CR.

Clin Transl Immunology. 2018 Jan 12;7(1):e1003. doi: 10.1002/cti2.1003. eCollection 2018.


A new checkpoint for Natural Killer cell activation.

Souza-Fonseca-Guimaraes F, Huntington ND.

Immunol Cell Biol. 2018 Jan;96(1):5-7. doi: 10.1111/imcb.1027. Epub 2017 Dec 15. No abstract available.


Identification of Novel Human NK Cell Progenitor Subsets.

Sathe P, Pang SHM, Delconte R, Elwood N, Huntington ND.

Int J Mol Sci. 2017 Dec 15;18(12). pii: E2716. doi: 10.3390/ijms18122716.


A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment.

Young A, Ngiow SF, Gao Y, Patch AM, Barkauskas DS, Messaoudene M, Lin G, Coudert JD, Stannard KA, Zitvogel L, Degli-Esposti MA, Vivier E, Waddell N, Linden J, Huntington ND, Souza-Fonseca-Guimaraes F, Smyth MJ.

Cancer Res. 2018 Feb 15;78(4):1003-1016. doi: 10.1158/0008-5472.CAN-17-2826. Epub 2017 Dec 11.


The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

Carrington EM, Tarlinton DM, Gray DH, Huntington ND, Zhan Y, Lew AM.

Immunol Cell Biol. 2017 Nov;95(10):870-877. doi: 10.1038/icb.2017.72. Epub 2017 Sep 6. Review.


Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells.

Kerdiles YM, Almeida FF, Thompson T, Chopin M, Vienne M, Bruhns P, Huntington ND, Raulet DH, Nutt SL, Belz GT, Vivier E.

Immunity. 2017 Aug 15;47(2):199-200. doi: 10.1016/j.immuni.2017.07.026. No abstract available.


Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.

Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng SS, Young A, Ngiow SF, Rautela J, Straube J, Waddell N, Blake SJ, Yan J, Bartholin L, Lee JS, Vivier E, Takeda K, Messaoudene M, Zitvogel L, Teng MWL, Belz GT, Engwerda CR, Huntington ND, Nakamura K, Hölzel M, Smyth MJ.

Nat Immunol. 2017 Sep;18(9):1004-1015. doi: 10.1038/ni.3800. Epub 2017 Jul 31.


Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis.

Young A, Ngiow SF, Madore J, Reinhardt J, Landsberg J, Chitsazan A, Rautela J, Bald T, Barkauskas DS, Ahern E, Huntington ND, Schadendorf D, Long GV, Boyle GM, Hölzel M, Scolyer RA, Smyth MJ.

Cancer Res. 2017 Sep 1;77(17):4684-4696. doi: 10.1158/0008-5472.CAN-17-0393. Epub 2017 Jun 26.


Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM.

Cell Death Differ. 2017 May;24(5):878-888. doi: 10.1038/cdd.2017.30. Epub 2017 Mar 31.


Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis.

Putz EM, Guillerey C, Kos K, Stannard K, Miles K, Delconte RB, Takeda K, Nicholson SE, Huntington ND, Smyth MJ.

Oncoimmunology. 2017 Feb 7;6(2):e1267892. doi: 10.1080/2162402X.2016.1267892. eCollection 2017.


Regulation of Murine Natural Killer Cell Development.

Goh W, Huntington ND.

Front Immunol. 2017 Feb 15;8:130. doi: 10.3389/fimmu.2017.00130. eCollection 2017. Review.


Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.

Viant C, Guia S, Hennessy RJ, Rautela J, Pham K, Bernat C, Goh W, Jiao Y, Delconte R, Roger M, Simon V, Souza-Fonseca-Guimaraes F, Grabow S, Belz GT, Kile BT, Strasser A, Gray D, Hodgkin PD, Beutler B, Vivier E, Ugolini S, Huntington ND.

J Exp Med. 2017 Feb;214(2):491-510. doi: 10.1084/jem.20160869. Epub 2017 Jan 5.


GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity.

Bunting MD, Varelias A, Souza-Fonseca-Guimaraes F, Schuster IS, Lineburg KE, Kuns RD, Fleming P, Locke KR, Huntington ND, Blazar BR, Lane SW, Tey SK, MacDonald KP, Smyth MJ, Degli-Esposti MA, Hill GR.

Blood. 2017 Feb 2;129(5):630-642. doi: 10.1182/blood-2016-08-734020. Epub 2016 Dec 7.


IL-15 signaling in NK cell cancer immunotherapy.

Rautela J, Huntington ND.

Curr Opin Immunol. 2017 Feb;44:1-6. doi: 10.1016/j.coi.2016.10.004. Epub 2016 Nov 11. Review.


