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Items: 1 to 50 of 134

1.

Ferrochelatase π-helix: Implications from examining the role of the conserved π-helix glutamates in porphyrin metalation and product release.

Gillam ME, Hunter GA, Ferreira GC.

Arch Biochem Biophys. 2018 Apr 15;644:37-46. doi: 10.1016/j.abb.2018.02.015. Epub 2018 Feb 23.

2.

Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.

Briollais L, Ozcelik H, Xu J, Kwiatkowski M, Lalonde E, Sendorek DH, Fleshner NE, Recker F, Kuk C, Olkhov-Mitsel E, Savas S, Hanna S, Juvet T, Hunter GA, Friedlander M, Li H, Chadwick K, Prassas I, Soosaipillai A, Randazzo M, Trachtenberg J, Toi A, Shiah YJ, Fraser M, van der Kwast T, Bristow RG, Bapat B, Diamandis EP, Boutros PC, Zlotta AR.

J Natl Cancer Inst. 2017 Apr 1;109(4). doi: 10.1093/jnci/djw258.

PMID:
28376164
3.

A Crowdsourcing Approach to Developing and Assessing Prediction Algorithms for AML Prognosis.

Noren DP, Long BL, Norel R, Rrhissorrakrai K, Hess K, Hu CW, Bisberg AJ, Schultz A, Engquist E, Liu L, Lin X, Chen GM, Xie H, Hunter GA, Boutros PC, Stepanov O; DREAM 9 AML-OPC Consortium, Norman T, Friend SH, Stolovitzky G, Kornblau S, Qutub AA.

PLoS Comput Biol. 2016 Jun 28;12(6):e1004890. doi: 10.1371/journal.pcbi.1004890. eCollection 2016 Jun.

4.

The Structure of the Complex between Yeast Frataxin and Ferrochelatase: CHARACTERIZATION AND PRE-STEADY STATE REACTION OF FERROUS IRON DELIVERY AND HEME SYNTHESIS.

Söderberg C, Gillam ME, Ahlgren EC, Hunter GA, Gakh O, Isaya G, Ferreira GC, Al-Karadaghi S.

J Biol Chem. 2016 May 27;291(22):11887-98. doi: 10.1074/jbc.M115.701128. Epub 2016 Mar 29.

5.

Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.

Fratz EJ, Clayton J, Hunter GA, Ducamp S, Breydo L, Uversky VN, Deybach JC, Gouya L, Puy H, Ferreira GC.

Biochemistry. 2015 Sep 15;54(36):5617-31. doi: 10.1021/acs.biochem.5b00407. Epub 2015 Sep 2.

6.

Catalytically active alkaline molten globular enzyme: Effect of pH and temperature on the structural integrity of 5-aminolevulinate synthase.

Stojanovski BM, Breydo L, Hunter GA, Uversky VN, Ferreira GC.

Biochim Biophys Acta. 2014 Dec;1844(12):2145-54. doi: 10.1016/j.bbapap.2014.09.013. Epub 2014 Sep 18.

7.

Unstable reaction intermediates and hysteresis during the catalytic cycle of 5-aminolevulinate synthase: implications from using pseudo and alternate substrates and a promiscuous enzyme variant.

Stojanovski BM, Hunter GA, Jahn M, Jahn D, Ferreira GC.

J Biol Chem. 2014 Aug 15;289(33):22915-25. doi: 10.1074/jbc.M114.574731. Epub 2014 Jun 11.

8.

Expression of murine 5-aminolevulinate synthase variants causes protoporphyrin IX accumulation and light-induced mammalian cell death.

Fratz EJ, Hunter GA, Ferreira GC.

PLoS One. 2014 Apr 9;9(4):e93078. doi: 10.1371/journal.pone.0093078. eCollection 2014.

9.

Mechanisms underlying the additive and redundant Qrr phenotypes in Vibrio harveyi and Vibrio cholerae.

Hunter GA, Keener JP.

J Theor Biol. 2014 Jan 7;340:38-49. doi: 10.1016/j.jtbi.2013.08.034. Epub 2013 Sep 7.

PMID:
24018202
10.

A mathematical model and quantitative comparison of the small RNA circuit in the Vibrio harveyi and Vibrio cholerae quorum sensing systems.

Hunter GA, Vasquez FG, Keener JP.

Phys Biol. 2013 Aug;10(4):046007. doi: 10.1088/1478-3975/10/4/046007. Epub 2013 Jul 3.

