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Items: 1 to 50 of 198

1.

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein.

Dawson A, Trumper P, de Souza JO, Parker H, Jones MJ, Hales TG, Hunter WN.

IUCrJ. 2019 Sep 4;6(Pt 6):1014-1023. doi: 10.1107/S205225251901114X. eCollection 2019 Nov 1.

2.

Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target.

Díaz-Sáez L, Torrie LS, McElroy SP, Gray D, Hunter WN.

FEBS J. 2019 Nov;286(22):4509-4524. doi: 10.1111/febs.14976. Epub 2019 Jul 16.

PMID:
31260169
3.

The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei.

Pankov G, Dawson A, Hunter WN.

Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):227-232. doi: 10.1107/S2053230X19001778. Epub 2019 Mar 13.

PMID:
30950822
4.

An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement.

Bueno R, Dawson A, Hunter WN.

Acta Crystallogr F Struct Biol Commun. 2019 Mar 1;75(Pt 3):148-152. doi: 10.1107/S2053230X18018083. Epub 2019 Feb 20.

PMID:
30839287
5.

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA.

Gottschald Chiodi C, Baptista-Hon DT, Hunter WN, Hales TG.

J Biol Chem. 2019 Feb 15;294(7):2375-2385. doi: 10.1074/jbc.RA118.006229. Epub 2018 Dec 13.

PMID:
30545943
6.

Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens.

Owen RA, Fyfe PK, Lodge A, Biboy J, Vollmer W, Hunter WN, Sargent F.

Biochem J. 2018 Jan 23;475(2):415-428. doi: 10.1042/BCJ20170633.

7.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

8.

An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.

Oliveira de Souza J, Dawson A, Hunter WN.

ChemMedChem. 2017 Apr 20;12(8):577-579. doi: 10.1002/cmdc.201700118. Epub 2017 Mar 31.

9.

Open and compressed conformations of Francisella tularensis ClpP.

Díaz-Sáez L, Pankov G, Hunter WN.

Proteins. 2017 Jan;85(1):188-194. doi: 10.1002/prot.25197. Epub 2016 Nov 20.

10.

Mutations in POGLUT1 in Galli-Galli/Dowling-Degos disease.

Wilson NJ, Cole C, Kroboth K, Hunter WN, Mann JA, McLean WH, Kernland Lang K, Beltraminelli H, Sabroe RA, Tiffin N, Sobey GJ, Borradori L, Simpson E, Smith FJ.

Br J Dermatol. 2017 Jan;176(1):270-274. doi: 10.1111/bjd.14914. Epub 2016 Sep 24. No abstract available.

11.

The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme.

Mercaldi GF, Dawson A, Hunter WN, Cordeiro AT.

FEBS Lett. 2016 Aug;590(16):2776-86. doi: 10.1002/1873-3468.12276. Epub 2016 Jul 19.

12.

EssC: domain structures inform on the elusive translocation channel in the Type VII secretion system.

Zoltner M, Ng WM, Money JJ, Fyfe PK, Kneuper H, Palmer T, Hunter WN.

Biochem J. 2016 Jul 1;473(13):1941-52. doi: 10.1042/BCJ20160257. Epub 2016 Apr 29.

13.

Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus.

Jäger F, Zoltner M, Kneuper H, Hunter WN, Palmer T.

FEBS Lett. 2016 Feb;590(3):349-57. doi: 10.1002/1873-3468.12065. Epub 2016 Feb 3.

14.

The state-of-the art in macromolecular crystallization: the IYCr series concludes.

Weiss MS, Hunter WN, Einspahr HM.

Acta Crystallogr F Struct Biol Commun. 2016 Jan;72(Pt 1):1. doi: 10.1107/S2053230X15023742. Epub 2016 Jan 1. No abstract available.

15.

The power of three.

Weiss MS, Hunter WN.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1453. doi: 10.1107/S2053230X15022050. Epub 2015 Nov 27. No abstract available.

16.

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.

Eadsforth TC, Pinto A, Luciani R, Tamborini L, Cullia G, De Micheli C, Marinelli L, Cosconati S, Novellino E, Lo Presti L, Cordeiro da Silva A, Conti P, Hunter WN, Costi MP.