Type 1 Innate Lymphoid Cell Biology: Lessons Learnt from Natural Killer Cells.

Jiao Y, Huntington ND, Belz GT, Seillet C.

Front Immunol. 2016 Oct 12;7:426. eCollection 2016. Review.


Deciphering the Innate Lymphoid Cell Transcriptional Program.

Seillet C, Mielke LA, Amann-Zalcenstein DB, Su S, Gao J, Almeida FF, Shi W, Ritchie ME, Naik SH, Huntington ND, Carotta S, Belz GT.

Cell Rep. 2016 Oct 4;17(2):436-447. doi: 10.1016/j.celrep.2016.09.025.


Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells.

Ushiki T, Huntington ND, Glaser SP, Kiu H, Georgiou A, Zhang JG, Metcalf D, Nicola NA, Roberts AW, Alexander WS.

PLoS One. 2016 Sep 1;11(9):e0162111. doi: 10.1371/journal.pone.0162111. eCollection 2016.


Targeting natural killer cells in cancer immunotherapy.

Guillerey C, Huntington ND, Smyth MJ.

Nat Immunol. 2016 Aug 19;17(9):1025-36. doi: 10.1038/ni.3518. Review.


Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.

Chow KV, Delconte RB, Huntington ND, Tarlinton DM, Sutherland RM, Zhan Y, Lew AM.

J Immunol. 2016 Sep 1;197(5):2000-8. doi: 10.4049/jimmunol.1600181. Epub 2016 Jul 29.


Granzyme M has a critical role in providing innate immune protection in ulcerative colitis.

Souza-Fonseca-Guimaraes F, Krasnova Y, Putoczki T, Miles K, MacDonald KP, Town L, Shi W, Gobe GC, McDade L, Mielke LA, Tye H, Masters SL, Belz GT, Huntington ND, Radford-Smith G, Smyth MJ.

Cell Death Dis. 2016 Jul 21;7:e2302. doi: 10.1038/cddis.2016.215.


CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, Burns CJ, Carotta S, Gray DH, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND.

Nat Immunol. 2016 Jul;17(7):816-24. doi: 10.1038/ni.3470. Epub 2016 May 23.


Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells.

Viant C, Rankin LC, Girard-Madoux MJ, Seillet C, Shi W, Smyth MJ, Bartholin L, Walzer T, Huntington ND, Vivier E, Belz GT.

Sci Signal. 2016 May 3;9(426):ra46. doi: 10.1126/scisignal.aaf2176.


PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.

Pang SH, Minnich M, Gangatirkar P, Zheng Z, Ebert A, Song G, Dickins RA, Corcoran LM, Mullighan CG, Busslinger M, Huntington ND, Nutt SL, Carotta S.

Leukemia. 2016 Jun;30(6):1375-87. doi: 10.1038/leu.2016.27. Epub 2016 Mar 2.


TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway.

Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T.

Sci Signal. 2016 Feb 16;9(415):ra19. doi: 10.1126/scisignal.aad1884.


The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

Delconte RB, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, Kolesnik TB, Rankin LC, Mielke LA, Zhang JG, Busslinger M, Smyth MJ, Hutchinson DS, Nutt SL, Nicholson SE, Alexander WS, Corcoran LM, Vivier E, Belz GT, Carotta S, Huntington ND.

Immunity. 2016 Jan 19;44(1):103-115. doi: 10.1016/j.immuni.2015.12.007. Epub 2016 Jan 12.


Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells.

Huntington ND, Carpentier S, Vivier E, Belz GT.

Curr Opin Immunol. 2016 Feb;38:86-93. doi: 10.1016/j.coi.2015.11.008. Epub 2015 Dec 29. Review.


Complementarity and redundancy of IL-22-producing innate lymphoid cells.

Rankin LC, Girard-Madoux MJ, Seillet C, Mielke LA, Kerdiles Y, Fenis A, Wieduwild E, Putoczki T, Mondot S, Lantz O, Demon D, Papenfuss AT, Smyth GK, Lamkanfi M, Carotta S, Renauld JC, Shi W, Carpentier S, Soos T, Arendt C, Ugolini S, Huntington ND, Belz GT, Vivier E.

Nat Immunol. 2016 Feb;17(2):179-86. doi: 10.1038/ni.3332. Epub 2015 Nov 30.


DNAM-1: would the real natural killer cell please stand up!

Huntington ND, Martinet L, Smyth MJ.

Oncotarget. 2015 Oct 6;6(30):28537-8. doi: 10.18632/oncotarget.5952. No abstract available.

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