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Selective neuronal silencing using synthetic botulinum molecules alleviates chronic pain in mice.

Maiarù M, Leese C, Certo M, Echeverria-Altuna I, Mangione AS, Arsenault J, Davletov B, Hunt SP.

Sci Transl Med. 2018 Jul 18;10(450). pii: eaar7384. doi: 10.1126/scitranslmed.aar7384.


The Hypothalamic-Pituitary-Adrenal Axis and Serotonin Metabolism in Individual Brain Nuclei of Mice with Genetic Disruption of the NK1 Receptor Exposed to Acute Stress.

Culman J, Mühlenhoff S, Blume A, Hedderich J, Lützen U, Hunt SP, Rupniak NMJ, Zhao Y.

Cell Mol Neurobiol. 2018 Aug;38(6):1271-1281. doi: 10.1007/s10571-018-0594-5. Epub 2018 Jun 15.


Management of non-tubal ectopic pregnancies at a large tertiary hospital.

Hunt SP, Talmor A, Vollenhoven B.

Reprod Biomed Online. 2016 Jul;33(1):79-84. doi: 10.1016/j.rbmo.2016.03.011. Epub 2016 Apr 19.


Nonparalytic botulinum molecules for the control of pain.

Mangione AS, Obara I, Maiarú M, Geranton SM, Tassorelli C, Ferrari E, Leese C, Davletov B, Hunt SP.

Pain. 2016 May;157(5):1045-55. doi: 10.1097/j.pain.0000000000000478.


Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice.

Obara I, Medrano MC, Signoret-Genest J, Jiménez-Díaz L, Géranton SM, Hunt SP.

Pain. 2015 Aug;156(8):1519-29. doi: 10.1097/j.pain.0000000000000197.


A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R-/- mice(1).

Porter AJ, Pillidge K, Tsai YC, Dudley JA, Hunt SP, Peirson SN, Brown LA, Stanford SC.

Genes Brain Behav. 2015 Feb;14(2):189-99. doi: 10.1111/gbb.12195. Epub 2015 Feb 1.


Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn.

Carr FB, Géranton SM, Hunt SP.

Mol Pain. 2014 Jun 20;10:39. doi: 10.1186/1744-8069-10-39.


Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome.

Sharp SI, McQuillin A, Marks M, Hunt SP, Stanford SC, Lydall GJ, Morgan MY, Asherson P, Curtis D, Gurling HM.

Am J Med Genet B Neuropsychiatr Genet. 2014 Jun;165B(4):373-80. doi: 10.1002/ajmg.b.32241. Epub 2014 May 9.


Axonal protein synthesis and the regulation of primary afferent function.

Obara I, Hunt SP.

Dev Neurobiol. 2014 Mar;74(3):269-78. doi: 10.1002/dneu.22133. Epub 2013 Nov 8. Review.


Synthetic self-assembling clostridial chimera for modulation of sensory functions.

Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B.

Bioconjug Chem. 2013 Oct 16;24(10):1750-9. doi: 10.1021/bc4003103. Epub 2013 Sep 20.


Novel molecular correlates of endocannabinoid-mediated fear-conditioned analgesia in rats.

Olango WM, Géranton SM, Roche M, Hunt SP, Finn DP.

Eur J Pain. 2014 Feb;18(2):182-91. doi: 10.1002/j.1532-2149.2013.00369.x. Epub 2013 Jul 19.


The influence of test experience and NK1 receptor antagonists on the performance of NK1R-/- and wild type mice in the 5-Choice Serial Reaction-Time Task.

Weir RK, Dudley JA, Yan TC, Grabowska EM, Peña-Oliver Y, Ripley TL, Stephens DN, Stanford SC, Hunt SP.

J Psychopharmacol. 2014 Mar;28(3):270-81. doi: 10.1177/0269881113495722. Epub 2013 Jul 11.


The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis.

Sharp SI, Hu Y, Weymer JF, Rizig M, McQuillin A, Hunt SP, Gurling HM.

Psychiatr Genet. 2013 Aug;23(4):153-62. doi: 10.1097/YPG.0b013e32835fe51d.


Antagonism of L-type Ca(v) channels with nifedipine differentially affects performance of wildtype and NK1R-/- mice in the 5-Choice Serial Reaction-Time Task.

Dudley JA, Weir RK, Yan TC, Grabowska EM, Grimmé AJ, Amini S, Stephens DN, Hunt SP, Stanford SC.

Neuropharmacology. 2013 Jan;64:329-36. doi: 10.1016/j.neuropharm.2012.06.056. Epub 2012 Aug 1.


Are biological actions of neurokinin A in the adult brain mediated by a cross-talk between the NK1 and NK2 receptors?