J Med Chem. 2015 Oct 22;58(20):7938-48. doi: 10.1021/acs.jmedchem.5b00687. Epub 2015 Sep 16.

17.

Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.

Baum B, Lecker LS, Zoltner M, Jaenicke E, Schnell R, Hunter WN, Brenk R.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1020-6. doi: 10.1107/S2053230X15010614. Epub 2015 Jul 28.

18.

Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major.

Barrack KL, Fyfe PK, Finney AJ, Hunter WN.

Mol Biochem Parasitol. 2015 May;201(1):26-30. doi: 10.1016/j.molbiopara.2015.05.003. Epub 2015 May 14.

19.

The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly.

Barrack KL, Fyfe PK, Hunter WN.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):539-46. doi: 10.1107/S2053230X15000990. Epub 2015 Apr 21.

20.

Macromolecular crystallography and what it can contribute to antiparasite drug discovery.

Hunter WN, Weiss MS.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):483-4. doi: 10.1107/S2053230X1500789X. Epub 2015 Apr 25. Review. No abstract available.

21.

The times they are a-changin' - news from Acta Crystallographica Section F.

Hunter WN, Weiss MS.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1575. doi: 10.1107/S2053230X14024789. Epub 2014 Nov 28. No abstract available.

22.

Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains.

Kneuper H, Cao ZP, Twomey KB, Zoltner M, Jäger F, Cargill JS, Chalmers J, van der Kooi-Pol MM, van Dijl JM, Ryan RP, Hunter WN, Palmer T.

Mol Microbiol. 2014 Sep;93(5):928-43. doi: 10.1111/mmi.12707. Epub 2014 Jul 30.

23.

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.

Khalaf AI, Huggan JK, Suckling CJ, Gibson CL, Stewart K, Giordani F, Barrett MP, Wong PE, Barrack KL, Hunter WN.

J Med Chem. 2014 Aug 14;57(15):6479-94. doi: 10.1021/jm500483b. Epub 2014 Jul 29.

24.

Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile.

Díaz-Sáez L, Srikannathasan V, Zoltner M, Hunter WN.

Biochem J. 2014 Sep 15;462(3):581-9. doi: 10.1042/BJ20140511.

25.

High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies.

Rimsa V, Eadsforth TC, Joosten RP, Hunter WN.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):279-89. doi: 10.1107/S1399004713026801. Epub 2014 Jan 29.

26.

How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase.

Bowman L, Flanagan L, Fyfe PK, Parkin A, Hunter WN, Sargent F.

Biochem J. 2014 Mar 15;458(3):449-58. doi: 10.1042/BJ20131520.

27.

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment.

O'Rourke PE, Kalinowska-Tłuścik J, Fyfe PK, Dawson A, Hunter WN.

BMC Struct Biol. 2014 Jan 10;14:1. doi: 10.1186/1472-6807-14-1.

28.

Two high-resolution structures of the human E3 ubiquitin ligase Siah1.

Rimsa V, Eadsforth TC, Hunter WN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1339-43. doi: 10.1107/S1744309113031448. Epub 2013 Nov 28.

29.

Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens.

Srikannathasan V, English G, Bui NK, Trunk K, O'Rourke PE, Rao VA, Vollmer W, Coulthurst SJ, Hunter WN.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2468-82. doi: 10.1107/S0907444913022725. Epub 2013 Nov 19.

30.

Structure of the SCAN domain of human paternally expressed gene 3 protein.

Rimsa V, Eadsforth TC, Hunter WN.

PLoS One. 2013 Jul 23;8(7):e69538. doi: 10.1371/journal.pone.0069538. Print 2013.

31.

Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.

Dawson A, Trumper P, Chrysostomou G, Hunter WN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):611-7. doi: 10.1107/S174430911301292X. Epub 2013 May 23.

32.

The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function.

Fleming JR, Morgan RE, Fyfe PK, Kelly SM, Hunter WN.

FEBS J. 2013 Jul;280(14):3270-80. doi: 10.1111/febs.12308. Epub 2013 May 24.

33.

Structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase.

Rao VA, Shepherd SM, Owen R, Hunter WN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):243-7. doi: 10.1107/S1744309113002352. Epub 2013 Feb 22.

34.

The architecture of EssB, an integral membrane component of the type VII secretion system.

Zoltner M, Norman DG, Fyfe PK, El Mkami H, Palmer T, Hunter WN.

Structure. 2013 Apr 2;21(4):595-603. doi: 10.1016/j.str.2013.02.007. Epub 2013 Mar 14.

35.

The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.

Moynie L, Schnell R, McMahon SA, Sandalova T, Boulkerou WA, Schmidberger JW, Alphey M, Cukier C, Duthie F, Kopec J, Liu H, Jacewicz A, Hunter WN, Naismith JH, Schneider G.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):25-34. doi: 10.1107/S1744309112044739. Epub 2012 Dec 25.

36.
37.

Acinetobacter baumannii FolD ligand complexes --potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571.

Eadsforth TC, Maluf FV, Hunter WN.

FEBS J. 2012 Dec;279(23):4350-60. doi: 10.1111/febs.12025. Epub 2012 Nov 5.

38.

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens.

English G, Trunk K, Rao VA, Srikannathasan V, Hunter WN, Coulthurst SJ.

Mol Microbiol. 2012 Nov;86(4):921-36. doi: 10.1111/mmi.12028. Epub 2012 Sep 27.

39.

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation.

Fyfe PK, Westrop GD, Silva AM, Coombs GH, Hunter WN.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11693-8. doi: 10.1073/pnas.1202593109. Epub 2012 Jul 2.

40.

Structure of Leishmania major cysteine synthase.

Fyfe PK, Westrop GD, Ramos T, Müller S, Coombs GH, Hunter WN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):738-43. doi: 10.1107/S1744309112019124. Epub 2012 Jun 22.

41.

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.

Tidten-Luksch N, Grimaldi R, Torrie LS, Frearson JA, Hunter WN, Brenk R.

PLoS One. 2012;7(4):e35792. doi: 10.1371/journal.pone.0035792. Epub 2012 Apr 25.

42.

Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target.

Eadsforth TC, Gardiner M, Maluf FV, McElroy S, James D, Frearson J, Gray D, Hunter WN.

PLoS One. 2012;7(4):e35973. doi: 10.1371/journal.pone.0035973. Epub 2012 Apr 25.

43.

Conserved signal peptide recognition systems across the prokaryotic domains.

Coulthurst SJ, Dawson A, Hunter WN, Sargent F.

Biochemistry. 2012 Feb 28;51(8):1678-86. doi: 10.1021/bi201852d. Epub 2012 Feb 13.

44.

Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco.

Barakate A, Stephens J, Goldie A, Hunter WN, Marshall D, Hancock RD, Lapierre C, Morreel K, Boerjan W, Halpin C.

Plant Cell. 2011 Dec;23(12):4492-506. doi: 10.1105/tpc.111.089037. Epub 2011 Dec 9.

45.

The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system.

Rao VA, Shepherd SM, English G, Coulthurst SJ, Hunter WN.

Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1065-72. doi: 10.1107/S0907444911046300. Epub 2011 Nov 18.

46.

The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target.

Eadsforth TC, Cameron S, Hunter WN.

Mol Biochem Parasitol. 2012 Feb;181(2):178-85. doi: 10.1016/j.molbiopara.2011.11.004. Epub 2011 Nov 15.

47.

Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme.

O'Rourke PE, Eadsforth TC, Fyfe PK, Shepherd SM, Hunter WN.

PLoS One. 2011;6(9):e24158. doi: 10.1371/journal.pone.0024158. Epub 2011 Sep 15.

49.

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate.

Morgan RE, Batot GO, Dement JM, Rao VA, Eadsforth TC, Hunter WN.

BMC Struct Biol. 2011 May 9;11:21. doi: 10.1186/1472-6807-11-21.

50.

Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity.

Dawson A, Fyfe PK, Gillet F, Hunter WN.

BMC Struct Biol. 2011 Apr 22;11:19. doi: 10.1186/1472-6807-11-19.

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