PMID:
23820088
11.

Aminolaevulinic acid synthase of Rhodobacter capsulatus: high-resolution kinetic investigation of the structural basis for substrate binding and catalysis.

Kaufholz AL, Hunter GA, Ferreira GC, Lendrihas T, Hering V, Layer G, Jahn M, Jahn D.

Biochem J. 2013 Apr 15;451(2):205-16. doi: 10.1042/BJ20121041. Erratum in: Biochem J. 2013 Jul 1;453(1):154.

PMID:
23363548
12.
13.

FERROCHELATASE: THE CONVERGENCE OF THE PORPHYRIN BIOSYNTHESIS AND IRON TRANSPORT PATHWAYS.

Hunter GA, Al-Karadaghi S, Ferreira GC.

J Porphyr Phthalocyanines. 2011;15(5-6):350-356.

14.

Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase.

Turbeville TD, Zhang J, Adams WC, Hunter GA, Ferreira GC.

Arch Biochem Biophys. 2011 Jul;511(1-2):107-17. doi: 10.1016/j.abb.2011.05.002. Epub 2011 May 11.

15.

Molecular enzymology of 5-aminolevulinate synthase, the gatekeeper of heme biosynthesis.

Hunter GA, Ferreira GC.

Biochim Biophys Acta. 2011 Nov;1814(11):1467-73. doi: 10.1016/j.bbapap.2010.12.015. Epub 2011 Jan 6. Review.

16.

Identification and characterization of an inhibitory metal ion-binding site in ferrochelatase.

Hunter GA, Ferreira GC.

J Biol Chem. 2010 Dec 31;285(53):41836-42. doi: 10.1074/jbc.M110.174243. Epub 2010 Oct 21.

17.

Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase.

Lendrihas T, Hunter GA, Ferreira GC.

J Biol Chem. 2010 Apr 30;285(18):13704-11. doi: 10.1074/jbc.M109.074237. Epub 2010 Mar 1.

18.

Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase.

Lendrihas T, Hunter GA, Ferreira GC.

J Biol Chem. 2010 Jan 29;285(5):3351-9. doi: 10.1074/jbc.M109.066548. Epub 2009 Nov 16.

19.

Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity.

Lendrihas T, Zhang J, Hunter GA, Ferreira GC.

Protein Sci. 2009 Sep;18(9):1847-59. doi: 10.1002/pro.195.

20.

5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis.

Hunter GA, Ferreira GC.

Cell Mol Biol (Noisy-le-grand). 2009 Feb 16;55(1):102-10. Review.

21.

Metal ion substrate inhibition of ferrochelatase.

Hunter GA, Sampson MP, Ferreira GC.

J Biol Chem. 2008 Aug 29;283(35):23685-91. doi: 10.1074/jbc.M803372200. Epub 2008 Jul 1.

22.

A framework for modeling of mechano-electrical feedback mechanisms of cardiac myocytes and tissues.

Sachse FB, Hunter GA, Weiss DL, Seemann G.

Conf Proc IEEE Eng Med Biol Soc. 2007;2007:160-3.

PMID:
18001913
23.

Transient kinetic studies support refinements to the chemical and kinetic mechanisms of aminolevulinate synthase.

Hunter GA, Zhang J, Ferreira GC.

J Biol Chem. 2007 Aug 10;282(32):23025-35. Epub 2007 May 7.

24.

Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis.

Turbeville TD, Zhang J, Hunter GA, Ferreira GC.

Biochemistry. 2007 May 22;46(20):5972-81. Epub 2007 May 1.

25.
26.

Intramolecular and intermolecular geometry of thiophenes with oxygen-containing substituents.

Blake AJ, Clark BA, Gierens H, Gould RO, Hunter GA, McNab H, Morrow M, Sommerville CC.

Acta Crystallogr B. 1999 Dec 1;55(Pt 6):963-974.

PMID:
10927439
27.

Lysine-313 of 5-Aminolevulinate Synthase Acts as a General Base during Formation of the Quinonoid Reaction Intermediates.

Hunter GA, Ferreira GC.

Biochemistry. 1999 Sep 21;38(38):12526. No abstract available.

PMID:
10493823
28.
29.

Lysine-313 of 5-aminolevulinate synthase acts as a general base during formation of the quinonoid reaction intermediates.

Hunter GA, Ferreira GC.

Biochemistry. 1999 Mar 23;38(12):3711-8. Erratum in: Biochemistry 1999 Sep 21;38(38):12526.