Tauer U, Zhao Y, Hunt SP, Culman J.

Neuropharmacology. 2012 Nov;63(6):958-65. doi: 10.1016/j.neuropharm.2012.06.041. Epub 2012 Jul 6.


A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia.

Rizig MA, McQuillin A, Ng A, Robinson M, Harrison A, Zvelebil M, Hunt SP, Gurling HM.

J Psychopharmacol. 2012 Sep;26(9):1218-30. doi: 10.1177/0269881112450780. Epub 2012 Jul 5.


Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects.

Amadesi S, Reni C, Katare R, Meloni M, Oikawa A, Beltrami AP, Avolio E, Cesselli D, Fortunato O, Spinetti G, Ascione R, Cangiano E, Valgimigli M, Hunt SP, Emanueli C, Madeddu P.

Circulation. 2012 Apr 10;125(14):1774-86, S1-19. doi: 10.1161/CIRCULATIONAHA.111.089763. Epub 2012 Mar 5.


The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states.

Tochiki KK, Cunningham J, Hunt SP, Géranton SM.

Mol Pain. 2012 Feb 27;8:14. doi: 10.1186/1744-8069-8-14.


Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression.

Roche M, Kerr DM, Hunt SP, Kelly JP.

Behav Brain Res. 2012 Mar 1;228(1):91-8. doi: 10.1016/j.bbr.2011.11.035. Epub 2011 Dec 6.


Axonal protein synthesis: a potential target for pain relief?

Obara I, Géranton SM, Hunt SP.

Curr Opin Pharmacol. 2012 Feb;12(1):42-8. doi: 10.1016/j.coph.2011.10.005. Epub 2011 Oct 25. Review.


Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice.

Obara I, Tochiki KK, Géranton SM, Carr FB, Lumb BM, Liu Q, Hunt SP.

Pain. 2011 Nov;152(11):2582-95. doi: 10.1016/j.pain.2011.07.025. Epub 2011 Sep 13.


Performance deficits of NK1 receptor knockout mice in the 5-choice serial reaction-time task: effects of d-amphetamine, stress and time of day.

Yan TC, Dudley JA, Weir RK, Grabowska EM, Peña-Oliver Y, Ripley TL, Hunt SP, Stephens DN, Stanford SC.

PLoS One. 2011 Mar 7;6(3):e17586. doi: 10.1371/journal.pone.0017586.


Altered host response to murine gammaherpesvirus 68 infection in mice lacking the tachykinin 1 gene and the receptor for substance P.

Quinn JP, Kipar A, Hughes DJ, Bennett E, Cox H, McLaughlin L, Zimmer A, Hunt SP, Stewart JP.

Neuropeptides. 2011 Feb;45(1):49-53. doi: 10.1016/j.npep.2010.10.004. Epub 2010 Nov 23.


Involvement of preprotachykinin A gene-encoded peptides and the neurokinin 1 receptor in endotoxin-induced murine airway inflammation.

Helyes Z, Elekes K, Sándor K, Szitter I, Kereskai L, Pintér E, Kemény A, Szolcsányi J, McLaughlin L, Vasiliou S, Kipar A, Zimmer A, Hunt SP, Stewart JP, Quinn JP.

Neuropeptides. 2010 Oct;44(5):399-406. doi: 10.1016/j.npep.2010.05.004. Epub 2010 Jun 25.


Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice.

Thorsell A, Schank JR, Singley E, Hunt SP, Heilig M.

Psychopharmacology (Berl). 2010 Mar;209(1):103-11. doi: 10.1007/s00213-010-1775-1. Epub 2010 Jan 30.


A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states.

Géranton SM, Jiménez-Díaz L, Torsney C, Tochiki KK, Stuart SA, Leith JL, Lumb BM, Hunt SP.

J Neurosci. 2009 Nov 25;29(47):15017-27. doi: 10.1523/JNEUROSCI.3451-09.2009.


Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.

Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M.

Alcohol. 2009 Nov;43(7):491-8. doi: 10.1016/j.alcohol.2009.08.003. Review.


Behavioural and neurochemical abnormalities in mice lacking functional tachykinin-1 (NK1) receptors: a model of attention deficit hyperactivity disorder.

Yan TC, Hunt SP, Stanford SC.

Neuropharmacology. 2009 Dec;57(7-8):627-35. doi: 10.1016/j.neuropharm.2009.08.021. Epub 2009 Sep 10. Review.


Genes and the dynamics of pain control.

Hunt SP.

Funct Neurol. 2009 Jan-Mar;24(1):9-15. Review.


Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.