PMID:
10090759
30.
31.

Role of arginine 439 in substrate binding of 5-aminolevulinate synthase.

Tan D, Harrison T, Hunter GA, Ferreira GC.

Biochemistry. 1998 Feb 10;37(6):1478-84.

PMID:
9484217
32.

Long-term outcomes after upper limb arterial injuries.

van der Sluis CK, Kucey DS, Brenneman FD, Hunter GA, Maggisano R, ten Duis HJ.

Can J Surg. 1997 Aug;40(4):265-70.

33.

Lower limb compartment syndrome: course after delayed fasciotomy.

Finkelstein JA, Hunter GA, Hu RW.

J Trauma. 1996 Mar;40(3):342-4.

PMID:
8601846
34.
35.
36.

The management of long bone fractures in the head-injured polytrauma patient.

Malisano LP, Stevens D, Hunter GA.

J Orthop Trauma. 1994;8(1):1-5.

PMID:
8169687
37.

Direct muscle neurotization recovers gastrocnemius muscle function.

Mackinnon SE, McLean JA, Hunter GA.

J Reconstr Microsurg. 1993 Mar;9(2):77-80.

PMID:
8468704
38.

Psychological factors leading to amputations in adults.

Hunter GA.

Prosthet Orthot Int. 1992 Dec;16(3):196-9.

PMID:
1491954
39.

Transmission of herpes simplex virus type 1 infection in an intensive care unit.

Perl TM, Haugen TH, Pfaller MA, Hollis R, Lakeman AD, Whitley RJ, Nicholson D, Hunter GA, Wenzel RP.

Ann Intern Med. 1992 Oct 1;117(7):584-6. No abstract available.

PMID:
1524332
40.

Liquefaction and calcification of a chronic compartment syndrome of the lower limb.

Malisano LP, Hunter GA.

J Orthop Trauma. 1992;6(2):245-7.

PMID:
1602347
42.

Method for relating the centre of pressure locus during dynamic stance to the anatomical structure of the foot.

Wevers OT, Hearn TC, Hunter GA, Ala-Korpi T.

Clin Biomech (Bristol, Avon). 1989 May;4(2):111-4. doi: 10.1016/0268-0033(89)90048-X.

PMID:
23916003
43.

Microdialysis studies of brain norepinephrine, serotonin, and dopamine release during ingestive behavior. Theoretical and clinical implications.

Hoebel BG, Hernandez L, Schwartz DH, Mark GP, Hunter GA.

Ann N Y Acad Sci. 1989;575:171-91; discussion 192-3. Review.

PMID:
2699187
44.

Traumatic partial foot amputations in adults. A long-term review.

Millstein SG, McCowan SA, Hunter GA.

J Bone Joint Surg Br. 1988 Mar;70(2):251-4.

PMID:
2894379
45.

The chlordiazepoxide/pentylenetetrazol discrimination: characterization of drug interactions and homeostatic responses to drug challenges.

Michaelis RC, Holohean AM, Criado JR, Harland RD, Hunter GA, Holloway FA.

Psychopharmacology (Berl). 1988;96(1):15-20.

PMID:
3147473
46.

The value of stump split skin grafting following amputation for trauma in adult upper and lower limb amputees.

Wood MR, Hunter GA, Millstein SG.

Prosthet Orthot Int. 1987 Aug;11(2):71-4.

PMID:
3309883
47.

The value of revision surgery after initial amputation of an upper or lower limb.

Wood MR, Hunter GA, Millstein SG.

Prosthet Orthot Int. 1987 Apr;11(1):17-20.

PMID:
3495782
48.

Endogenous adenosine-receptive systems do not mediate the discriminative stimulus properties of ethanol.

Michaelis RC, Holohean AM, Hunter GA, Holloway FA.

Alcohol Drug Res. 1987;7(3):175-85.

PMID:
3827998
49.

Bilateral lower extremity amputations after prolonged application of the pneumatic antishock garment: case report.

McLellan BA, Phillips JH, Hunter GA, Lane PL, Kellam JF, Faclier G.

Can J Surg. 1987 Jan;30(1):55-6.

PMID:
3815184
50.

Naloxone's effects on intake of sequentially presented fluids.

Talanian RV, Hunter GA, Beaman CM, Reichert-Hunter GL, Reid LD.

Pharmacol Biochem Behav. 1986 Sep;25(3):697-700.

PMID:
3774837

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