Lever IJ, Robinson M, Cibelli M, Paule C, Santha P, Yee L, Hunt SP, Cravatt BF, Elphick MR, Nagy I, Rice AS.

J Neurosci. 2009 Mar 25;29(12):3766-80. doi: 10.1523/JNEUROSCI.4071-08.2009.


NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD.

Yan TC, McQuillin A, Thapar A, Asherson P, Hunt SP, Stanford SC, Gurling H.

J Psychopharmacol. 2010 Jan;24(1):27-38. doi: 10.1177/0269881108100255. Epub 2009 Feb 9.


Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.

Inglis JJ, McNamee KE, Chia SL, Essex D, Feldmann M, Williams RO, Hunt SP, Vincent T.

Arthritis Rheum. 2008 Oct;58(10):3110-9. doi: 10.1002/art.23870.


Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons.

Tebar LA, Géranton SM, Parsons-Perez C, Fisher AS, Bayne R, Smith AJ, Turmaine M, Perez-Luz S, Sheasby A, De Felipe C, Ruff C, Raivich G, Hunt SP.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11400-5. doi: 10.1073/pnas.0711978105. Epub 2008 Aug 4.


Reg-2 expression in dorsal root ganglion neurons after adjuvant-induced monoarthritis.

Averill S, Inglis JJ, King VR, Thompson SW, Cafferty WB, Shortland PJ, Hunt SP, Kidd BL, Priestley JV.

Neuroscience. 2008 Sep 9;155(4):1227-36. doi: 10.1016/j.neuroscience.2008.06.049. Epub 2008 Jul 1.


Selective ablation of dorsal horn NK1 expressing cells reveals a modulation of spinal alpha2-adrenergic inhibition of dorsal horn neurones.

Rahman W, Suzuki R, Hunt SP, Dickenson AH.

Neuropharmacology. 2008 Jun;54(8):1208-14. doi: 10.1016/j.neuropharm.2008.03.014. Epub 2008 Apr 8.


Differential display of mRNA by PCR.

Livesey FJ, Hunt SP.

Curr Protoc Hum Genet. 2001 May;Chapter 11:Unit 11.5. doi: 10.1002/0471142905.hg1105s10.


Local translation in primary afferent fibers regulates nociception.

Jiménez-Díaz L, Géranton SM, Passmore GM, Leith JL, Fisher AS, Berliocchi L, Sivasubramaniam AK, Sheasby A, Lumb BM, Hunt SP.

PLoS One. 2008 Apr 9;3(4):e1961. doi: 10.1371/journal.pone.0001961.


Genetic background influences the behavioural and molecular consequences of neurokinin-1 receptor knockout.

McCutcheon JE, Fisher AS, Guzdar E, Wood SA, Lightman SL, Hunt SP.

Eur J Neurosci. 2008 Feb;27(3):683-90. doi: 10.1111/j.1460-9568.2008.06043.x.


Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.

George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt JE, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M.

Science. 2008 Mar 14;319(5869):1536-9. doi: 10.1126/science.1153813. Epub 2008 Feb 14.


Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice.

Pavlovic S, Daniltchenko M, Tobin DJ, Hagen E, Hunt SP, Klapp BF, Arck PC, Peters EM.

J Invest Dermatol. 2008 Feb;128(2):434-46. Epub 2007 Oct 4.


Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation.

Jones S, Tucker KL, Sage T, Kaiser WJ, Barrett NE, Lowry PJ, Zimmer A, Hunt SP, Emerson M, Gibbins JM.

Blood. 2008 Jan 15;111(2):605-12. Epub 2007 Sep 25.


Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex.

Guiard BP, Guilloux JP, Reperant C, Hunt SP, Toth M, Gardier AM.

Mol Pharmacol. 2007 Dec;72(6):1411-8. Epub 2007 Sep 21.


Superficial NK1 expressing spinal dorsal horn neurones modulate inhibitory neurotransmission mediated by spinal GABA(A) receptors.

Rahman W, Sikandar S, Suzuki R, Hunt SP, Dickenson AH.

Neurosci Lett. 2007 Jun 4;419(3):278-83. Epub 2007 Apr 22. Erratum in: Neurosci Lett. 2008 Apr 4;434(3):315. Sikander, Shafaq [corrected to Sikandar, Shafaq].


Experimental acute pancreatitis in PAP/HIP knock-out mice.

Gironella M, Folch-Puy E, LeGoffic A, Garcia S, Christa L, Smith A, Tebar L, Hunt SP, Bayne R, Smith AJ, Dagorn JC, Closa D, Iovanna JL.

Gut. 2007 Aug;56(8):1091-7. Epub 2007 Apr 4.

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